Publication Information

{'id': 'https://openalex.org/W2114785705', 'doi': 'https://doi.org/10.18632/aging.100201', 'title': 'Cellular senescence controls fibrosis in wound healing', 'display_name': 'Cellular senescence controls fibrosis in wound healing', 'publication_year': 2010, 'publication_date': '2010-09-17', 'ids': {'openalex': 'https://openalex.org/W2114785705', 'doi': 'https://doi.org/10.18632/aging.100201', 'mag': '2114785705', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20930261', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2984611'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/aging.100201', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210231119', 'display_name': 'Aging', 'issn_l': '1945-4589', 'issn': ['1945-4589'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.18632/aging.100201', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5036993982', 'display_name': 'Joon-Il Jun', 'orcid': 'https://orcid.org/0000-0002-6630-2699'}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joon-Il Jun', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.', 'institution_ids': ['https://openalex.org/I39422238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5014230378', 'display_name': 'Lester F. Lau', 'orcid': 'https://orcid.org/0000-0002-4364-2914'}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lester F. Lau', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA', 'institution_ids': ['https://openalex.org/I39422238']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.598, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 220, 'citation_normalized_percentile': {'value': 0.912218, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '2', 'issue': '9', 'first_page': '627', 'last_page': '631'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13223', 'display_name': 'Connective Tissue Growth Factor Research', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13223', 'display_name': 'Connective Tissue Growth Factor Research', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10771', 'display_name': 'Wound Healing and Treatments', 'score': 0.9673, 'subfield': {'id': 'https://openalex.org/subfields/2742', 'display_name': 'Rehabilitation'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11013', 'display_name': 'Skin Protection and Aging', 'score': 0.9303, 'subfield': {'id': 'https://openalex.org/subfields/2708', 'display_name': 'Dermatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/myofibroblast', 'display_name': 'Myofibroblast', 'score': 0.8554399}, {'id': 'https://openalex.org/keywords/cyr61', 'display_name': 'CYR61', 'score': 0.73939097}, {'id': 'https://openalex.org/keywords/senescence', 'display_name': 'Senescence', 'score': 0.6626605}, {'id': 'https://openalex.org/keywords/matricellular-protein', 'display_name': 'Matricellular protein', 'score': 0.52671057}], 'concepts': [{'id': 'https://openalex.org/C207865475', 'wikidata': 'https://www.wikidata.org/wiki/Q1467330', 'display_name': 'Myofibroblast', 'level': 3, 'score': 0.8554399}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7640241}, {'id': 'https://openalex.org/C2780269544', 'wikidata': 'https://www.wikidata.org/wiki/Q1509074', 'display_name': 'Wound healing', 'level': 2, 'score': 0.7518934}, {'id': 'https://openalex.org/C2778753947', 'wikidata': 'https://www.wikidata.org/wiki/Q18027691', 'display_name': 'CYR61', 'level': 5, 'score': 0.73939097}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.7157891}, {'id': 'https://openalex.org/C522857546', 'wikidata': 'https://www.wikidata.org/wiki/Q2070979', 'display_name': 'Senescence', 'level': 2, 'score': 0.6626605}, {'id': 'https://openalex.org/C2780559512', 'wikidata': 'https://www.wikidata.org/wiki/Q605709', 'display_name': 'Fibrosis', 'level': 2, 'score': 0.6041033}, {'id': 'https://openalex.org/C2775893135', 'wikidata': 'https://www.wikidata.org/wiki/Q6787792', 'display_name': 'Matricellular protein', 'level': 3, 'score': 0.52671057}, {'id': 'https://openalex.org/C2780631158', 'wikidata': 'https://www.wikidata.org/wiki/Q14907752', 'display_name': 'CTGF', 'level': 4, 'score': 0.4192174}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3783308}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34553415}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.33357912}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.28985023}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.27097785}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.22664037}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.21524844}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09053871}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.078150064}], 'mesh': [{'descriptor_ui': 'D016922', 'descriptor_name': 'Cellular Senescence', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D014945', 'descriptor_name': 'Wound Healing', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016922', 'descriptor_name': 'Cellular Senescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055515', 'descriptor_name': 'Cysteine-Rich Protein 61', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055515', 'descriptor_name': 'Cysteine-Rich Protein 61', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005355', 'descriptor_name': 'Fibrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005355', 'descriptor_name': 'Fibrosis', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058628', 'descriptor_name': 'Myofibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058628', 'descriptor_name': 'Myofibroblasts', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D014945', 'descriptor_name': 'Wound Healing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/aging.100201', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210231119', 'display_name': 'Aging', 'issn_l': '1945-4589', 'issn': ['1945-4589'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2984611', 'pdf_url': 'https://europepmc.org/articles/pmc2984611?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984611', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20930261', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/aging.100201', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210231119', 'display_name': 'Aging', 'issn_l': '1945-4589', 'issn': ['1945-4589'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1513192269', 'https://openalex.org/W1964646604', 'https://openalex.org/W1970924670', 'https://openalex.org/W1971090938', 'https://openalex.org/W1978888457', 'https://openalex.org/W1980325398', 'https://openalex.org/W1980878904', 'https://openalex.org/W1982395176', 'https://openalex.org/W1996789266', 'https://openalex.org/W1997795769', 'https://openalex.org/W2004273407', 'https://openalex.org/W2004314923', 'https://openalex.org/W2005248738', 'https://openalex.org/W2007716988', 'https://openalex.org/W2010417927', 'https://openalex.org/W2023696449', 'https://openalex.org/W2027954852', 'https://openalex.org/W2028975724', 'https://openalex.org/W2030460048', 'https://openalex.org/W2032691826', 'https://openalex.org/W2041591721', 'https://openalex.org/W2044341880', 'https://openalex.org/W2045264627', 'https://openalex.org/W2047330128', 'https://openalex.org/W2051379856', 'https://openalex.org/W2052388837', 'https://openalex.org/W2053865773', 'https://openalex.org/W2060632243', 'https://openalex.org/W2075600855', 'https://openalex.org/W2080769506', 'https://openalex.org/W2085293124', 'https://openalex.org/W2089384070', 'https://openalex.org/W2114171855', 'https://openalex.org/W2115852450', 'https://openalex.org/W2121682401', 'https://openalex.org/W2131078803', 'https://openalex.org/W2132224453', 'https://openalex.org/W2138631175', 'https://openalex.org/W2150740687', 'https://openalex.org/W2151209025', 'https://openalex.org/W2153805013', 'https://openalex.org/W2161080185', 'https://openalex.org/W2167928913', 'https://openalex.org/W2317831347', 'https://openalex.org/W2325727928', 'https://openalex.org/W2604337567'], 'related_works': ['https://openalex.org/W961504789', 'https://openalex.org/W2751552514', 'https://openalex.org/W2747977427', 'https://openalex.org/W2386525445', 'https://openalex.org/W2127428894', 'https://openalex.org/W2112509049', 'https://openalex.org/W2098118477', 'https://openalex.org/W2096620255', 'https://openalex.org/W2085721499', 'https://openalex.org/W2004849530'], 'abstract_inverted_index': {'Mammalian': [0], 'wound': [1, 52, 120], 'healing': [2, 121], 'involves': [3], 'the': [4, 59, 63, 112, 138, 142], 'rapid': [5], 'synthesis': [6], 'and': [7, 33, 44, 61, 68, 81, 131], 'deposition': [8], 'of': [9, 35, 106, 114, 144], 'extracellular': [10], 'matrix': [11], '(ECM)': [12], 'to': [13], 'maintain': [14], 'tissue': [15, 36], 'integrity': [16], 'during': [17], 'repair.': [18], 'This': [19], 'process': [20, 133], 'must': [21], 'be': [22, 135], 'tightly': [23], 'controlled,': [24], 'as': [25, 58, 125], 'its': [26], 'deregulation': [27], 'may': [28, 134], 'result': [29], 'in': [30, 51, 54, 89], 'fibrosis,': [31], 'scarring,': [32], 'loss': [34], 'function.': [37], 'Recent': [38], 'studies': [39], 'have': [40], 'uncovered': [41], 'an': [42], 'efficient': [43], 'parsimonious': [45], 'mechanism': [46, 128], 'for': [47, 129], 'rendering': [48], 'fibrogenesis': [49], 'self-limiting': [50, 127], 'healing:': [53], 'such': [55], 'diverse': [56], 'organs': [57], 'liver': [60], 'skin,': [62], 'myofibroblasts': [64], 'that': [65, 111, 123], 'initially': [66], 'proliferate': [67], 'produce': [69], 'ECM': [70, 139], 'are': [71], 'themselves': [72], 'eventually': [73], 'driven': [74], 'into': [75, 84], 'senescence,': [76], 'blocking': [77], 'their': [78], 'further': [79], 'proliferation': [80], 'converting': [82], 'them': [83], 'matrix-degrading': [85], 'cells.': [86], 'Myofibroblast': [87], 'senescence': [88, 116], 'skin': [90], 'wounds': [91], 'is': [92, 117], 'triggered': [93], 'by': [94, 137], 'a': [95, 118, 126], 'dynamically': [96], 'expressed': [97], 'matricellular': [98], 'protein,': [99], 'CCN1/CYR61,': [100], 'which': [101], 'acts': [102], 'through': [103, 141], 'integrin-mediated': [104], 'induction': [105], 'oxidative': [107], 'stress.': [108], 'We': [109], 'propose': [110], 'onset': [113], 'myofibroblast': [115], 'programmed': [119], 'response': [122], 'functions': [124], 'fibrogenesis,': [130], 'this': [132], 'regulated': [136], 'microenvironment': [140], 'expression': [143], 'CCN1/CYR61.': [145]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2114785705', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 25}, {'year': 2018, 'cited_by_count': 17}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 18}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2025-01-07T19:04:45.081527', 'created_date': '2016-06-24'}