Malignant glioma: genetics and biology of a grave matter

Name: Work Video:
Duration: 3 min 30 s
Elizabeth A. Maher; Frank B. Furnari; Robert Bachoo; David H. Rowitch; David N. Louis; Webster K. Cavenee; Ronald A. DePinho
{'id': 'https://openalex.org/W2114998237', 'doi': 'https://doi.org/10.1101/gad.891601', 'title': 'Malignant glioma: genetics and biology of a grave matter', 'display_name': 'Malignant glioma: genetics and biology of a grave matter', 'publication_year': 2001, 'publication_date': '2001-06-01', 'ids': {'openalex': 'https://openalex.org/W2114998237', 'doi': 'https://doi.org/10.1101/gad.891601', 'mag': '2114998237', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11390353'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/gad.891601', 'pdf_url': 'http://genesdev.cshlp.org/content/15/11/1311.full.pdf', 'source': {'id': 'https://openalex.org/S168778273', 'display_name': 'Genes & Development', 'issn_l': '0890-9369', 'issn': ['0890-9369', '1549-5477'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://genesdev.cshlp.org/content/15/11/1311.full.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062798238', 'display_name': 'Elizabeth A. Maher', 'orcid': 'https://orcid.org/0000-0002-9693-5155'}, 'institutions': [{'id': 'https://openalex.org/I4210102457', 'display_name': 'Center for Neuro-Oncology', 'ror': 'https://ror.org/00z2tp793', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I4210102457', 'https://openalex.org/I4210117453', 'https://openalex.org/I4210161994', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth A. Maher', 'raw_affiliation_strings': ['Center for Neuro-Oncology, Boston, Massachusetts 02115, USA.'], 'affiliations': [{'raw_affiliation_string': 'Center for Neuro-Oncology, Boston, Massachusetts 02115, USA.', 'institution_ids': ['https://openalex.org/I4210102457']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036985768', 'display_name': 'Frank B. Furnari', 'orcid': 'https://orcid.org/0000-0003-1909-4361'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Frank B. Furnari', 'raw_affiliation_strings': ['University of California at San Diego'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Diego', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044684517', 'display_name': 'Robert Bachoo', 'orcid': 'https://orcid.org/0000-0001-9229-9342'}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert M. Bachoo', 'raw_affiliation_strings': ['Harvard University'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043980648', 'display_name': 'David H. Rowitch', 'orcid': 'https://orcid.org/0000-0002-0079-0060'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David H. Rowitch', 'raw_affiliation_strings': ['Dana Farber Cancer Institute'], 'affiliations': [{'raw_affiliation_string': 'Dana Farber Cancer Institute', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109086577', 'display_name': 'David N. Louis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David N. Louis', 'raw_affiliation_strings': ['Harvard University'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072507966', 'display_name': 'Webster K. Cavenee', 'orcid': 'https://orcid.org/0000-0003-3804-9179'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Webster K. Cavenee', 'raw_affiliation_strings': ['University of California at San Diego'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Diego', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5008120994', 'display_name': 'Ronald A. DePinho', 'orcid': 'https://orcid.org/0000-0002-5625-577X'}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ronald A. DePinho', 'raw_affiliation_strings': ['Harvard University'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 10.747, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1229, 'citation_normalized_percentile': {'value': 0.994695, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '15', 'issue': '11', 'first_page': '1311', 'last_page': '1333'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10129', 'display_name': 'Glioma Diagnosis and Treatment', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10129', 'display_name': 'Glioma Diagnosis and Treatment', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.93824756}, {'id': 'https://openalex.org/C2778227246', 'wikidata': 'https://www.wikidata.org/wiki/Q1365309', 'display_name': 'Glioma', 'level': 2, 'score': 0.7147249}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4609246}, {'id': 'https://openalex.org/C78458016', 'wikidata': 'https://www.wikidata.org/wiki/Q840400', 'display_name': 'Evolutionary biology', 'level': 1, 'score': 0.43618363}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3721007}], 'mesh': [{'descriptor_ui': 'D005910', 'descriptor_name': 'Glioma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D005910', 'descriptor_name': 'Glioma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016161', 'descriptor_name': 'Genes, Retinoblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016147', 'descriptor_name': 'Genes, Tumor Suppressor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016158', 'descriptor_name': 'Genes, p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005910', 'descriptor_name': 'Glioma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005910', 'descriptor_name': 'Glioma', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': False}, {'descriptor_ui': 'D006133', 'descriptor_name': 'Growth Substances', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006133', 'descriptor_name': 'Growth Substances', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006133', 'descriptor_name': 'Growth Substances', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/gad.891601', 'pdf_url': 'http://genesdev.cshlp.org/content/15/11/1311.full.pdf', 'source': {'id': 'https://openalex.org/S168778273', 'display_name': 'Genes & Development', 'issn_l': '0890-9369', 'issn': ['0890-9369', '1549-5477'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11390353', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/gad.891601', 'pdf_url': 'http://genesdev.cshlp.org/content/15/11/1311.full.pdf', 'source': {'id': 'https://openalex.org/S168778273', 'display_name': 'Genes & Development', 'issn_l': '0890-9369', 'issn': ['0890-9369', '1549-5477'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.67, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 214, 'referenced_works': ['https://openalex.org/W1487914405', 'https://openalex.org/W1489145507', 'https://openalex.org/W1491861242', 'https://openalex.org/W1495551511', 'https://openalex.org/W1497143324', 'https://openalex.org/W1502418486', 'https://openalex.org/W1504875278', 'https://openalex.org/W1508293099', 'https://openalex.org/W1526030166', 'https://openalex.org/W1528440616', 'https://openalex.org/W1528559061', 'https://openalex.org/W1531180106', 'https://openalex.org/W1531753146', 'https://openalex.org/W1534734027', 'https://openalex.org/W1536306303', 'https://openalex.org/W1551696649', 'https://openalex.org/W1554558913', 'https://openalex.org/W1555346784', 'https://openalex.org/W1561313993', 'https://openalex.org/W1565264715', 'https://openalex.org/W1569324890', 'https://openalex.org/W1569698611', 'https://openalex.org/W1579641819', 'https://openalex.org/W1586476323', 'https://openalex.org/W1591350305', 'https://openalex.org/W1592582459', 'https://openalex.org/W1599090051', 'https://openalex.org/W1673025041', 'https://openalex.org/W1843891279', 'https://openalex.org/W1855056902', 'https://openalex.org/W1866366362', 'https://openalex.org/W1870813039', 'https://openalex.org/W1908619062', 'https://openalex.org/W1912789001', 'https://openalex.org/W1918387366', 'https://openalex.org/W1926043920', 'https://openalex.org/W1940514332', 'https://openalex.org/W1942092758', 'https://openalex.org/W1944062041', 'https://openalex.org/W1949259756', 'https://openalex.org/W1957871175', 'https://openalex.org/W1965375858', 'https://openalex.org/W1968700644', 'https://openalex.org/W1969523279', 'https://openalex.org/W1969647408', 'https://openalex.org/W1969857864', 'https://openalex.org/W1970174108', 'https://openalex.org/W1972036696', 'https://openalex.org/W1973071934', 'https://openalex.org/W1973812603', 'https://openalex.org/W1973886069', 'https://openalex.org/W1975288990', 'https://openalex.org/W1977116102', 'https://openalex.org/W1977416006', 'https://openalex.org/W1979050047', 'https://openalex.org/W1980326482', 'https://openalex.org/W1980441719', 'https://openalex.org/W1983348917', 'https://openalex.org/W1983751803', 'https://openalex.org/W1983841375', 'https://openalex.org/W1984513377', 'https://openalex.org/W1986927910', 'https://openalex.org/W1989095069', 'https://openalex.org/W1993465232', 'https://openalex.org/W1994131389', 'https://openalex.org/W1995117137', 'https://openalex.org/W1995387334', 'https://openalex.org/W1996030482', 'https://openalex.org/W1996430165', 'https://openalex.org/W1998038367', 'https://openalex.org/W2000108033', 'https://openalex.org/W2000862518', 'https://openalex.org/W2001493754', 'https://openalex.org/W2003008937', 'https://openalex.org/W2004654220', 'https://openalex.org/W2005542290', 'https://openalex.org/W2009015720', 'https://openalex.org/W2010552948', 'https://openalex.org/W2010677999', 'https://openalex.org/W2010745413', 'https://openalex.org/W2011557383', 'https://openalex.org/W2011642803', 'https://openalex.org/W2012768021', 'https://openalex.org/W2013681684', 'https://openalex.org/W2013878898', 'https://openalex.org/W2019017173', 'https://openalex.org/W2023131078', 'https://openalex.org/W2023563217', 'https://openalex.org/W2024220711', 'https://openalex.org/W2024825981', 'https://openalex.org/W2026401391', 'https://openalex.org/W2029080338', 'https://openalex.org/W2032294682', 'https://openalex.org/W2039463309', 'https://openalex.org/W2043732412', 'https://openalex.org/W2043850275', 'https://openalex.org/W2044142173', 'https://openalex.org/W2044616474', 'https://openalex.org/W2045164193', 'https://openalex.org/W2045978113', 'https://openalex.org/W2046006021', 'https://openalex.org/W2046193777', 'https://openalex.org/W2046352223', 'https://openalex.org/W2046516822', 'https://openalex.org/W2047814166', 'https://openalex.org/W2049085719', 'https://openalex.org/W2049635080', 'https://openalex.org/W2050689607', 'https://openalex.org/W2052935035', 'https://openalex.org/W2056530510', 'https://openalex.org/W2056987446', 'https://openalex.org/W2058355285', 'https://openalex.org/W2058566746', 'https://openalex.org/W2058737236', 'https://openalex.org/W2058902820', 'https://openalex.org/W20591230', 'https://openalex.org/W2059877177', 'https://openalex.org/W2060385194', 'https://openalex.org/W2060777041', 'https://openalex.org/W2061335575', 'https://openalex.org/W2063445389', 'https://openalex.org/W2066493788', 'https://openalex.org/W2066888615', 'https://openalex.org/W2067368732', 'https://openalex.org/W2067376187', 'https://openalex.org/W2068022987', 'https://openalex.org/W2068345721', 'https://openalex.org/W2068376202', 'https://openalex.org/W2068427129', 'https://openalex.org/W2070108346', 'https://openalex.org/W2072564410', 'https://openalex.org/W2076457965', 'https://openalex.org/W2077477013', 'https://openalex.org/W2077630079', 'https://openalex.org/W2079356804', 'https://openalex.org/W2082979850', 'https://openalex.org/W2084891010', 'https://openalex.org/W2086438568', 'https://openalex.org/W2086589412', 'https://openalex.org/W2087875382', 'https://openalex.org/W2088868608', 'https://openalex.org/W2089083607', 'https://openalex.org/W2092029005', 'https://openalex.org/W2092500174', 'https://openalex.org/W2092595396', 'https://openalex.org/W2093014822', 'https://openalex.org/W2093498435', 'https://openalex.org/W2094126824', 'https://openalex.org/W2095381863', 'https://openalex.org/W2097454127', 'https://openalex.org/W2098015360', 'https://openalex.org/W2099708088', 'https://openalex.org/W2099907467', 'https://openalex.org/W2101189919', 'https://openalex.org/W2102223877', 'https://openalex.org/W2102930268', 'https://openalex.org/W2104571407', 'https://openalex.org/W2107766440', 'https://openalex.org/W2108143410', 'https://openalex.org/W2111237988', 'https://openalex.org/W2111752734', 'https://openalex.org/W2112050795', 'https://openalex.org/W2114098415', 'https://openalex.org/W2117322456', 'https://openalex.org/W2117492061', 'https://openalex.org/W2119705388', 'https://openalex.org/W2122068837', 'https://openalex.org/W2122260580', 'https://openalex.org/W2122889044', 'https://openalex.org/W2124968502', 'https://openalex.org/W2125124408', 'https://openalex.org/W2127001212', 'https://openalex.org/W2129191040', 'https://openalex.org/W2129866793', 'https://openalex.org/W2130198345', 'https://openalex.org/W2131431538', 'https://openalex.org/W2133138712', 'https://openalex.org/W2135713829', 'https://openalex.org/W2136422121', 'https://openalex.org/W2137260277', 'https://openalex.org/W2137273750', 'https://openalex.org/W2137279272', 'https://openalex.org/W2137584473', 'https://openalex.org/W2139144917', 'https://openalex.org/W2140375000', 'https://openalex.org/W2141170572', 'https://openalex.org/W2143508222', 'https://openalex.org/W2147817953', 'https://openalex.org/W2149357952', 'https://openalex.org/W2150233389', 'https://openalex.org/W2152988906', 'https://openalex.org/W2154104720', 'https://openalex.org/W2154607583', 'https://openalex.org/W2155737059', 'https://openalex.org/W2157088766', 'https://openalex.org/W2160040915', 'https://openalex.org/W2161810908', 'https://openalex.org/W2161897593', 'https://openalex.org/W2162037543', 'https://openalex.org/W2162505525', 'https://openalex.org/W2165696859', 'https://openalex.org/W2169882020', 'https://openalex.org/W2245482469', 'https://openalex.org/W2313440299', 'https://openalex.org/W2320188351', 'https://openalex.org/W2322386893', 'https://openalex.org/W2332311127', 'https://openalex.org/W2399288126', 'https://openalex.org/W2408784510', 'https://openalex.org/W2411608409', 'https://openalex.org/W2412737068', 'https://openalex.org/W2427124571', 'https://openalex.org/W4213096412', 'https://openalex.org/W4301760855'], 'related_works': ['https://openalex.org/W2788277189', 'https://openalex.org/W2151865869', 'https://openalex.org/W2130076355', 'https://openalex.org/W2119695867', 'https://openalex.org/W2117258802', 'https://openalex.org/W2082860237', 'https://openalex.org/W2061542922', 'https://openalex.org/W2013243191', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418'], 'abstract_inverted_index': {'Malignant': [0, 16], 'brain': [1, 24, 277], 'tumors': [2, 33, 139], 'strike': [3], 'deep': [4], 'into': [5, 234], 'the': [6, 14, 18, 38, 87, 111, 121, 134, 144, 150, 182, 204, 235, 255, 258, 270, 281], 'psyche': [7], 'of': [8, 22, 40, 71, 81, 96, 113, 120, 136, 146, 156, 184, 189, 203, 237, 248, 257, 273, 280], 'those': [9, 12, 119], 'receiving': [10], 'and': [11, 30, 78, 83, 101, 124, 153, 216, 228, 261, 269], 'delivering': [13], 'diagnosis.': [15], 'gliomas,': [17, 174], 'most': [19, 45], 'common': [20, 115], 'subtype': [21], 'primary': [23], 'tumors,': [25], 'are': [26, 140], 'aggressive,': [27], 'highly': [28], 'invasive,': [29], 'neurologically': [31], 'destructive': [32], 'considered': [34], 'to': [35, 55, 168, 224, 254], 'be': [36], 'among': [37], 'deadliest': [39], 'human': [41, 116], 'cancers.': [42], 'In': [43], 'its': [44], 'aggressive': [46], 'manifestation,': [47], 'glioblastoma': [48], '(GBM),': [49], 'median': [50], 'survival': [51], 'ranges': [52], 'from': [53], '9': [54], '12': [56], 'months,': [57], 'despite': [58, 186], 'maximum': [59], 'treatment': [60, 112, 135, 145, 183], 'efforts—a': [61], 'statistical': [62], 'fact': [63], 'that': [64, 105, 129, 198, 239], 'has': [65, 92, 106, 165, 211], 'changed': [66], 'little': [67], 'over': [68], 'several': [69], 'decades': [70], 'technological': [72], 'advances': [73, 264], 'in': [74, 98, 110, 133, 143, 192, 208, 220, 229, 243, 265, 286], 'neurosurgery,': [75], 'radiation': [76], 'therapy,': [77], 'clinical': [79, 193, 271], 'trials': [80], 'conventional': [82], 'novel': [84], 'therapeutics.': [85], 'Over': [86], 'same': [88], 'time': [89], 'period,': [90], 'there': [91], 'been': [93, 166, 212], 'an': [94], 'explosion': [95], 'knowledge': [97], 'cancer': [99], 'biology': [100, 152], 'basic': [102, 232], 'science': [103], 'discovery': [104], 'fueled': [107], 'meaningful': [108], 'progress': [109], 'many': [114], 'cancers,': [117], 'including': [118], 'breast,': [122], 'lung,': [123], 'prostate.': [125], 'It': [126, 195], 'is': [127, 196], 'perplexing': [128], 'therapies': [130], 'used': [131], 'effectively': [132], 'these': [137, 225], 'solid': [138], 'overwhelmingly': [141], 'ineffective': [142], 'GBM,': [147, 185], 'perhaps': [148], 'reflecting': [149], 'eccentric': [151], 'cellular': [154], 'origin': [155], 'this': [157, 231], 'neoplasm.': [158], 'To': [159], 'date,': [160], 'only': [161], 'one': [162], 'new': [163], 'agent': [164], 'documented': [167], 'have': [169, 179], 'modest': [170], 'activity': [171], 'against': [172], 'intermediate-grade': [173], 'whereas': [175], 'no': [176], 'effective': [177], 'agents': [178], 'emerged': [180], 'for': [181], '20': [187], 'years': [188], 'enrolling': [190], 'patients': [191], 'trials.': [194], 'ironic': [197], 'although': [199], 'a': [200, 241], 'comprehensive': [201], 'view': [202], 'genetic': [205, 226], 'lesions': [206], 'encountered': [207], 'malignant': [209, 250], 'gliomas': [210, 251], 'compiled,': [213], 'substantive': [214], 'conceptual': [215], 'practical': [217], 'barriers': [218], 'remain': [219], 'assigning': [221], 'functional': [222], 'significance': [223], 'changes': [227], 'harnessing': [230], 'information': [233], 'development': [236], 'drugs': [238], 'make': [240], 'difference': [242], 'patient': [244], 'care.': [245], 'The': [246, 275], 'history': [247], 'treating': [249], 'dates': [252], 'back': [253], 'middle': [256], '19th': [259], 'century': [260], 'parallels': [262], 'landmark': [263], 'modern': [266, 282], 'surgical': [267], 'technique': [268], 'discipline': [272], 'neurology.': [274], 'first': [276], 'tumor': [278], 'surgery': [279], 'era': [283], 'was': [284], 'performed': [285], '1884': [287], 'by': [288], 'Rickman': [289]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2114998237', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 33}, {'year': 2022, 'cited_by_count': 26}, {'year': 2021, 'cited_by_count': 29}, {'year': 2020, 'cited_by_count': 39}, {'year': 2019, 'cited_by_count': 37}, {'year': 2018, 'cited_by_count': 37}, {'year': 2017, 'cited_by_count': 40}, {'year': 2016, 'cited_by_count': 58}, {'year': 2015, 'cited_by_count': 68}, {'year': 2014, 'cited_by_count': 67}, {'year': 2013, 'cited_by_count': 75}, {'year': 2012, 'cited_by_count': 64}], 'updated_date': '2024-12-10T15:19:02.570870', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
