Adult Cardiac Sca-1-positive Cells Differentiate into Beating Cardiomyocytes

Name: Work Video:
Duration: 3 min 30 s
Katsuhisa Matsuura; Toshio Nagai; Nobuhiro Nishigaki; Tomomi Oyama; Junichiro Nishi; Hiroshi Wada; Masanori Sano; Haruhiro Toko; Hiroshi Akazawa; Toshiaki Sato; Haruaki Nakaya; Hiroshi Kasanuki; Issei Komuro
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345, 417, 560, 626, 674, 680, 692, 718, 752, 803, 852, 936, 943, 975, 991, 1042, 1060, 1297, 1378, 1394, 1636, 1710, 1741, 1781, 1818, 1840, 1875, 1907, 2291, 2326, 2365, 2389, 2394, 2429, 2532, 2594, 2681, 2808, 2818, 2841, 2904, 2943, 2965, 2974, 3001, 3011, 3040, 3054, 3068, 3072, 3089, 3094, 3116, 3152, 3288, 3307, 3322, 3382, 3420, 3444, 3459, 3471, 3480, 3511, 3541, 3591, 3626, 3743, 3759, 3847, 3859, 3869, 3969, 3981, 3985, 3997, 4029, 4042, 4054, 4066, 4080, 4097, 4115, 4152, 4200, 4219], 'have': [4, 14, 34, 157, 175, 185, 205, 328, 402, 675, 747, 799, 846, 901, 969, 1194, 1287, 2883, 3975, 4090, 4229], 'been': [5, 15, 176, 186, 367, 553, 983, 1117, 1195, 3843, 4230], 'reported': [6, 177, 554, 707, 800, 847, 970, 984, 1196, 1288, 3844], 'to': [7, 67, 165, 178, 238, 336, 369, 371, 669, 913, 939, 1197, 1298, 2308, 2811, 2995, 3077, 3496, 3685], 'exist': [8, 179, 561], 'in': [9, 21, 31, 152, 180, 192, 202, 323, 422, 562, 863, 920, 976, 994, 1043, 1133, 1136, 1171, 1203, 1308, 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3456, 3468, 3507, 3516, 3522, 3532, 3538, 3557, 3579, 3623, 3715, 3720, 3727, 3753, 3773, 3788, 3800, 3819, 3830, 3858, 3995, 4004, 4008, 4064, 4070, 4150, 4168, 4179, 4184, 4198, 4212, 4236], 'features': [38, 209], 'cells.': [41, 212, 398, 946, 1100, 1383, 2846, 2928, 3111, 3525, 3732, 3833], 'Sca-1+': [42, 64, 78, 112, 129, 150, 213, 235, 249, 283, 300, 321, 802, 988, 1393, 1571, 1635, 1709, 1730, 1740, 1906, 2393, 2593, 2795, 2807, 2840, 2903, 2927, 2942, 2960, 2983, 3000, 3010, 3151, 3306, 3395, 3443, 3479, 3510, 3540, 3590, 3701, 3721, 3731, 3742, 3832, 3834, 3846, 3968, 3996, 4028, 4041, 4053, 4065, 4079, 4096, 4114, 4151, 4172, 4199], 'were': [44, 138, 215, 309, 937, 1415, 1427, 1448, 1462, 1473, 1548, 1563, 1695, 1711, 1742, 1782, 1819, 1841, 1876, 2143, 2191, 2238, 2284, 2292, 2306, 2327, 2342, 2366, 2434, 2513, 2533, 2564, 2682, 2809, 2819, 2944, 3002, 3012, 3028, 3069, 3073, 3090, 3165, 3204, 3249, 3313, 3356, 3592, 3776, 3998, 4025, 4055], 'isolated': [45, 216, 1820], 'from': [46, 217, 754, 804, 853, 1324, 1376, 1392, 1396, 1417, 1450, 1464, 1550, 1565, 1573, 1713, 1899, 2391, 2595, 2798, 2985, 3061, 3242, 3398, 3703, 3848, 3970], 'murine': [48, 155, 219, 326, 582, 1322, 1399, 1902, 2598, 2816, 2892, 3245, 3401, 3973], 'by': [50, 105, 221, 276, 378, 387, 1429, 1639, 1716, 1821, 1878, 1908, 2193, 2329, 2344, 2368, 2464, 2535, 2546, 2739, 2757, 2778, 2955, 3153, 3275, 3494, 4105], 'a': [51, 222, 698, 921, 1389, 1590, 1698, 1704, 2234, 2345, 2369, 2466, 2523, 2547, 3366, 3417, 4208, 4233], 'magnetic': [52, 223, 1732, 2931], 'cell': [53, 224, 420, 712, 1592, 1654, 2917, 3021], 'sorting': [54, 225, 1640, 1733, 1834, 2932], 'system': [55, 226, 1138, 1647, 1824, 2825], 'and': [56, 71, 86, 89, 93, 118, 137, 162, 227, 242, 257, 260, 264, 289, 308, 333, 374, 413, 557, 579, 686, 704, 757, 859, 944, 989, 1037, 1040, 1058, 1128, 1155, 1161, 1205, 1402, 1411, 1434, 1458, 1568, 1685, 1707, 1762, 1829, 1838, 1850, 1860, 1873, 1893, 1905, 1983, 1989, 2082, 2180, 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262, 3345, 3422, 3461, 4140], 'structure': [92, 263], 'spontaneous': [94, 265, 3134, 3505, 3536, 4158, 4187], 'beating.': [95, 266, 3135, 4159, 4188], 'Isoproterenol': [96, 267, 3617], 'treatment': [97, 268, 3035, 3083, 3118, 3156, 3175, 3389, 3414, 3548, 3746, 3768, 4031, 4106, 4162, 4193, 4225], 'increased': [98, 269, 372, 1315, 2582, 3561, 3619], 'beating': [100, 271, 348, 1256, 1299, 1405, 2364, 2388, 2428, 2531, 3088, 3106, 3506, 3524, 3537, 3586, 3621, 3681, 3699, 4101, 4222], 'rate,': [101, 272], 'which': [102, 273, 908, 1050, 2473, 3406, 3582], 'was': [103, 121, 274, 292, 1586, 1637, 1656, 1734, 1803, 1835, 1897, 2168, 2316, 2395, 2462, 2541, 2600, 2655, 2659, 2741, 2754, 2776, 2787, 2842, 2905, 3107, 3273, 3284, 3372, 3542, 3560, 3736], 'accompanied': [104, 275, 3543], 'intracellular': [107, 278, 3514], 'Ca2+': [108, 279, 2382, 2384], 'transients.': [109, 280, 3546], 'The': [110, 281, 363, 1189, 1470, 1693, 1739, 1868, 2174, 2188, 2427, 2459, 2511, 2574, 2769, 2782, 2836, 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'thought': [368], 'adapt': [370], 'work': [373], 'loss': [375], 'cardiomyocytes': [377, 392, 406, 1375, 1406, 2888, 3485, 4102, 4202, 4223], 'cellular': [380], 'hypertrophy': [381], 'residual': [383], 'cardiomyocytes,': [384, 2999, 3405], 'but': [385, 1247, 3431, 3466], 'not': [386, 1249, 1363, 1561, 3285, 3354, 3432, 3437, 3475, 4176], 'proliferation': [389], 'mature': [391, 694, 1255, 3404], 'or': [393, 1108, 1166, 1793, 2302, 3007, 3121, 3130, 3133, 3159, 3178, 3601, 4186], 'differentiation': [395, 687, 1246, 1253, 1292, 1331, 1373, 2591, 2658, 2997, 3393, 3829, 4197, 4214], 'undifferentiated': [397], 'However,': [399, 666], 'recent': [400], 'suggested': [403], 'can': [407, 1168, 3482, 4098], 'proliferate': [408], 'under': [409], 'certain': [410], 'pathologic': [411], 'conditions': [412, 2182], 'are': [416, 1241, 1248, 1560, 2183, 2763, 3486], 'expressing': [418], 'markers': [421, 714, 4007], '(1Kajstura': [426], 'J.': [427, 467, 492, 511, 534, 541, 832, 877, 881, 889, 890, 958, 1026, 1077, 1178, 1263, 1271, 1342, 1343, 1624, 1995, 1997, 2004, 2031, 2056, 2066, 2071, 2086, 2094, 2416, 2420, 2631, 2861, 3913, 3917, 3925, 3926, 3953], 'Leri': [428, 503, 535, 2858], 'A.': [429, 445, 455, 461, 478, 504, 536, 628, 735, 834, 887, 951, 955, 1064, 1278, 1340, 1598, 1935, 1999, 2068, 2101, 2113, 2401, 2405, 2665, 2859, 2874, 3923, 3940, 4257], 'Finato': [430, 495, 527], 'N.': [431, 496, 509, 528, 539, 822, 1025, 2624], 'Di': [432], 'Loreto': [433], 'C.': [434, 885, 3921], 'Beltrami': [435, 505, 525, 529], 'C.A.': [436, 506, 530, 1227], 'Anversa': [437, 470, 507, 537, 2866], 'P.': [438, 471, 508, 538, 567, 649, 953, 1210, 2001, 2867], 'Proc.': [439, 472, 729, 1272, 1929, 2095, 2868], 'Natl.': [440, 473, 730, 1273, 1930, 2096, 2869], 'Acad.': [441, 474, 731, 1274, 1931, 2097, 2870], 'Sci.': [442, 475, 732, 1275, 1932, 2098, 2871], 'U.': [443, 476, 733, 1276, 1933, 2099, 2872], 'S.': [444, 477, 724, 734, 786, 820, 830, 1277, 1334, 1928, 1934, 2046, 2050, 2062, 2070, 2100, 2855, 2865, 2873, 3891, 4247, 4279], '1998;': [446, 1975, 2422], '95:': [447], '8801-8805Crossref': [448], 'PubMed': [449, 482, 516, 546, 574, 641, 661, 739, 794, 841, 896, 964, 1032, 1083, 1150, 1184, 1221, 1236, 1282, 1348, 1628, 1939, 1958, 1978, 2013, 2040, 2077, 2105, 2122, 2163, 2637, 2674, 2878, 3899, 3932, 3959, 4295], 'Scopus': [450, 483, 517, 547, 575, 642, 662, 740, 795, 842, 897, 965, 1033, 1084, 1151, 1185, 1222, 1283, 1349, 1629, 1940, 1959, 1979, 2078, 2106, 2123, 2139, 2164, 2638, 2675, 2879, 3900, 3933, 3960, 4272, 4296], '(502)': [451], 'Google': [452, 485, 519, 549, 577, 644, 664, 742, 797, 844, 899, 967, 1035, 1086, 1153, 1187, 1224, 1237, 1285, 1351, 1631, 1942, 1961, 1981, 2014, 2041, 2080, 2108, 2125, 2141, 2166, 2425, 2640, 2677, 2881, 3902, 3935, 3962, 4274], 'Scholar,': [453, 486, 520, 645, 1225, 3903, 3936, 4275], '2Leri': [454], 'Barlucchi': [456], 'L.': [457], 'Limana': [458, 2847], 'F.': [459, 502, 522, 1002, 1010, 2052, 2851, 2857], 'Deptala': [460], 'Darzynkiewicz': [462], 'Z.': [463, 869, 2403, 3905], 'Hintze': [464], 'T.H.': [465], 'Kajstura': [466, 491, 533, 2860], 'Nadal-Ginard': [468, 499, 531, 568, 2862], 'B.': [469, 500, 532, 569, 871, 883, 1006, 2863, 3907, 3919], '2001;': [479, 513, 1029, 1955, 2119, 2671, 4292], '98:': [480], '8626-8631Crossref': [481], '(87)': [484], '3Beltrami': [487], 'A.P.': [488, 526], 'Urbanek': [489, 523, 2852], 'K.': [490, 524, 766, 778, 782, 1066, 1608, 2048, 2853, 3871, 3883, 3887, 3942, 4241, 4281], 'Yan': [493], 'S.M.': [494, 1269, 2092], 'Bussani': [497], 'R.': [498, 873, 879, 1614, 3909, 3915, 4287], 'Silvestri': [501], 'Eng.': [510, 540], 'Med.': [512, 542], '344:': [514], '1750-1757Crossref': [515], '(1300)': [518], '4Quaini': [521], '2002;': [543, 571, 633, 658, 893, 961, 1080, 1218, 1279, 1345, 2102, 2136, 2875, 3929, 3956], '346:': [544], '5-15Crossref': [545], '(1127)': [548], 'Scholar).': [550, 665, 743, 1087, 1188, 1238, 1352, 1632, 2426, 2641, 2678, 3963], 'It': [551, 981, 1115], 'Sca-1-': [556], 'c-kit-positive': [558], '(+)': [559], '(5Anversa': [566], 'Nature.': [570, 1217], '415:': [572], '240-243Crossref': [573], '(449)': [576], 'Scholar)': [578, 798, 845, 900, 968, 1036, 1286, 2142, 2167, 2882], 'contain': [584], 'cells;': [587], 'side': [588, 596], 'population': [589, 1391], '(SP)': [590], '1The': [591], 'abbreviations': [592], 'used': [593, 1474, 2169, 2176, 3250], 'are:': [594], 'SP,': [595], 'population;': [597], 'PE,': [598], 'phycoerythrin;': [599], 'PBS,': [600, 2297], 'phosphate-buffered': [601], 'saline;': [602], 'FBS,': [603, 1673, 1757, 2607, 3017], 'fetal': [604], 'bovine': [605, 2258, 2277], 'serum;': [606], 'MHC,': [607], 'myosin': [608, 612, 1527, 2016, 3346, 3423, 3462, 3473, 4141], 'heavy': [609, 1528, 1991, 3347, 3424, 4142], 'chain;': [610, 614], 'MLC,': [611], 'light': [613, 1514, 2017, 2537], 'MACS,': [615], 'Magnetic': [616, 1643, 1833], 'Cell': [617, 836, 891, 959, 1027, 1078, 1644, 2632, 2791, 3927, 3954], 'Sorting;': [618], 'ALP,': [619], 'phosphatase;': [621], 'MEF,': [622], 'muscle': [623, 759, 919, 926, 978, 1963, 3850], 'enhancer': [624, 1964], 'factor.': [625, 815], '(6Asakura': [627], 'Rudnicki': [629, 652, 956, 2116, 2668], 'M.A.': [630, 653, 957, 2117, 2669], 'Exp.': [631, 835], 'Hematol.': [632], '30:': [634], '1339-1345Abstract': [635], 'Full': [636, 638, 2010, 2037], 'Text': [637, 639, 2011, 2038], '(291)': [643, 2140], '7Hierlihy': [646], 'A.M.': [647], 'Seale': [648, 952], 'Lobe': [650], 'C.G.': [651], 'Megeney': [654], 'L.A.': [655], 'FEBS': [656], 'Lett.': [657], '530:': [659], '239-243Crossref': [660], '(386)': [663], 'it': [667, 4174], 'remains': [668], 'be': [670, 1094, 1198], 'clarified': [671], 'whether': [672, 3966, 3979], 'these': [673, 3980], 'characteristics': [677], 'such': [681, 2920, 3194, 3860, 4019], 'abilities': [683], 'self-renewal': [685], 'types': [690, 3857], 'including': [693, 1379, 1923, 1987, 3186, 4119, 4133], 'cardiomyocytes.': [695, 1257, 1300, 2912, 3988], 'Sca-1': [696, 858, 1092], 'is': [697, 1103, 1314, 1362, 3492, 4207], 'member': [699], 'Ly-6': [702], 'family': [703], 'first': [706, 1386, 4091], 'one': [709, 1736, 4003], 'surface': [713, 2918], 'hematopoietic': [716], '(8van': [719], 'der': [720], 'Rijn': [721], 'M.': [722, 875, 1004, 1008, 1013, 1212, 1216, 1267, 1336, 2058, 2090, 2115, 2667, 3911], 'Heimfeld': [723], 'Spangruade': [725], 'G.J.': [726], 'Wiessman': [727], 'I.L.': [728], '1989;': [736], '86:': [737], '4634-4638Crossref': [738], '(210)': [741], 'Recently': [744, 1258], 'many': [745], 'demonstrated': [748, 930, 4092], 'multipotential': [750], 'derived': [753, 1395, 2390, 3397], 'bone': [755, 805, 854, 1123, 3852], 'marrow': [756, 806, 855, 3853], 'skeletal': [758, 904, 918, 933, 977, 986, 1048, 3849], 'express': [760, 857, 910, 979, 1052], 'Sca-1.': [761, 980], 'Okumoto': [762], 'et': [763, 817, 866, 948, 1260, 2848], 'al.': [764, 818, 867, 949, 1261, 2849], '(9Okumoto': [765, 3870], 'Saito': [767, 781, 3872, 3886], 'T.': [768, 774, 776, 826, 1062, 1072, 1602, 1606, 1618, 1620, 1622, 2003, 2060, 3873, 3879, 3881, 3938, 3948, 4249, 4255, 4259, 4261], 'Hattori': [769, 3874], 'E.': [770, 2028, 3875, 4251], 'Ito': [771, 3876], 'J.I.': [772, 3877], 'Adachi': [773, 3878], 'Takeda': [775, 823, 3880], 'Sugahara': [777, 3882], 'Watanabe': [779, 3884], 'H.': [780, 784, 828, 1070, 1610, 1616, 2054, 2064, 3885, 3889, 3946], 'Togashi': [783, 3888], 'Kawata': [785, 3890], 'Biochem.': [787, 2633, 3892], 'Biophys.': [788, 3893], 'Res.': [789, 837, 3894], 'Commun.': [790, 3895], '2003;': [791, 838, 1625, 3896], '304:': [792, 3897], '691-695Crossref': [793, 3898], '(82)': [796, 3901], 'hepatocyte': [809], 'when': [810, 1329, 2814, 3075], 'hepatic': [813, 3868], 'growth': [814, 1109, 1157], 'Gojo': [816, 821], '(10Gojo': [819], 'Y.': [824, 998, 1068, 1176, 1604, 3944, 4245, 4263, 4277, 4283, 4285], 'Mori': [825], 'Abe': [827, 2063], 'Kyo': [829], 'Hata': [831, 2065], 'Umezawa': [833, 2067], '288:': [839], '51-59Crossref': [840], '(232)': [843], 'mesenchymal': [850], 'abundantly': [856], 'cardiomyocyte': [862, 3828], 'vivo.': [864], 'Qu-Petersen': [865], '(11Qu-Petersen': [868], 'Deasy': [870, 3906], 'Jankowski': [872, 1266, 1335, 2089, 3908], 'Ikezawa': [874, 3910], 'Cummins': [876, 3912], 'Pruchnic': [878, 3914], 'Mytinger': [880, 3916], 'Cao': [882, 3918], 'Gates': [884, 3920], 'Wernig': [886, 3922], 'Huard': [888, 3924], 'Biol.': [892, 960, 1028, 1079, 1180, 1954, 2005, 2032, 2159, 3928, 3955, 4268], '157:': [894, 1081, 3930, 3957], '851-864Crossref': [895, 3931], '(742)': [898, 3934], 'shown': [902, 1118, 3527], 'muscle-derived': [905, 934, 987], 'cells,': [907, 1731, 2961, 3396, 3722, 3864, 4173], 'highly': [909, 1051], 'Sca-1,': [911, 1053], 'mouse': [922, 1477, 1511, 1519, 1524, 1582], 'model': [923, 4235], 'Duchenne': [925], 'dystrophy.': [927], 'They': [928], 'also': [929, 3357, 4165], 'able': [938], 'neural': [942], 'endothelial': [945, 3863], 'Asakura': [947], '(12Asakura': [950], 'Girgis-Gabardo': [954], '159:': [962], '123-134Crossref': [963], '(585)': [966], '∼90%': [972], 'SP': [974], 'CD34+': [990, 1039], 'restore': [992], 'dystrophin': [993], 'mdx': [995], 'mice': [996, 1413], '(13Torrente': [997], 'Tremblay': [999], 'J.P.': [1000], 'Pisati': [1001], 'Belicchi': [1003], 'Rossi': [1005], 'Sironi': [1007], 'Fortunato': [1009], 'El': [1011], 'Fahime': [1012], "D'Angelo": [1014], 'M.G.': [1015], 'Caron': [1016], 'N.J.': [1017], 'Constantin': [1018], 'G.': [1019, 1023, 2132, 2413], 'Paulin': [1020], 'D.': [1021, 1338, 4253], 'Scarlato': [1022], 'Bresolin': [1024], '152:': [1030], '335-348Crossref': [1031], '(252)': [1034], 'CD45-': [1041, 3488], 'interstitial': [1045], 'spaces': [1046], 'muscle,': [1049, 3865], 'adipocytes,': [1056, 3862], 'endothelial,': [1057], 'myogenic': [1059], '(14Tamaki': [1061], 'Akatsuka': [1063, 3939], 'Ando': [1065, 3941], 'Nakamura': [1067, 3943], 'Matsuzawa': [1069, 3945], 'Hotta': [1071, 3947], 'Roy': [1073, 3949], 'R.R.': [1074, 3950], 'Edgerton': [1075, 3951], 'V.R.': [1076, 3952], '571-577Crossref': [1082, 3958], '(301)': [1085, 3961], 'findings': [1089, 3386], 'might': [1093], 'important': [1095, 1369, 3824], 'evidence': [1096], 'for': [1097, 1200, 1243, 1251, 1475, 1662, 1679, 1788, 1814, 1855, 2243, 2265, 2456, 2711, 2732, 3210, 3215, 3260, 3265, 3552, 3605, 3614, 4060], 'Currently': [1101], 'little': [1102, 3045], 'known': [1104], 'about': [1105], 'humoral': [1107], 'induce': [1112, 1169, 2996, 4177], 'cardiomyogenic': [1113], 'differentiation.': [1114], 'ectopic': [1120], 'application': [1121], 'morphological': [1124], 'protein': [1125, 1318, 3364], '(BMP)': [1126], '2': [1127, 1160, 2712], '4': [1129, 1683, 2288], 'elicits': [1130], 'cardiogenic': [1131], 'responses': [1132], 'chick': [1135, 1172, 1206], 'vivo': [1137], '(15Schultheiss': [1139], 'T.M.': [1140], 'Burch': [1141], 'J.B.': [1142], 'Lassar': [1143], 'A.B.': [1144], 'Genes': [1145], 'Dev.': [1146, 1179, 1953, 2158], '1997;': [1147, 1233, 2634], '11:': [1148], '451-462Crossref': [1149], '(587)': [1152], 'Scholar),': [1154, 1943, 1962, 1982, 2015, 2042, 2081, 2109, 2126], 'fibroblast': [1156], 'factor': [1158], '(FGF)': [1159], '4,': [1162, 3338], 'combined': [1163], 'BMP-2': [1165], 'BMP-4': [1167], 'cardiogenesis': [1170, 4239], 'non-precardiac': [1173], 'mesoderm': [1174], '(16Sugi': [1175], 'Lough': [1177], '1995;': [1181], '168:': [1182], '567-574Crossref': [1183], '(118)': [1186], 'non-canonical': [1190], 'Wnt/c-Jun-N-terminal': [1191], 'kinase': [1192], 'pathways': [1193], 'essential': [1199], 'frog': [1204], 'embryo': [1207], 'systems': [1208], '(17Pandur': [1209], 'Lasche': [1211], 'Eisenberg': [1213, 1230], 'L.M.': [1214, 1231], 'Kuhl': [1215], '418:': [1219], '636-641Crossref': [1220], '(463)': [1223], '18Eisenberg': [1226], 'Gourdie': [1228], 'R.G.': [1229], 'Development.': [1232], '124:': [1234], '525-536Crossref': [1235], 'prerequisites': [1242], 'early': [1244, 4006], 'sufficient': [1250], 'accomplishing': [1252], 'Paquin': [1259], '(19Paquin': [1262, 2085], 'Danalache': [1264, 2087], 'B.A.': [1265, 2088], 'McCann': [1268, 2091], 'Gutkowska': [1270, 1341, 2093], '99:': [1280, 2103, 2876], '9550-9555Crossref': [1281, 2104], '(205)': [1284, 2107], 'induces': [1291, 4196], 'P19': [1294, 4217], 'embryonic': [1295], 'carcinoma': [1296], 'In': [1301, 2958, 3782, 4086], 'support': [1302], 'role': [1305, 1370, 3714, 3825], 'development,': [1310], 'at': [1316, 1682, 1767, 2246, 2450, 2543, 2579, 3109, 3374, 3738], 'level': [1319, 2784, 3515], 'day': [1325], '7': [1326], 'gestation,': [1328], 'starts': [1332], '(20Mukaddam-Daher': [1333], 'Wang': [1337], 'Menaouar': [1339], 'Endocrinol.': [1344], '175:': [1346], '211-216Crossref': [1347], '(23)': [1350], 'precise': [1355], 'mechanism': [1356], 'effect': [1359, 3693, 3787], 'clear,': [1364], 'play': [1367], 'an': [1368, 2171, 2358, 2584, 2890, 3823], 'primitive': [1377], 'Here,': [1384], 'we': [1385, 2914, 3137, 3440, 3518, 3574, 3723, 3977, 4089], 'report': [1387], 'novel': [1390], 'proliferates': [1401], 'differentiates': [1403], 'Animals': [1410, 1420], 'Reagents—Wild': [1412], '(C57Bl/6)': [1414], 'purchased': [1416, 1449, 1463, 1549], 'Takasugi': [1418], 'Experimental': [1419], 'Supply,': [1421], 'Co,': [1422, 2552], 'LTD,': [1423], 'Japan.': [1424], 'All': [1425], 'protocols': [1426], 'approved': [1428], 'Institutional': [1431], 'Animal': [1432], 'Care': [1433], 'Use': [1435], 'Committee': [1436], 'Chiba': [1438], 'University.': [1439], 'Phycoerythrin': [1440], '(PE)': [1441], '-conjugated': [1442], 'anti-Sca-1': [1443, 1460, 1660, 1827, 2828, 2935], '(anti-Ly6A/E),': [1444], 'anti-c-kit': [1445, 1852], '(anti-CD117)': [1446], 'antibodies': [1447, 1461, 1472, 1547, 2269, 2305, 2952, 3317], 'eBio-science': [1451], '(San': [1452, 1467], 'Diego,': [1453, 1468], 'CA).': [1454, 1469, 1544, 1651, 2336], 'PE-conjugated': [1455, 1659, 1844, 1847, 1851, 2827, 2947], 'anti-CD34,': [1456], 'anti-CD45,': [1457, 2948], 'biotin-conjugated': [1459, 1826, 2934], 'BD': [1465], 'Pharmingen': [1466], 'following': [1471], 'immunostaining:': [1476], 'monoclonal': [1478, 1512, 1520, 1525], 'anti-cardiac': [1479], 'troponin': [1480, 3335, 3380, 3434, 4136, 4181], 'T': [1481, 3336, 3435], '(RV-C2,': [1482], 'DSMZ-Deutsche': [1483], 'Sammlung': [1484], 'von': [1485], 'Mikroorganismen': [1486], 'und': [1487], 'Zellkulturen': [1488], 'GmbH,': [1489], 'Germany),': [1490], 'rabbit': [1491, 1535], 'polyclonal': [1492, 1503, 1536], 'anti-atrial': [1493], 'natriuretic': [1494], 'factor-1': [1495], '(ANF)': [1496], '(Peninsula': [1497], 'Laboratories,': [1498, 1540], 'San': [1499, 1542], 'Carlos.': [1500], 'CA),': [1501, 1510], 'goat': [1502], 'anti-GATA4': [1504], '(Santa': [1505], 'Cruz': [1506], 'Biotechnology,': [1507], 'Santa': [1508], 'Cruz,': [1509], 'anti-myosin': [1513], 'chain-2v': [1515], '(MLC-2v)': [1516], '(BioCytex,': [1517], 'France),': [1518], 'anti-tropomyosin': [1521], '(Sigma': [1522], 'Aldrich),': [1523], 'anti-sarcomeric': [1526], 'chain': [1529, 1992, 3348, 3425], '(MF-20)': [1530], '(American': [1531], 'Type': [1532], 'Culture': [1533, 1569], 'Collection),': [1534], 'anti-connexin': [1537], '43': [1538, 3371], '(Zymed': [1539], 'South': [1541], 'Francisco,': [1543], 'Fluorescent': [1545], 'secondary': [1546, 2304], 'Jackson': [1551], 'ImmunoResearch': [1552], 'Laboratory': [1553], '(Bar': [1554], 'Harbor,': [1555], 'ME).': [1556], 'Other': [1557], 'reagents': [1558], 'specified': [1562], 'obtained': [1564, 2367, 3241], 'Sigma-Aldrich.': [1566], 'Isolation': [1567], 'Cells': [1572, 1813, 2796, 2984, 3702, 3835], 'Murine': [1576, 2801, 2988, 3706], 'Heart—A': [1577], 'C57Bl/6': [1581], '(10–12': [1583], 'weeks': [1584, 3033, 3080, 3173], 'old)': [1585], 'enzymatically': [1587], 'dissociated': [1588], 'single': [1591], 'suspension': [1593, 1655], 'described': [1595, 2184, 2399, 2621, 2662], 'previously': [1596, 2398, 2622, 2663], '(21Yao': [1597], 'Kohmoto': [1599], 'O.': [1600], 'Oyama': [1601], 'Sugishita': [1603], 'Shimizu': [1605], 'Harada': [1607], 'Matsui': [1609], 'Komuro': [1611, 4264, 4288], 'I.': [1612, 1926, 2187, 2407, 4243, 4265, 4289], 'Nagai': [1613, 4286], 'Matsuo': [1615], 'Serizawa': [1617], 'Maruyama': [1619], 'Takahashi': [1621, 2059], 'Circ.': [1623], '67:': [1626], '83-90Crossref': [1627], '(26)': [1630], 'Enrichment': [1633], 'achieved': [1638], 'using': [1641, 1884, 2145, 2374, 2826], 'Sorting': [1645], '(MACS)': [1646], '(Miltenyl': [1648], 'Biotec,': [1649], 'Sunnyvale,': [1650], 'Whole': [1652], 'primary': [1653, 2268], 'incubated': [1657, 1674, 1842, 2435, 2945], 'antibody': [1661, 1828, 2829, 2936], '10': [1663, 1785, 1856, 2617, 2708, 2728, 3633], 'min': [1664, 1681, 1857, 2245, 3607], 'ice,': [1666], 'washed': [1667, 1686, 1861, 2293, 2514], 'PBS': [1669, 1688, 1719, 1863, 2252, 2271], 'supplemented': [1670, 1689, 1720, 1754, 1864, 2604, 2690, 2722], '3%': [1672, 1691, 1722, 1866], 'anti-PE': [1676, 2831], 'micro': [1677, 1831, 2832, 2939], 'beads': [1678, 2833], '15': [1680, 2244], '°C,': [1684], 'FBS.': [1692, 1723, 1867, 2485], 'samples': [1694], 'passed': [1696], 'through': [1697], 'MACS': [1699, 1823, 2824], 'column': [1700, 1715], 'set': [1701], 'up': [1702], 'Miltenyl': [1705], 'magnet': [1706], 'eluted': [1712], 'washing': [1717], 'To': [1724, 3296, 3501, 3964], 'increase': [1725, 2585, 3679, 3697], 'purity': [1727], 'performed': [1735, 2144, 2317, 2565, 2755], 'more': [1737, 4209], 'time.': [1738], '1%': [1745], 'dishes': [1747], "Iscove's": [1749], 'Modified': [1750, 2686], "Dulbecco's": [1751, 2685, 2718], 'Medium': [1752, 2688], '(IMDM)': [1753], '10%': [1756, 2480, 2606], '100': [1758, 1794, 2467, 2704, 3219], 'μg/ml': [1759, 1764, 2709, 2729], 'penicillin,': [1761], '250': [1763], 'streptomycin': [1766], '37': [1768], '°C': [1769, 2452], 'humid': [1771], 'air': [1772], '5%': [1774, 2692, 2724], 'CO2.': [1775], 'Twenty-four': [1776], 'hours': [1777], 'seeding,': [1779], 'μm': [1786, 2442, 2468, 2609, 2614, 2702], '5′-azacytizine': [1787, 3006, 3120, 3158, 3177, 3211, 3312, 4164, 4195], 'initial': [1790], '72': [1791], 'h': [1792], 'nm': [1795, 2545, 2581, 3220], '(WAKO,': [1797], 'Japan).': [1798], 'After': [1799, 2249, 2929, 3413, 3547, 3767], 'treatment,': [1800, 3465], 'medium': [1802, 2721, 3015], 'changed': [1804], 'every': [1805], '3': [1806, 2470], 'days.': [1807], 'Characterization': [1808], 'Cardiac': [1810, 3281, 3490], 'Muscle-derived': [1811], 'Stem': [1812], 'Flow': [1815], 'Cytometric': [1816], 'Analysis—Sca-1+': [1817], 'anti-biotin': [1830, 2938], 'beads.': [1832], 'repeated': [1836, 2742, 2930], 'twice,': [1837], 'anti-CD45': [1845], 'antibody,': [1846, 1849, 1853], 'anti-CD34': [1848], 'respectively': [1854], 'ice': [1859], 'percentages': [1869], 'CD45+,': [1871], 'CD34+,': [1872], 'c-kit+': [1874], 'analyzed': [1877, 2954, 3519], 'EPICS': [1880], 'ALTRA': [1881], 'flow': [1882, 2956], 'cytometer': [1883], 'EXPO32': [1885], 'software': [1886, 2569], '(Beckman': [1887], 'Coulter,': [1888], 'Miami,': [1889], 'FL).': [1890], 'RNA': [1891, 1896, 3240, 3272], 'Extraction': [1892], 'Reverse': [1894, 1914], 'Transcriptase-PCR—Total': [1895], 'extracted': [1898], 'heart,': [1903, 3402], 'liver,': [1904], 'RNA-bee': [1909], 'reagent': [1910], '(TEL-TEST,': [1911], 'Friendswood,': [1912], 'TX).': [1913], 'transcriptase': [1915], '(RT)-PCR': [1916], 'factors,': [1922], 'Csx/Nkx-2.5': [1924, 3162], '(22Komuro': [1925], 'Izumo': [1927, 2864], '1993;': [1936], '90:': [1937], '8145-8149Crossref': [1938], '(464)': [1941], 'GATA4': [1944, 3164, 3327], '(23Brunskill': [1945], 'E.W.': [1946], 'Witte': [1947], 'D.P.': [1948], 'Yutzey': [1949], 'K.E.': [1950], 'Potter': [1951], 'S.S.': [1952], '235:': [1956], '507-520Crossref': [1957], '(35)': [1960], 'factor-2C': [1965], '(MEF-2C)': [1966], '(24Swanson': [1967], 'B.J.': [1968], 'Jack': [1969], 'H.M.': [1970], 'Lyons': [1971], 'G.E.': [1972], 'Mol.': [1973, 4266], 'Immunol.': [1974], '35:': [1976], '445-458Crossref': [1977], '(69)': [1980], 'structural': [1985, 3148, 3192], 'proteins,': [1986, 3304], 'α-': [1988, 3196], 'β-myosin': [1990], '(MHC)': [1993], '(25Robbins': [1994], 'Gulick': [1996], 'Sanchez': [1998], 'Howles': [2000], 'Doetschman': [2002], 'Chem.': [2006, 2033], '1990;': [2007], '265:': [2008], '11905-11909Abstract': [2009], 'chain-2a': [2018], '(MLC-2a),': [2019], 'MLC-2v': [2020, 3342], '(26Kubalak': [2021], 'S.W.': [2022], 'Miller-Hance': [2023], 'W.C.': [2024], "O'Brien": [2025], 'T.X.': [2026], 'Dyson': [2027], 'Chien': [2029], 'K.R.': [2030], '1994;': [2034], '269:': [2035], '16961-16970Abstract': [2036], 'α-actin': [2044, 2213, 3203], '(27Makino': [2045], 'Fukuda': [2047], 'Miyoshi': [2049], 'Konishi': [2051], 'Kodama': [2053], 'Pan': [2055], 'Sano': [2057], 'Hori': [2061], 'Ogawa': [2069], 'Clin.': [2072], 'Investig.': [2073], '1999;': [2074, 2160, 4269], '103:': [2075], '697-705Crossref': [2076], '(1720)': [2079], '(28Asakura': [2112, 2664], 'Komaki': [2114, 2666], 'Differentiation.': [2118, 2135, 2670], '68:': [2120, 2672], '245-253Crossref': [2121, 2673], '(649)': [2124, 2676], 'osteocalcin': [2127, 4024], '(29Zur': [2128], 'Nieden': [2129], 'N.I.': [2130], 'Kempka': [2131], 'Ahr': [2133], 'H.J.': [2134], '71:': [2137], '18-27Crossref': [2138], '0.1': [2146, 2613], 'μg': [2147], 'total': [2149, 2909], 'RNA.': [2150], 'β-actin': [2151, 3279], '(30Bi': [2152], 'W.': [2153], 'Drake': [2154], 'C.J.': [2155], 'Schwarz': [2156], 'J.J.': [2157], '211:': [2161], '255-267Crossref': [2162], '(161)': [2165], 'internal': [2172], 'control.': [2173], 'primers': [2175, 2199], 'this': [2178, 4087], 'study': [2179], 'PCR': [2181, 2189, 2201], 'Table': [2186], 'products': [2190], 'size-fractionated': [2192], '2%': [2194, 2254, 2257, 2273, 2276], 'agarose': [2195], 'gel': [2196], 'electrophoresis.Table': [2197], 'IPCR': [2198], 'conditionsPrimerProduct': [2202], 'sizeAnnealing': [2203], 'temperaturebp°Cα-MHC': [2204], '5′-GGAAGAGTGAGCGGCCATCAAGG-3′30265': [2205], '5′-CTGCTGGAGAGGTTATTCCTCG-3′β-MHC': [2206], '5′-GCCAACACCAACCTGTCCAAGTTC-3′20566': [2207], '5′-TGCAAAGGCTCCAGGTCTGAGGGC-3′MLC-2a': [2208], '5′-CAGACCTGAAGGAGACCT-3′28654': [2209], '5′-GTCAGCGTAAACAGTTGC-3′MLC-2v': [2210], '5′-GCCAAGAAGCGGATAGAAGG-3′49955': [2211], '5′-CTGTGGTTCAGGGCTCAGTC-3′Cardiac': [2212], '5′-CTGAGATGTCTCTCTCTCTCTTAG-3′9960': [2214], '5′-ACAATGACTGATGAGAGATG-3′Csx/Nkx-2.5': [2215], '5′-CAGTGGAGCTGGACAAAGCC-3′21655': [2216], '5′-TAGCGACGGTTCTGGAATTT-3′GATA4': [2217], '5′-CTGTCATCTCACTATGGGCA-3′27560': [2218], '5′-CCAAGTCCGAGCAGGAATTT-3′MEF-2C': [2219], '5′-GGCCATGGTACACCGAGTACAACGAGC-3′40162': [2220], '5′-GGGGATCCCTGTGTTACCTGCACTTGG-3′Oxytocin': [2221], '5′-AAGATGACCTTCATCATTGTTC-3′30361': [2223], '5′-CGACTCAGGACGAAGGTGGAGGA-3′ALP': [2224], '5′-TTGAAACTCCAAAAGCTCAACACCA-3′45062': [2225], '5′-TCTCGTTATCCGAGTACCAGTCCC-3′Osteocalcin': [2226], '5′-CCGGGAGCAGTGTGAGCTTA-3′9262': [2227], '5′-TAGATGCGTTTGTAGGCGGTC-3′β-Actin': [2228], '5′-GGACCTGGCTGGCCGGGACC-3′58360': [2229], '5′-GCGGTGCACGATGGAGGGGC-3′': [2230], 'table': [2232], 'new': [2235], 'tab': [2236], 'Immunocytochemistry—Cells': [2237], 'fixed': [2239], '4%': [2241], 'paraformaldehyde': [2242], 'room': [2247], 'temperature.': [2248], 'preblocking': [2250], 'containing': [2253, 2272, 2440, 3016], 'donkey': [2255, 2274], 'serum,': [2256, 2275], 'serum': [2259, 2278, 2694, 2726], 'albumin': [2260, 2279], '0.2%': [2262], 'Nonidet': [2263, 2282], 'P-40': [2264, 2283], '30': [2266, 2457, 3606], 'min,': [2267, 3554], '0.1%': [2281], 'applied': [2285, 2307], 'overnight': [2286], '°C.': [2289], 'Subsequently': [2290], 'three': [2294], 'times': [2295], 'then': [2299, 2715, 3609], 'fluorescein': [2300], 'isothiocyanate-': [2301], 'Cy5-conjugated': [2303], 'visualize': [2309], 'specific': [2312, 3316], 'proteins.': [2313, 3320], 'Nuclear': [2314], 'staining': [2315, 2648, 2753, 3360], 'TO-PRO-3': [2319], '(Molecular': [2320, 2478], 'Probes,': [2321], 'Eugene,': [2322], 'OR).': [2323], 'Images': [2324], 'taken': [2328, 2343], 'laser': [2330], 'confocal': [2331], 'microscopy': [2332], '(Radiance2000,': [2333], 'Bio-Rad,': [2334], 'Hercules,': [2335], 'Phase': [2337], 'Contrast': [2338], 'Live': [2339, 2361], 'Imaging—Live': [2340], 'images': [2341], 'Zeiss': [2346], 'inverted': [2347], 'microscope': [2348], '(Carl': [2349], 'Zeiss,': [2350], 'Jena,': [2351], 'Germany)': [2352], 'equipped': [2353], 'phasecontrast': [2355], 'objectives': [2356], 'AxioCam': [2359], 'camera.': [2360], 'image': [2362], 'chilled': [2370], 'CCD': [2371], 'camera': [2372], '(Hamamatsu)': [2373], 'I-O': [2375], 'DATA': [2376], 'Videorecorder': [2377], 'software.': [2378], 'Measurement': [2379], 'Intracellular': [2381], 'Concentration—Intracellular': [2383], 'concentration': [2385], '([Ca2+]i)': [2386], 'measured': [2396], '(31Yao': [2400], 'Su': [2402], 'Nonaka': [2404], 'Zubair': [2406], 'Spitzer': [2408], 'K.W.': [2409], 'Bridge': [2410], 'J.H.': [2411], 'Muelheims': [2412], 'Ross': [2414], 'Jr.,': [2415], 'Barry': [2417], 'W.H.': [2418], 'Am.': [2419], 'Physiol.': [2421], '275:': [2423], 'H1441-H1448PubMed': [2424], 'glass': [2432], 'coverslips': [2433, 2512], 'HEPES': [2437, 2486, 2518], '(loading)': [2438], 'solution': [2439, 2461, 2487, 2519], '1': [2441, 2701, 2733], 'fluo': [2443, 2469], '3-acetoxymethyl': [2444], 'ester': [2445], '(fluo': [2446], '3-AM;': [2447], 'Molecular': [2448], 'Probes)': [2449], '36': [2451], 'dark': [2455], 'min.': [2458, 3616], 'loading': [2460], 'prepared': [2463], 'diluting': [2465], 'stock': [2471], 'solution,': [2472], 'contained': [2474], '0.45%': [2475], 'Pluronic': [2476], 'F127': [2477], 'Probes),': [2479], 'dimethyl': [2481], 'sulfoxide,': [2482], '90%': [2484, 2813], 'consisted': [2488], '(in': [2490], 'mm)': [2491], '126': [2492], 'NaCl,': [2493], '4.4': [2494], 'KCl,': [2495], '1.0': [2496], 'MgCl2,': [2497], '1.08': [2498], 'CaCl2,': [2499], '24': [2500], 'HEPES,': [2501], '13': [2502], 'NaOH,': [2503], '11': [2504], 'glucose,': [2505], '0.5': [2507, 2698], 'probenecid': [2508], '(pH': [2509], '7.4).': [2510], 'twice': [2515, 2821], 'dye-free': [2517], 'placed': [2521], 'flow-through': [2524], 'chamber': [2525], 'microscope.': [2528], 'Fluo': [2529], '3-loaded': [2530], 'excited': [2534], '480-nm': [2536], 'emitted': [2539], 'fluorescence': [2540, 2578], 'recorded': [2542], '530': [2544, 2580], 'photomultiplier': [2548], 'tube': [2549], '(AIM-10,': [2550], 'InterMedical,': [2551], 'Japan)': [2553, 3227], 'digitized': [2555], '(PowerLab': [2556], '2/20,': [2557], 'AD-instruments,': [2558], 'Castle': [2559], 'Hill,': [2560], 'Australia).': [2561], 'Curve': [2562], 'fits': [2563], 'Origin': [2567], '7J': [2568], '(MicroCal': [2570], 'Software,': [2571], 'Northampton,': [2572], 'MA).': [2573], 'intensity': [2575], '[Ca2+]i.': [2587, 3500], 'Estimation': [2588], 'Pluripotency—Osteogenic': [2590], 'induced': [2601, 2660, 3392, 4026, 4166], 'IMDM': [2603], '50': [2608], 'ascorbic': [2610], 'acid': [2611], '2-phosphate,': [2612], 'dexamethasone,': [2615, 2703], 'mm': [2618, 2699, 2705], 'β-glycerophosphate': [2619], '(32Jaiswal': [2623], 'Haynesworth': [2625], 'S.E.': [2626, 2768], 'Caplan': [2627], 'A.I.': [2628], 'Bruder': [2629], 'S.P.': [2630], '64:': [2635], '295-312Crossref': [2636], '(1845)': [2639], 'For': [2642, 2745], 'detection': [2643, 2746], 'osteocytes,': [2645], '(leukocyte': [2649], 'assay': [2652], 'kit,': [2653], 'Sigma-Aldrich)': [2654], 'used.': [2656], 'Adipogenic': [2657], 'Briefly': [2679], "Eagle's": [2687, 2720], '(DMEM)': [2689], 'horse': [2693, 2725], 'MDI-I': [2696, 2737, 4058], 'mixture;': [2697], 'methyl-isobutylxanthine,': [2700], 'indomethacin,': [2706], 'insulin': [2710, 2731, 2740], 'days': [2713], 'modified': [2719], 'day.': [2734], 'Treatment': [2735, 3217], 'followed': [2738, 2756], 'four': [2743], 'times.': [2744], 'accumulated': [2748], 'oil': [2749, 4071], 'droplets,': [2750], 'nuclear': [2758], 'hematoxylin': [2759], 'counterstaining.': [2760], 'Statistical': [2761], 'Analysis—Values': [2762], 'presented': [2764], 'mean': [2766, 2774], '±': [2767, 3629, 3637, 3653, 3667], 'significance': [2770, 2786], 'differences': [2772], 'among': [2773, 3092], 'values': [2775], 'determined': [2777], 'analysis': [2779, 2804], 'variance.': [2781], 'accepted': [2783], 'p': [2788, 3642, 3658, 3672], '<': [2789, 3643, 3659, 3673], '0.05.': [2790], 'Surface': [2792], 'Antigens': [2793], 'Derived': [2797], 'Heart—Flow': [2802], 'cytometric': [2803], 'revealed': [2805, 4014], 'enriched': [2810, 2941, 2959], 'over': [2812], 'sorted': [2820, 3441], '(Fig.': [2834, 2968, 2977, 2981, 3030, 3168, 3206, 3235, 3256, 3292, 3328, 3331, 3337, 3343, 3349, 3383, 3429, 3566, 3688, 3747, 3763, 3778, 3804, 4010, 4035, 4084], '1A).': [2835], 'number': [2837, 2886, 2910], 'purified': [2839], '∼1': [2843], '×': [2844, 2896], '104': [2845], '(33Limana': [2850], 'Chimenti': [2854], 'Quaini': [2856], '6257-6262Crossref': [2877], '(88)': [2880], 'estimated': [2884], '∼3': [2895], '106.': [2897], 'Therefore': [2898], 'percentage': [2900], '∼0.3%': [2906], 'Next': [2913, 3136, 3439, 3573], 'examined': [2915, 3138, 3575, 3724, 3978], 'other': [2916, 3114, 3986, 4039], 'antigens': [2919], 'CD45,': [2922], 'CD34,': [2923], 'c-kit': [2925, 2951, 2980], 'beads,': [2940], 'CD34': [2949, 2976], 'cytometry.': [2957], '∼40%': [2962], 'CD45': [2967, 3449], '1B),': [2969], '∼10%': [2971], '1C)': [2978], '1D).': [2982], 'Heart': [2989, 3707], 'Differentiate': [2990, 3837], 'Beating': [2992], 'Cardiomyocytes—In': [2993], 'order': [2994], 'either': [3005], 'oxytocin.': [3008, 3454, 4108], 'they': [3018], 'shapes,': [3022], 'spindle-like': [3024], 'elongated': [3026], 'shapes': [3027], 'predominant': [3029, 3577], '2A).': [3031], 'Two': [3032], 'small': [3038], 'round': [3039, 3053, 3129], 'prominent': [3042], 'nucleus': [3043], 'cytoplasm': [3046], 'appeared': [3047], '(arrowheads': [3048], 'Fig.': [3050, 3097, 3533, 3645], '2B).': [3051], 'rapidly': [3055], 'proliferated,': [3056], 'formed': [3057], 'clusters,': [3058], 'detached': [3060], 'so': [3065], 'spindle-shaped': [3067, 3093, 3131], 'left.': [3070], 're-plated': [3074], 'reached': [3076], 'confluence.': [3078], 'Four': [3079, 3172], 'starting': [3082], 'spontaneously': [3087], 'recognized': [3091], '(arrow': [3095], '2,': [3098], 'C': [3099], 'D': [3101], 'Supplemental': [3103], 'Data).': [3104], 'Spontaneous': [3105], 'observed': [3108, 3286], '∼1%': [3110], 'On': [3112, 4037], 'hand,': [3115, 4040], 'vehicles': [3122], 'fibroblast-like': [3124], 'morphology,': [3125, 3132], 'never': [3127, 4046], 'exhibited': [3128], 'gene': [3140, 3282], 'RT-PCR.': [3154], 'Before': [3155], 'only': [3161], 'slightly': [3166], '3,': [3169, 3207, 3236, 3257, 3293], 'lane': [3170, 3208, 3213, 3237, 3258, 3263, 3294, 3749, 3765, 3780, 3806], 'P).': [3171, 3750], 'all': [3180], 'Csx/Nkx-2.5,': [3187, 4120], 'GATA4,': [3188, 4121, 4134], 'MEF-2C': [3190], 'β-MHC,': [3198, 4124], 'MLC-2a,': [3199, 4125], 'MLC-2v,': [3200, 4126, 4139], 'OT': [3214], 'oxytocin).': [3216], 'antagonist': [3222, 3790, 3796], '(OTA,': [3223], '[d(CH2)5-1,Tyr(Me)-2,Thr-4,Orn-8,Tyr-NH2-9]': [3224], 'vasotocin,': [3225], 'Wako,': [3226], 'completely': [3228], 'inhibited': [3229, 3797], 'oxytocin-induced': [3230, 3792, 3798, 3817, 3827], 'OT+OTA).': [3238, 3807], 'Total': [3239], 'liver': [3248], 'positive': [3252, 3813], 'negative': [3254], 'controls': [3255], 'H': [3259], 'L': [3264], 'liver).': [3266], 'Loading': [3267], 'equal': [3269], 'amounts': [3270], 'confirmed': [3274], 'gene.': [3280], 'vehicle': [3291, 3595, 3762], 'V).': [3295, 3766], 'examine': [3297], 'localization': [3301], 'against': [3318], '4A),': [3329], 'ANF': [3330], '4B),': [3332], 'B).': [3341], '4C),': [3344], '4D),': [3350], 'tropomyosin': [3352], '(data': [3353, 3436, 3474], 'shown)': [3355], 'expressed.': [3358], 'Notably,': [3359], 'each': [3362], 'fine': [3367], 'striated': [3368], 'pattern.': [3369], 'Connexin': [3370], 'junction': [3376], 'between': [3377], 'two': [3378], 'T-expressing': [3381], '4E).': [3384], 'indicate': [3387], 'had': [3407, 3691], 'well-organized': [3408], 'structures': [3409], 'electrical': [3411], 'junctions.': [3412], '5′-azacytizine,': [3416], 'fibrillar': [3427], 'pattern': [3428], '4F),': [3430], 'shown).': [3438], 'basis': [3447], 'Sca-1+/CD45-': [3458], 'none': [3467], 'Sca-1+/CD45+': [3470], 'shown),': [3476], 'suggesting': [3477], 'population.': [3489], 'contraction': [3491], 'regulated': [3493], 'beat': [3495, 3497], 'change': [3498], 'ascertain': [3502], 'differentiated': [3508, 3539, 4081], 'depends': [3512], 'Ca2+,': [3517], '[Ca2+]i': [3520, 3545, 3558], 'transients': [3521, 3559], 'As': [3526], 'upper': [3530, 3568], 'panel': [3531, 3569], '5A,': [3534, 3567], '10-7m': [3550], 'isoproterenol': [3551, 3612, 3686], '5': [3553, 3615], 'frequency': [3556], 'comparison': [3563], 'control': [3565, 3625], 'versus': [3570, 3634, 3661, 3675], 'lower': [3571], 'panel).': [3572], 'subtype': [3578], 'β': [3580], 'receptors,': [3581], 'mediates': [3583], 'changes': [3584], 'rate.': [3587, 3700], 'Differentiated': [3588], '(PBS),': [3596], 'propranolol,': [3597], 'CGP20712A': [3598, 3664], '(β1-selective': [3599], 'blocker),': [3600], 'ICI118551': [3602, 3690], '(β2-selective': [3603], 'blocker)': [3604], 'stimulated': [3610], 'alone': [3613], 'significantly': [3618, 3687], 'rate': [3622, 3682], '(control:': [3627], '131.9': [3628], '5.6,': [3630, 3654], 'n': [3631, 3639, 3655, 3669], '=': [3632, 3640, 3656, 3670], 'isoproterenol:': [3635], '228.9': [3636], '7.3,': [3638], '10,': [3641, 3657, 3671], '0.01,': [3644], '5B).': [3646, 3689], 'pretreatment': [3648], 'propranolol': [3650], '(average': [3651, 3665], '196.4': [3652], '0.05': [3660, 3674], 'isoproterenol)': [3662, 3676], '188.9': [3666], '7.5,': [3668], 'reduced': [3677], 'response': [3684], 'no': [3692], 'isoproterenol-induced': [3696], 'Express': [3708], 'Oxytocin': [3709, 3733], 'Receptor': [3710], 'mRNA—To': [3711], 'elucidate': [3712], 'cardiomyogenesis': [3719], 'mRNA': [3735], 'present': [3737], 'low': [3739, 3757], 'levels': [3740, 3752, 3772], 'before': [3744], '6,': [3748, 3764, 3779, 3805], 'Expression': [3751], 'remained': [3756], 'OT).': [3781], 'accordance': [3783], 'inhibitory': [3786], 'differentiation,': [3794], 'up-regulation': [3799, 3818], 'feedback': [3814], 'mechanism,': [3815], 'namely': [3816], 'receptor,': [3821], 'plays': [3822], 'Can': [3836], 'Osteocytes': [3839], 'Adipocytes—It': [3841], 'neural,': [3866], '11Qu-Petersen': [3904], '14Tamaki': [3937], 'determine': [3965], 'pluripotency,': [3976], 'could': [3982], 'than': [3987, 4215], 'inducers,': [3993], 'phosphatase,': [4002], 'osteogenesis': [4009], '7A).': [4011], 'RT-PCR': [4012], 'clearly': [4013], 'marker': [4017], 'mRNAs': [4018], 'inducers': [4034], '7B).': [4036], 'osteocalcin.': [4051], 'mixture': [4059], 'twelve': [4061], 'days,': [4062], 'cytoplasmic': [4068], 'accumulation': [4069], 'droplets': [4072], 'O,': [4076], 'indicating': [4077], 'adipocytes': [4083], '7C).': [4085], 'report,': [4088], 'vitro': [4104, 4238], 'MEF-2C,': [4122], 'α-MHC,': [4123], 'α-actin,': [4129], 'T,': [4137, 4182], 'tropomyosin,': [4138], 'chain,': [4143], 'ANF,': [4144], 'connexin': [4146], '43.': [4147], 'Furthermore,': [4148], 'well': [4154], 'organized': [4155], 'sarcomere': [4156, 4185], 'transient': [4161], 'did': [4175], 'assembly': [4183], 'incompletely': [4203], 'potent': [4210], 'inducer': [4211], '5′-azacytizine.': [4216], 'teratocarcinoma': [4218], 'Me2SO': [4227], 'considered': [4231], 'good': [4234], '(34Monzen': [4240], 'Shiojima': [4242], 'Hiroi': [4244], 'Kudoh': [4246, 4278], 'Oka': [4248], 'Takimoto': [4250], 'Hayashi': [4252], 'Hosoda': [4254], 'Habara-Ohkubo': [4256], 'Nakaoka': [4258], 'Fujita': [4260], 'Yazaki': [4262, 4284], 'Cell.': [4267], '19:': [4270], '1096-1105Crossref': [4271], '(214)': [4273], '35Hiroi': [4276], 'Monzen': [4280], 'Ikeda': [4282], 'Nat.': [4290], 'Genet.': [4291], '28:': [4293], '276-280Crossref': [4294], '(4': [4297]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2113074426', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 20}, {'year': 2017, 'cited_by_count': 25}, {'year': 2016, 'cited_by_count': 21}, {'year': 2015, 'cited_by_count': 29}, {'year': 2014, 'cited_by_count': 41}, {'year': 2013, 'cited_by_count': 53}, {'year': 2012, 'cited_by_count': 56}], 'updated_date': '2025-01-04T00:07:53.916214', 'created_date': '2016-06-24'}
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