Title: THE RELATIONSHIP BETWEEN THE IN VITRO AND THE IN VIVO ACTIVITY OF SULFONAMIDE COMPOUNDS
Abstract: A qualitative comparison of the in vitro and in vivo activity on β-hemo1ytic streptococcus of 126 compounds consisting of sulfanilamide derivatives, sulfonamides, suifones, sulfoxides, sulfides and certain miscellaneous compounds has been made. It has been shown that no compound is active in vivo unless it is active in vitro or can be decomposed in the animal body to a compound which would be active in vitro , and that compounds can be active in vitro but inactive in vivo.
Publication Year: 1941
Publication Date: 1941-05-01
Language: en
Type: article
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Cited By Count: 3
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