Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2115797273', 'doi': 'https://doi.org/10.1073/pnas.151253498', 'title': 'Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining', 'display_name': 'Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining', 'publication_year': 2001, 'publication_date': '2001-07-10', 'ids': {'openalex': 'https://openalex.org/W2115797273', 'doi': 'https://doi.org/10.1073/pnas.151253498', 'mag': '2115797273', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11447276', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/37489'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.151253498', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1073/pnas.151253498', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100532486', 'display_name': 'Fen Xia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106595', 'display_name': 'Sidney Kimmel Cancer Center', 'ror': 'https://ror.org/010h6g454', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106595']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fen Xia', 'raw_affiliation_strings': ['Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107', 'institution_ids': ['https://openalex.org/I4210106595', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046208059', 'display_name': 'Danielle Gioioso Taghian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106595', 'display_name': 'Sidney Kimmel Cancer Center', 'ror': 'https://ror.org/010h6g454', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106595']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Danielle G. Taghian', 'raw_affiliation_strings': ['Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107', 'institution_ids': ['https://openalex.org/I4210106595', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065399436', 'display_name': 'Jeffrey S. DeFrank', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106595', 'display_name': 'Sidney Kimmel Cancer Center', 'ror': 'https://ror.org/010h6g454', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106595']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey S. DeFrank', 'raw_affiliation_strings': ['Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107', 'institution_ids': ['https://openalex.org/I4210106595', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088712318', 'display_name': 'Zhao‐Chong Zeng', 'orcid': 'https://orcid.org/0000-0003-4330-3688'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I4210106595', 'display_name': 'Sidney Kimmel Cancer Center', 'ror': 'https://ror.org/010h6g454', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106595']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhao-Chong Zeng', 'raw_affiliation_strings': ['Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107', 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I4210087915', 'https://openalex.org/I4210106595']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054608545', 'display_name': 'Henning Willers', 'orcid': 'https://orcid.org/0000-0002-3938-5732'}, 'institutions': [{'id': 'https://openalex.org/I4210106595', 'display_name': 'Sidney Kimmel Cancer Center', 'ror': 'https://ror.org/010h6g454', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106595']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Henning Willers', 'raw_affiliation_strings': ['Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107', 'institution_ids': ['https://openalex.org/I4210106595', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076541190', 'display_name': 'George Iliakis', 'orcid': 'https://orcid.org/0000-0002-1152-5342'}, 'institutions': [{'id': 'https://openalex.org/I4210106595', 'display_name': 'Sidney Kimmel Cancer Center', 'ror': 'https://ror.org/010h6g454', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106595']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'George Iliakis', 'raw_affiliation_strings': ['Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107', 'institution_ids': ['https://openalex.org/I4210106595', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056895130', 'display_name': 'Simon N. Powell', 'orcid': 'https://orcid.org/0000-0002-8183-4765'}, 'institutions': [{'id': 'https://openalex.org/I4210106595', 'display_name': 'Sidney Kimmel Cancer Center', 'ror': 'https://ror.org/010h6g454', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106595']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Simon N. Powell', 'raw_affiliation_strings': ['Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular and Cellular Radiation Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129; and Department of Radiation Oncology, Division of Experimental Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Philadelphia, PA 19107', 'institution_ids': ['https://openalex.org/I4210106595', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.285, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 241, 'citation_normalized_percentile': {'value': 0.946746, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '98', 'issue': '15', 'first_page': '8644', 'last_page': '8649'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10769', 'display_name': 'Genetic Research on BRCA Mutations and Cancer Risk', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/non-homologous-end-joining', 'display_name': 'Non-homologous end joining', 'score': 0.8513234}, {'id': 'https://openalex.org/keywords/brca2-protein', 'display_name': 'BRCA2 Protein', 'score': 0.7036099}, {'id': 'https://openalex.org/keywords/brca2', 'display_name': 'BRCA2', 'score': 0.586613}, {'id': 'https://openalex.org/keywords/homologous-recombination', 'display_name': 'Homologous Recombination', 'score': 0.537521}, {'id': 'https://openalex.org/keywords/brca1', 'display_name': 'BRCA1', 'score': 0.527659}, {'id': 'https://openalex.org/keywords/breast-cancer', 'display_name': 'Breast Cancer', 'score': 0.518112}, {'id': 'https://openalex.org/keywords/cancer-susceptibility', 'display_name': 'cancer susceptibility', 'score': 0.503361}, {'id': 'https://openalex.org/keywords/homology-directed-repair', 'display_name': 'Homology directed repair', 'score': 0.44909036}, {'id': 'https://openalex.org/keywords/rad52', 'display_name': 'RAD52', 'score': 0.41932052}], 'concepts': [{'id': 'https://openalex.org/C2779012473', 'wikidata': 'https://www.wikidata.org/wiki/Q3235015', 'display_name': 'RAD51', 'level': 4, 'score': 0.8986778}, {'id': 'https://openalex.org/C102744134', 'wikidata': 'https://www.wikidata.org/wiki/Q22280388', 'display_name': 'Homologous recombination', 'level': 3, 'score': 0.86617506}, {'id': 'https://openalex.org/C122917832', 'wikidata': 'https://www.wikidata.org/wiki/Q2065945', 'display_name': 'Non-homologous end joining', 'level': 4, 'score': 0.8513234}, {'id': 'https://openalex.org/C2909462720', 'wikidata': 'https://www.wikidata.org/wiki/Q421651', 'display_name': 'BRCA2 Protein', 'level': 5, 'score': 0.7036099}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.6631214}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.619556}, {'id': 'https://openalex.org/C145803527', 'wikidata': 'https://www.wikidata.org/wiki/Q18032396', 'display_name': 'DNA repair protein XRCC4', 'level': 5, 'score': 0.6179178}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.46155167}, {'id': 'https://openalex.org/C109825262', 'wikidata': 'https://www.wikidata.org/wiki/Q1139164', 'display_name': 'Germline', 'level': 3, 'score': 0.45713413}, {'id': 'https://openalex.org/C178169997', 'wikidata': 'https://www.wikidata.org/wiki/Q2892636', 'display_name': 'Genome instability', 'level': 4, 'score': 0.45553565}, {'id': 'https://openalex.org/C74054111', 'wikidata': 'https://www.wikidata.org/wiki/Q5891445', 'display_name': 'Homology directed repair', 'level': 5, 'score': 0.44909036}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.44745722}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.44192374}, {'id': 'https://openalex.org/C2776630724', 'wikidata': 'https://www.wikidata.org/wiki/Q18031020', 'display_name': 'RAD52', 'level': 5, 'score': 0.41932052}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.41240188}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.39947072}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.379731}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.37099266}, {'id': 'https://openalex.org/C13514818', 'wikidata': 'https://www.wikidata.org/wiki/Q5552256', 'display_name': 'Germline mutation', 'level': 4, 'score': 0.34187472}, {'id': 'https://openalex.org/C60748783', 'wikidata': 'https://www.wikidata.org/wiki/Q2984243', 'display_name': 'DNA mismatch repair', 'level': 4, 'score': 0.24600619}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.20964187}], 'mesh': [{'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011995', 'descriptor_name': 'Recombination, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D024682', 'descriptor_name': 'BRCA2 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003434', 'descriptor_name': 'Crossing Over, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005785', 'descriptor_name': 'Gene Conversion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.151253498', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc37489', 'pdf_url': 'https://europepmc.org/articles/pmc37489?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC37489', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11447276', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.151253498', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.81, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W1494155703', 'https://openalex.org/W1634339254', 'https://openalex.org/W1785779992', 'https://openalex.org/W1879405016', 'https://openalex.org/W1967205646', 'https://openalex.org/W1976960697', 'https://openalex.org/W1986974099', 'https://openalex.org/W1987450173', 'https://openalex.org/W1989802855', 'https://openalex.org/W1992121629', 'https://openalex.org/W1992688638', 'https://openalex.org/W1997643829', 'https://openalex.org/W2000086775', 'https://openalex.org/W2002555966', 'https://openalex.org/W2010456654', 'https://openalex.org/W2012300945', 'https://openalex.org/W2015090136', 'https://openalex.org/W2019205168', 'https://openalex.org/W2024954071', 'https://openalex.org/W2025370752', 'https://openalex.org/W2028305335', 'https://openalex.org/W2032907237', 'https://openalex.org/W2034317592', 'https://openalex.org/W2037191150', 'https://openalex.org/W2038794308', 'https://openalex.org/W2039764581', 'https://openalex.org/W2039810557', 'https://openalex.org/W2041977470', 'https://openalex.org/W2045223918', 'https://openalex.org/W2045931000', 'https://openalex.org/W2050450620', 'https://openalex.org/W2057949133', 'https://openalex.org/W2059365987', 'https://openalex.org/W2061151099', 'https://openalex.org/W2066108933', 'https://openalex.org/W2066943850', 'https://openalex.org/W2072751885', 'https://openalex.org/W2075359803', 'https://openalex.org/W2075417812', 'https://openalex.org/W2079659589', 'https://openalex.org/W2080152855', 'https://openalex.org/W2083326500', 'https://openalex.org/W2091350790', 'https://openalex.org/W2091660221', 'https://openalex.org/W2093785124', 'https://openalex.org/W2100601749', 'https://openalex.org/W2102512189', 'https://openalex.org/W2108172661', 'https://openalex.org/W2111089659', 'https://openalex.org/W2128370098', 'https://openalex.org/W2130737261', 'https://openalex.org/W2134536765', 'https://openalex.org/W2136989353', 'https://openalex.org/W2137347518', 'https://openalex.org/W2139554694', 'https://openalex.org/W2149884878', 'https://openalex.org/W2153536915', 'https://openalex.org/W2154330972', 'https://openalex.org/W2160089420', 'https://openalex.org/W2168504426', 'https://openalex.org/W2168809955', 'https://openalex.org/W2172247857', 'https://openalex.org/W2318781517', 'https://openalex.org/W2335538541', 'https://openalex.org/W3021368244', 'https://openalex.org/W4253088182'], 'related_works': ['https://openalex.org/W3162159158', 'https://openalex.org/W2765142793', 'https://openalex.org/W2418358580', 'https://openalex.org/W2171353009', 'https://openalex.org/W2115797273', 'https://openalex.org/W2028138760', 'https://openalex.org/W2013694269', 'https://openalex.org/W2012090280', 'https://openalex.org/W2007919127', 'https://openalex.org/W1971867839'], 'abstract_inverted_index': {'Carriers': [0], 'of': [1, 17, 47, 59, 80, 125], 'BRCA2': [2, 19, 37, 62, 70, 103], 'germline': [3], 'mutations': [4], 'are': [5], 'at': [6], 'high': [7], 'risk': [8], 'to': [9, 22, 73, 90, 132], 'develop': [10], 'early-onset': [11], 'breast': [12], 'cancer.': [13], 'The': [14], 'underlying': [15], 'mechanisms': [16], 'how': [18], 'inactivation': [20], 'predisposes': [21], 'malignant': [23], 'transformation': [24], 'have': [25], 'not': [26], 'been': [27], 'established.': [28], 'Here,': [29], 'we': [30], 'provide': [31], 'direct': [32], 'functional': [33], 'evidence': [34], 'that': [35, 54], 'human': [36, 65], 'promotes': [38], 'homologous': [39], 'recombination': [40], '(HR),': [41], 'which': [42, 95, 129], 'comprises': [43], 'one': [44], 'major': [45], 'pathway': [46], 'DNA': [48, 100], 'double-strand': [49, 112], 'break': [50, 113], 'repair.': [51], 'We': [52], 'found': [53], 'up-regulated': [55], 'HR': [56, 81, 126], 'after': [57], 'transfection': [58], 'wild-type': [60], '(wt)': [61], 'into': [63], 'a': [64, 122], 'tumor': [66, 92, 138], 'line': [67], 'with': [68, 86], 'mutant': [69], 'was': [71], 'linked': [72], 'increased': [74], 'radioresistance.': [75], 'In': [76, 88], 'addition,': [77], 'BRCA2-mediated': [78], 'enhancement': [79], 'depended': [82], 'on': [83, 108], 'the': [84, 91, 109], 'interaction': [85], 'Rad51.': [87], 'contrast': [89], 'suppressor': [93], 'BRCA1,': [94], 'is': [96], 'involved': [97], 'in': [98, 140], 'multiple': [99], 'repair': [101, 114], 'pathways,': [102], 'status': [104], 'had': [105], 'no': [106], 'impact': [107], 'other': [110], 'principal': [111], 'pathway,': [115], 'nonhomologous': [116], 'end': [117], 'joining.': [118], 'Thus,': [119], 'there': [120], 'exists': [121], 'specific': [123], 'regulation': [124], 'by': [127], 'BRCA2,': [128], 'may': [130], 'function': [131], 'maintain': [133], 'genomic': [134], 'integrity': [135], 'and': [136], 'suppress': [137], 'development': [139], 'proliferating': [141], 'cells.': [142]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2115797273', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-09-10T01:09:56.589270', 'created_date': '2016-06-24'}