Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2112967578', 'doi': 'https://doi.org/10.1128/aac.45.3.825-836.2001', 'title': 'In Vitro and In Vivo Properties of Ro 63-9141, a Novel Broad-Spectrum Cephalosporin with Activity against Methicillin-Resistant Staphylococci', 'display_name': 'In Vitro and In Vivo Properties of Ro 63-9141, a Novel Broad-Spectrum Cephalosporin with Activity against Methicillin-Resistant Staphylococci', 'publication_year': 2001, 'publication_date': '2001-03-01', 'ids': {'openalex': 'https://openalex.org/W2112967578', 'doi': 'https://doi.org/10.1128/aac.45.3.825-836.2001', 'mag': '2112967578', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11181368', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/90381'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.45.3.825-836.2001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1128/aac.45.3.825-836.2001', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5037499996', 'display_name': 'Paul Hebeisen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Paul Hebeisen', 'raw_affiliation_strings': ['Pharmaceutical Research, F. Hoffmann-La Roche Ltd.,1 and'], 'affiliations': [{'raw_affiliation_string': 'Pharmaceutical Research, F. Hoffmann-La Roche Ltd.,1 and', 'institution_ids': ['https://openalex.org/I118019719']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065258830', 'display_name': 'Ingrid Heinze‐Krauss', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210141406', 'display_name': 'Basilea Pharmaceutica (Switzerland)', 'ror': 'https://ror.org/04n4q2213', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I4210141406']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Ingrid Heinze-Krauss', 'raw_affiliation_strings': ['Basilea Pharmaceutica,2 CH-4070 Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Basilea Pharmaceutica,2 CH-4070 Basel, Switzerland', 'institution_ids': ['https://openalex.org/I4210141406']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070193611', 'display_name': 'Peter Angehrn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Peter Angehrn', 'raw_affiliation_strings': ['Pharmaceutical Research, F. Hoffmann-La Roche Ltd.,1 and'], 'affiliations': [{'raw_affiliation_string': 'Pharmaceutical Research, F. Hoffmann-La Roche Ltd.,1 and', 'institution_ids': ['https://openalex.org/I118019719']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040104596', 'display_name': 'P. Hohl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Peter Hohl', 'raw_affiliation_strings': ['Pharmaceutical Research, F. Hoffmann-La Roche Ltd.,1 and'], 'affiliations': [{'raw_affiliation_string': 'Pharmaceutical Research, F. Hoffmann-La Roche Ltd.,1 and', 'institution_ids': ['https://openalex.org/I118019719']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047246055', 'display_name': 'Malcolm G. P. Page', 'orcid': 'https://orcid.org/0000-0002-0276-8174'}, 'institutions': [{'id': 'https://openalex.org/I4210141406', 'display_name': 'Basilea Pharmaceutica (Switzerland)', 'ror': 'https://ror.org/04n4q2213', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I4210141406']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Malcolm G. P. Page', 'raw_affiliation_strings': ['Basilea Pharmaceutica,2 CH-4070 Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Basilea Pharmaceutica,2 CH-4070 Basel, Switzerland', 'institution_ids': ['https://openalex.org/I4210141406']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007952962', 'display_name': 'Rudolf Then', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Rudolf L. Then', 'raw_affiliation_strings': ['Pharmaceutical Research, F. Hoffmann-La Roche Ltd.,1 and'], 'affiliations': [{'raw_affiliation_string': 'Pharmaceutical Research, F. Hoffmann-La Roche Ltd.,1 and', 'institution_ids': ['https://openalex.org/I118019719']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.666, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 215, 'citation_normalized_percentile': {'value': 0.963216, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '45', 'issue': '3', 'first_page': '825', 'last_page': '836'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10195', 'display_name': 'Antimicrobial Resistance in Staphylococcus', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10195', 'display_name': 'Antimicrobial Resistance in Staphylococcus', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10147', 'display_name': 'Antibiotic Resistance in Bacteria', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11036', 'display_name': 'Antibiotics Pharmacokinetics and Efficacy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cefepime', 'display_name': 'Cefepime', 'score': 0.5498075}], 'concepts': [{'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.78744507}, {'id': 'https://openalex.org/C2778719061', 'wikidata': 'https://www.wikidata.org/wiki/Q417968', 'display_name': 'Cefotaxime', 'level': 3, 'score': 0.7351281}, {'id': 'https://openalex.org/C64778159', 'wikidata': 'https://www.wikidata.org/wiki/Q271021', 'display_name': 'Cephalosporin', 'level': 3, 'score': 0.60256433}, {'id': 'https://openalex.org/C2777050379', 'wikidata': 'https://www.wikidata.org/wiki/Q2552927', 'display_name': 'Cefepime', 'level': 5, 'score': 0.5498075}, {'id': 'https://openalex.org/C2781253189', 'wikidata': 'https://www.wikidata.org/wiki/Q221179', 'display_name': 'Streptococcus pneumoniae', 'level': 3, 'score': 0.5152224}, {'id': 'https://openalex.org/C2776968632', 'wikidata': 'https://www.wikidata.org/wiki/Q808845', 'display_name': 'Ceftazidime', 'level': 4, 'score': 0.50381607}, {'id': 'https://openalex.org/C2776021129', 'wikidata': 'https://www.wikidata.org/wiki/Q244150', 'display_name': 'Ampicillin', 'level': 3, 'score': 0.4691583}, {'id': 'https://openalex.org/C2778512257', 'wikidata': 'https://www.wikidata.org/wiki/Q256602', 'display_name': 'Ciprofloxacin', 'level': 3, 'score': 0.4649832}, {'id': 'https://openalex.org/C174802600', 'wikidata': 'https://www.wikidata.org/wiki/Q12190', 'display_name': 'Penicillin', 'level': 3, 'score': 0.44143385}, {'id': 'https://openalex.org/C2779489039', 'wikidata': 'https://www.wikidata.org/wiki/Q188121', 'display_name': 'Staphylococcus aureus', 'level': 3, 'score': 0.42758694}, {'id': 'https://openalex.org/C2779375183', 'wikidata': 'https://www.wikidata.org/wiki/Q421670', 'display_name': 'Meropenem', 'level': 4, 'score': 0.4224767}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41895714}, {'id': 'https://openalex.org/C2777637488', 'wikidata': 'https://www.wikidata.org/wiki/Q31856', 'display_name': 'Pseudomonas aeruginosa', 'level': 3, 'score': 0.41880974}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.37456214}, {'id': 'https://openalex.org/C2779631663', 'wikidata': 'https://www.wikidata.org/wiki/Q425152', 'display_name': 'Imipenem', 'level': 4, 'score': 0.27022082}, {'id': 'https://openalex.org/C94665300', 'wikidata': 'https://www.wikidata.org/wiki/Q63391344', 'display_name': 'Antibiotic resistance', 'level': 3, 'score': 0.2613024}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.19980413}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002511', 'descriptor_name': 'Cephalosporins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D006602', 'descriptor_name': 'Hexosyltransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016106', 'descriptor_name': 'Methicillin Resistance', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010458', 'descriptor_name': 'Peptidyl Transferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013211', 'descriptor_name': 'Staphylococcus aureus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000038', 'descriptor_name': 'Abscess', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D000038', 'descriptor_name': 'Abscess', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002511', 'descriptor_name': 'Cephalosporins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002511', 'descriptor_name': 'Cephalosporins', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D002511', 'descriptor_name': 'Cephalosporins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004795', 'descriptor_name': 'Enzyme Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016106', 'descriptor_name': 'Methicillin Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002267', 'descriptor_name': 'Muramoylpentapeptide Carboxypeptidase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D002267', 'descriptor_name': 'Muramoylpentapeptide Carboxypeptidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046915', 'descriptor_name': 'Penicillin-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D013211', 'descriptor_name': 'Staphylococcus aureus', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D013211', 'descriptor_name': 'Staphylococcus aureus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013211', 'descriptor_name': 'Staphylococcus aureus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001618', 'descriptor_name': 'beta-Lactamases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001618', 'descriptor_name': 'beta-Lactamases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.45.3.825-836.2001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc90381', 'pdf_url': 'https://europepmc.org/articles/pmc90381?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC90381', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11181368', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.45.3.825-836.2001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.54, 'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1505626160', 'https://openalex.org/W1581962345', 'https://openalex.org/W1634144159', 'https://openalex.org/W1973518692', 'https://openalex.org/W1991536033', 'https://openalex.org/W2013754427', 'https://openalex.org/W2026032027', 'https://openalex.org/W2053889635', 'https://openalex.org/W2067296570', 'https://openalex.org/W2081139934', 'https://openalex.org/W2104923518', 'https://openalex.org/W2108051304', 'https://openalex.org/W2108677336', 'https://openalex.org/W2118094416', 'https://openalex.org/W2130671790', 'https://openalex.org/W2142369516', 'https://openalex.org/W2149829607', 'https://openalex.org/W2161743604', 'https://openalex.org/W2198367621', 'https://openalex.org/W2341545551', 'https://openalex.org/W2951000947'], 'related_works': ['https://openalex.org/W98568990', 'https://openalex.org/W2390426752', 'https://openalex.org/W2376400102', 'https://openalex.org/W2351680346', 'https://openalex.org/W2155444261', 'https://openalex.org/W2091939545', 'https://openalex.org/W2042572325', 'https://openalex.org/W2036297853', 'https://openalex.org/W1999260116', 'https://openalex.org/W1967321942'], 'abstract_inverted_index': {'Ro': [0, 37, 77, 95, 138, 180, 197, 208], '63-9141': [1, 38, 78, 96, 139, 181, 198], 'is': [2, 210], 'a': [3, 205], 'new': [4, 88], 'member': [5], 'of': [6, 11, 28, 54, 62, 84, 116, 137, 151, 170, 179, 185, 196], 'the': [7, 63, 87, 134, 166, 171, 176, 183], 'pyrrolidinone-3-ylidenemethyl': [8], 'cephem': [9], 'series': [10], 'cephalosporins.': [12], 'Its': [13, 57], 'antibacterial': [14, 41, 135], 'spectrum': [15, 136], 'was': [16, 74, 79, 92, 97, 111], 'evaluated': [17], 'against': [18, 45, 81, 102, 113, 120], 'significant': [19], 'gram-positive': [20, 46], 'and': [21, 35, 119, 125, 153], 'gram-negative': [22], 'pathogens': [23], 'in': [24, 42, 90, 141, 159, 163, 167, 203], 'comparison': [25], 'with': [26, 165], 'those': [27], 'reference': [29], 'drugs,': [30], 'including': [31, 148, 191], 'cefotaxime,': [32], 'cefepime,': [33], 'meropenem,': [34], 'ciprofloxacin.': [36], 'showed': [39], 'high': [40], 'vitro': [43, 168], 'activity': [44], 'bacteria': [47], 'except': [48, 122], 'ampicillin-resistant': [49], 'enterococci,': [50], 'particularly': [51], 'vancomycin-resistant': [52], 'strains': [53, 115], 'Enterococcus': [55], 'faecium.': [56], 'MIC': [58], 'at': [59], 'which': [60], '90%': [61], 'isolates': [64, 127], 'tested': [65], 'were': [66, 162], 'inhibited': [67], '(MIC(90))': [68], 'for': [69, 133, 182, 212], 'methicillin-resistant': [70], 'Staphylococcus': [71], 'aureus': [72], '(MRSA)': [73], '4': [75], 'microg/ml.': [76], 'bactericidal': [80], 'MRSA.': [82, 192], 'Development': [83], 'resistance': [85], 'to': [86, 144], 'compound': [89], 'MRSA': [91], 'not': [93], 'observed.': [94], 'more': [98], 'potent': [99], 'than': [100], 'cefotaxime': [101], 'penicillin-resistant': [103], 'Streptococcus': [104], 'pneumoniae': [105], '(MIC(90)': [106], '=': [107], '2': [108], 'microg/ml).': [109], 'It': [110], 'active': [112], 'ceftazidime-susceptible': [114], 'Pseudomonas': [117], 'aeruginosa': [118], 'Enterobacteriaceae': [121], 'Proteus': [123], 'vulgaris': [124], 'some': [126], 'producing': [128], 'extended-spectrum': [129], 'beta-lactamases.': [130, 157], 'The': [131, 158], 'basis': [132], 'lies': [140], 'its': [142, 154], 'affinity': [143], 'essential': [145], 'penicillin-binding': [146], 'proteins,': [147], 'PBP': [149], "2'": [150], 'MRSA,': [152], 'stability': [155], 'towards': [156], 'vivo': [160], 'findings': [161], 'accordance': [164], 'susceptibilities': [169], 'pathogens.': [172], 'These': [173], 'data': [174], 'suggest': [175], 'potential': [177], 'utility': [178], 'therapy': [184], 'infections': [186], 'caused': [187], 'by': [188], 'susceptible': [189], 'pathogens,': [190], 'Since': [193], 'insufficient': [194], 'solubility': [195], 'itself': [199], 'precludes': [200], 'parenteral': [201], 'administration': [202], 'humans,': [204], 'water-soluble': [206], 'prodrug,': [207], '65-5788,': [209], 'considered': [211], 'development.': [213]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2112967578', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-08T19:58:49.599966', 'created_date': '2016-06-24'}