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376, 396, 410, 412, 424, 434, 449, 453, 456, 458, 485, 495, 557, 571, 585, 616, 641, 654, 657, 676, 754, 786, 798, 829, 850, 856, 859, 912, 916, 925, 1024, 1146, 1181, 1195, 1212, 1249, 1260, 1275, 1280, 1292, 1314, 1333, 1346, 1353, 1411, 1453, 1470, 1484, 1491, 1521, 1536, 1546, 1555, 1572, 1582, 1609, 1647, 1678, 1697, 1710, 1743, 1758, 1773, 1794, 1802, 1805, 1815, 1825, 1828, 1834, 1845, 1849, 1858, 1862, 1915, 2026, 2069, 2080, 2121, 2157, 2269, 2317, 2431, 2446, 2453, 2457, 2467, 2477, 2509, 2599, 2617, 2662, 2757, 2763, 2821, 2834, 2865, 2873, 2924, 2992, 3028, 3061, 3105, 3116, 3120, 3183, 3200, 3279, 3285, 3312, 3317, 3386, 3394, 3403, 3440, 3448, 3517, 3611, 3629, 3664, 3724, 3734, 3832, 3838, 3970, 4057, 4067, 4116, 4187, 4219, 4292, 4335, 4343], 'Cardiac': [52, 67, 82, 683, 1357, 1859, 2712, 3794, 4013, 4338], 'Physiology,': [53, 68, 83, 1860, 3630, 3738, 4228, 4243, 4296], 'University': [54, 69, 84, 1861], 'Manchester,': [56, 71, 86, 1863], 'United': [57, 72, 87, 1874], 'Kingdom.': [58, 73, 88, 1875], ',': [59, 3626, 4289], 'CaldwellJessica': [61], 'TraffordAndrew': [76], 'Originally': [89, 4371], 'published27': [90], 'Sep': [91], '2013https://doi.org/10.1161/CIRCRESAHA.113.302187Circulation': [92], 'Research.': [93], '2013;113:958–961Relation': [94], 'Between': [95], 'Myocardial': [96, 3482, 3493], 'Function': [97, 354, 3519], 'Expressionof': [99], 'Sarcoplasmic': [100, 3687], 'Ca2+-ATPase': [102, 1917, 1984, 2029, 2868, 2949, 3123], 'in': [103, 131, 146, 169, 184, 211, 225, 242, 266, 278, 325, 338, 352, 355, 367, 379, 391, 463, 468, 562, 637, 667, 690, 716, 782, 795, 812, 880, 937, 946, 970, 978, 1010, 1063, 1088, 1106, 1128, 1140, 1178, 1201, 1208, 1228, 1356, 1363, 1368, 1433, 1464, 1479, 1531, 1563, 1600, 1634, 1644, 1716, 1752, 1780, 1838, 1886, 1891, 1922, 1951, 1987, 2030, 2049, 2075, 2117, 2191, 2208, 2214, 2250, 2282, 2326, 2384, 2460, 2514, 2556, 2604, 2630, 2672, 2760, 2794, 2824, 2857, 2869, 2921, 2952, 2994, 3020, 3064, 3108, 3124, 3196, 3348, 3490, 3520, 3573, 3617, 3660, 3692, 3790, 3924, 4119, 4184, 4222, 4227, 4235, 4283, 4340], 'Failingand': [104], 'Nonfailing': [105], 'Human': [106, 3350, 4009], 'MyocardiumHasenfuss': [107], 'et': [108, 204, 270, 510, 1076, 1661], 'alCirc': [109], 'Res.': [110, 1894, 1959, 2036, 2054, 2083, 2217, 2330, 2357, 2769], '1994;75:434–442.This': [111], 'article': [112, 210, 327, 1840], 'reflects': [113], 'on': [114, 141, 160, 255, 402, 630, 1042, 1152, 1746, 2512, 2601, 3193, 3944, 4177], 'impact': [116, 1742], 'a': [118, 152, 170, 182, 207, 346, 422, 454, 506, 569, 582, 638, 668, 696, 780, 789, 848, 853, 920, 965, 1134, 1144, 1193, 1247, 1272, 1289, 1450, 1461, 1468, 1499, 1532, 1708, 1753, 1822, 2619, 2626, 2673, 2719, 2870, 2922, 2953, 3069, 3112, 3282, 3389, 3491, 3657, 4064, 4126, 4341], 'classic': [119, 209, 1759, 1765], 'paper': [120], 'identifying': [121], 'effects': [123, 137, 401, 1151, 2616, 4218], 'loss': [125, 285], 'sarcoplasmic': [127, 189, 222, 702, 1982, 2027, 2204, 2322, 2380, 2663, 2789, 2866, 2913, 2947, 3121], 'reticulum': [128, 190, 223, 703, 1983, 2028, 2205, 2323, 2381, 2664, 2790, 2867, 2914, 2948, 3122, 3758, 4170], 'activity': [130, 239, 388, 619, 895, 963, 1009, 1052, 1060, 1113, 1200, 2048, 2277, 4282], 'heart': [132, 139, 148, 166, 243, 267, 339, 368, 377, 392, 464, 563, 642, 691, 799, 851, 938, 971, 1065, 1129, 1182, 1202, 1378, 1465, 1537, 1564, 1648, 1957, 1993, 2052, 2081, 2124, 2215, 2252, 2283, 2328, 2387, 2435, 2517, 2557, 2606, 2634, 2675, 2874, 2926, 2954, 3128, 3202, 3242, 3313, 3618, 3666, 3766, 3899, 3971, 4072, 4220], 'failure.The': [133, 2518], 'Classic': [134], 'ArticleUnderstanding': [135], 'failure': [140, 167, 340, 369, 378, 643, 800, 972, 1130, 1379, 1538, 2436, 2558, 2607, 2635, 2676, 2955, 3314, 3619, 3767, 4221], 'contraction': [142, 2115], 'Ca': [144, 178, 322, 403, 415, 427, 437, 459, 478, 539, 591, 608, 658, 684, 712, 720, 733, 740, 784, 1156, 1160, 1222, 1262], 'signaling': [145, 460, 981, 1005, 2249, 3572], 'has': [149, 328, 398, 445, 492, 896, 933, 990, 1306, 1318], 'long': [150], 'been': [151, 874, 897, 935, 991, 1232, 1428], 'priority.': [153], 'By': [154, 1808, 3254], 'late': [156], '1980s,': [157], 'many': [158, 548], 'studies': [159, 375, 549, 948, 1147, 1658], 'animal': [161], 'models': [162, 1180], 'had': [163, 233, 247, 319, 518], 'shown': [164, 234, 248, 446, 552, 1149], 'that': [165, 235, 249, 273, 386, 447, 461, 513, 553, 651, 1047, 1189, 1257, 1284, 1455, 1474, 1551, 1663, 1724, 1768, 1788], 'resulted': [168], 'slowing': [171], 'decay': [174, 411], 'systolic': [177, 414, 436, 544, 597], 'transient1': [179], 'because': [180, 911, 1211], 'decrease': [183, 395, 431, 475, 537, 781, 1291], 'expression': [186, 220, 237, 366, 487, 844, 1087, 1097, 1105, 1336, 1459, 1562, 1584, 1921, 1986, 2025, 2072, 3568, 3728], '(SR)': [191], '(SERCA).2': [193], 'Work': [194], 'using': [195, 1094, 1607], 'human': [196, 229, 1091, 1989, 2034, 2159, 2829], 'tissue': [197], 'found': [198, 650], 'similar': [199, 921], 'changes.3,4': [200], 'In': [201, 305, 505, 593, 919, 998, 1099, 1120], '1994,': [202], 'Hasenfuss': [203, 269, 509, 1660, 2000, 2130], 'al5': [205, 271], 'published': [206, 1715], 'now': [208, 551], 'Circulation': [212, 1698, 1705, 1734, 1816, 3927], 'Research': [213, 1699, 1706, 1735, 2521], 'entitled': [214], '"Relation': [215], 'between': [216, 2021, 2149], 'myocardial': [217, 1163, 1229, 1605, 1916, 2022, 2731, 2765, 2960, 3018, 3194], 'function': [218, 337, 521, 545, 846, 867, 1395, 2023, 2074, 2156, 2665, 2823, 2945, 3319], 'failing': [226, 317, 1090, 1107, 2031, 2158, 2192, 2828], 'non-failing': [228], 'myocardium."': [230], 'Previous': [231, 3248], 'work': [232, 246, 324, 444, 860], 'SERCA': [236, 293, 344, 365, 387, 397, 450, 618, 770, 787, 837, 843, 866, 881, 894, 926, 962, 1008, 1059, 1067, 1086, 1103, 1166, 1199, 1315, 1365, 1457, 1561, 4281], 'were': [240, 678, 956, 1078, 1361], 'decreased': [241, 390, 617, 769, 836, 842, 1273, 4280], 'failure.': [244, 268, 393, 465, 692, 764, 939, 1203, 1649], 'Other': [245], 'increase': [251, 484, 879, 889, 1054, 1085, 1198, 1207, 1259, 1265, 1569], 'force': [253, 296], 'seen': [254, 1139], 'increasing': [256, 1048, 1102], 'frequency': [258], 'stimulation': [260, 924], '(the': [261], 'positive': [262, 1135, 1423], 'force–frequency': [263, 280, 314, 1124, 1136], 'curve)': [264], 'disappeared': [265], 'showed': [272, 512], 'degree': [275], 'change': [277], 'relationship': [281], 'correlated': [282], 'with': [283, 289, 302, 515, 525, 604, 927, 1114, 1338, 1371, 1382, 1504, 1507, 1552, 1675, 1955, 2462, 2633, 3126, 3396, 3620, 3697, 4121, 4285], 'SERCA.': [287], 'Hearts': [288], 'low': [290, 1543], 'levels': [291, 1056, 2153], 'developed': [294], 'maximum': [295], 'at': [297, 1396, 1420, 1811], 'lower': [298, 526], 'frequencies': [299], 'than': [300, 522], 'those': [301, 524, 1844], 'higher': [303], 'levels.': [304], 'addition,': [306, 1121], 'suggested': [308], 'as': [309, 345, 421, 568, 620, 739, 788, 847, 964, 1138, 1192, 1246, 1494, 3281, 3388], 'causative': [310], 'reduced': [313, 320, 500, 1159, 1500, 2379, 3623, 3698], 'responses,': [315], 'hearts': [318, 2830, 3023], 'SERCA-mediated': [321], 'uptake.The': [323], 'this': [326, 857, 1038, 1100, 1829, 1839], 'influenced': [329], '2': [330, 399, 470, 1405, 1515, 2716, 3114, 4173, 4273, 4275], 'areas': [331], 'research:': [333], 'changes': [334, 363, 448, 457, 675, 689, 777], 'SR': [336, 426, 477, 538, 590, 746, 748, 783, 1261], 'restoration': [342], 'therapeutic': [347], 'strategy.': [348], 'We': [349], 'consider': [350], 'these': [351, 776, 999, 1485, 1629, 1744], 'turn.SR': [353], 'FailureTwenty': [357], 'years': [358], 'later,': [359], 'role': [361], 'is': [370, 389, 482, 560, 741, 1040, 1256, 1271, 1445, 1449, 1460, 1549, 1652, 1684, 1760, 1766, 1787, 1797, 2355], 'well-established.': [371], 'The': [372, 613, 707, 719, 1252, 1756, 3181, 3627, 3836, 4134], 'majority': [373], 'either': [380, 1169], 'humans': [381], 'or': [382, 488, 574, 752, 811, 845, 1174, 1612, 1616, 1848], 'experimental': [383, 947, 1064, 1887], 'animals': [384], 'show': [385, 695, 1408], 'This': [394, 490, 565, 576, 1317], 'immediate': [400], 'signaling.': [404], 'First,': [405, 480], 'it': [406, 429, 535, 648, 1651], 'slows': [407], 'rate': [409], 'transient,': [416], 'thereby': [417, 502, 542, 587], 'impairing': [418], 'relaxation.': [419, 504, 1119], 'Second,': [420, 547], 'consequence': [423, 1194], 'decreasing': [425, 588, 596], 'content,': [428], 'will': [430, 473, 536, 579, 1639], 'amplitude': [433], 'transient': [438], 'thus': [440], 'contraction.': [441], 'However,': [442, 528, 940, 1226, 1628], 'subsequent': [443, 507], 'are': [451, 1185, 1486, 1631, 1737, 1841, 4020, 4214], 'part': [452], 'group': [455, 1305], 'occur': [462, 567], 'As': [466], 'highlighted': [467, 1786], 'Figure,': [469], 'other': [471], 'factors': [472], 'also': [474, 602, 934, 974], 'content.': [479, 592], 'there': [481, 1270, 1448], 'an': [483, 878, 913, 1095, 1206, 1325, 1413, 1441, 1777, 2076, 2118], 'NCX': [486, 517, 531, 624, 677, 758], 'activity.6–8': [489], 'adaptation': [491], 'benefit': [494, 1556], 'making': [496], 'up': [497], 'for': [498, 834, 1215, 1310, 1597, 2426, 2441, 3309, 3391, 3524, 3528, 3765, 4063, 4070], 'SERCA,': [501], 'preserving': [503], 'article,': [508], 'al9': [511], 'patients': [514, 1369, 1577, 1954, 2631, 3125, 4120], 'increased': [516, 530, 561, 577, 623, 664, 773, 914, 1007, 1115, 1221], 'better': [519], 'diastolic': [520, 533, 583, 2155, 2602], 'did': [523, 1406], 'NCX.': [527, 774], 'although': [529], 'improves': [532], 'function,': [534, 598], 'content': [540, 1263, 2354, 2383], 'depress': [543], 'further.': [546], 'have': [550, 873, 973, 1148, 1231, 1425, 1665, 1703, 1725, 1790], 'open': [555, 730, 2343], 'probability': [556, 2344], 'RyR': [559, 626], 'failure.10–12': [564], 'may': [566, 601, 628, 815, 1190, 1235, 1585], 'result': [570, 1248], 'phosphorylation,10': [572], 'hyponitrosylation,13': [573], 'oxidation.14': [575], 'opening': [578], 'lead': [580, 1586], 'leak': [584, 600, 627, 2207, 2281, 2325, 2377, 2916], 'Ca,': [586], 'addition': [594], 'interfere': [603], 'relaxation': [605], 'by': [606, 645, 747, 757, 1224, 1350, 1659, 1686, 1731, 1749, 2274, 2473, 2559, 2666, 2831, 2958, 3058, 3102, 3320, 4113], 'opposing': [607], 'reuptake': [609], 'into': [610, 734, 744, 1324], 'SR.15': [612], 'relative': [614], 'importance': [615], 'opposed': [621], 'depend': [629], 'exact': [632], 'model': [633, 640, 2079, 2120, 2762, 2872, 2923, 2956, 3199], 'used.': [634], 'For': [635], 'example,': [636, 835], 'canine': [639, 2050, 2386], 'induced': [644, 1610, 2123, 2957], 'rapid': [646], 'pacing,16': [647], 'was': [649, 861, 1131, 1380], 'bulk': [653], 'problems': [656, 1188, 1472], 'handling': [659, 1885, 1950, 2722, 3613], 'could': [660, 1603], 'be': [661, 909, 1477, 1785], 'attributed': [662, 1415], 'leak,': [665], 'whereas': [666], 'rabbit': [669, 2078, 2996], 'model,': [670], 'aortic': [671], 'insufficiency': [672], 'stenosis': [674], 'most': [679, 987, 1799], 'important.11Download': [680], 'figureDownload': [681], 'PowerPointFigure.': [682], 'cycling': [685, 1157, 2555, 4212], 'showing': [686, 1046], 'important': [688, 1778], 'Both': [693], 'parts': [694], 'transverse': [697], '(T)': [698], 'tubule,': [699], 'surface': [700], 'membrane,': [701], '(SR),': [704], 'myofilaments.': [706], 'action': [708], 'potential': [709, 1187, 1471, 3829], 'opens': [710], 'L-type': [711], 'channels': [713], '(1)': [714], 'located': [715], 'T-tubules.': [718], 'entering': [721], 'binds': [722], 'RyRs': [725], '(2),': [726], 'causing': [727], 'them': [728, 1751], 'release': [732, 2185], 'cytoplasm.': [736], 'Relaxation': [737], 'occurs': [738], 'pumped': [742], 'back': [743, 1673, 1810], '(SERCA;': [750], '3)': [751], 'out': [753], 'cell': [756, 3150, 3191], '(4).': [759], 'A,': [760, 1901, 2237, 2299, 2362, 2396, 2406, 2415, 2417, 2817, 2849, 3093, 3140, 3711, 3806, 3865, 3996, 4043, 4092, 4094, 4098, 4102, 4148, 4159, 4200, 4260], 'Control.': [761], 'B,': [762, 2009, 2139, 2982, 3047, 3083, 3091, 3219, 3649, 3875, 4035, 4084, 4100, 4305], 'Note': [765], 'leaky': [767], 'RyR,': [768], 'activity,': [771], 'All': [775], 'contribute': [778], 'content.Restoration': [785], 'Therapeutic': [790], 'StrategyThe': [791], 'first-choice': [792], 'drugs': [793], 'used': [794, 809, 875], 'management': [797], 'include': [801, 1205], 'β-blockers,': [802], 'ACE': [803], 'inhibitors,': [804, 3323], 'aldosterone': [806], 'antagonists.17': [807], 'When': [808], 'individually': [810], 'combination,': [813], 'they': [814, 822, 1789], 'prolong': [816], 'life': [817], 'relieve': [819], 'symptoms,': [820], 'but': [821, 1033, 4345], 'do': [823], 'not': [824, 1034, 1407, 1842, 2347], 'correct': [825], 'underlying': [827], 'causes': [828], 'contractile': [830, 2822], 'dysfunction,': [831], 'such': [832, 1281], 'as,': [833], 'function.': [838, 882], 'Therefore,': [839], 'having': [840, 1511], 'identified': [841], 'hallmark': [849], 'failure,': [852, 1466, 1565, 3667, 3900, 4073], 'logical': [854], 'extension': [855], 'body': [858, 1452], 'attempt': [863, 1082], 'restore': [865], 'improve': [869, 968], 'contractility.': [870, 1251], 'Several': [871], 'strategies': [872], 'achieve': [877], 'Of': [883, 983, 1401], 'these,': [884, 984], 'pharmacological': [885, 923], 'phosphodiesterase': [886], 'inhibition': [887, 1002], 'cAMP': [890, 1055], 'availability': [891, 1571], 'hence': [893], 'translated': [898], 'from': [899, 1298, 1343, 1557, 1654, 1668, 1680, 1688, 1953, 2182, 2212, 2610, 2827, 3237, 3575, 3948, 4238], 'laboratory': [901, 1301], 'setting': [902, 1646], 'clinical': [904, 951, 954, 1020, 1312, 3073, 4065], 'trial': [905, 1360, 1444, 2629, 3115, 4066], 'stages,': [906], 'only': [907], 'withdrawn': [910], 'incidence': [915, 2991], 'sudden': [917], 'death.18': [918], 'vein,': [922], 'Na/K': [929], 'ATPase': [930, 1112, 4172], 'antagonist': [931], 'istaroxime19–21': [932], 'pursued': [936], 'once': [941], 'again,': [942], 'after': [943, 1165, 1399, 1430, 2730, 2862, 2946, 3243], 'initial': [944, 1300, 1435], 'promise': [945], 'early': [950, 1656], 'trials,': [952], 'substantive': [953], 'trials': [955, 1313, 1559], 'suspended.Other': [957], 'indirect': [958], 'approaches': [959, 1567], 'modulate': [961], 'means': [966], 'contractility': [969, 1062, 1116], 'targeted': [975], 'various': [976], 'points': [977], 'β-adrenergic': [980, 2110], 'cascade.': [982], 'perhaps': [985, 1617], 'extensively': [988], 'studied': [989], 'G-protein': [993], 'receptor': [994, 2272, 2342, 2714], 'kinase': [995, 2715], 'GRK2': [996, 2758], '(βARK).22,23': [997], 'studies,': [1000, 1302], 'GRK': [1001], 'restored': [1003], 'β-adrenoceptor': [1004], 'response': [1011, 1125, 1137, 1502, 1923], 'catecholamine': [1013], 'stimulation.': [1014], 'A': [1015, 3303, 3476, 3701, 3717, 3828, 3918, 3941, 3964, 4206], 'further': [1016], 'approach': [1017, 1593], 'currently': [1018, 1446], 'undergoing': [1019], 'evaluation': [1021], 'includes': [1022], 'upregulation': [1023, 3057, 3101, 4112], 'adenylyl': [1025, 1049], 'cyclase': [1026, 1050, 2784], 'VI': [1027, 1051, 2786], 'through': [1028], 'adenoviral-based': [1029], 'gene': [1030, 1167, 1335, 1366, 1458, 1583, 1598, 1985, 2755, 2832, 2863, 2910, 2950, 3062, 3106, 3118, 4068, 4117], 'delivery': [1031, 1367, 1495], '(recruiting': [1032], 'yet': [1035], 'reported).': [1036], 'Again,': [1037], 'study': [1039], 'based': [1041], 'extensive': [1043], 'preclinical': [1044], 'data': [1045], 'would': [1053], 'and,': [1057, 1506], 'hence,': [1058], 'failure.24Targeting': [1066], 'Directly—From': [1068], 'Bench': [1069], 'Clinical': [1071], 'TrialIn': [1072], '1999,': [1073], 'del': [1074, 2801, 2839, 2972], 'Monte': [1075, 2802, 2840, 2973], 'al25': [1077], 'first': [1080], 'directly': [1084], 'single': [1089], 'ventricular': [1092, 1394, 2210, 2919, 2997], 'myocytes': [1093, 1108, 2211], 'adenoviral': [1096], 'system.': [1098], 'study,': [1101], 'protein': [1104, 2152, 3659, 4181], 'led': [1109], 'enhanced': [1111, 1588], 'accelerated': [1118], 'blunted': [1123], 'ordinarily': [1126], 'observed': [1127], 'converted': [1132], 'healthy': [1141], 'cells.': [1142], 'Subsequently,': [1143], 'number': [1145, 1469], 'beneficial': [1150, 3026], 'cardiac': [1153, 1513, 1626, 2788, 2860, 2944, 3065, 3109, 3158, 3318, 3436, 3730, 3833, 3894, 3945, 4122], 'structure,': [1154], 'contractility,': [1155, 3731], '(including': [1158], 'leak),': [1161], 'energetics': [1164, 1230, 3019], 'delivery,': [1168], 'via': [1170, 1175], 'direct': [1171], 'intramyocardial': [1172], 'injection': [1173], 'coronary': [1176], 'perfusion,': [1177], 'diverse': [1179], 'failure.26–29': [1183], 'There': [1184], 'several': [1186], 'arise': [1191], 'attempts': [1196], 'These': [1204], 'energy/oxygen': [1209], 'demand': [1210], 'requirement': [1214], 'ATP': [1216], 'hydrolysis': [1217], 'drive': [1219], 'transport': [1223], 'SERCA.30': [1225], 'improvements': [1227], 'reported26': [1233], 'reflect': [1236], 'improved': [1238, 1250, 1383], 'blood': [1239], 'supply': [1240], 'myocardium': [1243, 1952], 'oxygenation': [1245], 'second': [1253], 'major': [1254, 1516], 'concern': [1255], 'might': [1264], 'Ca-dependent': [1266], 'arrhythmias.': [1267], 'Interestingly,': [1268], 'however,': [1269], 'incidence29': [1274], 'aftercontractions,': [1276], 'cellular': [1278], 'correlate': [1279], 'arrhythmias,': [1282], 'suggesting': [1283], 'reverse': [1286], 'remodeling': [1287, 2729], 'produced': [1288], 'compensatory': [1290], 'arrhythmogenic': [1293, 2077, 2349], 'potential.After': [1294], 'promising': [1296], 'results': [1297, 2609], 'Hajjar': [1304, 2818, 2854, 2899, 2983, 3054, 3098, 4050], 'paved': [1307], 'way': [1309], 'in-human': [1311], 'expression.': [1316], 'involved': [1319], 'repackaging': [1320], 'original': [1322, 1340], 'vectors': [1323, 1493, 1526], 'adeno-associated': [1326, 1492, 1525, 1547], 'vector': [1327], 'overcome': [1329, 1478], 'proinflammatory': [1330], 'persistence': [1332], 'target': [1334], 'issues': [1337, 1487], 'adenoviruses.': [1341], 'Results': [1342], 'phase': [1344, 1436, 3071, 3113, 4131], 'I': [1345], 'Calcium': [1348, 3056, 3100, 3788, 3920, 4111, 4234], 'Upregulation': [1349, 2068], 'Percutaneous': [1351], 'Administration': [1352], 'Gene': [1354, 3690, 4074], 'Therapy': [1355, 3691], 'Disease': [1358, 3772, 3793], '(CUPID)': [1359], 'reported': [1362, 1429], '2009.31': [1364], 'enrolled': [1370], 'New': [1372, 1387], 'York': [1373, 1388], 'Association': [1375, 1390, 2466], 'class': [1376], 'III/IV': [1377], 'associated': [1381], '6-minute': [1384], 'walk': [1385], 'tests,': [1386], 'classification,': [1391], 'left': [1393], '6': [1397, 1722, 4230], 'months': [1398], 'treatment.': [1400], 'surviving': [1403], 'patients,': [1404, 1539], 'any': [1409], 'form': [1410, 1623], 'improvement,': [1412], 'effect': 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