Title: The Helix-Loop-Helix Inhibitor Id2 and Cell Differentiation Control
Abstract: Transcription factors play pivotal roles not only in the regulation of cellular functions but also in the control of cell differentiation. They can be classified on the basis of their structural features, i.e. motifs that mediate functional properties such as DNA binding and protein-protein interactions. The family of helix-loop-helix (HLH) factors is one of the well-studied examples [1-3]. Most members have DNA binding activity and directly regulate the expression of their downstream genes. Some, however, do not bind DNA and negatively regulate the functions of other HLH transcription factors at the protein level [4, 5]. These HLH inhibitors are called Id, inhibitor of DNA binding/differentiation [4, 5]. Here we focus on and describe the immunological aspects of mice lacking Id2.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 12
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