Title: Can nongenotoxic carcinogens be detected with the lacl transgenic mouse mutation assay?
Abstract: Environmental and Molecular MutagenesisVolume 21, Issue 3 p. 209-211 Article Can nongenotoxic carcinogens be detected with the lacl transgenic mouse mutation assay? Daniela Gunz, Daniela Gunz Institute of Toxicology, Swiss Federal Institute of Technology and University of Zurich, CH-8603 Schwerzenbach, SwitzerlandSearch for more papers by this authorSarah E. Shephard, Sarah E. Shephard Institute of Toxicology, Swiss Federal Institute of Technology and University of Zurich, CH-8603 Schwerzenbach, SwitzerlandSearch for more papers by this authorWerner K. Lutz, Corresponding Author Werner K. Lutz Institute of Toxicology, Swiss Federal Institute of Technology and University of Zurich, CH-8603 Schwerzenbach, SwitzerlandInstitute of Toxicology, ETH and Univ. of Zurich. CH-8603 Schwerzenbach. SwitzerlandSearch for more papers by this author Daniela Gunz, Daniela Gunz Institute of Toxicology, Swiss Federal Institute of Technology and University of Zurich, CH-8603 Schwerzenbach, SwitzerlandSearch for more papers by this authorSarah E. Shephard, Sarah E. Shephard Institute of Toxicology, Swiss Federal Institute of Technology and University of Zurich, CH-8603 Schwerzenbach, SwitzerlandSearch for more papers by this authorWerner K. Lutz, Corresponding Author Werner K. Lutz Institute of Toxicology, Swiss Federal Institute of Technology and University of Zurich, CH-8603 Schwerzenbach, SwitzerlandInstitute of Toxicology, ETH and Univ. of Zurich. CH-8603 Schwerzenbach. SwitzerlandSearch for more papers by this author First published: 1993 https://doi.org/10.1002/em.2850210302Citations: 37AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Ames BN (1989): Endogenous DNA damage as related to cancer and aging. Mutat Res 214: 41–46. Ashby J, Leigibel U (1992): Transgenic mouse mutation assays—potential for confusion of genotoxic and non-genotoxic carcinogenesis—a proposed solution. Environ Mol Mutagen 20: 145–147. Ashby J, Tennant RW (1988): Chemical structure, Salmonella mutagenicily and extent of carcinogenicity as indicators of genotexic carcinogenesis among 222 chemicals tested in rodents by the U. S. NCI/NTP. Mutal Res 204: 17–115. Becker FF (1982): Morphological classification of mouse liver tumors based on biological characteristics. Cancer Res 42: 3918–3923. Butterworth BE (1987): Genetic toxicology of di(2-ethylhexyl)phthalate. In BE Buderworth, TJ Slaga (eds): “ Nongenotoxic Mechanisms in Carcinogenesis.” Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, pp 257–276. Butterworth BE (1990): Consideration of both genotoxic and nongenotoxic mechanisms in predicting carcinogenic potential. Mutat Res 239: 117–132. Cavaliere A, Bufalari A, Vitali R (1986): Carcinogenicity and cocarcinogenicity test of phenobarbital sodium in adult BALB/c mice. Tumori 72: 125–128. Cohen SM, Ellwein LB (1991): Genetic errors, cell proliferation, and carcinogenesis. Cancer Res 51: 6493–6505. Dietrich DR, Swenberg JA (1991): The presence of alpha-2u-globulin is necessary for d-limonene promotion of male rat kidney tumors. Cancer Res 51: 3512–3521. Kohler SW, Provost GS, Kretz PL, Dycaico MJ, Sorge JA, Short JM (1990): Development of a short-term, in vivo mutagenesis assay: the effects of methylation on the recovery of a lambda phage shuttle vector from transgenic mice. Nucleic Acids Res 18: 3007–3013. Littlefield NA, Farmer JH, Gaylor DW (1980): Effects of dose and time in a long-term, low-dose carcinogenic study. J Environ Pathol Toxicol 3: 17–34. Loeb LA (1989): Endogenous carcinogenesis: molecular oncology into the twenty-first century—Presidential address. Cancer Res 49: 5489–5496. Lutz WK (1990): Endogenous genotoxic agents and processes as a basis of spontaneous carcinogenesis. Mutat Res 238: 287–295. Melnick RL (1992): Does chemically induced hepatocyte proliferation predict liver carcinogenesis? FASEB J 6: 2698–2706. Ponomarkov V, Tomatis L (1976): The effect of long-term administration of phenobarbitone in CF-1 mice. Cancer Lett 1: 165–172. Thorpe E, Walker AIT (1973): The toxicology of dieldrin (HEOD*). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, beta-BHC and gamma-BHC. Fd Cosmet Toxicol 11: 433–442. Citing Literature Volume21, Issue31993Pages 209-211 ReferencesRelatedInformation
Publication Year: 1993
Publication Date: 1993-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 45
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