Publication Information

{'id': 'https://openalex.org/W2112300479', 'doi': 'https://doi.org/10.1074/jbc.m601299200', 'title': 'Ubiquitous Calpains Promote Caspase-12 and JNK Activation during Endoplasmic Reticulum Stress-induced Apoptosis', 'display_name': 'Ubiquitous Calpains Promote Caspase-12 and JNK Activation during Endoplasmic Reticulum Stress-induced Apoptosis', 'publication_year': 2006, 'publication_date': '2006-04-06', 'ids': {'openalex': 'https://openalex.org/W2112300479', 'doi': 'https://doi.org/10.1074/jbc.m601299200', 'mag': '2112300479', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16597616'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m601299200', 'pdf_url': 'http://www.jbc.org/article/S0021925820559218/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820559218/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108833690', 'display_name': 'Yinfei Tan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210096394', 'display_name': 'Queens University', 'ror': 'https://ror.org/00strmv13', 'country_code': 'BD', 'type': 'education', 'lineage': ['https://openalex.org/I4210096394']}, {'id': 'https://openalex.org/I204722609', 'display_name': "Queen's University", 'ror': 'https://ror.org/02y72wh86', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I204722609']}], 'countries': ['BD', 'CA'], 'is_corresponding': False, 'raw_author_name': 'Yinfei Tan', 'raw_affiliation_strings': ["Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute"], 'affiliations': [{'raw_affiliation_string': "Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute", 'institution_ids': ['https://openalex.org/I4210096394', 'https://openalex.org/I204722609']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042937704', 'display_name': 'Nathalie Dourdin', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Nathalie Dourdin', 'raw_affiliation_strings': ['Department of Biochemistry'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083313615', 'display_name': 'Chao Wu', 'orcid': 'https://orcid.org/0000-0002-8417-7043'}, 'institutions': [{'id': 'https://openalex.org/I4210096394', 'display_name': 'Queens University', 'ror': 'https://ror.org/00strmv13', 'country_code': 'BD', 'type': 'education', 'lineage': ['https://openalex.org/I4210096394']}, {'id': 'https://openalex.org/I204722609', 'display_name': "Queen's University", 'ror': 'https://ror.org/02y72wh86', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I204722609']}], 'countries': ['BD', 'CA'], 'is_corresponding': False, 'raw_author_name': 'Chao Wu', 'raw_affiliation_strings': ["Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute"], 'affiliations': [{'raw_affiliation_string': "Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute", 'institution_ids': ['https://openalex.org/I4210096394', 'https://openalex.org/I204722609']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025080911', 'display_name': 'Teresa De Veyra', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210096394', 'display_name': 'Queens University', 'ror': 'https://ror.org/00strmv13', 'country_code': 'BD', 'type': 'education', 'lineage': ['https://openalex.org/I4210096394']}, {'id': 'https://openalex.org/I204722609', 'display_name': "Queen's University", 'ror': 'https://ror.org/02y72wh86', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I204722609']}], 'countries': ['BD', 'CA'], 'is_corresponding': False, 'raw_author_name': 'Teresa De Veyra', 'raw_affiliation_strings': ["Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute"], 'affiliations': [{'raw_affiliation_string': "Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute", 'institution_ids': ['https://openalex.org/I4210096394', 'https://openalex.org/I204722609']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028063113', 'display_name': 'John S. Elce', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'John S. Elce', 'raw_affiliation_strings': ['Department of Biochemistry'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035463544', 'display_name': 'Peter A. Greer', 'orcid': 'https://orcid.org/0000-0002-7809-5105'}, 'institutions': [{'id': 'https://openalex.org/I204722609', 'display_name': "Queen's University", 'ror': 'https://ror.org/02y72wh86', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I204722609']}, {'id': 'https://openalex.org/I4210096394', 'display_name': 'Queens University', 'ror': 'https://ror.org/00strmv13', 'country_code': 'BD', 'type': 'education', 'lineage': ['https://openalex.org/I4210096394']}], 'countries': ['BD', 'CA'], 'is_corresponding': True, 'raw_author_name': 'Peter A. Greer', 'raw_affiliation_strings': ['Department of Biochemistry', "Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario K7L 3N6, Canada", "Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute"], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry', 'institution_ids': []}, {'raw_affiliation_string': "Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario K7L 3N6, Canada", 'institution_ids': ['https://openalex.org/I204722609']}, {'raw_affiliation_string': "Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute", 'institution_ids': ['https://openalex.org/I4210096394', 'https://openalex.org/I204722609']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5035463544'], 'corresponding_institution_ids': ['https://openalex.org/I204722609', 'https://openalex.org/I4210096394'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 7.313, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 232, 'citation_normalized_percentile': {'value': 0.999848, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '281', 'issue': '23', 'first_page': '16016', 'last_page': '16024'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12610', 'display_name': 'RNA regulation and disease', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.88495266}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.7638352}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.67497987}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.61843663}, {'id': 'https://openalex.org/C56928146', 'wikidata': 'https://www.wikidata.org/wiki/Q2934402', 'display_name': 'Calpain', 'level': 3, 'score': 0.5699632}, {'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.4692837}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45147318}, {'id': 'https://openalex.org/C12519072', 'wikidata': 'https://www.wikidata.org/wiki/Q14914370', 'display_name': 'Caspase 3', 'level': 4, 'score': 0.43468416}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23702878}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.20250678}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13380775}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.08561045}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002154', 'descriptor_name': 'Calpain', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D020169', 'descriptor_name': 'Caspases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D048670', 'descriptor_name': 'MAP Kinase Kinase 4', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002154', 'descriptor_name': 'Calpain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053454', 'descriptor_name': 'Caspase 12', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020169', 'descriptor_name': 'Caspases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048670', 'descriptor_name': 'MAP Kinase Kinase 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018613', 'descriptor_name': 'Microscopy, Confocal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m601299200', 'pdf_url': 'http://www.jbc.org/article/S0021925820559218/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16597616', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m601299200', 'pdf_url': 'http://www.jbc.org/article/S0021925820559218/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W1599120754', 'https://openalex.org/W1607531254', 'https://openalex.org/W1905806846', 'https://openalex.org/W1966081420', 'https://openalex.org/W1969268163', 'https://openalex.org/W1969419810', 'https://openalex.org/W1979431065', 'https://openalex.org/W1984611855', 'https://openalex.org/W1985327599', 'https://openalex.org/W1985339713', 'https://openalex.org/W1986737010', 'https://openalex.org/W1988740497', 'https://openalex.org/W1989858437', 'https://openalex.org/W1996952569', 'https://openalex.org/W2003362321', 'https://openalex.org/W2015616869', 'https://openalex.org/W2022680168', 'https://openalex.org/W2032444047', 'https://openalex.org/W2034213169', 'https://openalex.org/W2043260674', 'https://openalex.org/W2060184827', 'https://openalex.org/W2060857878', 'https://openalex.org/W2061016075', 'https://openalex.org/W2064122617', 'https://openalex.org/W2064950130', 'https://openalex.org/W207305739', 'https://openalex.org/W2073173679', 'https://openalex.org/W2080901528', 'https://openalex.org/W2081607456', 'https://openalex.org/W2082734784', 'https://openalex.org/W2085158671', 'https://openalex.org/W2087261949', 'https://openalex.org/W2087734679', 'https://openalex.org/W2087877138', 'https://openalex.org/W2093241572', 'https://openalex.org/W2097672870', 'https://openalex.org/W2099128795', 'https://openalex.org/W2106104034', 'https://openalex.org/W2114111268', 'https://openalex.org/W2115205812', 'https://openalex.org/W2117494250', 'https://openalex.org/W2120736516', 'https://openalex.org/W2123280495', 'https://openalex.org/W2125726816', 'https://openalex.org/W2127639686', 'https://openalex.org/W2144135883', 'https://openalex.org/W2147655289', 'https://openalex.org/W2149227688', 'https://openalex.org/W2149721868', 'https://openalex.org/W2162797237', 'https://openalex.org/W2165301262', 'https://openalex.org/W2167307101', 'https://openalex.org/W2169436026', 'https://openalex.org/W2178185732', 'https://openalex.org/W2395622462'], 'related_works': ['https://openalex.org/W3031468220', 'https://openalex.org/W2991046320', 'https://openalex.org/W2922191166', 'https://openalex.org/W2766222389', 'https://openalex.org/W2385169084', 'https://openalex.org/W2356853174', 'https://openalex.org/W2148632242', 'https://openalex.org/W2095713125', 'https://openalex.org/W2089198803', 'https://openalex.org/W2039420809'], 'abstract_inverted_index': {'Ubiquitously': [0], 'expressed': [1], 'mu-': [2, 49], 'and': [3, 10, 22, 26, 46, 50, 83, 97, 116, 129], 'm-calpain': [4], 'proteases': [5], 'are': [6], 'implicated': [7], 'in': [8, 57, 110, 125], 'development': [9], 'apoptosis.': [11], 'They': [12], 'consist': [13], 'of': [14, 48, 55, 94], '80-kDa': [15], 'catalytic': [16], 'subunits': [17], 'encoded': [18, 32], 'by': [19, 33], 'the': [20, 34, 44, 58, 98, 114, 122], 'capn1': [21], 'capn2': [23], 'genes,': [24], 'respectively,': [25], 'a': [27, 89, 118], 'common': [28], '28-kDa': [29], 'regulatory': [30, 38], 'subunit': [31, 39], 'capn4': [35, 56], 'gene.': [36], 'The': [37], 'is': [40], 'required': [41], 'to': [42, 77, 88], 'maintain': [43], 'stability': [45], 'activity': [47], 'm-calpains.': [51], 'Accordingly,': [52], 'genetic': [53, 105], 'disruption': [54], 'mouse': [59], 'eliminated': [60], 'both': [61, 95], 'ubiquitous': [62, 123], 'calpain': [63, 72, 90], 'activities.': [64], 'In': [65], 'embryonic': [66], 'fibroblasts': [67], 'derived': [68], 'from': [69], 'these': [70], 'mice,': [71], 'deficiency': [73], 'correlated': [74], 'with': [75], 'resistance': [76], 'endoplasmic': [78], 'reticulum': [79], '(ER)': [80], 'stress-induced': [81], 'apoptosis,': [82], 'this': [84], 'was': [85], 'directly': [86], 'related': [87], 'requirement': [91], 'for': [92, 107, 121], 'activation': [93, 112], 'caspase-12': [96, 111], 'ASK1-JNK': [99], 'cascade.': [100], 'This': [101], 'study': [102], 'provides': [103], 'compelling': [104], 'evidence': [106], "calpain's": [108], 'role': [109, 120], 'at': [113], 'ER,': [115], 'reveals': [117], 'novel': [119], 'calpains': [124], 'ER-stress': [126], 'induced': [127], 'apoptosis': [128], 'JNK': [130], 'activation.': [131]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2112300479', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 17}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-12-30T22:10:25.530469', 'created_date': '2016-06-24'}