Title: INFLUENCE OF THYMUS EXTRACT (TFX) ON LIPID PEROXIDATION IN THE PLASMA OF RATS FOLLOWING THERMAL INJURY
Abstract:Lipid peroxidation products in burn alone and after TFX treatment were assessed. Obtained results showed that lipid peroxidation process began immediately after severe burn and was continued during th...Lipid peroxidation products in burn alone and after TFX treatment were assessed. Obtained results showed that lipid peroxidation process began immediately after severe burn and was continued during the whole 48 h post burn period. Burn enhanced the lipid peroxidation products and the TFX treatment slightly diminished the malonyldialdehyde (MDA) and conjugate dienes (CD) plasma concentration. Our investigations suggest that TFX treatment enhanced the post burn lipid hydroperoxides (HPETE) generation. This effect may be the consequence of modulation of immune system, which causes the enhanced activity of lipoxygenase and simultaneously decrease in cyclooxygenase activity after TFX treatment. TFX treatment one hour after burn prevented the ongoing post burn peroxidation 24 and 48 h after burn. The observations suggest that it may be helpful to improve the peroxidation antioxidation imbalance which is the consequence of severe burn.Read More
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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Cited By Count: 3
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