Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis

Name: Work Video:
Duration: 3 min 30 s
Annie Lauzier; Martine Charbonneau; Marilène Paquette; Kelly Harper; Claire M. Dubois
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'(shRNA)-treated': [76], 'joint': [77], 'tissues.': [78], 'TGase': [79, 141, 153, 168, 181, 204, 230], 'control': [82], '(C-FLS)': [83], '(A-FLS)': [86], 'rat': [87, 103, 189], 'FLSs': [88, 104], 'measured': [90, 101], 'situ': [93, 117], '5-(biotinamido)-pentylamine': [94], 'incorporation.': [95], 'Invadopodia': [96], 'formation': [97, 187, 198, 218], 'functions': [99], 'cells': [106], 'from': [107], 'normal': [108], '(control;': [109], 'C-FLS)': [110], 'RA': [112], 'patients': [113], '(RA-FLS)': [114], 'ECM': [118, 174, 235], 'degradation.': [119], 'Immunoblotting,': [120], 'enzyme-linked': [121], 'immunosorbent': [122], 'assay': [123], '(ELISA),': [124], 'p3TP-Lux': [126], 'reporter': [127], 'assays': [128], 'used': [130], 'transforming': [133], 'growth': [134], 'factor-β': [135], '(TGF-β)': [136], 'production': [137], 'activation.TG2': [139], 'associated': [144], 'CIA': [149, 241], 'In': [151, 194], 'contrast,': [152, 195], 'reduced': [159, 185], 'joints': [161], 'knockdown.': [164], 'A-FLSs': [165], 'displayed': [166], 'higher': [167], 'expression': [172], 'than': [175], 'did': [176], 'C-FLSs.': [177], 'inhibition': [182, 225], 'resulted': [183], 'invadopodia': [186, 197, 217], 'human': [191], 'FLSs.': [193], 'increased': [196], 'noted': [200], 'response': [202], 'induced': [206], 'TGF-β,': [208], 'dithiothreitol': [209], '(DTT),': [210], 'overexpression.': [213], 'TG2-induced': [214], 'increases': [215], 'blocked': [220], 'TGF-β': [222], 'neutralization': [223], 'TGF-βR1.TG2,': [227], 'through': [228], 'its': [229], 'activity,': [231], 'required': [233], 'for': [234], 'FLS': [239], 'Our': [243], 'findings': [244], 'provide': [245], 'a': [246], 'target': [248], 'prevent': [250], 'RA.': [254]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2114896059', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 8}], 'updated_date': '2024-12-10T09:59:10.210711', 'created_date': '2016-06-24'}
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