An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

Name: Work Video:
Duration: 3 min 30 s
Manal Morsy; Mingcheng Gu; Sherri L. Motzel; Jing Zhao; Lin Jing; Qin Su; Henry Allen; Laura L. Franlin; Robin J. Parks; Frank L. Graham; Stefan Kochanek; Andrew J. Bett; C. Thomas Caskey
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Departments of Biology and Pathology, McMaster University, Hamilton, ON, Canada L8S 4K1; and Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Genetics; Department of Laboratory Animal Resources, and Safety Assessment, Merck Research Laboratories, West Point, PA 19486; Departments of Biology and Pathology, McMaster University, Hamilton, ON, Canada L8S 4K1; and Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030', 'institution_ids': ['https://openalex.org/I181547552', 'https://openalex.org/I98251732', 'https://openalex.org/I192545095']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101433308', 'display_name': 'Jing Zhao', 'orcid': 'https://orcid.org/0000-0001-8089-2093'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}, {'id': 'https://openalex.org/I192545095', 'display_name': 'United States Military Academy', 'ror': 'https://ror.org/01jepya76', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1304082316', 'https://openalex.org/I1330347796', 'https://openalex.org/I192545095', 'https://openalex.org/I4210088792']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jing Zhao', 'raw_affiliation_strings': ['Department of Human Genetics; Department of Laboratory Animal Resources, and Safety Assessment, Merck Research Laboratories, West Point, PA 19486; Departments of Biology and Pathology, McMaster University, Hamilton, ON, Canada L8S 4K1; and Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Genetics; Department of Laboratory Animal Resources, and Safety Assessment, Merck Research Laboratories, West Point, PA 19486; Departments of Biology and Pathology, McMaster University, Hamilton, ON, Canada L8S 4K1; and Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030', 'institution_ids': ['https://openalex.org/I181547552', 'https://openalex.org/I98251732', 'https://openalex.org/I192545095']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102751051', 'display_name': 'Lin Jing', 'orcid': 'https://orcid.org/0000-0002-3759-4442'}, 'institutions': [{'id': 'https://openalex.org/I192545095', 'display_name': 'United States Military Academy', 'ror': 'https://ror.org/01jepya76', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1304082316', 'https://openalex.org/I1330347796', 'https://openalex.org/I192545095', 'https://openalex.org/I4210088792']}, {'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jing Lin', 'raw_affiliation_strings': ['Department of Human Genetics; Department of Laboratory Animal Resources, and Safety Assessment, Merck Research Laboratories, West Point, PA 19486; Departments of Biology and Pathology, McMaster University, Hamilton, ON, Canada L8S 4K1; and Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Genetics; Department of Laboratory Animal Resources, and Safety Assessment, Merck Research Laboratories, West Point, PA 19486; Departments of Biology and Pathology, McMaster University, Hamilton, ON, Canada L8S 4K1; and Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030', 'institution_ids': ['https://openalex.org/I192545095', 'https://openalex.org/I181547552', 'https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036576811', 'display_name': 'Qin Su', 'orcid': 'https://orcid.org/0000-0001-9437-6292'}, 'institutions': [{'id': 'https://openalex.org/I192545095', 'display_name': 'United States Military Academy', 'ror': 'https://ror.org/01jepya76', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1304082316', 'https://openalex.org/I1330347796', 'https://openalex.org/I192545095', 'https://openalex.org/I4210088792']}, {'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Qin Su', 'raw_affiliation_strings': ['Department of Human Genetics; 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