Title: Antitussive Properties of Inhaled Bronchodilators on Induced Cough
Abstract: We have studied the antitussive effects of two anticholinergic agents, oxitropium bromide (200 μg) and ipratropium bromide (80 μg), and a combined beta-agonist and anticholinergic preparation containing fenoterol hydrobromide (200 μg) and ipratropium bromide (80 μg), in 16 normal and ten asthmatic volunteers in a double-blind, randomized, placebo-controlled crossover trial. Cough was induced by inhalation of ultrasonically nebulized distilled water and hypotonic saline solution. All treatments significantly reduced the cough response to inhaled distilled water aerosol when compared with placebo (p<0.001). There was no difference between oxitropium bromide and ipratropium bromide (p>0.05), but the combination preparation displayed a greater antitussive effect than either oxitropium bromide (p<0.05) or ipratropium bromide (p<0.025). Cough frequencies in response to hypotonic 0.18 and 0.32 percent saline aerosol were lower than those obtained with distilled water (p<0.005) for all treatments. Asthmatic patients coughed less frequently than normal volunteers in response to all solutions when placebo was given (p<0.05), but there is no evidence to suggest that the response to treatment was different in the two groups. Our results suggest that inhaled anticholinergic bronchodilators alone or in combination with beta2-adrenergic agonists might be effective in the treatment of pathologic cough. We have studied the antitussive effects of two anticholinergic agents, oxitropium bromide (200 μg) and ipratropium bromide (80 μg), and a combined beta-agonist and anticholinergic preparation containing fenoterol hydrobromide (200 μg) and ipratropium bromide (80 μg), in 16 normal and ten asthmatic volunteers in a double-blind, randomized, placebo-controlled crossover trial. Cough was induced by inhalation of ultrasonically nebulized distilled water and hypotonic saline solution. All treatments significantly reduced the cough response to inhaled distilled water aerosol when compared with placebo (p<0.001). There was no difference between oxitropium bromide and ipratropium bromide (p>0.05), but the combination preparation displayed a greater antitussive effect than either oxitropium bromide (p<0.05) or ipratropium bromide (p<0.025). Cough frequencies in response to hypotonic 0.18 and 0.32 percent saline aerosol were lower than those obtained with distilled water (p<0.005) for all treatments. Asthmatic patients coughed less frequently than normal volunteers in response to all solutions when placebo was given (p<0.05), but there is no evidence to suggest that the response to treatment was different in the two groups. Our results suggest that inhaled anticholinergic bronchodilators alone or in combination with beta2-adrenergic agonists might be effective in the treatment of pathologic cough.
Publication Year: 1988
Publication Date: 1988-06-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 50
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