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2136, 2163, 2654, 3006, 3202, 3432, 3507, 3935], 'Translational': [55, 81, 1763], 'Neuromedicine,': [56, 82, 1764], 'Department': [57, 83, 1735, 1765], 'Neurosurgery,': [59, 85, 1767], 'University': [60, 86, 1768], 'Rochester': [62, 88, 1770], 'Medical': [63, 89, 1771, 3267, 3515], 'Center,': [64, 90, 1772], 'Rochester,': [65, 91, 1778], 'NY.': [66, 92], 'NedergaardMaiken': [69], 'Nedergaard': [70, 2130, 2310, 2940], 'Originally': [93], 'published1': [94], 'Jun': [95], '2013https://doi.org/10.1161/STROKEAHA.112.678698Stroke.': [96], '2013;44:S93–S95IntroductionThe': [97], 'brain': [98, 184, 228, 262, 299, 337, 369, 391, 540, 552, 626, 709, 724, 746, 776, 946, 1005, 1078, 1138, 1173, 1254, 1278, 1284, 1304, 1367, 1407, 1424, 1449, 1544, 1589, 1640, 1704, 1791, 1834, 1884, 1986, 2027, 2069, 2104, 2199, 2319, 2354, 2388, 3195], 'is': [99, 202, 300, 321, 371, 482, 584, 838, 1060, 1089, 1102, 1129, 1145, 1265, 1287, 1306, 1323, 1411, 1467, 1944], 'unique': [100], 'among': [101], 'virtually': [102, 782], 'all': [103, 750, 783], 'somatic': [104], 'organs': [105], 'in': [106, 158, 496, 507, 646, 683, 789, 840, 845, 902, 909, 962, 967, 1040, 1052, 1131, 1291, 1316, 1325, 1363, 1385, 1392, 1398, 1452, 1469, 1507, 1511, 1518, 1538, 1557, 1568, 1643, 1652, 1857, 1883, 2011, 2046, 2070, 2166, 2174, 2229, 2390, 2471, 2496, 2510, 2587, 2618, 2695, 2722, 2761, 2764, 2793, 2893, 2915, 2966, 3036, 3135, 3266, 3272, 3302, 3308, 3337, 3396, 3406, 3436, 3472, 3476, 3511, 3537, 3543, 3580, 3584, 3647, 3690, 3727, 3770, 3798, 3836, 3876, 3940, 4002], 'its': [107, 145, 1683, 1844, 3600, 4000], 'lack': [108], 'conventional': [111], 'lymphatic': [112, 118, 175, 1023, 3189, 3293, 3303, 3834], 'vasculature.1–3': [113], 'In': [114, 526, 1095, 1220, 1332, 1440, 1677], 'periphery,': [116], 'circulation': [119, 2010, 2826], 'facilitates': [120, 172, 411, 445, 603, 997, 2099], 'clearance': [122, 176, 273, 292, 413, 454, 475, 521, 605, 787, 858, 892, 943, 950, 957, 987, 999, 1144, 1206, 1225, 1248, 1560, 1624, 1635, 2108, 2138, 3724], 'extracellular': [124, 160, 178, 669, 1656, 1835, 1861, 1885, 2044], 'proteins': [125], 'excess': [127], 'fluid': [128, 181, 233, 311, 531, 554, 573, 878, 1836, 1862, 1954, 1989, 2009, 2067, 2427, 2825], 'from': [129, 182, 218, 226, 297, 420, 458, 533, 609, 633, 879, 944, 1003, 1171, 1252, 1329, 1597, 1636, 1818, 1910, 2028], 'interstitium,': [131, 392, 887], 'role': [133, 1552, 3301, 4001], 'critical': [134, 1551, 1576], 'tissue': [136, 263, 1390], 'homeostasis': [137], 'function.4,5': [139], 'Yet': [140], 'within': [141, 1436, 1455], 'brain,': [143, 529, 1057, 1509, 3839], 'despite': [144], 'complex': [146, 2323], 'architecture': [147], 'high': [149, 318], 'metabolic': [150, 418], 'activity': [151], 'neural': [153], "cells'": [154], 'sensitivity': [155], 'changes': [157, 1290, 1451, 1567, 3646], 'environment,': [161], 'no': [162], 'specialized': [163], 'organ-wide': [164, 994], 'anatomic': [165, 400, 442], 'structure': [166, 2822], 'has': [167], 'yet': [168], 'been': [169], 'identified': [170], 'that': [171, 206, 320, 336, 444, 481, 615, 698, 849, 866, 954, 974, 996, 1051, 1235, 1553, 1593, 1619, 1662], 'efficient': [174, 272, 650, 1607], 'solutes': [179, 296, 314, 416, 457, 558, 608, 1002, 1169, 1909], 'parenchyma.Current': [185], 'Understanding': [186], 'Brain': [188, 2501, 2723, 3009, 3239, 3473, 3938], 'Insterstitial': [189], 'Solute': [190, 429], 'ClearanceFor': [191], 'small': [192, 2460], 'molecules': [193, 280], 'hydrophobic': [195], 'compounds,': [196], 'efflux': [197, 582], 'across': [198, 3970], 'blood–brain': [200, 211], 'barrier': [201, 212], 'relatively': [203], 'unrestricted.': [204], 'Molecules': [205], 'are': [207, 214, 238, 268, 559, 1121, 1395, 1461, 1535, 1663, 2788], 'substrates': [208], 'specific': [210, 795], 'transporters': [213], 'also': [215, 1203, 1536], 'readily': [216], 'cleared': [217, 225, 560, 815, 1170], 'brain.6,7': [220], 'Other': [221], 'compounds': [222], 'must': [223], 'be': [224, 355, 375, 1430, 1691], 'interstitium': [229, 807, 1174], 'cerebrospinal': [232, 530, 1953, 2066, 2426], '(CSF)': [234, 532], 'compartment,': [235], 'where': [236], 'they': [237], 'ultimately': [239], 'eliminated': [240], 'blood': [243, 348, 1838], 'stream': [244], 'via': [245, 488, 1987], 'arachnoid': [246], 'granulations': [247], 'or': [248, 623, 678, 812, 1188, 1405, 1702], 'peripheral': [250, 1022], 'lymphatics': [251], 'along': [252, 315, 343, 398, 541, 595, 711, 781, 889, 981, 988, 1175, 1239], 'cranial': [253], 'nerves.1,8,9': [254], 'However,': [255, 381], 'distances': [257], 'between': [258, 575], 'much': [259, 1426], 'CSF': [266, 342, 366, 387, 410, 449, 469, 578, 694, 705, 720, 756, 767, 771, 854, 882, 900, 921, 979, 2100, 3034, 3104], 'compartments': [267], 'too': [269], 'great': [270, 823], 'by': [274, 305, 358, 586, 907, 960, 1228, 1289, 1308, 1479, 1720, 1967, 2018, 2140, 3068, 3725], 'simple': [275], 'diffusion,': [276], 'particularly': [277], 'large': [279, 565, 700], '(such': [281, 674], 'as': [282, 621, 675, 1584, 1650, 1670, 2283], 'peptides': [283], 'proteins)': [285], 'with': [286, 341, 551, 918, 1155, 1198, 1231, 1400, 1520, 3102, 3602], 'low': [287], 'diffusion': [288], 'coefficients.6': [289], 'Rather,': [290], 'these': [294, 351, 852, 867, 971, 1415], 'interstitial': [295, 310, 415, 456, 519, 553, 607, 651, 659, 761, 941, 955, 1001, 1562, 1622, 1687, 1792, 2110, 3394], 'attributed': [301], 'bulk': [303, 572, 601, 652, 875, 976, 1237, 1788, 1919], 'flow,': [304], 'which': [306], 'convective': [307, 600, 874], 'currents': [308], '(ISF)': [312], 'sweep': [313], 'at': [316, 1379, 1493], 'rate': [319, 939], 'largely': [322], 'independent': [323], 'molecular': [325, 1295], 'size.1,2,6,7In': [326], 'controversial': [328], 'series': [329], 'studies,': [331], 'Grady': [332, 1979, 2003], 'et': [333, 360, 1903, 2094, 2132, 2221, 2279, 3442], 'al10,11': [334], 'suggested': [335], 'ISF': [338, 451, 474, 556, 581, 786, 857, 986, 1133], 'may': [339, 663, 871, 1429, 1574, 1628, 1690, 1707], 'exchange': [340, 447, 765], 'paravascular': [344, 542, 562, 577, 712, 754, 853, 899, 1195, 1617, 1988, 2097], 'routes': [345], 'surrounding': [346, 544, 564, 714, 1067], 'cerebral': [347, 820, 1070, 2381, 2657, 4003], 'vessels.': [349], 'Because': [350, 1414], 'findings': [352, 972], 'seemed': [353, 778], 'subsequently': [356], 'refuted': [357], 'Cserr': [359, 1803, 1826, 2040, 2061], 'al,12,13': [361], 'such': [362, 620, 1583, 1649, 1669], 'retrograde': [363], 'movement': [364], 'into': [367, 759, 805, 923, 1185, 1212, 1612, 1837, 2068, 2846], 'parenchyma': [370, 710, 927, 2105], 'now': [372], 'thought': [373, 1146], 'comparatively': [377], 'minor': [378], 'physiological': [379], 'importance.1': [380], 'if': [382, 394], 'substantial': [384], 'amount': [385], 'moves': [388], 'through': [389, 590, 726, 885, 925, 1682, 2102], 'this': [395, 402, 753, 1011, 1028, 1428, 1678], 'flux': [396, 574, 1609], 'occurs': [397, 616], 'defined': [399], 'pathways,': [401, 788, 2827], 'would': [403], 'fundamentally': [404], 'alter': [405], 'our': [406, 968, 1330, 1441, 2920], 'understanding': [407], 'how': [409], 'wastes': [419], 'brain.Glymphatic': [422], 'Pathway:': [423], 'A': [424, 2096, 2491, 2651, 2781, 2784, 2796, 2837, 2911, 2957, 2960, 3263, 3357, 3360, 3501, 3683, 3718, 3756, 3994], 'Paravascular': [425], 'Pathway': [426, 1262], 'Interstitial': [428], 'ClearanceIn': [430], 'two': [431], 'recent': [432, 969, 1327], 'studies,14,15': [433], 'we': [434, 696, 897, 936, 952, 1025], 'define': [435], 'first': [438], 'time': [439, 1946], 'brain-wide': [441], 'pathway': [443, 462, 480, 505, 884, 984, 1030, 1242, 2098, 2135], 'brain.': [460, 511, 611, 719], 'This': [461, 599, 644, 1322, 1627], 'consists': [463], '3': [465], 'elements:': [466], 'para-arterial': [468, 881, 983], 'influx': [470, 579, 772, 855, 883, 901, 922, 980], 'route;': [471, 476], 'para-venous': [473, 891, 990], 'transparenchymal': [479], 'dependent': [483], 'on': [484, 1260, 1686, 2356, 2424, 2754, 3064, 3238], 'astroglial': [485, 587, 834, 2191], 'water': [486, 493, 588, 836, 869, 1611, 2164], 'transport': [487, 589, 1983, 2165], 'astrocytic': [490, 597, 642, 847, 1065, 1603], 'aquaporin-4': [491, 591, 1041, 2173, 2357], '(AQP4)': [492, 592, 1042], 'channel': [494, 837], '(represented': [495], 'Figure': [497], '1A).Download': [498, 1035], 'figureDownload': [499, 1036], 'PowerPointFigure': [500, 1037], '1.': [501], 'Schematic': [502], 'glymphatic': [504, 518, 658, 1032, 1177, 1241, 1559, 2528, 2557, 3113, 3597, 3997], 'function': [506], 'healthy': [508, 528, 1054, 1136, 1508], 'diseased': [510], 'Conceptual': [512], 'framework': [513], 'failure': [516, 656, 1141, 1632], 'solute': [520, 660, 942, 956, 1623, 1965, 1982], 'after': [522, 617, 680, 1044, 1075, 1123, 1360, 1383, 1474, 1482, 1497, 1541, 1571, 2386, 2499], 'diffuse': [523, 618, 681, 1045, 1124, 1317, 1337, 1458, 1475, 1572, 1700], 'injury.': [524, 1046, 1483, 1498, 1590], 'A,': [525, 1047, 1934, 2220, 2268, 2272, 2344, 2408, 2518, 2595, 2636, 2769, 2771, 3152, 3156, 3158, 3162, 3164, 3168, 3176, 3220, 3222, 3496, 3626, 3707, 3821, 3892, 3898, 3922, 4037], 'subarachnoid': [535, 704, 1940, 2030, 2531], 'space': [536, 1941, 3689], 'rapidly': [537, 706], 'enters': [538, 707], 'channels': [543, 870], 'penetrating': [545, 715, 784, 2353], 'arteries': [546, 716], '(green': [547], 'arrow)': [548], 'exchanges': [550], '(ISF).': [555], 'spaces': [563, 713, 1618, 2048], 'caliber': [566], 'draining': [567, 799], 'veins': [568, 821], '(orange': [569], 'arrows).': [570], 'Convective': [571], 'pathways': [583, 859, 1196], 'facilitated': [585], 'expressed': [593, 839], 'exclusively': [594], 'perivascular': [596, 635, 846, 868, 1064, 1504, 1522, 1554, 1599, 2047, 2190, 3033, 3688], 'endfeet.': [598], 'flow': [602, 653, 876, 977, 1238, 1789, 1920, 2064, 2101], 'B,': [612, 1072, 2307, 2442, 3634, 4025, 4029], 'Reactive': [613], 'astrogliosis': [614, 1082, 1264, 2258], 'injury,': [619, 627, 1079, 1279, 1285, 1425], 'microinfarction': [622, 1338], 'mild': [624, 1076, 1365, 1447, 1542, 3693], 'traumatic': [625, 1077, 1283, 1303, 1366, 1406, 1423, 1448, 1543, 1588, 1675, 1703, 2318, 2387], 'causes': [628], 'mislocalization': [630, 1594], 'AQP4': [632, 835, 1058, 1100, 1393, 1409, 1434, 1453, 1465, 1487, 1510, 1528, 1533, 1555, 1569, 1596, 2327], 'endfeet': [636, 848, 1066, 1600], 'rest': [639], 'soma.': [643], 'results': [645, 1315], 'loss': [648, 1107, 2228], 'clearance,': [661, 1689], 'contribute': [664, 1620], 'deposition': [667, 1150], 'intracellular': [671, 1658], 'protein': [672, 1086, 1660, 2024], 'aggregates': [673, 1661], 'amyloid': [676, 1126, 2113], 'β': [677, 1127], 'tau)': [679], 'injury.Using': [682], 'vivo': [684, 688, 910, 914], '2-photon': [685, 911], 'ex': [687, 913], 'confocal': [689], 'imaging': [690], 'small-molecular-weight': [692], 'fluorescent': [693, 1200], 'tracers,': [695], 'found': [697, 953], 'proportion': [701], '(>40%)14': [702], 'throughout': [717, 774, 1091, 1350, 1984, 2025], 'tracer': [721, 757, 802, 2023], 'entered': [722, 758], 'initially': [725], 'Virchow–Robin': [728], 'space,': [729, 762], 'then': [730], 'followed': [731], 'arterial': [733], 'vascular': [734, 1585, 2472], 'smooth': [735], 'muscle': [736], 'basement': [737], 'membrane': [738, 2161], 'reach': [740], 'basal': [742], 'lamina': [743], 'capillary': [747, 1922], 'bed.': [748], 'At': [749], 'levels': [751], 'route,': [755, 991], 'reflecting': [763], 'ISF.14': [769], 'Para-arterial': [770], 'extended': [773], 'occur': [780], 'arteries.': [785], 'contrast,': [790], 'were': [791], 'restricted': [792], 'group': [796], 'large-caliber': [798], 'veins.': [800], 'Fluorescent': [801], 'injected': [803, 1184, 1210], 'directly': [804, 1211], 'cortex,': [810], 'striatum,': [811, 1189], 'thalamus': [813], 'was': [814, 931, 958, 1183, 1226, 1348, 1376, 1718], 'medially': [816], 'internal': [819], 'vein': [824], 'Galen': [826], 'ventrolaterally': [828], 'caudal': [831], 'rhinal': [832], 'vein.14The': [833], 'highly': [842, 1061, 1502], 'polarized': [843, 1503], 'manner': [844], 'immediately': [850], 'bound': [851], '(Figures': [860], '1A': [861], '2A).16,17': [863], 'We': [864, 1159, 1202, 1591], 'proposed': [865, 2660], 'facilitate': [872], 'route.': [893], 'To': [894], 'test': [895], 'this,': [896], 'evaluated': [898, 937, 1161], 'global': [903], 'Aqp4': [904], 'knockout': [905], 'mice': [906, 930], 'both': [908], 'fluorescence': [915], 'imaging.': [916], 'Compared': [917], 'wild-type': [919, 1216, 1232], 'controls,': [920], 'Aqp4-null': [929, 963, 1218, 1221], 'dramatically': [932], 'reduced.14': [933], 'Similarly,': [934, 1362], 'when': [935], 'using': [947, 2359], 'radiotracer': [949], 'assay,': [951], 'reduced': [959, 1227], '≈70%': [961], 'mice.': [964, 1219], 'As': [965], 'detailed': [966], 'study,14': [970], 'demonstrate': [973], 'AQP4-dependent': [975, 1236], 'couples': [978], 'forming': [992], 'an': [993, 2201], 'system': [995, 1033, 2529, 3295, 3395, 3598, 3998], 'parenchyma.': [1006], 'On': [1007], 'basis': [1009], 'glial': [1012, 1309, 1438, 2167, 2260], 'dependence': [1013], 'functional': [1016], 'structural': [1018], 'homology': [1019], 'system,': [1024, 2016, 3114], 'have': [1026, 1575], 'termed': [1027], 'glio-vascular': [1029], '(Figure': [1034, 1546, 1625], '2.': [1038], 'Changes': [1039], 'localization': [1043, 1101, 1505, 1570], 'Immunofluorescent': [1048], 'double-labeling': [1049], 'demonstrates': [1050], 'young': [1055, 1137], 'mouse': [1056, 1334, 2231], 'expression': [1059, 1119, 1296, 1394, 1410, 1435, 1454, 1466, 2358], 'localized': [1062], 'entire': [1069], 'microvasculature.': [1071], 'Seven': [1073], 'days': [1074, 1473, 1481], 'widespread': [1080, 1345, 1370, 1631], 'reactive': [1081, 1098, 1320, 1346, 1374, 1401, 1459, 1512, 1539, 1680, 2247, 2257], '(glial': [1083], 'fibrillary': [1084], 'acidic': [1085], '[GFAP]': [1087], 'immunoreactivity)': [1088], 'observed': [1090, 1122, 1197, 1397, 1506, 1537], 'ipsilateral': [1093], 'cortex.': [1094], 'regions': [1096, 1456, 1471], 'astrogliosis,': [1099], 'severely': [1103], 'perturbed,': [1104], 'exhibiting': [1105, 1339], 'polarization': [1109], 'endfoot': [1112], 'process': [1113], 'increased': [1115], 'somal': [1116, 1527], 'labeling.': [1117], 'Similar': [1118, 1530], 'patters': [1120], 'microinfarction.18Soluble': [1125], '(Aβ)': [1128], 'present': [1130], 'Aβ': [1143, 1152, 1164, 1182, 1209, 1224, 1251], 'underlie': [1148], 'plaques': [1153], 'associated': [1154], 'Alzheimer': [1156, 1671], 'disease': [1157, 1672, 2462], 'progression.10,11': [1158], 'next': [1160], 'whether': [1162], 'soluble': [1163, 1250, 1565], 'constitutes': [1165, 1243], 'one': [1166], 'pathway.': [1178], 'When': [1179], 'fluorescently': [1180], 'labeled': [1181], 'cortex': [1187, 1352], 'it': [1190, 1945, 2918], 'accumulated': [1191], 'around': [1192], 'same': [1194], 'other': [1199], 'tracers.14': [1201], 'measured': [1204], 'radiolabeled': [1208, 1223, 1813], 'striatum': [1214, 1354], 'mice,': [1222, 1233, 3037], '≈65%': [1229], 'compared': [1230], 'suggesting': [1234], 'key': [1245, 1693, 1710], 'mechanism': [1246], 'interstitium.14Effect': [1255], 'Diffuse': [1257], 'Gliotic': [1258], 'Injury': [1259, 2502, 3939], 'Glymphatic': [1261, 2689, 2888, 2988], 'FunctionReactive': [1263], 'cellular': [1267], 'response': [1268, 2071], 'injury': [1270, 1305, 1313, 1368, 1384, 1545, 1573, 1705, 2320, 2355, 2385, 2389, 3438], 'common': [1271], 'many': [1273], 'mechanistically': [1274], 'distinct': [1275], 'forms': [1276], 'including': [1280, 1564, 2112], 'ischemic': [1281, 1301, 1343, 1404, 1421, 1701], 'characterized': [1288], 'astrocyte': [1292], 'morphology': [1293], 'patterns.19–21': [1297], 'Although': [1298], 'more': [1299, 1462], 'severe': [1300, 1420, 3103], 'accompanied': [1307], 'scar': [1310, 2261], 'formation,': [1311], 'low-intensity': [1312], 'frequently': [1314], 'long-lasting': [1319], 'astrogliosis.': [1321, 1402], 'reflected': [1324], '2': [1326, 3480], 'studies': [1328, 1416, 1443], 'group.': [1331], 'model': [1335, 2232, 2315], 'only': [1340], 'low-level': [1341], 'aggregate': [1342], 'burden,': [1344], 'gliosis': [1347, 1375, 1460], 'evident': [1349, 1377], 'up': [1356], 'month': [1359, 1382, 1496], 'injury.18': [1361], 'model,': [1369], 'cortical': [1371], 'subcortical': [1373], 'least': [1380, 1494], '1': [1381, 1495], 'absence': [1387], 'frank': [1389], 'destruction.22Changes': [1391], 'often': [1396], 'conjunction': [1399], 'After': [1403], 'injury,23,24': [1408], 'typically': [1412], 'elevated.': [1413], 'use': [1417], 'moderate': [1418], 'attributable': [1431], 'altered': [1433], 'scar.': [1439], 'own': [1442], 'microinfarction18': [1445], 'injury,22': [1450], 'complex.': [1463], 'General': [1464], 'elevated': [1468], 'gliotic': [1470, 1639], '7': [1472], 'microinfarction,': [1476], 'but': [1477], 'normalizes': [1478], '14': [1480, 2591, 3773], 'The': [1484, 2189, 2527, 2684, 2943, 2970, 3059, 3292, 3596, 3802, 3996], 'distribution': [1485, 2021, 3035, 3686], 'expression,': [1488], 'however,': [1489], 'remains': [1490], 'perturbed': [1491], 'Rather': [1499], 'than': [1500], 'astrocytes': [1513, 1540], 'exhibits': [1514], 'marked': [1516], 'reduction': [1517], 'polarity,': [1519], 'lower': [1521], 'APQ4': [1523], 'immunoreactivity': [1524], 'higher': [1526], 'immunoreactivity.': [1529], 'patterns': [1531, 2324], 'dysregulation': [1534], '2B).In': [1547], 'light': [1548], 'plays': [1556, 3299], 'solutes,': [1563, 2111], 'Aβ14,': [1566], 'implications': [1577], 'pathogenesis': [1580], 'conditions,': [1582], 'dementia': [1586], 'propose': [1592], 'soma': [1604], 'prevents': [1605], 'directional': [1608], 'out': [1614], '1B).': [1626], 'cause': [1629], 'waste': [1634, 1688, 2137], 'diffusely': [1638], 'tissue,': [1641], 'resulting': [1642], 'accumulation': [1645], 'neurotoxic': [1647], 'metabolites,': [1648], 'Aβ,': [1651], 'addition': [1653], 'cytotoxic': [1659], 'hallmark': [1665], 'neurodegenerative': [1667], 'diseases,': [1668, 3440, 3604], 'chronic': [1674], 'encephalopathy.': [1676], 'way,': [1679], 'gliosis,': [1681], 'detrimental': [1684], 'effects': [1685], 'driver': [1694], 'pathology': [1696], 'under': [1697], 'conditions': [1698], 'represent': [1708], 'target': [1711], 'therapeutic': [1713, 3733], 'intervention.Sources': [1714], 'FundingThis': [1716], 'work': [1717], 'supported': [1719], 'National': [1722, 3843], 'Institutes': [1723], 'Health': [1725], '(Dr': [1726, 1733, 1738, 1749], 'Dr': [1728], 'Nedergaard),': [1729, 1739], 'American': [1730, 2849], 'Heart': [1731], 'Association': [1732], 'Iliff),': [1734], 'Defense': [1737], 'Harold': [1742], 'Leila': [1744], 'Y.': [1745], 'Mathers': [1746], 'Charitable': [1747], 'Foundation': [1748], 'Nedergaard).DisclosuresNone.FootnotesCorrespondence': [1750], 'PhD,': [1754], 'Box': [1773], '645,': [1774], '601': [1775], 'Elmwood': [1776], 'Ave,': [1777], 'NY': [1779], '14642.': [1780], 'E-mail': [1781], '[email': [1782], 'protected]References1.': [1783], 'Abbott': [1784], 'NJ.': [1785], 'Evidence': [1786, 2005], 'fluid:': [1793], 'significance': [1794], 'physiology': [1796], 'pathology.Neurochem': [1798], 'Int.': [1799], '2004;': [1800], '45:545–552.CrossrefMedlineGoogle': [1801], 'Scholar2.': [1802], 'HF,': [1804, 1827], 'Cooper': [1805], 'DN,': [1806], 'Suri': [1807], 'PK,': [1808], 'Patlak': [1809], 'CS.': [1810], 'Efflux': [1811, 1905], 'polyethylene': [1814], 'glycols': [1815], 'albumin': [1817], 'rat': [1819, 2051, 2175, 2361], 'brain.Am': [1820], 'J': [1821, 2075, 2488, 2522, 3185, 3498, 3680, 3991], 'Physiol.': [1822, 2076], '1981;': [1823], '240:F319–F328.MedlineGoogle': [1824], 'Scholar3.': [1825], 'Harling-Berg': [1828], 'CJ,': [1829, 2340], 'Knopf': [1830], 'PM.': [1831], 'Drainage': [1832], 'deep': [1840], 'cervical': [1841], 'lymph': [1842, 1872], 'immunological': [1845], 'significance.Brain': [1846], 'Pathol.': [1847], '1992;': [1848], '2:269–276.CrossrefMedlineGoogle': [1849], 'Scholar4.': [1850], 'Aukland': [1851], 'K,': [1852, 2002, 3084, 3589, 3670], 'Reed': [1853], 'RK.': [1854], 'Interstitial-lymphatic': [1855], 'mechanisms': [1856, 2662, 3731], 'control': [1859], 'volume.Physiol': [1863], 'Rev.': [1864, 1874, 1887], '1993;': [1865], '73:1–78.CrossrefMedlineGoogle': [1866], 'Scholar5.': [1867], 'Schmid-Schönbein': [1868], 'GW.': [1869], 'Microlymphatics': [1870], 'flow.Physiol': [1873], '1990;': [1875, 1992], '70:987–1028.CrossrefMedlineGoogle': [1876], 'Scholar6.': [1877], 'Syková': [1878], 'E,': [1879, 2597, 3088, 3154, 3180, 3347, 3558], 'Nicholson': [1880], 'C.': [1881], 'Diffusion': [1882], 'space.Physiol': [1886], '2008;': [1888], '88:1277–1340.CrossrefMedlineGoogle': [1889], 'Scholar7.': [1890], 'Groothuis': [1891], 'DR,': [1892], 'Vavra': [1893], 'MW,': [1894], 'Schlageter': [1895], 'KE,': [1896], 'Kang': [1897], 'EW,': [1898], 'Itskovich': [1899], 'AC,': [1900], 'Hertzler': [1901], 'S,': [1902, 2149, 2404, 2516, 2626, 2638, 2707, 2835, 3022, 3178, 3349, 3525, 3562, 3638, 3785, 3888, 3896, 3906, 3910, 3916, 3985, 4017, 4023], 'al.': [1904, 2095, 2133, 2222, 2280], 'drugs': [1907], 'brain:': [1911, 3398], 'interactive': [1913], 'roles': [1914], 'diffusional': [1916], 'transcapillary': [1917], 'transport,': [1918], 'transporters.J': [1923], 'Cereb': [1924, 2329], 'Blood': [1925, 2330, 3933], 'Flow': [1926, 2331, 2989], 'Metab.': [1927, 2332], '2007;': [1928, 1972, 2364], '27:43–56.CrossrefMedlineGoogle': [1929], 'Scholar8.': [1930], 'Koh': [1931], 'L,': [1932, 2299, 2593, 3052, 3090, 3283, 3353, 3914], 'Zakharov': [1933], 'Johnston': [1935], 'M.': [1936, 2243, 2311], 'Integration': [1937], 'lymphatics:': [1943], 'embrace': [1948], 'new': [1950, 3200], 'concept': [1951], 'absorption?Cerebrospinal': [1955], 'Fluid': [1956], 'Res.': [1957, 2032, 2053], '2005;': [1958, 2249], '2:6.CrossrefMedlineGoogle': [1959], 'Scholar9.': [1960], 'Praetorius': [1961], 'Water': [1963], 'secretion': [1966], 'choroid': [1969, 3100], 'plexus.Pflugers': [1970], 'Arch.': [1971], '454:1–18.CrossrefMedlineGoogle': [1973], 'Scholar10.': [1974], 'Rennels': [1975, 1995], 'ML,': [1976, 1996], 'Blaumanis': [1977, 1999], 'OR,': [1978, 2000], 'PA.': [1980, 2004], 'Rapid': [1981], 'pathways.Adv': [1990], 'Neurol.': [1991], '52:431–439.MedlineGoogle': [1993], 'Scholar11.': [1994], 'Gregory': [1997], 'TF,': [1998], 'Fujimoto': [2001], "'paravascular'": [2008], 'mammalian': [2013], 'central': [2014], 'nervous': [2015], 'provided': [2017], 'rapid': [2020], 'space.Brain': [2031], '1985;': [2033], '326:47–63.CrossrefMedlineGoogle': [2034], 'Scholar12.': [2035], 'Ichimura': [2036], 'T,': [2037, 2127, 3632], 'Fraser': [2038], 'PA,': [2039], 'HF.': [2041, 2062], 'Distribution': [2042], 'tracers': [2045], 'brain.Brain': [2052], '1991;': [2054], '545:103–113.CrossrefMedlineGoogle': [2055], 'Scholar13.': [2056], 'Pullen': [2057], 'RG,': [2058], 'DePasquale': [2059], 'M,': [2060, 2085, 2125, 2131, 2153, 2210, 2241, 2452, 2601, 2628, 2675, 2773, 2871, 3020, 3082, 3166, 3355, 3618, 3636, 3672, 3709, 3713, 3862, 3908, 3926, 3956, 4027, 4031, 4035], 'Bulk': [2063], 'acute': [2073], 'hyperosmolality.Am': [2074], '1987;': [2077], '253(3': [2078], 'Pt': [2079], '2):F538–F545.MedlineGoogle': [2080], 'Scholar14.': [2081], 'JJ,': [2083, 2121, 2212, 2278, 2297], 'Wang': [2084, 2209, 2306, 2456, 2681, 2749, 2880, 2883, 3282, 3286, 3615, 3778, 3780], 'Liao': [2086, 2213], 'Y,': [2087, 2214, 2448, 2520, 2566, 2673, 2677, 2711, 2814, 3560, 3781, 3783, 3854, 3860, 3866, 3987, 4019], 'Plogg': [2088], 'BA,': [2089], 'Peng': [2090], 'W,': [2091, 2412, 3676, 3775, 4033], 'Gundersen': [2092], 'GA,': [2093], 'beta.Science': [2114], 'translational': [2115], 'medicine.': [2116], '2012;': [2117, 2237, 2291, 2393], '4:147ra111CrossrefMedlineGoogle': [2118], 'Scholar15.': [2119], 'Lee': [2122, 2341, 3988], 'H,': [2123, 2709, 3126, 3285, 3326, 3492, 3527, 3628, 3674, 3678, 3858, 3954, 3979, 3989], 'Yu': [2124, 2878], 'Feng': [2126, 3053], 'Logan': [2128], 'J,': [2129, 2370, 2406, 2410, 2450, 2705, 2861, 2869, 2873, 3218, 3255, 3281, 3324, 3620, 3622, 3624, 3666, 3777], 'Brain-wide': [2134], 'captured': [2139], 'contrast-enhanced': [2141], 'MRI.J': [2142], 'Clin': [2143], 'Invest.': [2144], '2013;': [2145, 2333], '123:1299–1309.CrossrefMedlineGoogle': [2146], 'Scholar16.': [2147], 'Nielsen': [2148], 'Nagelhus': [2150], 'EA,': [2151], 'Amiry-Moghaddam': [2152], 'Bourque': [2154], 'C,': [2155, 2777, 3494, 3614, 3751, 3819, 3900], 'Agre': [2156], 'P,': [2157, 2486, 3351, 3630, 3890, 3983], 'Ottersen': [2158, 2187], 'OP.': [2159, 2188], 'Specialized': [2160], 'domains': [2162], 'cells:': [2168], 'high-resolution': [2169], 'immunogold': [2170], 'cytochemistry': [2171], 'brain.J': [2176], 'Neurosci.': [2177, 2236, 2263], '1997;': [2178], '17:171–180.CrossrefMedlineGoogle': [2179], 'Scholar17.': [2180], 'Mathiisen': [2181], 'TM,': [2182], 'Lehre': [2183], 'KP,': [2184], 'Danbolt': [2185], 'NC,': [2186, 2274], 'sheath': [2192], 'provides': [2193], 'complete': [2195], 'covering': [2196], 'microvessels:': [2200], 'electron': [2202], 'microscopic': [2203], '3D': [2204], 'reconstruction.Glia.': [2205], '2010;': [2206], '58:1094–1103.CrossrefMedlineGoogle': [2207], 'Scholar18.': [2208], 'Chen': [2215, 2300, 2302, 2676, 2744, 3280, 3786, 4024, 4028], 'MJ,': [2216, 2303], 'Shinseki': [2217], 'MS,': [2218], 'Venkataraman': [2219], 'Cognitive': [2223, 2891], 'deficits': [2224], 'delayed': [2226], 'neuronal': [2227], 'multiple': [2234], 'microinfarcts.J': [2235], '32:17948–60.CrossrefMedlineGoogle': [2238], 'Scholar19.': [2239], 'Pekny': [2240], 'Nilsson': [2242], 'Astrocyte': [2244, 2964, 3133], 'activation': [2245], 'gliosis.Glia.': [2248], '50:427–434.CrossrefMedlineGoogle': [2250], 'Scholar20.': [2251], 'Sofroniew': [2252, 2269], 'MV.': [2253], 'Molecular': [2254, 3072, 3447, 3486, 3548, 3758, 3968], 'dissection': [2255], 'formation.Trends': [2262], '2009;': [2264], '32:638–647.CrossrefMedlineGoogle': [2265], 'Scholar21.': [2266], 'Verkhratsky': [2267, 4036], 'MV,': [2270], 'Messing': [2271], 'deLanerolle': [2273], 'Rempe': [2275], 'D,': [2276, 2446, 2599, 2863, 2875, 3920], 'Rodríguez': [2277], 'Neurological': [2281], 'diseases': [2282], 'primary': [2284], 'gliopathies:': [2285], 'reassessment': [2287], 'neurocentrism.ASN': [2289], 'Neuro.': [2290], '4:131–149CrossrefGoogle': [2292], 'Scholar22.': [2293], 'Ren': [2294], 'Z,': [2295, 2444, 2775, 2879, 3048, 3747, 4021], 'Yang': [2298, 2437, 2678, 3746, 3776], 'X,': [2301, 2309, 2440, 2867, 2877, 3749], 'Giese': [2304], 'RN,': [2305], 'Shi': [2308], "'Hit": [2312], '&': [2313, 3808], "Run'": [2314], 'closed-skull': [2317], '(TBI)': [2321], 'reveals': [2322], 'post-traumatic': [2326], 'dysregulation.J': [2328], '[epub': [2334], 'ahead': [2335], 'print].CrossrefMedlineGoogle': [2337], 'Scholar23.': [2338], 'Neal': [2339], 'EY,': [2342], 'Gyorgy': [2343], 'Ecklund': [2345], 'JM,': [2346], 'Agoston': [2347], 'DV,': [2348], 'Ling': [2349], 'GS.': [2350], 'Effect': [2351], 'model.J': [2362], 'Neurotrauma.': [2363], '24:1609–1617.CrossrefMedlineGoogle': [2365], 'Scholar24.': [2366], 'Kimbler': [2367], 'DE,': [2368], 'Shields': [2369], 'Yanasak': [2371], 'N,': [2372, 2634, 3421, 3664, 3924], 'Vender': [2373], 'JR,': [2374], 'Dhandapani': [2375], 'KM.': [2376], 'Activation': [2377], 'P2X7': [2379], 'promotes': [2380], 'edema': [2382], 'neurological': [2384, 3603], 'mice.PLoS': [2391], 'ONE.': [2392], '7:e41229.CrossrefMedlineGoogle': [2394], 'Scholar': [2395], 'Previous': [2396], 'Back': [2397, 2845], 'top': [2399], 'Next': [2400], 'FiguresReferencesRelatedDetailsCited': [2401], 'By': [2402], 'Yildiz': [2403], 'Grinstead': [2405], 'Hildebrand': [2407], 'Oshinski': [2409], 'Rooney': [2411], 'Lim': [2413, 3493], 'M': [2414, 2605, 2608, 2679, 2881, 2938, 2941, 3459, 3529, 3594, 3640, 3828], 'Oken': [2416], 'B': [2417, 2525, 2716, 4042], '(2022)': [2418, 2458, 2492, 2526, 2547, 2572, 2609, 2652, 2683, 2717, 2751, 2785, 2820, 2912, 2942, 2961, 2985, 3003], 'Immediate': [2419], 'impact': [2420], 'yogic': [2422], 'breathing': [2423], 'pulsatile': [2425], 'dynamics,': [2428], 'Scientific': [2429], 'Reports,': [2430], '10.1038/s41598-022-15034-8,': [2431], '12:1,': [2432], 'Online': [2433, 2481, 2740, 2809, 2856, 2906, 2930, 3043, 3077, 3121, 3143, 3209, 3213, 3250, 3317, 3382, 3412, 3416, 3454, 3520, 3553, 3702, 3742, 3849, 3949, 4012], 'publication': [2434, 2482, 2741, 2810, 2857, 2907, 2931, 3044, 3078, 3122, 3144, 3210, 3214, 3251, 3318, 3383, 3413, 3417, 3455, 3521, 3554, 3703, 3743, 3850, 3950, 4013], 'date:': [2435, 2483, 2742, 2811, 2858, 2908, 2932, 3045, 3079, 3123, 3145, 3211, 3215, 3252, 3319, 3384, 3414, 3418, 3456, 3522, 3555, 3704, 3744, 3851, 3951, 4014], '1-Dec-2022.': [2436], 'Q,': [2438, 3779], 'Wei': [2439, 3789], 'Deng': [2441], 'Chang': [2443], 'Jin': [2445, 2453], 'Huang': [2447], 'Zhang': [2449, 3056, 3748, 4026], 'Yenari': [2451], 'K': [2454, 3227], 'Q': [2457, 3290, 3643], 'vessel': [2461], 'alters': [2463], 'neurovascular': [2464], 'unit': [2465], 'regulation': [2466], 'microcirculation': [2468], 'integrity': [2469], 'involved': [2470], 'cognitive': [2473, 2791, 3694], 'impairment,': [2474, 3695], 'Neurobiology': [2475, 3696], 'Disease,': [2477, 2699, 3450, 3545, 3768], '10.1016/j.nbd.2022.105750,': [2478], '170,': [2479], '(105750),': [2480], '1-Aug-2022.': [2484], 'Badyal': [2485], 'Kaur': [2487], 'Kuhad': [2490], 'Role': [2493, 2686, 2962, 3061, 3471, 3534], '5-HT': [2495], 'Edema': [2498], 'Traumatic': [2500], 'Serotonin': [2503], 'CNS': [2506, 3298, 3437], '-': [2507, 3446], 'New': [2508], 'Developments': [2509], 'Pharmacology': [2511], '10.5772/intechopen.96460': [2514], 'Quintin': [2515], 'Barpujari': [2517], 'Mehkri': [2519], 'Hernandez': [2521], 'Lucke-Wold': [2524], 'hemorrhage:': [2532], 'disruption': [2533], 'recovery,': [2535], 'Exploration': [2536, 2559], 'Neuroprotective': [2538, 2561], 'Therapy,': [2539, 2562], '10.37349/ent.2022.00023,': [2540], '(118-130)': [2541], 'Wostyn': [2542], 'P': [2543, 2546, 3567, 3825], 'Goddaer': [2545], 'Can': [2548], 'meditation-based': [2549], 'approaches': [2550], 'improve': [2551], 'cleansing': [2553], 'power': [2554], 'system?,': [2558], '10.37349/ent.2022.00022,': [2563], '(110-117)': [2564], 'Sun': [2565, 3386, 3389], 'Koyama': [2567], 'Y': [2568, 2682, 2819, 3054, 3287, 3387], 'Shimada': [2570], 'S': [2571, 3095, 3128, 3131, 3328, 3426, 3532, 3564, 3715, 3753, 3787], 'Inflammation': [2573, 2583], 'Peripheral': [2575], 'Organs': [2576], 'Brain:': [2579], 'How': [2580], 'Does': [2581], 'Systemic': [2582, 3792], 'Cause': [2584], 'Neuroinflammation?,': [2585], 'Frontiers': [2586, 2763, 3583, 3769], 'Aging': [2588, 3010], 'Neuroscience,': [2589, 3771], '10.3389/fnagi.2022.903455,': [2590], 'Cacciaguerra': [2592], 'Carotenuto': [2594], 'Pagani': [2596], 'Mistri': [2598], 'Radaelli': [2600], 'Martinelli': [2602], 'V,': [2603, 2640, 3170, 3174, 3616], 'Filippi': [2604, 2980], 'Rocca': [2607], 'Magnetic': [2610], 'Resonance': [2611], 'Imaging': [2612, 2986], 'Evaluation': [2613], 'Perivascular': [2615], 'Space': [2616], 'Abnormalities': [2617, 3573], 'Neuromyelitis': [2619], 'Optica,': [2620], 'Annals': [2621], 'Neurology,': [2623, 2669, 2765, 3585], '10.1002/ana.26419': [2624], 'Cardali': [2625], 'Caffo': [2627], 'Caruso': [2629], 'G,': [2630, 2632, 2644, 2646, 2936, 3086, 3662, 3711], 'Scalia': [2631], 'Gorgoglione': [2633], 'Conti': [2635], 'Vinci': [2637], 'Barresi': [2639], 'Granata': [2641], 'F,': [2642, 2745, 2779, 3050, 3660], 'Ricciardo': [2643], 'Garufi': [2645], 'Raffa': [2647], 'G': [2648, 3591], 'Germanò': [2650], 'Cisternostomy': [2653], 'malignant': [2655], 'middle': [2656], 'artery': [2658], 'infarction:': [2659], 'pathophysiological': [2661], 'preliminary': [2664], 'results,': [2665], 'Stroke': [2666], 'Vascular': [2668, 3234], '10.1136/svn-2021-000918,': [2670], '(svn-2021-000918)': [2671], 'Tian': [2672], 'Zhao': [2674], 'Underlying': [2685, 3760], 'System': [2690], 'Meningeal': [2692], 'Vessels': [2694], 'Small': [2697], 'Vessel': [2698], 'Biomolecules,': [2700], '10.3390/biom12060748,': [2701], '12:6,': [2702], '(748)': [2703], 'Wan': [2704], 'Zhou': [2706, 3774], 'Mea': [2708], 'Guo': [2710, 2866], 'Ku': [2712], 'H': [2713, 3423], 'Urbina': [2715], 'Emerging': [2718], 'Roles': [2719], 'Microfluidics': [2721], 'Research:': [2724], 'Fluids': [2727], 'Manipulation': [2728], 'Brain-on-a-Chip': [2730], 'Neuroelectronic': [2732], 'Devices': [2733], 'Engineering,': [2734], 'Chemical': [2735], 'Reviews,': [2736], '10.1021/acs.chemrev.1c00480,': [2737], '122:7,': [2738], '(7142-7181),': [2739], '13-Apr-2022.': [2743], 'Xie': [2746, 2870, 3755], 'X': [2747, 3390, 4039], 'L': [2750, 3331, 3961], 'Research': [2752], 'Progress': [2753], 'Intracranial': [2755], 'Circulation': [2757], 'Its': [2759], 'Involvement': [2760], 'Disorders,': [2762], '10.3389/fneur.2022.865714,': [2766], '13': [2767], 'Papp': [2768], 'Horváth': [2770], 'Virág': [2772], 'Tóth': [2774], 'Borbély': [2776], 'Gombos': [2778], 'Szűcs': [2780], 'Kamondi': [2783], 'Sleep': [2786, 3764], 'alterations': [2787, 2914], 'related': [2789], 'symptoms': [2792], "Parkinson's": [2794, 2967, 3767], 'disease:': [2795, 3729], '24-hour': [2797], 'ambulatory': [2798], 'polygraphic': [2799], 'EEG': [2800], 'study,': [2801], 'International': [2802, 3244, 3483], 'Journal': [2803, 2850, 3038, 3241, 3310, 3484, 3736, 3943, 4005], 'Psychophysiology,': [2805], '10.1016/j.ijpsycho.2022.01.010,': [2806], '173,': [2807], '(93-103),': [2808], '1-Mar-2022.': [2812], 'Kondor': [2813], 'Tykholaz': [2815], 'V': [2816], 'Guminskyi': [2818], 'Histological': [2821], 'intercellular': [2824], 'Reports': [2828], 'Morphology,': [2830], '10.31393/morphology-journal-2022-28(1)-09,': [2831], '28:1,': [2832], '(59-63)': [2833], 'Lu': [2834, 4018], 'Brusic': [2836], 'Gaillard': [2839], 'F': [2840, 3057], '(2021)': [2841, 2885, 3028, 3058, 3096, 3132, 3186, 3228, 3261, 3291, 3332, 3361, 3391, 3427, 3463, 3502, 3568, 3595, 3644, 3684, 3719, 3757, 3791, 3829, 3872, 3932], 'Arachnoid': [2842], 'Membranes:': [2843], 'Crawling': [2844], 'Radiologic': [2847], 'Consciousness,': [2848], 'Neuroradiology,': [2852], '10.3174/ajnr.A7309,': [2853], '43:2,': [2854], '(167-175),': [2855], '1-Feb-2022.': [2859, 2909], 'Cao': [2860], 'Yao': [2862], 'Li': [2864, 2872, 3750, 4020, 4022, 4041], 'R,': [2865, 3322, 3668, 3856, 3864, 3894, 3902, 3904, 3912, 3918, 3981], 'Hao': [2868], 'Pan': [2874], 'Luo': [2876], 'W': [2884, 3462, 3790], 'Digoxin': [2886], 'Ameliorates': [2887], 'Transport': [2889], 'Impairment': [2892], 'Mouse': [2895], 'Model': [2896], 'Chronic': [2898], 'Hypoperfusion,': [2900], 'Neuroscience': [2901, 3268], 'Bulletin,': [2902], '10.1007/s12264-021-00772-y,': [2903], '38:2,': [2904], '(181-199),': [2905], 'Hadjihambi': [2910], 'Cerebrovascular': [2913], 'NAFLD:': [2916], 'Is': [2917], 'increasing': [2919], 'risk': [2921], 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