Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2112323718', 'doi': 'https://doi.org/10.1142/s0192415x14500049', 'title': 'Therapeutic Angiogenesis after Ischemic Stroke: Chinese Medicines, Bone Marrow Stromal Cells (BMSCs) and their Combinational Treatment', 'display_name': 'Therapeutic Angiogenesis after Ischemic Stroke: Chinese Medicines, Bone Marrow Stromal Cells (BMSCs) and their Combinational Treatment', 'publication_year': 2014, 'publication_date': '2014-01-01', 'ids': {'openalex': 'https://openalex.org/W2112323718', 'doi': 'https://doi.org/10.1142/s0192415x14500049', 'mag': '2112323718', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24467535'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1142/s0192415x14500049', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S118315377', 'display_name': 'The American Journal of Chinese Medicine', 'issn_l': '0192-415X', 'issn': ['0192-415X', '1793-6853'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319815', 'host_organization_name': 'World Scientific', 'host_organization_lineage': ['https://openalex.org/P4310319815'], 'host_organization_lineage_names': ['World Scientific'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5115603610', 'display_name': 'Qian Zhang', 'orcid': 'https://orcid.org/0000-0001-5975-9781'}, 'institutions': [{'id': 'https://openalex.org/I111950717', 'display_name': 'Macau University of Science and Technology', 'ror': 'https://ror.org/03jqs2n27', 'country_code': 'MO', 'type': 'education', 'lineage': ['https://openalex.org/I111950717', 'https://openalex.org/I4391767947']}], 'countries': ['MO'], 'is_corresponding': False, 'raw_author_name': 'Qian Zhang', 'raw_affiliation_strings': ['State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macao 999078, Macao SAR of P. R. China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macao 999078, Macao SAR of P. R. China', 'institution_ids': ['https://openalex.org/I111950717']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066843483', 'display_name': 'Yonghua Zhao', 'orcid': 'https://orcid.org/0000-0001-8714-0476'}, 'institutions': [{'id': 'https://openalex.org/I111950717', 'display_name': 'Macau University of Science and Technology', 'ror': 'https://ror.org/03jqs2n27', 'country_code': 'MO', 'type': 'education', 'lineage': ['https://openalex.org/I111950717', 'https://openalex.org/I4391767947']}], 'countries': ['MO'], 'is_corresponding': False, 'raw_author_name': 'Yong-Hua Zhao', 'raw_affiliation_strings': ['State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macao 999078, Macao SAR of P. R. China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macao 999078, Macao SAR of P. R. China', 'institution_ids': ['https://openalex.org/I111950717']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.962, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 38, 'citation_normalized_percentile': {'value': 0.557604, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '42', 'issue': '01', 'first_page': '61', 'last_page': '77'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10176', 'display_name': 'Mesenchymal stem cell research', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10176', 'display_name': 'Mesenchymal stem cell research', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10422', 'display_name': 'Angiogenesis and VEGF in Cancer', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T14144', 'display_name': 'Neurological Disease Mechanisms and Treatments', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/therapeutic-angiogenesis', 'display_name': 'Therapeutic angiogenesis', 'score': 0.6573911}, {'id': 'https://openalex.org/keywords/stroke', 'display_name': 'Stroke', 'score': 0.58698946}], 'concepts': [{'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.8903227}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8190633}, {'id': 'https://openalex.org/C2781188250', 'wikidata': 'https://www.wikidata.org/wiki/Q4455440', 'display_name': 'Therapeutic angiogenesis', 'level': 4, 'score': 0.6573911}, {'id': 'https://openalex.org/C2780007613', 'wikidata': 'https://www.wikidata.org/wiki/Q546523', 'display_name': 'Bone marrow', 'level': 2, 'score': 0.6538503}, {'id': 'https://openalex.org/C16930146', 'wikidata': 'https://www.wikidata.org/wiki/Q4381253', 'display_name': 'Stromal cell', 'level': 2, 'score': 0.6408297}, {'id': 'https://openalex.org/C4746552', 'wikidata': 'https://www.wikidata.org/wiki/Q1456827', 'display_name': 'Neurogenesis', 'level': 2, 'score': 0.627184}, {'id': 'https://openalex.org/C2780645631', 'wikidata': 'https://www.wikidata.org/wiki/Q671554', 'display_name': 'Stroke (engine)', 'level': 2, 'score': 0.58698946}, {'id': 'https://openalex.org/C3020199598', 'wikidata': 'https://www.wikidata.org/wiki/Q12202', 'display_name': 'Ischemic stroke', 'level': 3, 'score': 0.4310242}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.42874065}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.42226824}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.37647492}, {'id': 'https://openalex.org/C2778271429', 'wikidata': 'https://www.wikidata.org/wiki/Q1281049', 'display_name': 'Neovascularization', 'level': 3, 'score': 0.32732114}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.30641374}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.27676082}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.27668595}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.22741234}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.086740166}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016026', 'descriptor_name': 'Bone Marrow Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018919', 'descriptor_name': 'Neovascularization, Physiologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008517', 'descriptor_name': 'Phytotherapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D064591', 'descriptor_name': 'Allografts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003131', 'descriptor_name': 'Combined Modality Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003373', 'descriptor_name': 'Coumaric Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036145', 'descriptor_name': 'Ginsenosides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051793', 'descriptor_name': 'Hypoxia-Inducible Factor 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051793', 'descriptor_name': 'Hypoxia-Inducible Factor 1', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D057888', 'descriptor_name': 'Iridoid Glucosides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009416', 'descriptor_name': 'Nerve Regeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055495', 'descriptor_name': 'Neurogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052250', 'descriptor_name': 'Nitric Oxide Synthase Type III', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1142/s0192415x14500049', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S118315377', 'display_name': 'The American Journal of Chinese Medicine', 'issn_l': '0192-415X', 'issn': ['0192-415X', '1793-6853'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319815', 'host_organization_name': 'World Scientific', 'host_organization_lineage': ['https://openalex.org/P4310319815'], 'host_organization_lineage_names': ['World Scientific'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24467535', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.81, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 79, 'referenced_works': ['https://openalex.org/W1205300651', 'https://openalex.org/W1507985414', 'https://openalex.org/W1548786914', 'https://openalex.org/W1964210744', 'https://openalex.org/W1966391164', 'https://openalex.org/W1966841015', 'https://openalex.org/W1974547403', 'https://openalex.org/W1974962627', 'https://openalex.org/W1978139448', 'https://openalex.org/W1978501014', 'https://openalex.org/W1983042527', 'https://openalex.org/W1984485541', 'https://openalex.org/W1988786919', 'https://openalex.org/W1989560466', 'https://openalex.org/W1991958278', 'https://openalex.org/W1992069177', 'https://openalex.org/W2000163024', 'https://openalex.org/W2008843664', 'https://openalex.org/W2009957795', 'https://openalex.org/W2010327815', 'https://openalex.org/W2011398127', 'https://openalex.org/W2011823445', 'https://openalex.org/W2013142897', 'https://openalex.org/W2016688634', 'https://openalex.org/W2020707728', 'https://openalex.org/W2021810164', 'https://openalex.org/W2022886345', 'https://openalex.org/W2032337032', 'https://openalex.org/W2032936777', 'https://openalex.org/W2033822330', 'https://openalex.org/W2034669746', 'https://openalex.org/W2039402076', 'https://openalex.org/W2042113238', 'https://openalex.org/W2043052859', 'https://openalex.org/W2049088250', 'https://openalex.org/W2051943392', 'https://openalex.org/W2052393880', 'https://openalex.org/W2063011477', 'https://openalex.org/W2070532771', 'https://openalex.org/W2072166605', 'https://openalex.org/W2074406001', 'https://openalex.org/W2082889675', 'https://openalex.org/W2087485327', 'https://openalex.org/W2090334773', 'https://openalex.org/W2097255042', 'https://openalex.org/W2100975089', 'https://openalex.org/W2102129021', 'https://openalex.org/W2103006621', 'https://openalex.org/W2103291754', 'https://openalex.org/W2104376512', 'https://openalex.org/W2111349583', 'https://openalex.org/W2113892795', 'https://openalex.org/W2117381245', 'https://openalex.org/W2125655281', 'https://openalex.org/W2129282529', 'https://openalex.org/W2130929362', 'https://openalex.org/W2136876490', 'https://openalex.org/W2147112697', 'https://openalex.org/W2147981359', 'https://openalex.org/W2154844975', 'https://openalex.org/W2155945484', 'https://openalex.org/W2157955737', 'https://openalex.org/W2162711505', 'https://openalex.org/W2165673197', 'https://openalex.org/W2349166478', 'https://openalex.org/W2349472728', 'https://openalex.org/W2350052881', 'https://openalex.org/W2355454764', 'https://openalex.org/W2356643039', 'https://openalex.org/W2365985190', 'https://openalex.org/W2368272116', 'https://openalex.org/W2369740856', 'https://openalex.org/W2374236682', 'https://openalex.org/W2377933297', 'https://openalex.org/W2384691771', 'https://openalex.org/W2419641984', 'https://openalex.org/W2468844649', 'https://openalex.org/W2804842145', 'https://openalex.org/W2871268'], 'related_works': ['https://openalex.org/W53666519', 'https://openalex.org/W4248753785', 'https://openalex.org/W2884299723', 'https://openalex.org/W2418948529', 'https://openalex.org/W2188501710', 'https://openalex.org/W2135820098', 'https://openalex.org/W2054354069', 'https://openalex.org/W1999705906', 'https://openalex.org/W1982147073', 'https://openalex.org/W1967228040'], 'abstract_inverted_index': {'Ischemic': [0], 'stroke': [1], 'is': [2, 21, 37], 'a': [3, 13], 'clinical': [4], 'acute': [5], 'disease': [6], 'which': [7], 'causes': [8], 'neurological': [9, 64], 'dysfunction': [10], 'and': [11, 23, 62, 89, 105, 119], 'threatens': [12], "patient's": [14], 'life.': [15], 'Because': [16], 'the': [17, 27, 32, 35, 53, 113], 'mechanism': [18], 'of': [19, 34, 116], 'pathology': [20], 'complicated': [22], 'most': [24], 'patients': [25], 'miss': [26], 'best': [28], 'therapeutic': [29], 'window': [30], 'time,': [31], 'effect': [33], 'treatment': [36, 92], 'not': [38, 47], 'satisfied': [39], 'at': [40], 'present.': [41], 'Numerous': [42], 'studies': [43], 'indicated': [44], 'new': [45], 'vessels': [46], 'only': [48], 'recuperated': [49], 'blood': [50], 'flow': [51], 'in': [52, 77, 99, 103, 106, 125], 'ischemic': [54, 67], 'boundary': [55], 'zone,': [56], 'but': [57], 'also': [58], 'facilitated': [59], 'endogenous': [60], 'neurogenesis': [61], 'improved': [63], 'function': [65], 'after': [66], 'stroke.': [68], 'Therefore,': [69], 'angiogenesis': [70, 101, 131], 'has': [71], 'been': [72], 'an': [73], 'important': [74], 'research': [75], 'field': [76], 'neurovascular': [78], 'regeneration.': [79], 'Recently,': [80], 'some': [81], 'Chinese': [82, 117, 128], 'medicines,': [83], 'bone': [84], 'marrow': [85], 'stromal': [86], 'cells': [87], '(BMSCs)': [88], 'their': [90], 'combination': [91, 126], 'were': [93], 'demonstrated': [94], 'to': [95], 'have': [96], 'beneficial': [97], 'effects': [98], 'promoting': [100], 'both': [102], 'vitro': [104], 'vivo.': [107], 'In': [108], 'this': [109], 'review,': [110], 'we': [111], 'summarized': [112], 'effective': [114], 'mechanisms': [115], 'medicines': [118, 129], 'BMSCs,': [120], 'as': [121, 123], 'well': [122], 'BMSCs': [124], 'with': [127], 'on': [130], 'post-stroke.': [132]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2112323718', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 6}], 'updated_date': '2024-12-24T14:10:43.502152', 'created_date': '2016-06-24'}