Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2113172514', 'doi': 'https://doi.org/10.1002/jcb.24165', 'title': 'IL‐17 mediates estrogen‐deficient osteoporosis in an Act1‐dependent manner', 'display_name': 'IL‐17 mediates estrogen‐deficient osteoporosis in an Act1‐dependent manner', 'publication_year': 2012, 'publication_date': '2012-04-17', 'ids': {'openalex': 'https://openalex.org/W2113172514', 'doi': 'https://doi.org/10.1002/jcb.24165', 'mag': '2113172514', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22511335', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3640304'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcb.24165', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3640304?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077029577', 'display_name': 'Carl J. DeSelm', 'orcid': 'https://orcid.org/0000-0001-7645-5798'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carl J. DeSelm', 'raw_affiliation_strings': ['Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri', 'Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, Missouri'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I204465549']}, {'raw_affiliation_string': 'Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047135045', 'display_name': 'Yoshifumi Takahata', 'orcid': 'https://orcid.org/0000-0002-3322-0515'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yoshifumi Takahata', 'raw_affiliation_strings': ['Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001246958', 'display_name': 'Julia T. Warren', 'orcid': 'https://orcid.org/0000-0003-2017-6444'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julia Warren', 'raw_affiliation_strings': ['Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri', 'Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, Missouri'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I204465549']}, {'raw_affiliation_string': 'Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015206673', 'display_name': 'Jean Chappel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jean C. Chappel', 'raw_affiliation_strings': ['Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102491624', 'display_name': 'Taimur Khan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Taimur Khan', 'raw_affiliation_strings': ['Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100348756', 'display_name': 'Xiaoxia Li', 'orcid': 'https://orcid.org/0000-0002-4872-9525'}, 'institutions': [{'id': 'https://openalex.org/I1316902750', 'display_name': 'Cleveland Clinic', 'ror': 'https://ror.org/03xjacd83', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiaoxia Li', 'raw_affiliation_strings': ['Department of Immunology, Cleveland Clinic, Cleveland, Ohio'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Cleveland Clinic, Cleveland, Ohio', 'institution_ids': ['https://openalex.org/I1316902750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060875400', 'display_name': 'Caini Liu', 'orcid': 'https://orcid.org/0000-0002-9314-7145'}, 'institutions': [{'id': 'https://openalex.org/I1316902750', 'display_name': 'Cleveland Clinic', 'ror': 'https://ror.org/03xjacd83', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Caini Liu', 'raw_affiliation_strings': ['Department of Immunology, Cleveland Clinic, Cleveland, Ohio'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Cleveland Clinic, Cleveland, Ohio', 'institution_ids': ['https://openalex.org/I1316902750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079411311', 'display_name': 'Yongwon Choi', 'orcid': 'https://orcid.org/0000-0002-1007-7998'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yongwon Choi', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066077925', 'display_name': 'Youngmi Faith Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Youngmi Faith Kim', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015577084', 'display_name': 'Wei Zou', 'orcid': 'https://orcid.org/0000-0001-8081-268X'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Zou', 'raw_affiliation_strings': ['Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001716316', 'display_name': 'Steven L. Teitelbaum', 'orcid': 'https://orcid.org/0000-0002-4054-6679'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Steven L. Teitelbaum', 'raw_affiliation_strings': ['Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri', 'Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri'], 'affiliations': [{'raw_affiliation_string': 'Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I204465549']}, {'raw_affiliation_string': 'Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I204465549']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5001716316'], 'corresponding_institution_ids': ['https://openalex.org/I204465549'], 'apc_list': {'value': 4640, 'currency': 'USD', 'value_usd': 4640, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.442, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 119, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '113', 'issue': '9', 'first_page': '2895', 'last_page': '2902'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11219', 'display_name': 'Bone Metabolism and Diseases', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11219', 'display_name': 'Bone Metabolism and Diseases', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10277', 'display_name': 'Vitamin D Research Studies', 'score': 0.9894, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mediator', 'display_name': 'Mediator', 'score': 0.45794648}, {'id': 'https://openalex.org/keywords/bone-remodeling', 'display_name': 'Bone remodeling', 'score': 0.44923267}, {'id': 'https://openalex.org/keywords/pathogenesis', 'display_name': 'Pathogenesis', 'score': 0.42776364}], 'concepts': [{'id': 'https://openalex.org/C2779428903', 'wikidata': 'https://www.wikidata.org/wiki/Q418934', 'display_name': 'RANKL', 'level': 4, 'score': 0.82453823}, {'id': 'https://openalex.org/C673006', 'wikidata': 'https://www.wikidata.org/wiki/Q4941581', 'display_name': 'Bone resorption', 'level': 2, 'score': 0.7039356}, {'id': 'https://openalex.org/C2776033226', 'wikidata': 'https://www.wikidata.org/wiki/Q828410', 'display_name': 'Osteoclast', 'level': 3, 'score': 0.57419866}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5525256}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.537723}, {'id': 'https://openalex.org/C2777164284', 'wikidata': 'https://www.wikidata.org/wiki/Q277954', 'display_name': 'Estrogen', 'level': 2, 'score': 0.5218372}, {'id': 'https://openalex.org/C2776541429', 'wikidata': 'https://www.wikidata.org/wiki/Q165328', 'display_name': 'Osteoporosis', 'level': 2, 'score': 0.5168455}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5037784}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.47042915}, {'id': 'https://openalex.org/C2107291', 'wikidata': 'https://www.wikidata.org/wiki/Q14886885', 'display_name': 'Mediator', 'level': 2, 'score': 0.45794648}, {'id': 'https://openalex.org/C170033053', 'wikidata': 'https://www.wikidata.org/wiki/Q952019', 'display_name': 'Bone remodeling', 'level': 2, 'score': 0.44923267}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.43322214}, {'id': 'https://openalex.org/C2780942790', 'wikidata': 'https://www.wikidata.org/wiki/Q372016', 'display_name': 'Pathogenesis', 'level': 2, 'score': 0.42776364}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.42377216}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.32732722}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.27575266}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26631945}, {'id': 'https://openalex.org/C88045685', 'wikidata': 'https://www.wikidata.org/wiki/Q174576', 'display_name': 'Activator (genetics)', 'level': 3, 'score': 0.10983044}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020381', 'descriptor_name': 'Interleukin-17', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010024', 'descriptor_name': 'Osteoporosis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020381', 'descriptor_name': 'Interleukin-17', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020381', 'descriptor_name': 'Interleukin-17', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010010', 'descriptor_name': 'Osteoclasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010010', 'descriptor_name': 'Osteoclasts', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D010010', 'descriptor_name': 'Osteoclasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010024', 'descriptor_name': 'Osteoporosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010024', 'descriptor_name': 'Osteoporosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010052', 'descriptor_name': 'Ovariectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053245', 'descriptor_name': 'RANK Ligand', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053245', 'descriptor_name': 'RANK Ligand', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053722', 'descriptor_name': 'Receptors, Interleukin-17', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053722', 'descriptor_name': 'Receptors, Interleukin-17', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053722', 'descriptor_name': 'Receptors, Interleukin-17', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055114', 'descriptor_name': 'X-Ray Microtomography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcb.24165', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3640304', 'pdf_url': 'https://europepmc.org/articles/pmc3640304?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640304', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22511335', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3640304', 'pdf_url': 'https://europepmc.org/articles/pmc3640304?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1555919277', 'https://openalex.org/W1600472471', 'https://openalex.org/W1646288869', 'https://openalex.org/W1931885032', 'https://openalex.org/W1965404141', 'https://openalex.org/W1975204978', 'https://openalex.org/W1980619336', 'https://openalex.org/W1981803131', 'https://openalex.org/W1985478291', 'https://openalex.org/W1986714785', 'https://openalex.org/W1988158769', 'https://openalex.org/W2005552681', 'https://openalex.org/W2007093051', 'https://openalex.org/W2007897124', 'https://openalex.org/W2012538973', 'https://openalex.org/W2020233428', 'https://openalex.org/W2021674244', 'https://openalex.org/W2035377083', 'https://openalex.org/W2037454778', 'https://openalex.org/W2041084338', 'https://openalex.org/W2049489791', 'https://openalex.org/W2062028959', 'https://openalex.org/W2068674433', 'https://openalex.org/W2079148101', 'https://openalex.org/W2083361647', 'https://openalex.org/W2087726670', 'https://openalex.org/W2087810525', 'https://openalex.org/W2088885697', 'https://openalex.org/W2092099741', 'https://openalex.org/W2100564391', 'https://openalex.org/W2109955020', 'https://openalex.org/W2114982159', 'https://openalex.org/W2122724238', 'https://openalex.org/W2127988622', 'https://openalex.org/W2128887382', 'https://openalex.org/W2132933661', 'https://openalex.org/W2133281510', 'https://openalex.org/W2136357996', 'https://openalex.org/W2137512902', 'https://openalex.org/W2140373863', 'https://openalex.org/W2145468317', 'https://openalex.org/W2159203244', 'https://openalex.org/W2168143492', 'https://openalex.org/W4234708959'], 'related_works': ['https://openalex.org/W4366436000', 'https://openalex.org/W3116940347', 'https://openalex.org/W2789429347', 'https://openalex.org/W2544129566', 'https://openalex.org/W2288534739', 'https://openalex.org/W2269245066', 'https://openalex.org/W2074483736', 'https://openalex.org/W2073927082', 'https://openalex.org/W2033552162', 'https://openalex.org/W1884845882'], 'abstract_inverted_index': {'Abstract': [0], 'Estrogen‐deficient': [1], 'osteoporosis': [2, 43, 187], 'may': [3], 'be': [4], 'an': [5, 90], 'inflammatory': [6], 'disorder': [7, 190], 'and': [8, 93, 170], 'we': [9], 'therefore': [10], 'asked': [11], 'if': [12], 'IL‐17': [13, 22, 38, 53, 179], 'participates': [14], 'in': [15, 39, 83, 116, 158, 173], 'its': [16, 40, 145, 150, 156], 'pathogenesis.': [17], 'Deletion': [18], 'of': [19, 37, 88, 114, 128, 177, 191], 'the': [20, 51, 67, 178, 183], 'principal': [21], 'receptor': [23], '(IL‐17RA)': [24], 'protects': [25], 'mice': [26], 'from': [27, 106], 'ovariectomy': [28], '(OVX)‐induced': [29], 'bone': [30, 108, 171], 'loss.': [31, 109], 'Further': [32], 'supporting': [33, 182], 'a': [34, 47, 189], 'central': [35], 'role': [36], 'pathogenesis,': [41], 'OVX‐induced': [42, 107], 'is': [44, 188], 'prevented': [45], 'by': [46, 56, 62, 66, 80], 'blocking': [48], 'antibody': [49], 'targeting': [50], 'cytokine.': [52], 'promotes': [54, 167], 'osteoclastogenesis': [55, 122], 'stimulating': [57], 'RANK': [58], 'ligand': [59], '(RANKL)': [60], 'expression': [61, 79, 169], 'osteoblastic': [63], 'cells,': [64], 'mediated': [65], 'IL‐17RA': [68, 77, 98], 'SEFIR/TILL': [69], 'domain.': [70], 'Estrogen': [71, 164], 'deprivation,': [72, 165], 'however': [73], 'does': [74], 'not': [75, 119], 'enhance': [76], 'mRNA': [78], 'osteoblasts': [81, 134], 'or': [82, 149], 'bone,': [84], 'but': [85, 118], 'augments': [86], 'that': [87, 185], 'Act1,': [89, 181], 'IL‐17RA‐interacting': [91], 'protein': [92], 'signaling': [94], 'mediator.': [95], 'Similar': [96], 'to': [97, 161], '−/−': [99, 133], 'mice,': [100], 'those': [101], 'lacking': [102, 144], 'Act1': [103, 115, 130, 132], 'are': [104], 'protected': [105], 'Also': [110], 'mirroring': [111], 'IL‐17RA‐deficiency,': [112], 'absence': [113], 'osteoblasts,': [117], 'osteoclasts,': [120], 'impairs': [121], 'via': [123], 'dampened': [124], 'RANKL': [125, 168], 'expression.': [126], 'Transduction': [127], 'WT': [129], 'into': [131], 'substantially': [135], 'rescues': [136], 'their': [137], 'osteoclastogenic': [138], 'capacity.': [139], 'The': [140], 'same': [141], 'construct,': [142], 'however,': [143], 'E3': [146], 'ligase': [147], 'U‐box': [148], 'SEFIR': [151], 'domain,': [152], 'which': [153], 'interacts': [154], 'with': [155, 175], 'counterpart': [157], 'IL‐17RA,': [159], 'fails': [160], 'do': [162], 'so.': [163], 'therefore,': [166], 'resorption': [172], 'association': [174], 'upregualtion': [176], 'effector,': [180], 'concept': [184], 'post‐menopausal': [186], 'innate': [192], 'immunity.': [193], 'J.': [194], 'Cell.': [195], 'Biochem.': [196], '113:': [197], '2895–2902,': [198], '2012.': [199], '©': [200], '2012': [201], 'Wiley': [202], 'Periodicals,': [203], 'Inc.': [204]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2113172514', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-02T20:18:48.018160', 'created_date': '2016-06-24'}