Publication Information

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'https://openalex.org/W2088972036', 'https://openalex.org/W2093226717', 'https://openalex.org/W2100807457', 'https://openalex.org/W2102487598', 'https://openalex.org/W2107092244', 'https://openalex.org/W2112668385', 'https://openalex.org/W2113001027', 'https://openalex.org/W2120879594', 'https://openalex.org/W2122108815', 'https://openalex.org/W2122163057', 'https://openalex.org/W2127441616', 'https://openalex.org/W2134271951', 'https://openalex.org/W2134597119', 'https://openalex.org/W2136812809', 'https://openalex.org/W2149907284', 'https://openalex.org/W2152396103', 'https://openalex.org/W2154655439', 'https://openalex.org/W2157246902', 'https://openalex.org/W2159565935', 'https://openalex.org/W2165803049', 'https://openalex.org/W2168586729', 'https://openalex.org/W2169332291', 'https://openalex.org/W2170503323', 'https://openalex.org/W2331439722'], 'related_works': ['https://openalex.org/W4239005955', 'https://openalex.org/W2944822442', 'https://openalex.org/W2771906889', 'https://openalex.org/W2124417063', 'https://openalex.org/W2121545064', 'https://openalex.org/W2108806825', 'https://openalex.org/W2055200787', 'https://openalex.org/W2015679500', 'https://openalex.org/W2009671568', 'https://openalex.org/W1995319895'], 'abstract_inverted_index': {'Cell': [0, 230, 460, 527, 542, 655, 675, 708, 751, 764, 793, 808, 823, 946, 1155, 1186, 1293, 1387, 1446, 1510, 1608, 1795, 2194, 2232, 2378, 2466, 3097, 3259, 3426, 3773, 3853], 'migration': [1, 38, 121, 231, 268, 351, 461, 743, 1576, 1675, 1856, 1880, 1886, 1925, 2683, 2692, 2761, 2775, 3048, 3791, 3811, 3890, 3956, 3967, 4225, 4261, 4289, 4312, 4320], 'is': [2, 17, 232, 247, 462, 571, 1043, 1254, 1267, 1458, 1920, 3797, 4030], 'essential': [3, 233, 463], 'throughout': [4, 234], 'embryonic': [5, 235, 472], 'and': [6, 26, 61, 71, 91, 117, 124, 137, 176, 236, 256, 291, 301, 321, 347, 354, 367, 406, 467, 479, 600, 692, 869, 893, 912, 973, 992, 1129, 1143, 1204, 1229, 1260, 1265, 1305, 1423, 1478, 1529, 1540, 1573, 1674, 1824, 1848, 1857, 1872, 1943, 1947, 2022, 2027, 2039, 2061, 2070, 2160, 2165, 2337, 2403, 2410, 2448, 2468, 2483, 2501, 2514, 2547, 2581, 2637, 2730, 2768, 2847, 2875, 2933, 2948, 2959, 2967, 3016, 3057, 3066, 3069, 3165, 3177, 3183, 3209, 3215, 3221, 3236, 3304, 3317, 3386, 3402, 3420, 3479, 3517, 3532, 3562, 3621, 3626, 3664, 3755, 3768, 3780, 3813, 3825, 3910, 3938, 3948, 3963, 4019, 4246, 4249, 4329], 'adult': [7, 237], 'life.': [8, 238], 'In': [9, 130, 239, 360, 483, 1246, 1549, 2529, 3953, 4111], 'numerous': [10, 240], 'cell': [11, 85, 228, 241, 315, 458, 481, 486, 489, 601, 894, 913, 1202, 1205, 1227, 1230, 1575, 1855, 1879, 3463, 3488, 3785, 3805, 3810, 4122], 'systems,': [12, 132, 242, 362], 'the': [13, 23, 30, 50, 67, 133, 138, 190, 203, 212, 243, 253, 260, 280, 297, 363, 368, 420, 433, 442, 476, 492, 499, 575, 584, 687, 734, 857, 980, 988, 994, 1250, 1323, 1403, 1461, 1479, 1553, 1677, 1831, 1846, 1930, 1948, 2004, 2013, 2028, 2044, 2050, 2065, 2166, 2458, 2510, 2526, 2532, 2566, 2601, 2626, 2638, 2645, 2648, 2681, 2711, 2721, 2724, 2732, 2736, 2760, 2774, 2788, 2800, 2805, 2808, 2811, 2826, 2834, 2838, 2848, 2856, 2859, 2881, 2886, 2955, 2970, 2974, 3041, 3055, 3224, 3290, 3305, 3311, 3330, 3348, 3367, 3421, 3454, 3461, 3475, 3487, 3509, 3525, 3572, 3577, 3648, 3651, 3776, 3801, 3821, 3886, 3900, 3915, 3918, 3922, 3942, 4012, 4025, 4054, 4070, 4085, 4104, 4125, 4128, 4134, 4144, 4156, 4164, 4181, 4219, 4224, 4236, 4259, 4273, 4276, 4281, 4287, 4309, 4317, 4346, 4358], 'small': [14, 244, 503], 'GTPase': [15, 245], 'Rac': [16, 35, 81, 142, 181, 200, 222, 246, 265, 311, 372, 411, 430, 452, 570, 683, 740, 924, 960, 1142, 1145, 1258, 1433, 1915, 3269, 4297, 4306, 4326, 4354], 'required': [18, 119, 248, 349, 1268], 'for': [19, 120, 249, 350, 464, 597, 923, 984, 1051, 1256, 1269, 1939, 2007, 2016, 2318, 2674, 2686, 2749, 2773, 2830, 2961, 2980, 3206, 3226, 3293, 3319, 3556, 3642, 3669, 3686, 3701, 3809, 3941, 4000, 4003, 4052, 4143, 4336], 'lamellipodia': [20, 250, 588], 'formation': [21, 136, 251, 366, 585], 'at': [22, 206, 252, 436, 574, 851, 1830, 1893, 2551, 2702, 2899, 2986, 3296, 3508, 3559, 3672, 3689, 3704, 4243, 4247], 'leading': [24, 33, 254, 263, 576, 698, 1404, 3620], 'edge': [25, 255, 577, 699, 1405], 'movement': [27, 257, 490, 602, 3923], 'ability.': [28, 258], 'However,': [29, 259, 1031], 'molecular': [31, 261], 'mechanisms': [32, 262, 737], 'to': [34, 49, 79, 140, 155, 184, 192, 194, 264, 279, 309, 370, 385, 414, 422, 424, 591, 847, 1309, 1421, 1566, 1828, 1876, 1923, 1936, 2042, 2525, 2538, 2565, 2600, 2625, 2647, 2669, 2710, 2824, 2855, 2935, 2945, 2950, 3006, 3018, 3190, 3276, 3338, 3407, 3486, 3707, 3744, 3819, 3899, 3914, 4124, 4161, 4163, 4263, 4278, 4280, 4291], 'activation': [36, 182, 201, 223, 266, 412, 431, 453, 741, 1916], 'during': [37, 267, 742], 'are': [39, 269, 744, 1398, 1486, 1864, 2053, 3584, 3591], 'still': [40, 174, 270, 404], 'unclear.': [41, 271], 'Recently,': [42, 272], 'a': [43, 77, 94, 103, 126, 225, 273, 307, 324, 333, 356, 455, 496, 593, 864, 963, 1133, 1315, 2036, 2560, 2570, 2630, 2727, 2795, 2817, 2821, 2864, 2900, 3007, 3027, 3036, 3341, 3634, 3680, 3694, 3731, 3789, 3798, 3929, 3936, 3954, 3998, 4046, 4050, 4075, 4191, 4301], 'mammalian': [44, 84, 274, 314, 854, 1049, 1854, 3784], 'superfamily': [45, 153, 275, 383, 844, 1466, 1477], 'of': [46, 69, 89, 102, 115, 161, 217, 276, 299, 319, 332, 345, 391, 447, 494, 498, 502, 578, 586, 689, 850, 860, 982, 990, 1000, 1312, 1322, 1406, 1412, 1464, 1474, 1489, 1538, 1547, 1562, 1669, 1676, 1835, 1861, 1899, 1905, 1933, 2025, 2031, 2163, 2252, 2347, 2457, 2531, 2604, 2640, 2655, 2693, 2706, 2723, 2735, 2741, 2751, 2807, 2850, 2858, 2868, 2902, 2964, 2969, 3160, 3168, 3283, 3307, 3355, 3456, 3477, 3569, 3571, 3580, 3593, 3631, 3710, 3738, 3778, 3800, 3823, 3829, 3888, 3917, 3924, 3945, 3950, 3959, 3987, 4009, 4036, 4103, 4127, 4133, 4147, 4158, 4208, 4223, 4275, 4300, 4305, 4319, 4332, 4351], 'proteins': [47, 277, 1360, 1850, 1863, 2753, 3230, 3274, 3782, 4002], 'related': [48, 278], 'prototype': [51, 281, 858], 'member': [52, 282, 497, 859, 1411], 'Dock180': [53, 70, 90, 116, 152, 179, 283, 300, 320, 346, 382, 409, 848, 1033, 1128, 1264, 1304, 1350, 1539, 1847, 1871, 2032, 2164, 2874, 3161, 3163, 3518, 3632, 3643, 3649, 3767, 3779, 3824, 3962, 3988, 4018, 4086, 4212, 4333], 'has': [54, 284, 838, 2353, 3814, 4338], 'been': [55, 285, 1951, 2170, 2354, 3816, 4340], 'identified': [56, 112, 286, 342], 'with': [57, 178, 189, 287, 408, 419, 696, 845, 867, 957, 1140, 1402, 1903, 2012, 2305, 2496, 2557, 2587, 2610, 2617, 2697, 2726, 2804, 2844, 2863, 2896, 2906, 2973, 3013, 3032, 3035, 3157, 3199, 3223, 3281, 3289, 3329, 3334, 3352, 3373, 3534, 3548, 3576, 3596, 3618, 3656, 3679, 3730, 3735, 3793, 3969, 4083, 4149, 4211, 4321], 'homologues': [58, 288, 1131, 1537, 3164], 'in': [59, 83, 93, 122, 125, 180, 227, 289, 313, 323, 352, 355, 410, 457, 1045, 1148, 1482, 1527, 1552, 1568, 1658, 1667, 1838, 1883, 1917, 2010, 2049, 2308, 2321, 2473, 2490, 2563, 2569, 2583, 2598, 2667, 2785, 2794, 2816, 3052, 3310, 3327, 3340, 3360, 3379, 3460, 3474, 3529, 3586, 3633, 3783, 3827, 3977, 4045, 4058, 4096, 4101, 4108, 4121, 4131, 4155, 4218, 4240, 4272], 'Drosophila': [60, 290, 1528], 'Caenorhabditis': [62, 292, 1530], 'elegans.': [63, 293, 2323], 'Here,': [64, 294, 1866], 'we': [65, 111, 295, 341, 1867, 3787, 3892, 3927, 4067, 4113, 4167, 4204], 'addressed': [66, 296], 'role': [68, 226, 298, 456, 3777, 3822], 'ELMO1': [72, 92, 118, 149, 162, 218, 302, 322, 348, 379, 392, 448, 868, 1035, 1266, 1306, 1352, 1541, 1849, 1873, 1912, 1934, 2009, 2026, 3169, 3193, 3769, 3781, 3826, 3964, 3991, 4020, 4088, 4214, 4343], 'proteins,': [73, 303], 'which': [74, 187, 304, 417, 1042, 1397, 1483, 1559, 1858, 2309, 2680, 3053, 3934, 4195], 'function': [75, 305, 1468, 1485, 1542, 1829], 'as': [76, 97, 99, 306, 327, 329, 874, 962, 1469, 1543, 2054, 2559, 2770, 2908, 2989, 3047, 3073, 3609, 3759], 'complex': [78, 135, 205, 308, 365, 435, 866, 872], 'mediate': [80, 310, 686, 1144], 'activation,': [82, 312], 'migration.': [86, 157, 229, 316, 387, 459, 1941], 'Using': [87, 317], 'mutants': [88, 160, 318, 390, 1904, 2024, 2162], 'Transwell': [95, 325, 1885, 2608, 2633, 2672, 2791, 2822, 3790, 3908, 4129, 4165], 'assay': [96, 326, 2762, 3465, 3792, 4226], 'well': [98, 328, 2819], 'transgenic': [100, 330, 2882, 3002], 'rescue': [101, 331, 1898], 'C.': [104, 334, 606, 930, 1170, 1277, 1371, 2178, 2322, 2362, 2869, 3081, 3243, 3837], 'elegans': [105, 335, 1531, 2870], 'mutant': [106, 336, 2030, 2052, 2067, 2168], 'lacking': [107, 337], 'CED-5': [108, 338, 1660, 1823, 1900], '(Dock180': [109, 339], 'homologue),': [110, 340], 'specific': [113, 343, 922], 'regions': [114, 344, 3568], 'vitro': [123, 353, 1149, 1884], 'whole': [127, 357], 'animal': [128, 358], 'model.': [129, 359], 'both': [131, 361, 3054, 4001], 'Dock180·ELMO1': [134, 364, 4150, 4217, 4264, 4292, 4322], 'ability': [139, 369, 4157, 4274], 'activate': [141, 371, 1425], 'were': [143, 373, 1826, 2033, 2040, 2073, 2340, 2417, 2452, 2460, 2471, 2488, 2506, 2517, 2554, 2577, 2596, 2635, 2663, 2765, 2781, 2840, 2878, 2894, 2931, 2943, 2957, 2978, 2984, 3004, 3023, 3060, 3063, 3071, 3154, 3175, 3212, 3231, 3279, 3301, 3313, 3324, 3350, 3369, 3395, 3405, 3418, 3423, 3493, 3527, 3545, 3607, 3654, 3676, 3713, 3757, 4021, 4042, 4177], 'required.': [144, 374], 'We': [145, 375, 1888, 4229, 4283], 'also': [146, 376, 685, 1361, 1467, 1851, 1889, 2623, 2664, 3815, 4015, 4043, 4114, 4230], 'found': [147, 377, 1420, 3893, 4115, 4205], 'that': [148, 172, 199, 378, 402, 429, 738, 1136, 1318, 1460, 1534, 1870, 2799, 2953, 3010, 3038, 3894, 4017, 4032, 4069, 4116, 4258, 4316, 4342], 'regulated': [150, 380], 'multiple': [151, 381, 3594], 'members': [154, 384, 1463], 'promote': [156, 185, 386, 415, 979, 1310, 1355, 1877, 3995], 'Interestingly,': [158, 388, 1357, 1907], 'deletion': [159, 389], 'missing': [163, 393], 'their': [164, 394, 732, 3398, 3951, 4196], 'first': [165, 168, 395, 398], '531': [166, 396], 'or': [167, 397, 1417, 1662, 2314, 2814, 3162, 3285, 3336, 3472, 3513, 3616, 3990, 4087, 4216], '330': [169, 214, 399, 444], 'amino': [170, 215, 400, 445, 4349], 'acids': [171, 216, 401, 446, 4350, 4362], 'can': [173, 403, 684, 1137, 1354], 'bind': [175, 405, 1422], 'cooperate': [177, 407, 1308], 'failed': [183, 413], 'migration,': [186, 416, 3786, 3996], 'correlated': [188, 418], 'inability': [191, 421], 'localize': [193, 423], 'lamellipodia.': [195, 425], 'This': [196, 426, 3796, 4255], 'finding': [197, 427, 4256], 'suggests': [198, 428, 4257], 'by': [202, 211, 432, 441, 966, 986, 1897, 2002, 2035, 2075, 2210, 2329, 2509, 2653, 2716, 2754, 2885, 3234, 3315, 3388, 3397, 3469, 3564, 3639, 3693, 4074, 4081], 'ELMO·Dock180': [204, 434], 'discrete': [207, 437], 'intracellular': [208, 438], 'locations': [209, 439], 'mediated': [210, 440], 'N-terminal': [213, 443, 4347], 'rather': [219, 449, 1431, 1927], 'than': [220, 450, 1432], 'generalized': [221, 451, 1914], 'plays': [224, 454], 'many': [465], 'normal': [466, 3666], 'abnormal': [468], 'biological': [469, 1472], 'processes': [470], 'including': [471], 'development,': [473], 'wound': [474], 'healing,': [475], 'immune': [477], 'response,': [478], 'tumor': [480], 'metastasis.': [482], 'virtually': [484], 'every': [485], 'type': [487, 3961], 'examined,': [488], 'requires': [491, 4345], 'activity': [493, 1271, 2657, 4057], 'Rac,': [495], 'Rho': [500, 1052, 1428], 'family': [501, 1053, 1429], 'GTPases': [504, 1054], '(1Etienne-Manneville': [505, 1492], 'S.': [506, 553, 612, 1060, 1493, 1584, 1627, 2083, 2134, 2224, 2993], 'Hall': [507, 539, 554, 632, 1004, 1494, 1771], 'A.': [508, 540, 555, 633, 1003, 1005, 1495, 1772], 'Nature.': [509, 1022, 1496, 1731], '2002;': [510, 657, 710, 795, 810, 825, 948, 1008, 1157, 1188, 1295, 1389, 1448, 1497, 1512, 2196, 2380, 3099, 3261, 3855], '420:': [511, 1498], '629-635Crossref': [512, 1499], 'PubMed': [513, 532, 547, 565, 619, 641, 665, 680, 713, 726, 756, 774, 798, 813, 833, 951, 1011, 1026, 1077, 1122, 1160, 1191, 1298, 1344, 1392, 1451, 1500, 1520, 1596, 1613, 1635, 1722, 1735, 1760, 1785, 1800, 1819, 1994, 2100, 2126, 2153, 2199, 2237, 2298, 2383, 2924, 2998, 3102, 3147, 3264, 3449, 3858, 3880], 'Scopus': [514, 533, 548, 566, 620, 642, 666, 714, 727, 775, 799, 814, 834, 952, 1012, 1027, 1078, 1123, 1161, 1192, 1299, 1345, 1393, 1452, 1501, 1521, 1597, 1614, 1636, 1723, 1736, 1761, 1786, 1801, 1995, 2101, 2127, 2154, 2200, 2238, 2299, 2384, 2925, 3103, 3148, 3265, 3450, 3859, 3881], '(3768)': [515, 1502], 'Google': [516, 535, 550, 568, 622, 644, 668, 681, 716, 729, 757, 777, 801, 816, 836, 954, 1014, 1029, 1080, 1125, 1163, 1194, 1301, 1347, 1395, 1454, 1503, 1523, 1599, 1616, 1638, 1654, 1725, 1738, 1763, 1788, 1803, 1820, 1997, 2103, 2129, 2156, 2202, 2240, 2301, 2386, 2927, 2999, 3105, 3150, 3267, 3452, 3861, 3883], 'Scholar,': [517, 536, 551, 623, 645, 669, 717, 758, 802, 817, 1015, 1081, 1164, 1504, 1600, 1617, 1639, 1726, 1739, 1764, 1789, 1804, 2104, 2130, 3106, 3862], '2Allen': [518], 'W.E.': [519], 'Zicha': [520], 'D.': [521, 631], 'Ridley': [522], 'A.J.': [523, 625, 749], 'Jones': [524], 'G.E.': [525], 'J.': [526, 541, 674, 750, 762, 807, 821, 1021, 1154, 1508, 1607, 1629, 2115, 2231, 2920, 3438, 3869], 'Biol.': [528, 543, 656, 709, 765, 794, 824, 947, 1073, 1187, 1294, 1340, 1388, 1447, 1511, 1609, 1796, 2096, 2116, 2195, 2233, 2379, 3098, 3260, 3439, 3854, 3870], '1998;': [529, 1632, 1732, 2118], '141:': [530], '1147-1157Crossref': [531], '(444)': [534], '3Nobes': [537], 'C.D.': [538], '1999;': [544, 723, 2150, 2234], '144:': [545], '1235-1244Crossref': [546], '(1201)': [549], '4Etienne-Manneville': [552], 'Cell.': [556, 634, 1072, 1113, 1339, 1587, 1713, 1751, 1776, 1985, 2095, 2289, 3138], '2001;': [557, 677, 753, 1114, 1341, 1588, 1714, 1752, 1777, 1816, 1986, 2290, 3139, 3441, 3872], '106:': [558], '489-498Abstract': [559], 'Full': [560, 562, 638, 660, 662, 769, 771, 828, 830, 1117, 1119, 1515, 1517, 1591, 1593, 1717, 1719, 1755, 1757, 1780, 1782, 1989, 1991, 2121, 2123, 2293, 2295, 3142, 3144, 3444, 3446, 3875, 3877], 'Text': [561, 563, 639, 661, 663, 770, 772, 829, 831, 1118, 1120, 1516, 1518, 1592, 1594, 1718, 1720, 1756, 1758, 1781, 1783, 1990, 1992, 2122, 2124, 2294, 2296, 3143, 3145, 3445, 3447, 3876, 3878], 'PDF': [564, 640, 664, 773, 832, 1121, 1519, 1595, 1721, 1759, 1784, 1993, 2125, 2297, 3146, 3448, 3879], '(843)': [567], 'Scholar).': [569, 682, 730, 778, 955, 1030, 1126, 1195, 1302, 1348, 1455, 1524, 1655, 1821, 1998, 2157, 2203, 2241, 2387, 2928, 3000, 3151, 3268, 3884], 'preferentially': [572], 'activated': [573], 'migrating': [579, 1407, 2642], 'cells': [580, 1680, 1918, 2470, 2487, 2505, 2516, 2550, 2576, 2595, 2641, 2662, 2695, 2707, 2719, 2742, 2764, 2780, 2852, 3153, 3174, 3287, 3323, 3349, 3394, 3458, 3471, 3498, 3526, 3595, 3606, 3653, 3831, 3896, 3947, 3971, 4010, 4037, 4160, 4209, 4277], 'where': [581], 'it': [582, 1457], 'induces': [583], 'actin-rich': [587, 1399], 'protrusions': [589, 700, 1400], 'thought': [590], 'be': [592, 1937, 4153], 'key': [594], 'driving': [595], 'force': [596], 'membrane': [598, 1364], 'extension': [599], '(5Kraynov': [603], 'V.S.': [604], 'Chamberlain': [605], 'Bokoch': [607], 'G.M.': [608], 'Schwartz': [609, 790, 1443], 'M.A.': [610, 789, 791, 1442, 1444], 'Slabaugh': [611], 'Hahn': [613], 'K.M.': [614, 1619], 'Science.': [615, 722], '2000;': [616, 766, 1023, 1797], '290:': [617], '333-337Crossref': [618], '(559)': [621], '6Ridley': [624], 'Paterson': [626], 'H.F.': [627], 'Johnston': [628], 'C.L.': [629], 'Diekmann': [630], '1992;': [635], '70:': [636], '401-410Abstract': [637], '(3041)': [643], '7Small': [646], 'J.V.': [647], 'Stradal': [648], 'T.': [649, 671, 1068, 1103, 1703, 1975, 2091, 2110, 2142, 2279, 3128], 'Vignal': [650], 'E.': [651, 926, 1058, 1085, 1166, 1273, 1367, 1641, 1685, 1768, 1770, 1810, 1957, 2081, 2106, 2174, 2261, 2358, 3077, 3110, 3239, 3435, 3833, 3866], 'Rottner': [652], 'K.': [653, 806, 819, 1062, 1093, 1153, 1506, 1580, 1621, 1693, 1965, 2085, 2144, 2269, 3118], 'Trends': [654, 763, 822, 1509], '12:': [658, 826, 1513, 1633], '112-120Abstract': [659], '(723)': [667], '8Wittmann': [670], 'Waterman-Storer': [672], 'C.M.': [673], 'Sci.': [676, 752, 809, 1156], '114:': [678, 754], '3795-3803Crossref': [679], 'assembly': [688], 'multi-molecular': [690], 'signaling': [691, 736], 'adhesion': [693, 2758, 4242], 'complexes': [694], 'associated': [695, 1401], 'these': [697, 1358, 1839, 1862, 1891, 4064, 4159, 4202], '(9Webb': [701], 'D.J.': [702], 'Parsons': [703, 720, 2345], 'J.T.': [704, 721], 'Horwitz': [705], 'A.F.': [706], 'Nat.': [707, 792, 945, 1185, 1292, 1336, 1386, 1445, 1794, 2193, 2377, 3096, 3258, 3852], '4:': [711, 796, 949, 1189, 1296, 1390, 1449, 2197, 2381, 3100, 3262, 3856], 'E97-E100Crossref': [712], '(594)': [715], '10Horwitz': [718], 'A.R.': [719], '286:': [724], '1102-1103Crossref': [725], '(341)': [728], 'Despite': [731], 'importance,': [733], 'upstream': [735, 1545, 1561, 1834], 'facilitate': [739], 'not': [745, 1921, 3481, 3614, 3645, 3912, 3994, 4253, 4267], 'fully': [746], 'understood': [747], '(11Ridley': [748], '2713-2722Crossref': [755], '12Symons': [759], 'M.': [760, 784, 932, 1066, 1070, 1172, 1279, 1373, 1437, 1649, 2089, 2093, 2114, 2146, 2180, 2364, 3083, 3245, 3839], 'Settleman': [761, 1628], '10:': [767, 2922], '415-419Abstract': [768], '(196)': [776], 'Recent': [779], 'work': [780], '(13Meller': [781, 1434], 'N.': [782, 1064, 1435, 2087, 2140], 'Irani-Tehrani': [783, 1436], 'Kiosses': [785, 1438], 'W.B.': [786, 1439], 'Del': [787, 1440], 'Pozo': [788, 1441], '639-647Crossref': [797, 1450], '(145)': [800, 1453], '14Cote': [803], 'J.F.': [804, 1151], 'Vuori': [805, 1152], '115:': [811, 1158], '4901-4913Crossref': [812, 1159], '(335)': [815, 1162], '15Reif': [818, 1505], 'Cyster': [820, 1507], '368-373Abstract': [827, 1514], '(79)': [835, 1522], 'Scholar)': [837, 2302], 'revealed': [839], 'an': [840, 875, 969, 974, 1037, 1261, 1882, 1894, 2605, 3736, 3906, 4007, 4033, 4140, 4187], 'evolutionarily': [841], 'conserved': [842, 1536], 'protein': [843, 1209, 1234, 3200], 'homology': [846, 1040, 1211, 1217, 1236, 1242], 'comprised': [849], 'least': [852], '11': [853], 'members.': [855], 'Dock180,': [856, 2064, 4352], 'this': [861, 871, 1413, 1465, 1475, 3889, 4004, 4109, 4169], 'superfamily,': [862, 1414], 'forms': [863], 'basal': [865], 'together': [870], 'functions': [873, 961], 'unconventional': [876], 'two-part': [877], 'guanine': [878, 1196, 1221], 'nucleotide': [879, 888, 907, 1197, 1222], 'exchange': [880, 889, 908, 981, 1147, 1198, 1223], 'factor': [881, 1199, 1224], '(GEF)': [882], '1The': [883], 'abbreviations': [884, 903], 'used': [885, 904, 3406, 3743, 3808, 3817, 3928], 'are:': [886, 905], 'GEFguanine': [887, 906], 'factorDTCdistal': [890, 909], 'tip': [891, 910, 1201, 1226, 1679], 'cellELMOengulfment': [892, 911], 'motilityGFPgreen': [895, 914], 'fluorescent': [896, 915, 1208, 1233, 3358], 'proteinSHSrc': [897, 916], 'homologyCMVcytomegalovirusHAhemagglutininGSTglutathione': [898, 917], 'S-transferasePHpleckstrin': [899, 918], 'homologyCRIBCdc42/Rac': [900, 919], 'interactive': [901, 920, 1219, 1244], 'binding.1The': [902], 'binding.': [921, 1220, 1245], '(16Brugnera': [925, 1272, 1366, 2173, 2357, 3076, 3238, 3832], 'Haney': [927, 1090, 1167, 1274, 1368, 1690, 1962, 2175, 2266, 2359, 3078, 3115, 3240, 3834], 'L.': [928, 1108, 1168, 1275, 1369, 1708, 1980, 2176, 2284, 2360, 3079, 3133, 3241, 3835], 'Grimsley': [929, 1169, 1276, 1370, 2177, 2361, 3080, 3242, 3836], 'Lu': [931, 1171, 1278, 1372, 1622, 2179, 2363, 3082, 3244, 3838], 'Walk': [933, 1094, 1173, 1280, 1374, 1694, 1966, 2181, 2270, 2365, 3084, 3119, 3246, 3840], 'S.F.': [934, 1095, 1174, 1281, 1375, 1695, 1967, 2182, 2271, 2366, 3085, 3120, 3247, 3841], 'Tosello-Trampont': [935, 1086, 1175, 1282, 1376, 1686, 1958, 2183, 2262, 2367, 3086, 3111, 3248, 3842], 'A.C.': [936, 1087, 1176, 1283, 1377, 1687, 1959, 2184, 2263, 2368, 3087, 3112, 3249, 3433, 3843, 3864], 'Macara': [937, 1098, 1177, 1284, 1378, 1698, 1970, 2185, 2274, 2369, 3088, 3123, 3250, 3844], 'I.G.': [938, 1099, 1178, 1285, 1379, 1699, 1971, 2186, 2275, 2370, 3089, 3124, 3251, 3845], 'Madhani': [939, 1179, 1286, 1380, 2187, 2371, 3090, 3252, 3846], 'H.': [940, 1056, 1180, 1287, 1381, 2079, 2112, 2132, 2188, 2372, 3091, 3253, 3847], 'Fink': [941, 1181, 1288, 1382, 2189, 2373, 3092, 3254, 3848], 'G.R.': [942, 1182, 1289, 1383, 2190, 2374, 3093, 3255, 3849], 'Ravichandran': [943, 1111, 1183, 1290, 1384, 1711, 1983, 2191, 2287, 2375, 3094, 3136, 3256, 3436, 3850, 3867], 'K.S.': [944, 1112, 1184, 1291, 1385, 1712, 1984, 2192, 2288, 2376, 3095, 3137, 3257, 3437, 3851, 3868], '574-582Crossref': [950, 1190, 1297, 1391, 2198, 2382, 3101, 3263, 3857], '(464)': [953, 1193, 1300, 1394, 2201, 2385, 3104, 3266, 3860], 'As': [956, 3429], 'other': [958, 1047, 1410, 1462], 'GTPases,': [959], 'binary': [964], 'switch': [965], 'cycling': [967], 'between': [968, 1263, 2543], 'inactive': [970], 'GDP-bound': [971], 'form': [972, 4304], 'active': [975], 'GTP-bound': [976], 'form.': [977], 'GEFs': [978, 1050], 'GDP': [983, 991], 'GTP': [985, 1001], 'stimulating': [987], 'dissociation': [989], 'stabilizing': [993], 'nucleotide-free': [995, 1141], 'form,': [996], 'thereby': [997], 'facilitating': [998], 'association': [999], '(17Schmidt': [1002], 'Genes': [1006, 1630], 'Dev.': [1007, 1631, 1750, 1775], '16:': [1009, 1075, 2098], '1587-1609Crossref': [1010], '(967)': [1013], '18Worthylake': [1016], 'D.K.': [1017], 'Rossman': [1018], 'K.L.': [1019], 'Sondek': [1020], '408:': [1024], '682-688Crossref': [1025], '(303)': [1028], 'neither': [1032], 'nor': [1034, 1351], 'contains': [1036], 'obvious': [1038], 'Dbl': [1039], 'domain,': [1041], 'present': [1044, 3309], 'most': [1046], 'known': [1048], '(19Hasegawa': [1055, 2078], 'Kiyokawa': [1057, 2080], 'Tanaka': [1059, 2082], 'Nagashima': [1061, 2084, 2143], 'Gotoh': [1063, 2086], 'Shibuya': [1065, 2088], 'Kurata': [1067, 2090, 2109, 2141], 'Matsuda': [1069, 2077, 2092, 2113, 2145], 'Mol.': [1071, 1338, 2094], '1996;': [1074, 2097], '1770-1776Crossref': [1076, 2099], '(289)': [1079, 2102], '20Gumienny': [1082, 3107], 'T.L.': [1083, 1683, 1955, 2259, 3108], 'Brugnera': [1084, 1684, 1956, 2260, 3109, 3434, 3865], 'Kinchen': [1088, 1688, 1960, 2264, 3113], 'J.M.': [1089, 1689, 1961, 2265, 2914, 3114], 'L.B.': [1091, 1691, 1963, 2267, 3116], 'Nishiwaki': [1092, 1692, 1964, 2268, 3117], 'Nemergut': [1096, 1696, 1968, 2272, 3121], 'M.E.': [1097, 1697, 1969, 2273, 3122], 'Francis': [1100, 1700, 1972, 2276, 3125], 'R.': [1101, 1643, 1701, 1973, 2277, 3126], 'Schedl': [1102, 1702, 1974, 2278, 3127], 'Qin': [1104, 1704, 1976, 2280, 3129], 'Y.': [1105, 1623, 1705, 1977, 2108, 2136, 2281, 3130], 'Van': [1106, 1706, 1978, 2282, 3131], 'Aelst': [1107, 1707, 1979, 2283, 3132], 'Hengartner': [1109, 1709, 1981, 2285, 3134], 'M.O.': [1110, 1710, 1982, 2286, 3135], '107:': [1115, 1589, 1715, 1987, 2291, 3140], '27-41Abstract': [1116, 1716, 1988, 2292, 3141], '(447)': [1124, 1724, 1996, 2300, 3149], 'Instead,': [1127], 'its': [1130], 'contain': [1132], 'Docker': [1134, 1251, 4359], 'domain': [1135, 1252, 4360], 'interact': [1138], 'directly': [1139, 3188, 4185], 'GDP/GTP': [1146], '(14Cote': [1150], '16Brugnera': [1165], 'distal': [1200, 1225, 1678], 'engulfment': [1203, 1228, 1668, 3478], 'motility': [1206, 1231, 4148], 'green': [1207, 1232, 3573], 'Src': [1210, 1235], 'cytomegalovirus': [1212, 1237], 'hemagglutinin': [1213, 1238], 'glutathione': [1214, 1239], 'S-transferase': [1215, 1240], 'pleckstrin': [1216, 1241], 'Cdc42/Rac': [1218, 1243], 'intact': [1247], 'cells,': [1248, 1314, 1671, 3926], 'however,': [1249, 1844], 'alone': [1253, 1353, 1919, 2699, 3974, 3989, 3992], 'insufficient': [1255], 'efficient': [1257], 'GTP-loading': [1259, 3270], 'interaction': [1262], 'GEF': [1270], 'Moreover,': [1303], 'functionally': [1307, 1874], 'phagocytosis': [1311, 3828], 'apoptotic': [1313, 1670, 3830], 'Rac-dependent': [1316, 1853, 1878], 'process': [1317, 3476], 'involves': [1319], 'dynamic': [1320], 'reorganization': [1321], 'actin': [1324], 'cytoskeleton': [1325], '(for': [1326], 'review': [1327], 'see': [1328], 'Ref.': [1329], '21Henson': [1330], 'P.M.': [1331], 'Bratton': [1332], 'D.L.': [1333], 'Fadok': [1334], 'V.A.': [1335], 'Rev.': [1337], '2:': [1342, 1798], '627-633Crossref': [1343], '(287)': [1346], 'Neither': [1349], 'phagocytosis.': [1356], 'two': [1359], 'colocalize': [1362], 'on': [1363, 1909, 2787, 3500, 3905, 4186, 4296, 4325], 'ruffles': [1365], 'Scholar),': [1396, 3453], 'cells.': [1408, 2738, 3412, 3795], 'One': [1409], 'termed': [1415], 'Dock9': [1416], 'Zizimin,': [1418], 'was': [1419, 2000, 2208, 2245, 2303, 2316, 2326, 2430, 2438, 2536, 2622, 2651, 2684, 2700, 2714, 2747, 2861, 3011, 3045, 3197, 3637, 3742, 3750, 4079, 4099, 4118, 4199, 4294], 'specifically': [1424], 'Cdc42': [1426], '(another': [1427], 'member)': [1430], 'Thus,': [1456], 'likely': [1459], 'GEFs.': [1470], 'The': [1471, 2047, 2158, 2204, 2242, 2334, 2690, 2704, 3299, 3392, 3567, 3588, 3629, 3747], 'roles': [1473], 'new': [1476], 'cellular': [1480], 'contexts': [1481], 'they': [1484], 'important': [1487], 'areas': [1488], 'continuing': [1490], 'investigation': [1491], 'Genetic': [1525], 'studies': [1526, 1910, 3812], 'have': [1532, 1950, 2169, 2936], 'suggested': [1533], 'highly': [1535], 'critical': [1544, 1938], 'regulators': [1546], 'Rac.': [1548, 3320], 'Drosophila,': [1550], 'mutations': [1551, 2048], 'gene': [1554], 'encoding': [1555], 'Myoblast': [1556], 'City': [1557], '(Dock180),': [1558], 'acts': [1560], 'Drac1': [1563], '(Rac),': [1564], 'lead': [1565], 'defects': [1567, 1666], 'myoblast': [1569], 'fusion,': [1570], 'dorsal': [1571], 'closure,': [1572], 'border': [1574], '(22Duchek': [1577], 'P.': [1578, 1586], 'Somogyi': [1579], 'Jekely': [1581], 'G.': [1582], 'Beccari': [1583], 'Rorth': [1585], '17-26Abstract': [1590], '(348)': [1598], '23Erickson': [1601], 'M.R.': [1602], 'Galletta': [1603], 'B.J.': [1604], 'Abmayr': [1605, 1644], 'S.M.': [1606, 1645], '1997;': [1610], '138:': [1611], '589-603Crossref': [1612], '(230)': [1615], '24Nolan': [1618], 'Barrett': [1620], 'Hu': [1624], 'K.Q.': [1625], 'Vincent': [1626], '3337-3342Crossref': [1634], '(179)': [1637], '25Rushton': [1640], 'Drysdale': [1642], 'Michelson': [1646], 'A.M.': [1647], 'Bate': [1648], 'Development.': [1650, 1815], '1995;': [1651], '121:': [1652], '1979-1988PubMed': [1653], 'Worms': [1656, 2952, 2983, 3022, 3034], 'deficient': [1657, 1901], 'either': [1659, 2783, 4084], '(Dock180)': [1661], 'CED-12': [1663, 1825], '(ELMO1)': [1664], 'display': [1665], 'axonal': [1672], 'pathfinding,': [1673], '(DTCs)': [1681], '(20Gumienny': [1682, 1954, 2258], '26Wu': [1727], 'Y.C.': [1728, 1741], 'Horvitz': [1729, 1773, 1792, 1811], 'H.R.': [1730, 1774, 1793, 1812], '392:': [1733], '501-504Crossref': [1734], '(136)': [1737], '27Wu': [1740], 'Tsai': [1742], 'M.C.': [1743], 'Cheng': [1744], 'L.C.': [1745], 'Chou': [1746], 'C.J.': [1747], 'Weng': [1748], 'N.Y.': [1749], '1:': [1753, 1778], '491-502Abstract': [1754], '(132)': [1762], '28Zhou': [1765], 'Z.': [1766], 'Caron': [1767], 'Hartwieg': [1769, 1809], '477-489Abstract': [1779], '(139)': [1787], '29Reddien': [1790], 'P.W.': [1791, 1808], '131-136Crossref': [1799], '(329)': [1802], '30Lundquist': [1805], 'E.A.': [1806], 'Reddien': [1807], 'Bargmann': [1813], 'C.I.': [1814], '128:': [1817], '4475-4488Crossref': [1818], 'Genetically,': [1822], 'shown': [1827, 3430, 3590], 'same': [1832, 2789, 4013], 'step': [1833], 'CED-10': [1836], '(Rac)': [1837], 'processes.': [1840], 'It': [1841, 4029], 'remains': [1842], 'unknown,': [1843], 'whether': [1845, 4286], 'regulate': [1852], 'structural': [1859], 'features': [1860], 'involved.': [1865], 'provide': [1868], 'evidence': [1869], 'synergize': [1875], 'using': [1881, 1911, 2462, 2520, 2579, 3185, 3425, 3504, 3624, 3715, 3762], 'assay.': [1887, 2776, 2866], 'confirm': [1890, 2043], 'observations': [1892], 'organismal': [1895], 'level': [1896], 'worms': [1902, 2893, 3003, 3051], 'Dock180.': [1906, 3711], 'based': [1908], 'mutants,': [1913], 'sufficient': [1922], 'enhance': [1924], 'but': [1926, 3613], 'targeting': [1928], 'via': [1929, 4357], 'N': [1931], 'terminus': [1932], 'appears': [1935], 'Dock180·ELMO1-mediated': [1940], 'Plasmids': [1942], 'Antibodies—GFP-tagged': [1944], 'ELMO1,': [1945], 'ELMO1-Δ330-GFP': [1946], 'ELMO1-FLAG-CAAX': [1949, 2011], 'described': [1952, 2171, 2355, 2771, 2909, 2990, 3074], 'previously': [1953, 2172, 2356, 2910, 2991, 3075, 3431, 3818, 4339], 'ELMO1-Δ531-FLAG-CAAX': [1999], 'generated': [2001, 2034], 'replacing': [2003], 'coding': [2005, 2014], 'region': [2006, 2015], 'full-length': [2008], 'residues': [2017], '532-727.': [2018], 'GFP-tagged': [2019], 'T707,': [2020], '6M,': [2021], 'Δ531': [2023], 'ΔSH3': [2029], 'PCR-based': [2037], 'approach': [2038], 'sequenced': [2041], 'appropriate': [2045], 'mutations.': [2046], '6M': [2051], 'follows:': [2055], 'L689A,': [2056], 'M691S,': [2057], 'E692D,': [2058], 'R696K,': [2059], 'L697A,': [2060], 'L698A.': [2062], 'Full-length': [2063], 'DOHRS': [2066], 'plasmid,': [2068], 'Dock180-CAAX,': [2069], 'FLAG-tagged': [2071, 2310, 2335], 'Dock2': [2072], 'provided': [2074, 2209, 2328, 3935], 'Dr.': [2076, 2211, 2248, 2343], '32Kiyokawa': [2105], 'Hashimoto': [2107, 2135], 'Sugimura': [2111], 'Chem.': [2117, 3440, 3871], '273:': [2119], '24479-24484Abstract': [2120], '(181)': [2128], '38Nishihara': [2131], 'Kobayashi': [2133], 'Ohba': [2137], 'F.': [2138], 'Mochizuki': [2139], 'Biochim.': [2147], 'Biophys.': [2148], 'Acta.': [2149], '1452:': [2151], '179-187Crossref': [2152], '(75)': [2155], 'Δ357': [2159], 'Dock-ISP': [2161], 'ELMO1-T625': [2167], 'plasmid-encoding': [2205], 'Tiam1': [2206], '(C1199)': [2207], 'John': [2212], 'Collard': [2213, 2229], '(Netherlands': [2214], 'Cancer': [2215], 'Institute)': [2216], '(48Sander': [2217], 'E.E.': [2218], 'ten': [2219], 'Klooster': [2220], 'J.P.': [2221], 'van': [2222, 2225], 'Delft': [2223], 'der': [2226], 'Kammen': [2227], 'R.A.': [2228], 'J.G.': [2230], '147:': [2235], '1009-1022Crossref': [2236], '(729)': [2239], 'pGL3-CMV-luciferase': [2243, 2558], 'plasmid': [2244, 2541], 'obtained': [2246, 2341], 'from': [2247, 2342, 2418, 2431, 2439, 2453, 2720, 2743, 3040, 3411, 3599, 4011, 4038, 4180, 4269], 'Michael': [2249], 'Smith': [2250], '(University': [2251, 2346], 'Virginia).': [2253, 2348], 'A': [2254], 'Peft-3': [2255, 2887], 'expression': [2256, 2320, 2750, 2962, 3630, 3709, 3986, 4098], 'construct': [2257, 2562], 'modified': [2304, 2475, 2492], 'NcoI-NotI': [2306], 'sites': [2307], 'DOCK180(wild': [2311], 'type),': [2312], 'DOCK180(ISP→AAA),': [2313], 'DOCK180-(358-1865)': [2315], 'cloned': [2317], 'subsequent': [2319], 'HA-tagged': [2324], 'Dock3': [2325], 'kindly': [2327], 'David': [2330], 'Schubert': [2331], '(Salk': [2332], 'Institute).': [2333], 'Rac1Q61L': [2336], 'Rac1T17N': [2338], 'plasmids': [2339, 2568, 3332, 3492, 4089], 'Tom': [2344], 'Purified': [2349], 'rabbit': [2350, 2405], 'polyclonal': [2351, 2399, 2406, 3682], 'anti-ELMO1': [2352, 3195], 'Mouse': [2388, 2425, 2433], 'monoclonal': [2389, 2394, 2426, 2434], 'anti-GFP': [2390], '(clone': [2391, 2396, 2408, 2428, 2436], 'B2),': [2392], 'mouse': [2393], 'anti-HA': [2395], 'F7),': [2397], 'goat': [2398, 3681], 'anti-Dock180': [2400, 3683], '(clones': [2401], 'N19': [2402], 'C19),': [2404], 'anti-GST': [2407], 'Z5),': [2409], 'horseradish': [2411], 'peroxidase-conjugated': [2412, 2446], 'donkey': [2413, 3667, 3697], 'anti-goat': [2414, 3698], 'IgG': [2415], 'antibodies': [2416, 2451], 'Santa': [2419], 'Cruz': [2420, 3203], 'Biotechnology': [2421, 2441, 3204], '(Santa': [2422, 3202], 'Cruz,': [2423], 'CA).': [2424], 'anti-FLAG': [2427, 3186], 'M2)': [2429], 'Sigma.': [2432], 'anti-Rac': [2435], '23A8)': [2437], 'Upstate': [2440], '(Lake': [2442], 'Placid,': [2443], 'NY).': [2444], 'Horseradish': [2445], 'anti-mouse': [2447], 'anti-rabbit': [2449], 'secondary': [2450], 'Amersham': [2454], 'Biosciences.': [2455], 'All': [2456], 'immunoblots': [2459], 'developed': [2461, 3788], 'enhanced': [2463, 4260, 4288], 'chemiluminescence': [2464], '(Pierce).': [2465], 'Culture': [2467], 'Transfection—293T': [2469], 'maintained': [2472, 2489, 2985], "Dulbecco's": [2474], "Eagle's": [2476, 2493], 'medium': [2477, 2494, 2585, 2615, 3362, 3381, 3717], 'containing': [2478, 3659], '10%': [2479, 2497, 3665], 'fetal': [2480, 2498, 2589, 2619], 'calf': [2481, 2499], 'serum': [2482, 2500, 2621, 3542, 3662, 3668], '1%': [2484, 2502], 'penicillin/streptomycin/glutamine.': [2485, 2503], 'LR73': [2486, 2515, 3284, 3497, 3794, 3895], "Alpha's": [2491], 'supplemented': [2495, 2586, 2616], '293T': [2504, 3152, 3286], 'transiently': [2507, 2518, 2555, 3155, 3325, 3494], 'transfected': [2508, 2519, 2556, 2696, 2752, 2851, 3156, 3326, 3393, 3470, 3495, 3925, 3946, 4060, 4210, 4238], 'calcium': [2511], 'phosphate': [2512], 'method,': [2513], 'LipofectAMINE': [2521, 3505], '2000': [2522, 3506], '(Invitrogen)': [2523], 'according': [2524], "manufacturer's": [2527], 'instruction.': [2528], 'all': [2530], 'experiments,': [2533], 'carrier': [2534], 'DNA': [2535, 2898], 'added': [2537, 2597, 2624, 2666], 'keep': [2539], 'equal': [2540, 4034], 'concentration': [2542, 2901], 'different': [2544, 4026, 4182], 'samples.': [2545], 'Migration': [2546], 'Adhesion': [2548], 'Assay—LR73': [2549, 3322], '∼70%': [2552], 'confluency': [2553], 'reporter': [2561, 3932], 'addition': [2564], 'indicated': [2567, 2835, 2873, 3291, 3331, 3491], '6-well': [2571], 'plate.': [2572, 3343], 'After': [2573, 2629, 3364], '20': [2574, 2987, 3344, 3557, 3670], 'h,': [2575, 3366], 'harvested': [2578, 3176, 3214], 'trypsin-EDTA': [2580], 'resuspended': [2582, 2769, 3378], 'Opti-MEM': [2584, 2614], '2%': [2588, 2618], 'bovine': [2590, 2620, 3541, 3661], 'serum.': [2591], '1': [2592, 2659, 2777, 3207, 3227, 3294, 4248], '×': [2593, 2660, 2778], '105': [2594, 2661, 2779], 'duplicate': [2599, 2786, 3328, 3635], 'upper': [2602], 'chamber': [2603, 2650, 3502, 3636, 3902, 4048], 'untreated': [2606], 'polycarbonate': [2607], 'filter': [2609, 2646, 2712, 2725, 2792, 2801, 2823, 2860, 3909, 4130, 4189, 4241], '8-μm': [2611], 'pores': [2612], '(Costar).': [2613], 'lower': [2627, 2649], 'chamber.': [2628], '6-h': [2631, 3955, 4220], 'incubation,': [2632], 'filters': [2634, 2673, 2839], 'removed': [2636], 'number': [2639, 4035], 'completely': [2643, 3897], 'through': [2644], 'assessed': [2652, 2715, 3233], 'quantitation': [2654], 'luciferase': [2656, 2677, 2698, 2733, 2828, 2865, 3931, 3973, 4056, 4065, 4071, 4097], '(Promega).': [2658], 'separately': [2665], 'parallel': [2668], 'wells': [2670, 3368], 'without': [2671, 2820], 'estimating': [2675, 4053], 'total': [2676, 2827, 4055], 'activity,': [2678], 'upon': [2679], 'percent': [2682, 2691], 'estimated': [2685], 'each': [2687, 2744, 2831, 3414, 4039, 4059], 'transfection': [2688, 2745, 3182, 3220, 4027, 4040, 4105, 4135, 4183], 'condition.': [2689, 2832], 'control': [2694, 3970], 'set': [2701], '100%.': [2703], 'percentage': [2705, 2849], 'remaining': [2708, 2737, 2853], 'attached': [2709, 2854], 'underside': [2713, 3916, 4126], 'mechanically': [2717], 'removing': [2718], 'top': [2722, 2857], 'cotton': [2728], 'swab': [2729], 'determining': [2731], 'counts': [2734, 2829], 'An': [2739, 3724], 'aliquot': [2740, 4008], 'condition': [2746, 4041], 'analyzed': [2748, 3314, 3387, 3424, 3563], 'immunoblotting.': [2755], 'To': [2756, 2889, 3603, 3920], 'examine': [2757], 'under': [2759, 3026, 4024, 4173], 'conditions,': [2763, 3985, 4203], 'transfected,': [2766], 'harvested,': [2767], 'above': [2772], 'then': [2782, 2841, 3024, 3213, 3232, 3302, 3370, 3546, 3677], 'plated': [2784, 2815, 3499, 4044, 4179], '24-well': [2790, 3342], 'placed': [2793, 3904], '12-well': [2796], 'plate': [2797, 3009], '(so': [2798], 'lies': [2802], 'flush': [2803], 'bottom': [2806, 2812, 3901, 4192], 'well,': [2809], 'eliminating': [2810], 'chamber)': [2813], 'separate': [2818, 4047], 'estimate': [2825], 'At': [2833, 3521], 'time': [2836, 4221], 'points,': [2837], 'gently': [2842], 'washed': [2843, 3371], 'phosphate-buffered': [2845, 3375, 3535, 3657], 'saline': [2846, 3658], 'determined': [2862, 4341], 'Scoring': [2867], 'DTC': [2871], 'Migration—The': [2872], 'CED-5-coding': [2876], 'sequences': [2877], 'subcloned': [2879], 'into': [2880, 3496], 'vector': [2883], 'driven': [2884, 4073], 'promoter.': [2888], 'create': [2890], 'DOCK180-transgenic': [2891], 'lines,': [2892], 'injected': [2895], 'test': [2897], '10': [2903, 3158], 'ng/μl': [2904], 'along': [2905], 'Plim-7::GFP': [2907], '(52Mello': [2911], 'C.C.': [2912], 'Kramer': [2913], 'Stinchcomb': [2915], 'D.T.': [2916], 'Ambros': [2917], 'V.': [2918], 'EMBO': [2919], '1991;': [2921], '3959-3970Crossref': [2923], '(2392)': [2926], 'Injected': [2929], 'hermaphrodites': [2930], 'picked': [2932], 'allowed': [2934, 2949, 3017], 'progeny.': [2937], 'Transgenic': [2938], 'progeny': [2939], '(that': [2940], 'expressed': [2941, 4023], 'Plim-7::GFP)': [2942], 'moved': [2944, 3005], 'individual': [2946], 'plates': [2947], 'grow.': [2951], 'transmitted': [2954], 'array': [2956], 'kept': [2958, 2979], 'assayed': [2960], '(brightness': [2963], 'GFP': [2965, 3335, 3399], 'signal)': [2966], 'transmittance': [2968], 'array.': [2971], 'Strains': [2972], 'highest': [2975], 'transmittance/GFP': [2976], 'signal': [2977], 'further': [2981], 'analysis.': [2982], '°C': [2988, 3691, 3706], '(53Brenner': [2992], 'Genetics.': [2994], '1974;': [2995], '77:': [2996], '71-94Crossref': [2997], 'Clean': [3001], 'large': [3008], 'seeded': [3012], 'OP50': [3014], 'bacteria': [3015], 'propagate': [3019], 'one': [3020], 'generation.': [3021], 'scored': [3025, 3046, 3459], 'Zeiss': [3028], 'M2Bio-dissecting': [3029], 'microscope': [3030, 3729], 'equipped': [3031], 'epifluorescence.': [3033], 'gonad': [3037], 'deviated': [3039], 'standard': [3042], 'U-shaped': [3043], 'tube': [3044], 'defective.': [3049], 'Only': [3050], 'anterior': [3056], 'posterior': [3058], 'arms': [3059], 'clearly': [3061], 'visible': [3062, 3619], 'scored.': [3064], 'Immunoprecipitations': [3065], 'Immunoblotting—Lysis,': [3067], 'immunoprecipitation,': [3068], 'immunoblotting': [3070, 3237, 3318], 'performed': [3072], 'μg': [3159, 3167], '3': [3166, 4250], 'plasmids.': [3170], 'For': [3171, 3192, 3413], 'FLAG': [3172], 'immunoprecipitations,': [3173, 3194], 'lysed': [3178, 3216], '36': [3179], 'h': [3180, 3208, 3218, 3295, 3345, 3523, 4251], 'after': [3181, 3219, 3346, 4194], 'immunoprecipitated': [3184], 'antibody': [3187, 3196, 3684, 3699], 'coupled': [3189], 'Sepharose.': [3191], 'incubated': [3198, 3222, 3280, 3351], 'A-Sepharose': [3201], 'Inc.)': [3205], 'washed.': [3210], 'Cells': [3211, 3544, 3675, 3712, 4176], '24': [3217, 3522], 'beads': [3225, 3278, 3300, 3359, 3410, 3483], 'h.': [3228], 'Precipitated': [3229], 'SDS-PAGE': [3235, 3316], 'Assay—Bacterially': [3271], 'produced': [3272], 'GST-CRIB': [3273], 'bound': [3275, 3485], 'glutathione-Sepharose': [3277], 'lysates': [3282, 3312], '(transfected': [3288], 'plasmids)': [3292], '4': [3297, 3690, 3705], '°C.': [3298], 'washed,': [3303], 'levels': [3306], 'Rac-GTP': [3308], 'Phagocytosis': [3321], '(either': [3333], 'fused': [3337], 'GFP)': [3339], 'transfection,': [3347], '2': [3353, 3365, 3739], 'μm': [3354], 'carboxylate-modified': [3356], 'red': [3357, 3578], 'serum-free': [3361], '(Sigma).': [3363], 'twice': [3372], 'cold': [3374, 3380], 'saline,': [3376, 3536], 'trypsinized,': [3377], '(with': [3382], '0.5%': [3383], 'sodium': [3384], 'azide),': [3385], 'two-color': [3389], 'flow': [3390], 'cytometry.': [3391], 'recognized': [3396], 'fluorescence.': [3400], 'Forward': [3401], 'side-scatter': [3403], 'parameters': [3404], 'distinguish': [3408], 'unbound': [3409], 'point,': [3415], '30,000': [3416], 'events': [3417], 'collected': [3419], 'data': [3422], 'Quest': [3427], 'software.': [3428], '(31Tosello-Trampont': [3432], '276:': [3442, 3873], '13797-13802Abstract': [3443, 3874], '(66)': [3451, 3882], 'majority': [3455], 'double-positive': [3457], 'fluorescence-activated': [3462], 'sorter': [3464], 'represents': [3466], 'particles': [3467, 3473], 'engulfed': [3468], 'do': [3480], 'represent': [3482], 'simply': [3484], 'surface.': [3489], 'Microscopy—The': [3490], 'Labtek': [3501], 'slides': [3503], 'reagent': [3507], 'following': [3510], 'concentrations:': [3511], 'ELMO1-GFP': [3512, 3574], 'Δ531-GFP': [3514], '(1.0': [3515], 'μg)': [3516], '(1.5': [3519], 'μg).': [3520], 'post-transfection,': [3524], 'fixed': [3528], '3.7%': [3530], 'paraformaldehyde': [3531], 'permeabilized': [3533, 3652], '0.1%': [3537, 3540, 3660], 'Triton': [3538], 'X-100,': [3539], 'albumin.': [3543], 'stained': [3547, 3678], 'Alexa': [3549, 3581], 'Fluor-568': [3550, 3582], 'phalloidin': [3551, 3583], '(Molecular': [3552], 'Probes,': [3553], 'Eugene,': [3554], 'OR)': [3555], 'min': [3558, 3671, 3688, 3703, 4245], 'room': [3560, 3673], 'temperature': [3561], 'confocal': [3565, 3625], 'microscopy.': [3566], 'overlay': [3570], 'fluorescence': [3575, 3579], 'represented': [3585], 'yellow.': [3587], 'images': [3589, 3756], 'representative': [3592], 'similar': [3597, 3984, 4174], 'phenotypes': [3598], 'three': [3600], 'independent': [3601, 3979], 'experiments.': [3602], 'quantitate': [3604], 'morphology,': [3605], 'classified': [3608], '1-rounded': [3610], 'appearance,': [3611], '2-spread': [3612], 'polarized,': [3615], '3-polarized': [3617], 'tail': [3622], 'edges': [3623], 'epifluorescence': [3627], 'analyses.': [3628], 'confirmed': [3638, 4016, 4068], 'direct': [3640], 'immunostaining': [3641], '(data': [3644, 4252], 'shown).': [3646, 4254], 'Before': [3647], 'staining,': [3650], 'blocked': [3655], 'albumin': [3663], 'temperature.': [3674], '(1:40)': [3685, 3700], '30': [3687, 3702, 4244], 'followed': [3692], 'Texas': [3695], 'Red-labeled': [3696], 'visualize': [3708], 'mounted': [3714], 'Vectashield-mounting': [3716], '(Vector': [3718], 'Laboratories,': [3719], 'Inc.,': [3720], 'Burlingame,': [3721], 'CA': [3722], '94010).': [3723], 'Olympus': [3725], 'Fluoview': [3726, 3751], 'BX50WI': [3727], 'laser-scanning': [3728], '×60': [3732], 'LumPlanFI': [3733], 'lens': [3734], 'aperture': [3737], '(zoom': [3740], '×1.5)': [3741], 'obtain': [3745], 'images.': [3746], 'acquisition': [3748], 'software': [3749], 'FV200,': [3752], 'version': [3753, 3765], '3.3,': [3754], 'processed': [3758], 'entire': [3760], 'pictures': [3761], 'Adobe': [3763], 'PhotoShop,': [3764], '6.0.': [3766], 'Coexpression': [3770], 'Promotes': [3771], 'Mammalian': [3772], 'Migration—To': [3774], 'probe': [3775], 'variant': [3799], 'Chinese': [3802], 'hamster': [3803], 'ovary': [3804], 'line': [3806], 'commonly': [3807], 'investigate': [3820], '31Tosello-Trampont': [3863], 'During': [3885], 'development': [3887], 'assay,': [3891, 3957], 'migrated': [3898], 'when': [3903], 'uncoated': [3907], 'did': [3911, 3993], 'move': [3913], 'filter.': [3919, 4282], 'score': [3921], 'cotransfected': [3930], 'gene,': [3933], 'convenient': [3937], 'quantitative': [3939], 'readout': [3940], 'simultaneous': [3943], 'marking': [3944], 'scoring': [3949], 'motility.': [3952], 'coexpression': [3958, 4151, 4265, 4293, 4323], 'wild': [3960], 'strongly': [3965], 'promoted': [3966], 'compared': [3968], 'expressing': [3972], '(generally': [3975], '4-6-fold': [3976], '>20': [3978], 'experiments)': [3980], '(Fig.': [3981, 4090, 4137, 4227, 4313], '1A).': [3982], 'Under': [3983, 4201], 'indicating': [3997], 'requirement': [3999], 'effect.': [4005], 'Immunoblotting': [4006], 'experiment': [4014], 'comparably': [4022], 'conditions.': [4028, 4175], 'noteworthy': [4031], '(without': [4049, 4190], 'filter)': [4051], 'population.': [4061], 'By': [4062], 'analyzing': [4063], 'counts,': [4066], 'expression,': [4072], 'constitutive': [4076], 'CMV': [4077], 'promoter,': [4078], 'unaffected': [4080], 'cotransfection': [4082], '1B).': [4091, 4138], 'Furthermore,': [4092], 'no': [4093, 4119, 4232], 'significant': [4094, 4233], 'difference': [4095], 'detected': [4100, 4231], 'any': [4102, 4132], 'conditions': [4106, 4136, 4184], 'reported': [4107], 'paper.': [4110], 'addition,': [4112], 'there': [4117], 'increase': [4120], 'attachment': [4123, 4207], 'Because': [4139], 'alternate': [4141], 'explanation': [4142], 'observed': [4145], 'enhancement': [4146, 4318], 'could': [4152], 'differences': [4154, 4234, 4271], 'attach': [4162], 'filter,': [4166], 'examined': [4168, 4285], 'possibility': [4170], 'more': [4171], 'closely': [4172], 'independently': [4178], 'isolated': [4188], 'chamber),': [4193], 'relative': [4197], 'adherence': [4198], 'measured.': [4200], 'comparable': [4206], 'alone,': [4213, 4215], 'frame': [4222], '1C).': [4228], 'among': [4235], 'various': [4237], 'samples': [4239], 'due': [4262, 4290], 'does': [4266], 'result': [4268], 'overall': [4270], 'adhere': [4279], 'next': [4284], 'dependent': [4295], 'activity.': [4298], 'Cotransfection': [4299], 'dominant': [4302], 'negative': [4303], '(RacT17N)': [4307], 'inhibited': [4308], 'Dock180·ELMO1-dependent': [4310], 'increased': [4311], '1A),': [4314], 'suggesting': [4315], 'depends': [4324], 'activation.': [4327], 'ELMO1-': [4328], 'Rac-binding': [4330], 'Regions': [4331], 'Are': [4334], 'Required': [4335], 'Migration—It': [4337], 'binding': [4344, 4355], '357': [4348], 'whereas': [4353], 'occurs': [4356], '(amino': [4361], '1111-1657': [4363]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2114936261', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-26T23:48:58.429384', 'created_date': '2016-06-24'}