Publication Information

{'id': 'https://openalex.org/W2115379144', 'doi': 'https://doi.org/10.1111/j.1471-4159.1993.tb13389.x', 'title': 'Isoform-Specific Effects of Transforming Growth Factors-? on Degeneration of Primary Neuronal Cultures Induced by Cytotoxic Hypoxia or Glutamate', 'display_name': 'Isoform-Specific Effects of Transforming Growth Factors-? on Degeneration of Primary Neuronal Cultures Induced by Cytotoxic Hypoxia or Glutamate', 'publication_year': 1993, 'publication_date': '1993-05-01', 'ids': {'openalex': 'https://openalex.org/W2115379144', 'doi': 'https://doi.org/10.1111/j.1471-4159.1993.tb13389.x', 'mag': '2115379144', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8097233'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1471-4159.1993.tb13389.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075015717', 'display_name': 'Jochen H.M. Prehn', 'orcid': 'https://orcid.org/0000-0003-3479-7794'}, 'institutions': [{'id': 'https://openalex.org/I161103922', 'display_name': 'Philipps University of Marburg', 'ror': 'https://ror.org/01rdrb571', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161103922']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jochen H. M. Prehn', 'raw_affiliation_strings': ['Institut für Pharmakologie und Toxikologie, Philipps Universität Marburg, F.R.G.'], 'affiliations': [{'raw_affiliation_string': 'Institut für Pharmakologie und Toxikologie, Philipps Universität Marburg, F.R.G.', 'institution_ids': ['https://openalex.org/I161103922']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111907841', 'display_name': 'Barbara Peruchc', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161103922', 'display_name': 'Philipps University of Marburg', 'ror': 'https://ror.org/01rdrb571', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161103922']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Barbara Peruchc', 'raw_affiliation_strings': ['Insuted of Pharmalologie and Knologie Philipps-University, Marburg'], 'affiliations': [{'raw_affiliation_string': 'Insuted of Pharmalologie and Knologie Philipps-University, Marburg', 'institution_ids': ['https://openalex.org/I161103922']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047686228', 'display_name': 'Klaus Unsicker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Klaus Unsicker', 'raw_affiliation_strings': ['Instinat for Anatomic and lellblogic University Heidelberg Heideberg. F.R.G.'], 'affiliations': [{'raw_affiliation_string': 'Instinat for Anatomic and lellblogic University Heidelberg Heideberg. F.R.G.', 'institution_ids': ['https://openalex.org/I223822909']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028603581', 'display_name': 'Josef Krieglstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161103922', 'display_name': 'Philipps University of Marburg', 'ror': 'https://ror.org/01rdrb571', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161103922']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Josef Krieglstein', 'raw_affiliation_strings': ['Insuted of Pharmalologie and Knologie Philipps‐University, Marburg'], 'affiliations': [{'raw_affiliation_string': 'Insuted of Pharmalologie and Knologie Philipps‐University, Marburg', 'institution_ids': ['https://openalex.org/I161103922']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.194, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 95, 'citation_normalized_percentile': {'value': 0.92268, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '60', 'issue': '5', 'first_page': '1665', 'last_page': '1672'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12963', 'display_name': 'Anesthesia and Neurotoxicity Research', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12963', 'display_name': 'Anesthesia and Neurotoxicity Research', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12030', 'display_name': 'S100 Proteins and Annexins', 'score': 0.9942, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glutamic-acid', 'display_name': 'Glutamic acid', 'score': 0.4766101}], 'concepts': [{'id': 'https://openalex.org/C61174792', 'wikidata': 'https://www.wikidata.org/wiki/Q420510', 'display_name': 'Glutamate receptor', 'level': 3, 'score': 0.72975063}, {'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.6434315}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.5872896}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.568668}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.50335044}, {'id': 'https://openalex.org/C2778740566', 'wikidata': 'https://www.wikidata.org/wiki/Q181136', 'display_name': 'Glutamic acid', 'level': 3, 'score': 0.4766101}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.46784577}, {'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.44543225}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4324924}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42155138}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.41062796}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.37341273}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.3212462}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.32039815}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.22664621}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.21456891}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.121177554}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.08970368}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.083079815}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015687', 'descriptor_name': 'Cell Hypoxia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005971', 'descriptor_name': 'Glutamates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009410', 'descriptor_name': 'Nerve Degeneration', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002642', 'descriptor_name': 'Chick Embryo', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005971', 'descriptor_name': 'Glutamates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018698', 'descriptor_name': 'Glutamic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007536', 'descriptor_name': 'Isomerism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009410', 'descriptor_name': 'Nerve Degeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013687', 'descriptor_name': 'Telencephalon', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013687', 'descriptor_name': 'Telencephalon', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D013687', 'descriptor_name': 'Telencephalon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1471-4159.1993.tb13389.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8097233', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1500403088', 'https://openalex.org/W1515063177', 'https://openalex.org/W1595132023', 'https://openalex.org/W1775749144', 'https://openalex.org/W1980920786', 'https://openalex.org/W1984114485', 'https://openalex.org/W2016575029', 'https://openalex.org/W2020333978', 'https://openalex.org/W2024935441', 'https://openalex.org/W2026394731', 'https://openalex.org/W2030059771', 'https://openalex.org/W2036083437', 'https://openalex.org/W2039758676', 'https://openalex.org/W2043725292', 'https://openalex.org/W2046511312', 'https://openalex.org/W2076211518', 'https://openalex.org/W2088017195', 'https://openalex.org/W2115756131', 'https://openalex.org/W2117507292', 'https://openalex.org/W2346002398', 'https://openalex.org/W4211166816', 'https://openalex.org/W88851328'], 'related_works': ['https://openalex.org/W4295886409', 'https://openalex.org/W2995727304', 'https://openalex.org/W2095198015', 'https://openalex.org/W2077655479', 'https://openalex.org/W2034773528', 'https://openalex.org/W2022320815', 'https://openalex.org/W1988725105', 'https://openalex.org/W1593223226', 'https://openalex.org/W1540936366', 'https://openalex.org/W1517805603'], 'abstract_inverted_index': {'Abstract:': [0], 'The': [1], 'transforming': [2], 'growth': [3], 'factors‐β': [4], '(TGFs‐β)': [5], 'are': [6, 220], 'multifunctional': [7], 'peptide‐growth': [8], 'factors': [9], 'that': [10, 159, 201, 217], 'have': [11], 'been': [12, 161, 203], 'localized': [13], 'in': [14, 61, 94, 167, 241], 'neuronal': [15, 42, 97, 120, 228], 'and': [16, 25, 35, 100, 126, 140, 145, 182, 236], 'glial': [17], 'cells': [18], 'of': [19, 22, 80, 103, 124, 138, 153, 175, 194, 226, 238], 'the': [20, 30, 50, 74, 104, 110, 118, 151, 218, 224], "C'NS": [21], 'mice.': [23], 'rats,': [24], 'chick': [26, 63, 155], 'embryos.': [27], 'We': [28], 'tested': [29], 'TGF‐β': [31], 'isoforms': [32], '1.': [33], '2.': [34], '3': [36], 'for': [37, 172], 'their': [38], 'protective': [39], 'ctlects': [40], 'against': [41], 'degeneration': [43, 152, 225], 'caused': [44, 232], 'by': [45, 49, 67, 233], 'cytotoxic': [46, 57], 'hypoxia': [47, 58], 'or': [48], 'excitatory': [51], 'amino': [52], 'acid': [53], 'i': [54], '‐glutamate.': [55], 'A': [56], 'was': [59, 114, 231], 'induced': [60], 'cultured': [62, 154, 195], 'embryo': [64, 156], 'telencephalic': [65, 157], 'neurons': [66, 158, 196], 'adding': [68], 'I': [69, 82, 164], 'm.l/': [70], 'sodium': [71], 'cyanide': [72], 'to': [73, 89, 116, 163, 183, 205, 222], 'culture': [75, 207], 'medium': [76, 208], 'tor': [77], 'a': [78, 90, 168, 173, 184], 'period': [79, 174], '30min.': [81], 'reatment': [83], 'with': [84, 147, 210], 'TGF‐81': [85], '(1‐30': [86], 'ng/ml)': [87], 'led': [88], 'statistically': [91], 'significant': [92], 'increase': [93], 'cell': [95], 'viability,': [96], 'ATP': [98], 'levels.': [99], 'protein': [101], 'content': [102], 'cultures': [105], 'assessed': [106], '72': [107], 'h': [108], 'after': [109], 'toxic': [111], 'insult.': [112], 'TGF‐33': [113], 'able': [115, 221], 'reduce': [117], 'cyanide‐induced': [119], 'damage': [121], 'at': [122, 136], 'concentrations': [123, 137], '0.3': [125], '1': [127, 211], 'ng/': [128], 'ml.': [129], 'whereas': [130], 'TGF‐33,': [131], 'only': [132], 'showed': [133], 'neuroprotective': [134], 'activity': [135], '30': [139], '50': [141], 'ng/ml.': [142], 'Both': [143], 'pre‐': [144], 'posttreatment': [146], 'TGF‐31,': [148], 'also': [149], 'prevented': [150], 'had': [160, 202], 'exposed': [162, 204], 'mM': [165], 'L‐glutamate': [166], 'buffered': [169], 'salt': [170], 'solution': [171], '60': [176], 'min.': [177], 'Furthermore,': [178], 'TGF‐β1': [179], '(0.3‐3': [180], 'ng/ml).': [181, 189], 'lesser': [185], 'extent': [186], 'TGF‐β3': [187], '(0.1‐1': [188], 'significantly': [190], 'reduced': [191], 'excitotoxic': [192], 'injury': [193], 'from': [197], 'rat': [198], 'cerebral': [199], 'cortex': [200], 'serum‐free': [206], 'supplemented': [209], 'm.M': [212], 'L‐glutamate.': [213], 'These': [214], 'results': [215], 'demonstrate': [216], 'TGFs‐β': [219], 'prevent': [223], 'primary': [227], 'cultures,': [229], 'which': [230], 'energy': [234], 'depletion': [235], 'activation': [237], 'glutamate': [239], 'receptors,': [240], 'an': [242], 'isoform‐specific': [243], 'manner.': [244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2115379144', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-11T03:15:19.034968', 'created_date': '2016-06-24'}