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[293], 'diseases': [294], 'aberrant': [297], 'reported': [303, 1119, 1498], 'across': [304], 'systems.3Download': [306], 'figureDownload': [307, 1501], 'PowerPointFigure': [308, 1502], '1.': [309], 'Number': [310], 'published': [313, 333], 'on': [314, 391, 410, 470, 587, 642, 656, 932, 976, 984, 1261, 1603, 2183], 'over': [316, 354], 'past': [318, 356], '11': [319], 'years.': [320, 358], 'white': [322], 'bar': [323], 'represents': [324], 'predicted': [326], 'additional': [329], '2011.Various': [335], 'cells': [336, 377, 2181, 2224], 'cardiovascular': [339, 1742], 'system': [340], 'express': [341], 'subject': [350, 639, 1605], 'intense': [352], 'study': [353], 'few': [357], 'include': [360, 1588], 'bicistronic': [362, 1590], 'miR1/133a': [363, 381, 434, 459], 'miR143/145': [365, 1228, 1478, 1546, 1574], 'genes': [366, 435, 507, 773, 1709], 'highly': [369], 'specific': [370], 'cardiac': [372, 429, 461, 576, 754, 763, 1432], 'myocytes': [373, 755, 764], 'smooth': [375, 1509, 1835, 1876, 1902, 1984, 2014, 2045, 2053, 2074, 2111, 2179, 2222, 2253, 2289, 2326], 'muscle': [376, 462, 1221, 1510, 1836, 1877, 1903, 1936, 1985, 2007, 2015, 2046, 2054, 2075, 2112, 2180, 2223, 2254, 2290, 2327], '(SMC),': [378], 'respectively.4': [379], 'particular': [385], 'interest': [386], 'because': [387], 'it': [388, 1363, 1469], 'duplicated': [390], 'separate': [392], 'chromosomes;': [393], 'miR1-1/133a-2': [394], 'intron': [399], 'hypothetical': [402], 'locus': [403], 'humans,': [405], 'whereas': [406], 'miR1-2/133a-1': [407], 'found': [409], 'opposite': [412], 'strand': [413], 'MIB1': [416], 'locus,': [417], 'encoding': [418, 947], 'E3': [420], 'ubiquitin-protein': [421], 'ligase.': [422], 'Consistent': [423], 'their': [425, 467, 1283], 'abundant': [426], 'skeletal': [431, 1935], 'muscle,': [432], 'both': [433, 516, 738, 806, 1229], 'under': [437], 'transcriptional': [439, 694, 1452, 2041], 'control': [440, 460], 'several': [442, 659, 671], 'myogenic': [443], 'factors,': [445, 1282], 'including': [446], 'serum': [447, 1524], 'response': [448, 1525, 1755, 1948, 2321], 'factor': [449, 454, 609, 943, 1526, 1756, 2281], '(SRF)': [450], 'myocyte': [452], 'enhancer': [453, 1791], '2.5,6': [455], 'Further': [456], 'showed': [458, 790], 'growth': [463, 602, 608, 978, 1006, 1222, 1557, 2280], 'differentiation': [465, 661, 2076], 'repressive': [468], 'action': [469, 973], 'validated': [474, 505], 'target': [475, 506, 744, 865, 877, 917, 1284, 1289, 1691], 'genes.4': [476], 'However,': [477, 699, 1036, 1549], 'miR133a': [483, 509, 536, 570, 596, 615, 654, 675, 807, 849, 864, 928, 975, 995, 1010, 1014, 1050, 1107, 1136, 1170, 1190, 1226, 1375, 1407, 1480], 'SMC': [485, 513, 541, 550, 562, 572, 599, 605, 636, 660, 672, 678, 697, 846, 958, 977, 1019, 1094, 1143, 1166, 1193, 1240, 1252, 1265, 1360, 1390, 1414, 1520, 1536, 1570], 'have,': [486], 'until': [487], 'now,': [488], 'unexplored.In': [491], 'issue': [493], 'Circulation': [495, 2435, 2444, 2448, 2457, 2461], 'Research,': [496, 2436, 2449, 2462], 'Torella': [497, 528, 645, 824, 922, 966, 1081, 1203, 1306, 1808], 'et': [498, 529, 646, 718, 788, 825, 923, 967, 1082, 1204, 1307], 'al7': [499], 'demonstrated': [501, 532], 'new': [502, 1207, 1579], 'contribute': [511], 'phenotypic': [514, 1194, 1262, 1301, 1838, 2114], 'states': [515], 'vitro': [518, 1078, 1159, 1841], 'vivo.': [521, 1846], 'Using': [522, 578], 'battery': [524], 'sensitive': [526], 'assays,': [527], 'al': [530, 647, 826, 924, 968, 1083, 1205, 1308], 'first': [531], 'measureable': [533], '(but': [537], 'not': [538, 758, 833, 1633], 'miR1)': [539], 'vessel': [544, 962, 1139, 1563], 'wall,': [545, 1564], 'well': [547, 1596], 'dissociated': [549], 'culture.': [552], 'fact': [554], 'miR1': [556, 568, 1385, 1405], 'levels': [557, 655, 700, 725, 1372, 1383, 1529], 'very': [559], 'low': [560, 1388], 'suggests': [563], 'differential': [564], 'processing': [566], 'versus': [569], 'compared': [574], 'myocytes.': [577], 'acute': [579], 'gain-of-function': [580], 'loss-of-function': [582], 'experiments,': [583], 'authors': [585], 'went': [586, 931], 'show': [589, 759, 934, 1235], 'inverse': [591], 'relationship': [592], 'between': [593, 1951], 'vascular': [598, 1093, 1339, 1359, 1434, 1493, 1834, 1843, 2052, 2080, 2119, 2252, 2288, 2363], 'proliferation.': [600], 'Moreover,': [601], 'stimulation': [603, 1558], 'platelet-derived': [607, 2279], 'resulted': [610], 'decrease': [613, 1690], 'expression.': [616, 1956], 'findings': [618, 1079, 1160], 'reminiscent': [620], 'similar': [622, 1114, 1447], 'phenomena': [623], 'seen': [624, 1148], 'miR145,': [626, 666], 'indicating': [627], 'network': [629], 'maintains': [633], 'quiescent': [635], 'phenotype': [637, 794, 1032, 1522, 1538, 2175], 'downregulation': [641], 'cell-cycle': [643], 'entry.': [644], 'next': [648], 'examined': [649], 'effect': [651], 'modulating': [653], 'genes.': [662], 'In': [663, 784, 812, 1122], 'contrast': [664, 813], 'promotes': [668], 'contractile': [673, 1251, 1521, 1537, 2174], 'genes,8': [674], 'inhibited': [676], 'markers,': [679], 'CNN1': [680, 735, 746, 799, 819], 'ACTA2.': [682], 'There': [683], 'was': [684, 979, 1015, 1040], 'no': [685], 'change': [686], 'myocardin,': [691], 'major': [693, 867], 'switch': [695, 1517, 1839, 1900], 'differentiation.9': [698], 'SRF': [702, 727, 743, 1231], 'protein': [705, 1153], 'were': [706, 809, 1084, 1108, 1128], 'reduced': [707, 732, 1109, 1145, 1171], 'miR133a,': [709, 823, 1576], 'result': [711], 'consistent': [712, 1055], 'previous': [714], 'from': [716, 1058], 'Chen': [717, 1886, 1912, 2344], 'al.10': [719], 'results': [721, 1183], 'suggest': [722], 'lower': [724], 'probably': [728], 'accounted': [729], 'ACTA2,': [737], 'known': [742], 'genes.11': [745], 'ACTA2': [748, 801, 821], 'expressed': [750, 834, 1628, 1713], 'transiently': [751], 'embryonic': [753], 'do': [757], 'adult': [762], 'unless': [765], 'heart': [767, 792, 838, 1412], 'undergoes': [768], 'failure,': [769], 'then': [771, 1085], 'may': [774, 1416], 'reactivated': [776], 'part': [778], 'fetal': [781, 1427], 'program.': [783], 'context,': [786], 'Liu': [787, 1770, 1964, 2090, 2232, 2342], 'al12': [789], 'failure': [793], 'elevated': [796, 952, 1533], 'mice': [803], 'alleles': [808], 'genetically': [810], 'inactivated.': [811], 'attenuated': [816, 1141], 'observed': [827, 1048, 1450], 'increases': [828, 1147, 1544], 'MYH11,': [830], 'developing': [837], 'gold': [842], 'standard': [843], 'marker': [844, 2077, 2115], 'lineages.13': [847], 'How': [848], 'increased': [850, 1130], 'SRF-dependent': [854], 'MYH11': [855, 1047, 1066], 'required': [857], 'astute': [859], 'observations': [860], 'putative': [863, 927], 'transcripts.A': [866], 'bottleneck': [868], 'miR': [870, 1211, 1288, 1345, 1398, 1582], 'research': [871], 'confident': [874], 'identification': [875, 919], 'mRNAs': [878, 1290, 1334], 'how': [880, 1356], 'targeting': [882], 'impacts': [883], 'Several': [886], 'computer': [887], 'programs': [888, 1429, 1953], 'available': [890], 'assist': [892], 'investigators': [893], 'endeavor;': [896], 'however,': [897], 'each': [898, 1374], 'program': [899], 'uses': [900], 'slightly': [901], 'different': [902], 'criteria': [903], 'scoring': [905], 'transcript': [908, 1376, 1462], 'possible': [911], 'target,': [912], 'making': [913], 'task': [915], 'challenging.': [920], 'Nevertheless,': [921], 'noted': [925], 'two': [926], 'targets': [929, 1762, 2408], 'miR133a-mediated': [935], 'repression': [936, 1064], 'SP1': [939, 953, 989, 1026, 1038, 1150], 'zinc': [940], 'finger-containing': [941], 'transcription': [942, 1281], 'muscle-restricted': [945], 'moesin,': [946], 'actin-binding': [949], 'protein.7': [950], 'Because': [951], 'associated': [956, 1430, 1566], 'hyperplasia': [959, 1095], 'wall': [963, 1140], 'after': [964, 1110, 1131, 1179, 1343, 2079], 'injury,14': [965], 'considered': [969], 'whether': [970, 1021, 1483], 'inhibitory': [972], 'linked': [980], 'its': [982, 1392], 'effects': [983], 'SP1.': [985], 'Indeed,': [986], 'carrying': [990], 'mutation': [992], 'binding': [996], 'site,': [997], 'located': [998], '3′': [1001], 'untranslated': [1002], 'region,': [1003], 'rescued': [1004], 'inhibition': [1007], 'conferred': [1008], 'SMC.': [1012, 1340], 'Although': [1013], 'shown': [1016], 'reduce': [1018], 'migration,': [1020], 'mutant': [1023, 1039, 2143], 'form': [1024], 'or': [1027, 1347, 1463, 1559, 1639, 1649, 1674], 'moesin': [1028, 1127, 1152], 'rescues': [1029], 'migration': [1031], 'presently': [1034], 'unknown.': [1035], 'able': [1041], 'antagonize': [1043], 'overexpression.': [1051], 'This': [1052], 'finding': [1053], 'laboratory': [1060], 'Owens15': [1062], 'showing': [1063], 'SP1-binding': [1069], 'GC-rich': [1070, 2037], 'element': [1071, 2039], 'upstream': [1074], 'promoter': [1075], 'region.The': [1076], 'extended': [1086], 'vivo': [1090], 'model': [1091, 1164], 'lesion': [1097, 1198, 2121, 2365], 'development': [1098, 1725], '(balloon': [1099], 'injury': [1100, 1560], 'rat': [1102], 'carotid': [1103], 'artery).': [1104], 'Levels': [1105], 'injury,': [1111], 'changes': [1118], 'miR143/145.8,16': [1121], 'contrast,': [1123], 'miR221,': [1124], 'SP1,': [1125], 'injury.': [1132, 1181, 2081, 2226], 'Adenoviral': [1133], 'transfer': [1134], 'proliferating': [1142], 'expression,': [1154], 'thus': [1155], 'confirming': [1156], 'animal': [1163], 'hyperplasia.': [1167, 2259], 'More': [1168], 'importantly,': [1169], 'antimiR133a': [1173], 'augmented': [1174], 'neointimal': [1175, 2120, 2258, 2364], 'formation': [1176, 1409], '14': [1177], 'days': [1178], 'balloon': [1180], 'establish': [1184], 'pathophysiologically': [1186], 'relevant': [1187], 'minimizing': [1192], 'adaptation': [1195], 'resultant': [1197], 'formation.The': [1199], 'detailed': [1200], 'provides': [1206], 'insight': [1208, 1354, 1419], 'into': [1209, 1355, 1420], 'previously': [1212, 1497], 'thought': [1213], 'limited': [1216, 1327], 'striated': [1220], 'differentiation.': [1224, 1904, 1939], 'That': [1225], 'require': [1230], 'overlapping': [1236], 'phenotype,': [1241, 1571], 'highlights': [1242], 'redundant': [1243], 'miR-dependent': [1244], 'pathways': [1245], 'maintenance': [1248], 'phenotype.': [1253, 1513, 2291], 'counterbalanced': [1257], 'other': [1259], 'switching': [1263], '2).': [1267], 'Therefore,': [1268], 'what': [1269], 'emerges': [1270], 'complex': [1273], 'web': [1274], 'feedback': [1276], 'feed-forward': [1278], 'circuits': [1279], 'involving': [1280], 'miRs,': [1285], 'themselves': [1291], 'encoded': [1293], 'proteins': [1294], 'perform': [1295], 'states.': [1302], 'provokes': [1309], 'many': [1311], 'questions': [1312], 'those': [1314, 1496, 1635], 'answered': [1315], 'series': [1318], 'elegant': [1320], 'experiments': [1321], 'presented.': [1322], 'First,': [1323], 'we': [1324], 'still': [1325], 'regarding': [1329], 'full': [1331], 'repertoire': [1332], 'Next-generation': [1341], 'sequencing': [1342], 'either': [1344], 'overexpression': [1346], 'Argonaute': [1348], 'pull-down': [1349], 'will': [1350, 1364, 1470, 1489], 'likely': [1351], 'provide': [1352, 1417], 'further': [1353, 1418], 'maintain': [1358], 'homeostasis.': [1361], 'Second,': [1362], 'interesting': [1366], 'ascertain': [1368], 'relative': [1370], '(133a-1': [1377], 'vs': [1378], '133a-2)': [1379], 'understand': [1381], 'why': [1382], 'so': [1387], 'despite': [1391], 'assumed': [1393], 'presence': [1394], 'primary': [1397, 1515], 'transcript.': [1399], 'Delineating': [1400], 'potential': [1402], 'roles': [1403, 1738], 'during': [1408, 1764, 2017], 'lineages': [1415], 'factors': [1422], 'governing': [1423], 'reactivation': [1424], 'remodeling.': [1435], 'Finally,': [1436], 'mounting': [1439], 'evidence': [1440], 'combinatorial': [1443], 'microRNA': [1444, 1760], 'code': [1445], 'exists,': [1446], 'regulators,': [1453], 'multiple': [1455], 'seemingly': [1456], 'unrelated': [1457], 'regulating': [1459, 1508], 'same': [1461], 'common': [1465], 'process.17': [1467], 'Thus,': [1468], 'informative': [1472], 'generate': [1474], 'compound': [1475], 'mutants': [1476], 'determine': [1482], 'absence': [1485], 'latter': [1488, 1587], 'evoke': [1490], 'more': [1491], 'dramatic': [1492], 'phenotypes': [1494, 2144], 'than': [1495], 'miR143/145.18,19Download': [1500], '2.': [1503], 'Known': [1504], 'involved': [1506], '(SMC)': [1512], 'molecular': [1516, 1899], '(SRF)/myocardin.': [1527], 'When': [1528], 'SRF/myocardin': [1531], '(left),': [1534], 'promoted,': [1540], 'part,': [1542], 'miR133a.': [1548], 'reduction': [1551], 'SRF/myocardin,': [1553], 'occurs': [1555], 'proliferative': [1569], 'decreases': [1572], 'circuit': [1580], '(right).': [1585], 'miR221/22220,21': [1591], 'miR199a2/21422': [1593], 'genes,': [1594], 'miR21.23Sources': [1598], 'FundingThe': [1600], "authors'": [1601], 'funded': [1607], 'National': [1609], 'Institutes': [1610], 'Health': [1612], 'grants': [1613], 'HL-62572': [1614], 'HL-091168': [1616], '(J.M.M.)': [1617], 'American': [1620, 1642, 2480], 'Heart': [1621, 1643, 2481], 'Association': [1622], 'Scientist': [1623], 'Development': [1624], 'grant': [1625], '(E.M.S.).DisclosuresNone.FootnotesThe': [1626], 'opinions': [1627], 'article': [1631], 'necessarily': [1634], 'editors': [1638], 'Association.Correspondence': [1644], 'Small,': [1652], 'Aab': [1653], '601': [1665], 'Elmwood': [1666], 'Avenue,': [1667], 'NY': [1669], '14642.': [1670], 'E-mail': [1671], 'j.m.[email': [1672], 'protected]edu': [1673], '[email': [1675], 'protected]rochester.eduReferences1.': [1676], 'Guo': [1677], 'H,': [1678, 2345], 'Ingolia': [1679], 'NT,': [1680, 1855], 'Weissman': [1681], 'JS,': [1682], 'Bartel': [1683], 'DP.': [1684], 'Mammalian': [1685], 'predominantly': [1687], 'act': [1688], 'levels.': [1693], 'Nature.': [1694, 1744, 1766, 1882], '2010;': [1695, 2154], '466:835–840.CrossrefMedlineGoogle': [1696], 'Scholar2.': [1697], 'Lagos-Quintana': [1698], 'M,': [1699, 2003, 2166, 2195, 2384], 'Rauhut': [1700], 'R,': [1701, 1785, 1975, 2209, 2335, 2388, 2391], 'Lendeckel': [1702], 'W,': [1703, 2317, 2393], 'Tuschl': [1704], 'T.': [1705, 2170], 'Identification': [1706], 'novel': [1708, 2110], 'coding': [1710], 'small': [1712], 'RNAs.': [1714], 'Science.': [1715], '2001;': [1716], '294:853–858.CrossrefMedlineGoogle': [1717], 'Scholar3.': [1718], 'Sayed': [1719], 'D,': [1720, 1809, 1813, 2309], 'Abdellatif': [1721], 'MicroRNAs': [1723, 2212], 'disease.': [1727], 'Physiol': [1728], 'Rev.': [1729], '2011;': [1730, 1745, 1849, 2331], '91:827–887.CrossrefMedlineGoogle': [1731], 'Scholar4.': [1732], 'EM,': [1734, 1915, 2197], 'Olson': [1735, 1786, 1976, 2004, 2210], 'EN.': [1736, 1787, 1977, 2005, 2211], 'Pervasive': [1737], 'biology.': [1743], '469:336–342.CrossrefMedlineGoogle': [1746], 'Scholar5.': [1747], 'Zhao': [1748], 'Y,': [1749, 1775, 2089, 2095, 2103, 2235, 2239, 2337], 'Samal': [1750], 'E,': [1751], 'Srivastava': [1752, 1870], 'D.': [1753, 1871], 'Serum': [1754, 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