Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2113490296', 'doi': 'https://doi.org/10.18632/oncotarget.2386', 'title': 'Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation', 'display_name': 'Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation', 'publication_year': 2014, 'publication_date': '2014-10-30', 'ids': {'openalex': 'https://openalex.org/W2113490296', 'doi': 'https://doi.org/10.18632/oncotarget.2386', 'mag': '2113490296', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25230151', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4259435'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2386', 'pdf_url': 'https://www.oncotarget.com/article/2386/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/2386/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012100572', 'display_name': 'Eng‐Yen Huang', 'orcid': 'https://orcid.org/0000-0002-2041-0782'}, 'institutions': [{'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}, {'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Eng-Yen Huang', 'raw_affiliation_strings': ['Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan', 'Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taiwan', 'School of Traditional Chinese Medicine, Chang Gung University College of Medicine, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan', 'institution_ids': ['https://openalex.org/I173093425', 'https://openalex.org/I4210093821']}, {'raw_affiliation_string': 'Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taiwan', 'institution_ids': ['https://openalex.org/I173093425']}, {'raw_affiliation_string': 'School of Traditional Chinese Medicine, Chang Gung University College of Medicine, Taiwan', 'institution_ids': ['https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051642293', 'display_name': 'Feng‐Sheng Wang', 'orcid': 'https://orcid.org/0000-0001-5266-2346'}, 'institutions': [{'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Feng-Sheng Wang', 'raw_affiliation_strings': ['Center for Laboratory Animals, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan', 'Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan', 'Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Center for Laboratory Animals, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}, {'raw_affiliation_string': 'Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taiwan', 'institution_ids': ['https://openalex.org/I173093425']}, {'raw_affiliation_string': 'Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100726531', 'display_name': 'Yumin Chen', 'orcid': 'https://orcid.org/0000-0003-4487-8264'}, 'institutions': [{'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yu-Min Chen', 'raw_affiliation_strings': ['Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100405153', 'display_name': 'Yifan Chen', 'orcid': 'https://orcid.org/0000-0003-2080-843X'}, 'institutions': [{'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yi-Fan Chen', 'raw_affiliation_strings': ['Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027379048', 'display_name': 'Chung‐Chi Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chung-Chi Wang', 'raw_affiliation_strings': ['Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049473521', 'display_name': 'I-Hui Lin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'I-Hui Lin', 'raw_affiliation_strings': ['Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103269341', 'display_name': 'Yu-Jie Huang', 'orcid': 'https://orcid.org/0000-0002-5729-3305'}, 'institutions': [{'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yu-Jie Huang', 'raw_affiliation_strings': ['Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5042999985', 'display_name': 'Kuender D. Yang', 'orcid': 'https://orcid.org/0000-0002-3967-4964'}, 'institutions': [{'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}, {'id': 'https://openalex.org/I4210087697', 'display_name': 'National Yang Ming University Hospital', 'ror': 'https://ror.org/003xdw211', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087697']}, {'id': 'https://openalex.org/I4210124028', 'display_name': 'Chang Bing Show Chwan Memorial Hospital', 'ror': 'https://ror.org/02ntc9t93', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124028']}, {'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Kuender D. Yang', 'raw_affiliation_strings': ['Department of Medical Research, Show Chwan Memorial Hospital in Chang Bing, 6-1 Lu-Kung Road, Chang Bing Industrial Center, Lu-Kang, Changhua 505, Taiwan', 'Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taiwan', 'Institute of Clinical Medicine, National Yang Ming University, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taiwan', 'institution_ids': ['https://openalex.org/I173093425']}, {'raw_affiliation_string': 'Institute of Clinical Medicine, National Yang Ming University, Taiwan', 'institution_ids': ['https://openalex.org/I4210087697', 'https://openalex.org/I148366613']}, {'raw_affiliation_string': 'Department of Medical Research, Show Chwan Memorial Hospital in Chang Bing, 6-1 Lu-Kung Road, Chang Bing Industrial Center, Lu-Kang, Changhua 505, Taiwan', 'institution_ids': ['https://openalex.org/I4210124028']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.2, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.801466, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '5', 'issue': '20', 'first_page': '9756', 'last_page': '9769'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13526', 'display_name': '14-3-3 Proteins: Structure, Function, and Regulation', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cancer-therapy', 'display_name': 'Cancer Therapy', 'score': 0.543404}, {'id': 'https://openalex.org/keywords/amifostine', 'display_name': 'Amifostine', 'score': 0.5231974}, {'id': 'https://openalex.org/keywords/tumor-suppression', 'display_name': 'Tumor Suppression', 'score': 0.510494}, {'id': 'https://openalex.org/keywords/apoptosis-regulation', 'display_name': 'apoptosis regulation', 'score': 0.500046}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.68180287}, {'id': 'https://openalex.org/C2779387952', 'wikidata': 'https://www.wikidata.org/wiki/Q251698', 'display_name': 'Amifostine', 'level': 3, 'score': 0.5231974}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.4140342}, {'id': 'https://openalex.org/C512399662', 'wikidata': 'https://www.wikidata.org/wiki/Q3505712', 'display_name': 'Family medicine', 'level': 1, 'score': 0.3844977}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.3034429}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.24507338}], 'mesh': [{'descriptor_ui': 'D048948', 'descriptor_name': '14-3-3 Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004999', 'descriptor_name': 'Amifostine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': True}, {'descriptor_ui': 'D011833', 'descriptor_name': 'Radiation Injuries, Experimental', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011837', 'descriptor_name': 'Radiation-Protective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D048948', 'descriptor_name': '14-3-3 Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004999', 'descriptor_name': 'Amifostine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D045325', 'descriptor_name': 'HCT116 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011833', 'descriptor_name': 'Radiation Injuries, Experimental', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011833', 'descriptor_name': 'Radiation Injuries, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011833', 'descriptor_name': 'Radiation Injuries, Experimental', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D011833', 'descriptor_name': 'Radiation Injuries, Experimental', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011837', 'descriptor_name': 'Radiation-Protective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2386', 'pdf_url': 'https://www.oncotarget.com/article/2386/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4259435', 'pdf_url': 'https://europepmc.org/articles/pmc4259435?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259435', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25230151', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2386', 'pdf_url': 'https://www.oncotarget.com/article/2386/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1496422305', 'https://openalex.org/W1500571651', 'https://openalex.org/W1583196972', 'https://openalex.org/W1862654781', 'https://openalex.org/W1967955844', 'https://openalex.org/W1968220278', 'https://openalex.org/W1977039418', 'https://openalex.org/W1978240169', 'https://openalex.org/W1983282393', 'https://openalex.org/W1991415638', 'https://openalex.org/W1995317658', 'https://openalex.org/W2016799814', 'https://openalex.org/W2024568523', 'https://openalex.org/W2043470971', 'https://openalex.org/W2048907308', 'https://openalex.org/W2053743600', 'https://openalex.org/W2055687679', 'https://openalex.org/W2057858743', 'https://openalex.org/W2060618478', 'https://openalex.org/W2062106419', 'https://openalex.org/W2064330613', 'https://openalex.org/W2066648007', 'https://openalex.org/W2077031396', 'https://openalex.org/W2082537826', 'https://openalex.org/W2082979850', 'https://openalex.org/W2083273986', 'https://openalex.org/W2091867909', 'https://openalex.org/W2095738224', 'https://openalex.org/W2113880766', 'https://openalex.org/W2114455569', 'https://openalex.org/W2124809046', 'https://openalex.org/W2128495110', 'https://openalex.org/W2130603065', 'https://openalex.org/W2144996732', 'https://openalex.org/W2152718737', 'https://openalex.org/W2157952439', 'https://openalex.org/W2165226414', 'https://openalex.org/W2214069856', 'https://openalex.org/W2334373331', 'https://openalex.org/W4300154704'], 'related_works': ['https://openalex.org/W97595756', 'https://openalex.org/W4298007414', 'https://openalex.org/W4247306052', 'https://openalex.org/W3150124368', 'https://openalex.org/W2490089377', 'https://openalex.org/W2404379492', 'https://openalex.org/W2384708512', 'https://openalex.org/W2348296723', 'https://openalex.org/W2240800314', 'https://openalex.org/W2059462011'], 'abstract_inverted_index': {'//': [0], 'Eng-Yen': [1], 'Huang': [2, 36], '1': [3, 21, 25, 29, 33, 37, 46], ',': [4, 6, 8, 10, 14, 18, 22, 26, 30, 34, 38, 43], '2': [5, 13, 42, 70], '5': [7, 132], '*': [9, 17, 178], 'Feng-Sheng': [11], 'Wang': [12, 28], '3,': [15], '4,': [16], 'Yu-Min': [19], 'Chen': [20, 24], 'Yi-Fan': [23], 'Chung-Chi': [27], 'I-Hui': [31], 'Lin': [32], 'Yu-Jie': [35], 'Kuender': [39, 189], 'D.': [40, 190], 'Yang': [41, 174], '6,': [44], '7': [45, 168], 'Department': [47, 85, 146], 'of': [48, 60, 73, 81, 86, 98, 122, 134, 142, 147, 170, 254, 271, 327, 343, 349, 378, 383, 386], 'Radiation': [49], 'Oncology,': [50], 'Kaohsiung': [51, 67, 89, 105, 113, 129], 'Chang': [52, 56, 77, 90, 94, 114, 118, 138, 155, 160], 'Gung': [53, 57, 78, 91, 95, 115, 119, 139], 'Memorial': [54, 92, 116, 152], 'Hospital,': [55, 93, 117], 'University': [58, 79, 96, 120, 140], 'College': [59, 80, 97, 121, 141], 'Medicine,': [61, 82, 99, 123, 137, 143, 172], '123': [62, 100, 124], 'Ta-Pei': [63, 101, 125], 'Road,': [64, 102, 126, 159], 'Niao-Sung': [65, 103, 127], 'District,': [66, 104, 128], '833,': [68, 106, 130], 'Taiwan': [69, 83, 107, 131, 144, 167, 177], 'Graduate': [71], 'Institute': [72, 169], 'Clinical': [74, 171], 'Medical': [75, 87, 148], 'Sciences,': [76], '3': [84], 'Research,': [88, 149], '4': [108], 'Center': [109], 'for': [110, 241], 'Laboratory': [111], 'Animals,': [112], 'School': [133], 'Traditional': [135], 'Chinese': [136], '6': [145], 'Show': [150], 'Chwan': [151], 'Hospital': [153], 'in': [154, 228, 237, 299, 308, 358, 391, 394], 'Bing,': [156], '6-1': [157], 'Lu-Kung': [158], 'Bing': [161], 'Industrial': [162], 'Center,': [163], 'Lu-Kang,': [164], 'Changhua': [165], '505,': [166], 'National': [173], 'Ming': [175], 'University,': [176], 'These': [179], 'authors': [180], 'contributed': [181], 'equally': [182], 'to': [183, 291], 'this': [184], 'work': [185], 'Correspondence': [186], 'to:': [187], 'Dr.': [188], 'Yang,': [191], 'e-mail:': [192], '[email protected]': [193], 'Keywords:': [194], 'amifostine,': [195], 'p53,': [196], 'small': [197, 257, 372, 400], 'bowel,': [198], 'whole-abdominal': [199, 262], 'irradiation,': [200], '14-3-3σ,': [201], 'MDM2': [202, 335], 'Received:': [203], 'June': [204], '29,': [205], '2014': [206, 210, 214], 'Accepted:': [207], 'August': [208], '23,': [209, 213], 'Published:': [211], 'September': [212], 'ABSTRACT': [215], 'Amifostine': [216], '(AM)': [217], 'is': [218, 226], 'a': [219], 'radioprotector': [220], 'that': [221, 368, 397], 'scavenges': [222], 'free': [223], 'radicals': [224], 'and': [225, 273, 318, 354, 380], 'used': [227], 'patients': [229], 'undergoing': [230], 'radiotherapy.': [231], 'p53': [232, 282, 305, 309, 315, 319, 328, 332, 338, 355, 392], 'has': [233], 'long': [234], 'been': [235], 'implicated': [236], 'cell': [238], 'cycle': [239], 'arrest': [240], 'cellular': [242], 'repair': [243], 'after': [244, 260], 'radiation': [245], 'exposure.': [246], 'We': [247], 'therefore': [248], 'investigated': [249], 'the': [250, 268, 325, 347, 362, 376, 387, 395], 'protective': [251], 'p53-dependent': [252], 'mechanism': [253], 'AM': [255, 265, 292, 294, 312, 330, 350, 369], 'on': [256, 351], 'bowel': [258, 373, 401], 'damage': [259, 374], 'lethal': [261, 277, 371, 399], 'irradiation': [263, 323], '(WAI).': [264], 'increased': [266, 296, 314], 'both': [267], 'survival': [269, 275, 298, 353], 'rate': [270], 'rats': [272], 'crypt': [274], 'following': [276], '18': [278], 'Gy': [279], 'WAI.': [280], 'The': [281], 'inhibitor': [283], 'PFT-α': [284], 'compromised': [285, 346], 'AM-mediated': [286], 'effects': [287], 'when': [288], 'administered': [289], 'prior': [290], 'administration.': [293], 'significantly': [295, 313], 'clonogenic': [297, 352], 'IEC-6': [300, 359], 'cells': [301], 'expressing': [302], 'wild': [303], 'type': [304], 'but': [306, 336], 'not': [307], 'knockdown': [310], 'cells.': [311, 360], 'nuclear': [316, 356], 'accumulation': [317, 357, 382], 'tetramer': [320], 'expression': [321], 'before': [322], 'through': [324, 375], 'inhibition': [326], 'degradation.': [329], 'inhibited': [331], 'interactions': [333, 339], 'with': [334, 340], 'enhanced': [337], '14-3-3σ.': [341], 'Knockdown': [342], '14-3-3σ': [344, 379], 'also': [345], 'effect': [348], 'For': [361], 'first': [363], 'time,': [364], 'our': [365], 'data': [366], 'reveal': [367], 'alleviates': [370], 'induction': [377], 'subsequent': [381], 'p53.': [384], 'Enhancement': [385], 'p53/14-3-3σ': [388], 'interaction': [389], 'results': [390], 'tetramerization': [393], 'nucleus': [396], 'rescues': [398], 'damage.': [402]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2113490296', 'counts_by_year': [{'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-09-13T22:57:24.673012', 'created_date': '2016-06-24'}