Title: Metabolomics Enables the Structure Elucidation of a Diatom Sex Pheromone
Abstract: Angewandte Chemie International EditionVolume 52, Issue 3 p. 854-857 Communication Metabolomics Enables the Structure Elucidation of a Diatom Sex Pheromone† Dr. Jeroen Gillard, Dr. Jeroen Gillard Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.html Present address: J. Craig Venter Institute, San Diego, CA 92121 (USA) These authors contributed equally to this work.Search for more papers by this authorJohannes Frenkel, Johannes Frenkel Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.html These authors contributed equally to this work.Search for more papers by this authorValerie Devos, Valerie Devos Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.html These authors contributed equally to this work.Search for more papers by this authorProf. Dr. Koen Sabbe, Prof. Dr. Koen Sabbe Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.htmlSearch for more papers by this authorCarsten Paul, Carsten Paul Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.htmlSearch for more papers by this authorDr. Martin Rempt, Dr. Martin Rempt Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.htmlSearch for more papers by this authorProf. Dr. Dirk Inzé, Prof. Dr. Dirk Inzé Department of Plant Systems Biology, VIB, 9052 Gent (Belgium) http://www.psb.ugent.be/marnik-vuylsteke Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent (Belgium)Search for more papers by this authorProf. Dr. Georg Pohnert, Corresponding Author Prof. Dr. Georg Pohnert [email protected] Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.html Georg Pohnert, Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.html Marnik Vuylsteke, Department of Plant Systems Biology, VIB, 9052 Gent (Belgium) http://www.psb.ugent.be/marnik-vuylsteke Wim Vyverman, Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.htmlSearch for more papers by this authorProf. Dr. Marnik Vuylsteke, Corresponding Author Prof. Dr. Marnik Vuylsteke [email protected] Department of Plant Systems Biology, VIB, 9052 Gent (Belgium) http://www.psb.ugent.be/marnik-vuylsteke Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent (Belgium) Georg Pohnert, Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.html Marnik Vuylsteke, Department of Plant Systems Biology, VIB, 9052 Gent (Belgium) http://www.psb.ugent.be/marnik-vuylsteke Wim Vyverman, Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.htmlSearch for more papers by this authorProf. Dr. Wim Vyverman, Corresponding Author Prof. Dr. Wim Vyverman [email protected] Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.html Georg Pohnert, Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.html Marnik Vuylsteke, Department of Plant Systems Biology, VIB, 9052 Gent (Belgium) http://www.psb.ugent.be/marnik-vuylsteke Wim Vyverman, Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.htmlSearch for more papers by this author Dr. Jeroen Gillard, Dr. Jeroen Gillard Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.html Present address: J. Craig Venter Institute, San Diego, CA 92121 (USA) These authors contributed equally to this work.Search for more papers by this authorJohannes Frenkel, Johannes Frenkel Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.html These authors contributed equally to this work.Search for more papers by this authorValerie Devos, Valerie Devos Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.html These authors contributed equally to this work.Search for more papers by this authorProf. Dr. Koen Sabbe, Prof. Dr. Koen Sabbe Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.htmlSearch for more papers by this authorCarsten Paul, Carsten Paul Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.htmlSearch for more papers by this authorDr. Martin Rempt, Dr. Martin Rempt Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.htmlSearch for more papers by this authorProf. Dr. Dirk Inzé, Prof. Dr. Dirk Inzé Department of Plant Systems Biology, VIB, 9052 Gent (Belgium) http://www.psb.ugent.be/marnik-vuylsteke Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent (Belgium)Search for more papers by this authorProf. Dr. Georg Pohnert, Corresponding Author Prof. Dr. Georg Pohnert [email protected] Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.html Georg Pohnert, Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.html Marnik Vuylsteke, Department of Plant Systems Biology, VIB, 9052 Gent (Belgium) http://www.psb.ugent.be/marnik-vuylsteke Wim Vyverman, Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.htmlSearch for more papers by this authorProf. Dr. Marnik Vuylsteke, Corresponding Author Prof. Dr. Marnik Vuylsteke [email protected] Department of Plant Systems Biology, VIB, 9052 Gent (Belgium) http://www.psb.ugent.be/marnik-vuylsteke Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent (Belgium) Georg Pohnert, Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.html Marnik Vuylsteke, Department of Plant Systems Biology, VIB, 9052 Gent (Belgium) http://www.psb.ugent.be/marnik-vuylsteke Wim Vyverman, Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.htmlSearch for more papers by this authorProf. Dr. Wim Vyverman, Corresponding Author Prof. Dr. Wim Vyverman [email protected] Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.html Georg Pohnert, Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena (Germany) http://www.uni-jena.de/prof_pohnert.html Marnik Vuylsteke, Department of Plant Systems Biology, VIB, 9052 Gent (Belgium) http://www.psb.ugent.be/marnik-vuylsteke Wim Vyverman, Laboratory of Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Gent (Belgium) http://www.pae.ugent.be/academic.htmlSearch for more papers by this author First published: 12 December 2012 https://doi.org/10.1002/anie.201208175Citations: 87 † Financial support (G.P., J.F., C.P.) from the Volkswagen Foundation, the IMPRS (“Exploration of Ecological Interactions with Molecular and Chemical Techniques”), and the Jena School for Microbial Communication is acknowledged. J.G. and V.D. were funded by the Institute for the Promotion of Innovation by Science and Technology (IWT)—Flanders“, J.G. by an EMBO short-term fellowship (ASTF 410.00-2008). W.V., K.S., D.I., and M. V. acknowledge Belspo for funding the Belgian-coordinated ”Culture Collections of Microorganisms (BCCM)“ and Ghent University Research Funding (BOFGOA 01G01911). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Finding a mate: Diatoms use chemical signals to sense the presence of and find their mating partners. When the metabolic profiles of sexually active and inactive cells were compared, a highly up-regulated metabolite generated in the attracting mating type was identified as di-L-prolyl diketopiperazine, the first diatom pheromone. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201208175_sm_attraction_18seczoom.wmv1.3 MB attraction_18seczoom anie_201208175_sm_miscellaneous_information.pdf260.6 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume52, Issue3January 14, 2013Pages 854-857 RelatedInformation