Connective Tissue Growth Factor (CTGF) Is Regulated by Wnt and Bone Morphogenetic Proteins Signaling in Osteoblast Differentiation of Mesenchymal Stem Cells

Name: Work Video:
Duration: 3 min 30 s
Qing Luo; Quan Kang; Weike Si; Wei Jiang; Jong Kyung Park; Ying Peng; Xinmin Li; Hue H. Luu; Jeffrey Luo; Anthony Montag; Rex C. Haydon; Tong‐Chuan He
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741, 757, 857, 907, 925, 929, 972, 977, 1278, 1360, 1366, 1376, 1386, 1429, 1653, 1770, 1774, 1780, 1935, 2072, 2096, 2146, 2224, 2241, 2276, 2284, 2309, 2552, 2568, 2575, 2600, 2612, 2618, 2639, 2642, 2656, 2660, 2670, 2696, 2923, 2928, 3163, 3183, 3223, 3228, 3252, 3266, 3284, 3375, 3380, 3390, 3406, 3500, 3537, 3553, 3563, 3579, 3698, 3703, 3714, 3782, 3798, 3826, 3850, 3994, 4031, 4095, 4112, 4117, 4144, 4185, 4207, 4278, 4291, 4311, 4353, 4381, 4398, 4402, 4496], 'expression': [36, 90, 98, 121, 135, 197, 245, 299, 307, 330, 344, 406, 930, 974, 1439, 2258, 2569, 2598, 2673, 2952, 3538], 'profiles': [37, 246, 975], 'stimulated': [42, 251, 983, 2266], 'with': [43, 252, 856, 922, 936, 984, 1277, 1383, 1403, 2079, 2095, 2104, 2763, 2799, 3144, 3149, 3227, 3254, 3449, 3573, 3722, 3732, 3741, 3747, 3761, 3786, 3800, 3832, 3985, 4081, 4100, 4158, 4177, 4322, 4336], 'Wnt3A': [44, 84, 109, 158, 253, 293, 318, 367, 1270, 2239, 2272, 2581, 2933, 4521], 'osteogenic': [46, 105, 132, 166, 255, 314, 341, 375, 738, 762, 985, 1025, 2251, 2269, 2605, 2678, 4399], 'BMPs,': [47, 256, 746, 2830, 4407], 'identified': [50, 259, 626], 'connective': [51, 260, 511], 'tissue': [52, 261, 512, 1320], 'growth': [53, 262, 513, 520], 'factor': [54, 263], '(CTGF)': [55, 264], 'as': [56, 182, 265, 391, 1457, 2297, 2726, 2846, 2850, 2998, 3053, 3358, 3420, 3513, 3597, 3837, 3857, 4509, 4511], 'potential': [58, 185, 267, 394], 'target': [59, 268, 932, 3194, 3564], 'BMP': [63, 272, 1124, 2216, 4385], 'signaling.': [64, 273], 'We': [65, 274, 968, 2134, 2565], 'confirmed': [66, 275, 3497], 'microarray': [68, 277, 3233], 'results,': [69, 278], 'demonstrated': [72, 281, 750, 1023, 2136, 2566, 4409], 'that': [73, 87, 108, 153, 192, 282, 296, 317, 362, 401, 751, 981, 1024, 1039, 1314, 1634, 1766, 2064, 2137, 2195, 2235, 2274, 2318, 2567, 2630, 2648, 2665, 3268, 4320, 4490], 'CTGF': [74, 89, 97, 123, 137, 154, 179, 196, 283, 298, 306, 332, 346, 363, 388, 405, 2281, 2294, 2556, 2571, 2597, 2616, 2631, 2671, 2974, 3364, 3384, 3545, 3589, 3816], 'was': [75, 91, 124, 138, 284, 300, 333, 347, 2572, 2942, 2962, 2975, 3170, 3279, 3335, 3365, 3401, 3419, 3489, 3511, 3584, 3706, 3818, 3847, 4047, 4120, 4275, 4329], 'up-regulated': [76, 156, 285, 365, 2287], 'at': [77, 161, 286, 370, 2574, 2779, 2809, 3394, 3432, 3457, 3479, 3578, 3724, 3751, 3810, 3980, 4035, 4071, 4115, 4164, 4194], 'early': [79, 163, 288, 372, 2211, 2228, 2250, 2576, 2643], 'stage': [80, 164, 289, 373, 2577], 'BMP-9': [82, 160, 291, 369, 755, 2237, 2291, 2562, 2579, 2624, 4494, 4519], 'stimulations': [85, 294], 'Wnt3A-regulated': [88, 297], 'β-catenin-dependent.': [92, 301], 'RNA': [93, 302, 516, 3169, 3175, 3189, 3319, 3560, 3673], 'interference-mediated': [94, 303], 'knockdown': [95, 304, 2595], 'significantly': [99, 308, 2286], 'diminished': [100, 309, 2599], 'BMP-9-induced,': [101, 310, 2601], 'not': [103, 312, 495, 2603], 'Wnt3A-induced,': [104, 313, 2604], 'differentiation,': [106, 167, 315, 376], 'suggesting': [107, 191, 316, 400, 2194], 'may': [110, 169, 198, 319, 378, 407, 1040, 1706, 2632, 2674], 'also': [111, 320, 2319], 'regulate': [112, 170, 321, 379], 'CTGF-independent': [117, 326], 'fashion.': [118, 327], 'However,': [119, 328, 2611], 'constitutive': [120, 329, 2613], 'shown': [125, 139, 334, 348, 1758, 4515], 'to': [126, 140, 335, 349, 674, 1365, 1373, 1407, 1428, 1437, 1759, 2071, 2550, 2585, 2652, 2677, 2989, 3182, 3198, 3200, 3241, 3322, 3373, 3519, 3586, 3671, 3685, 3713, 4012, 4030, 4204, 4260, 4284, 4310, 4341, 4499], 'inhibit': [127, 336], 'both': [128, 337, 764, 2215, 2236, 2290, 4050, 4123], 'BMP-9-': [129, 338], 'Wnt3A-induced': [131, 340, 4387], 'differentiation.': [133, 342, 2077], 'Exogenous': [134, 343], 'promote': [141, 350], 'cell': [142, 351, 2691, 3134, 4045, 4075], 'migration': [143, 352, 4046, 4208], 'recruitment': [145, 174, 354, 383], 'cells.': [149, 208, 358, 417, 2256, 2610, 4287], 'Our': [150, 359, 1021, 2627], 'findings': [151, 360, 2062, 2628], 'demonstrate': [152, 361, 2234, 2629], 'by': [157, 366, 854, 1363, 1413, 1416, 2214, 2267, 2289, 2561, 2623, 2710, 2936, 3037, 3249, 3264, 3282, 3367, 3404, 3475, 3491, 3498, 3536, 3758, 3796, 3849, 4019, 4317, 4351], 'which': [168, 377, 915, 2087, 4244], 'proliferation': [172, 381, 2075, 2640], 'osteoprogenitor': [176, 385], 'cells;': [177, 386], 'however,': [178, 387], 'down-regulated': [181, 390, 2654], 'committed': [187, 396, 2661], 'pre-osteoblasts': [188, 397], 'increases,': [189, 398], 'strongly': [190, 399], 'tight': [193, 402, 2197], 'regulation': [194, 403, 2198, 2668], 'be': [199, 408, 2653, 2675], 'essential': [200, 409, 2676], 'for': [201, 410, 1405, 2204, 2312, 3137, 3193, 3273, 3326, 3424, 3427, 3435, 3440, 3446, 3460, 3465, 3471, 3529, 3599, 3632, 3727, 3754, 3776, 3792, 3807, 4199, 4262, 4298, 4305, 4365], 'normal': [202, 411, 2073, 2205, 2681], 'from': [421, 1397, 2695, 2822, 3517, 3562, 4060, 4131], 'pluripotent': [423], 'orchestrated': [430], 'process': [431, 2621], '(1Pittenger': [432], 'M.F.': [433, 1583], 'Mackay': [434], 'A.M.': [435, 464, 1797], 'Beck': [436], 'S.C.': [437, 1990, 2330, 2380, 2443, 2493], 'Jaiswal': [438], 'R.K.': [439], 'Douglas': [440], 'R.': [441, 1292, 1328, 1342, 1446, 1540, 1909, 2006, 2112, 2162, 2360, 2376, 2473, 2489], 'Mosca': [442], 'J.D.': [443, 2121], 'Moorman': [444], 'M.A.': [445, 1565, 1953, 2178], 'Simonetti': [446], 'D.W.': [447], 'Craig': [448], 'S.': [449, 1195, 1235, 1250, 1548, 1603, 1795, 1815, 1819, 1998, 2022, 2744, 2895, 2910, 3004, 3019, 3087, 3102, 3297], 'Marshak': [450], 'D.R.': [451, 2345, 2374, 2421, 2458, 2487, 2534], 'Science.': [452, 609, 1447, 1485, 1694, 3075], '1999;': [453, 1216, 1295, 1503, 1521, 1550, 2334, 2447], '284:': [454], '143-147Crossref': [455], 'PubMed': [456, 475, 489, 613, 636, 653, 667, 692, 727, 804, 844, 881, 897, 947, 963, 1016, 1075, 1117, 1147, 1161, 1191, 1203, 1219, 1240, 1263, 1298, 1334, 1351, 1451, 1489, 1511, 1524, 1553, 1608, 1628, 1673, 1698, 1730, 1747, 1923, 1967, 2056, 2129, 2189, 2337, 2352, 2368, 2400, 2415, 2427, 2450, 2465, 2481, 2513, 2528, 2540, 2749, 2887, 2915, 3024, 3079, 3107, 3302, 3894, 3934, 3965, 4445, 4485], 'Scopus': [457, 476, 490, 614, 637, 654, 668, 693, 728, 805, 845, 882, 898, 948, 964, 1017, 1076, 1118, 1148, 1162, 1204, 1220, 1241, 1264, 1299, 1335, 1352, 1452, 1490, 1512, 1525, 1554, 1609, 1674, 1699, 1731, 1748, 1924, 1968, 2057, 2130, 2190, 2338, 2353, 2369, 2401, 2416, 2428, 2451, 2466, 2482, 2514, 2529, 2541, 2750, 2888, 2916, 3025, 3080, 3108, 3303, 3895, 3935, 3966, 4446, 4486], '(18406)': [458], 'Google': [459, 478, 492, 591, 616, 639, 656, 670, 695, 705, 730, 807, 847, 884, 900, 950, 966, 1019, 1078, 1120, 1150, 1164, 1192, 1206, 1222, 1243, 1266, 1301, 1337, 1354, 1454, 1492, 1514, 1527, 1556, 1611, 1629, 1676, 1701, 1733, 1750, 1926, 1970, 2059, 2132, 2192, 2340, 2355, 2371, 2403, 2418, 2430, 2453, 2468, 2484, 2516, 2531, 2543, 2752, 2890, 2918, 3027, 3082, 3110, 3305, 3897, 3937, 3968, 4448, 4488], 'Scholar,': [460, 479, 592, 640, 657, 696, 808, 885, 951, 1079, 1151, 1193, 1207, 1223, 1244, 1338, 1493, 1515, 1528, 1557, 1612, 1677, 1734, 1971, 2341, 2356, 2372, 2404, 2419, 2454, 2469, 2485, 2517, 2532, 2891, 3083, 3898, 3938, 4449], '2Olsen': [461], 'B.R.': [462, 1911], 'Reginato': [463, 1796], 'Wang': [465, 607, 1798, 2731], 'W.': [466, 579, 773, 822, 1001, 1060, 1087, 1089, 1813, 1892, 1899, 2164, 2856, 3863, 3912, 3950, 4414, 4463], 'Annu.': [467, 875, 941, 1139, 1343], 'Rev.': [468, 482, 663, 876, 942, 1140, 1344], 'Cell': [469, 1141, 1156, 1345, 2332, 2410, 2445, 2523, 2684, 3971, 4065], 'Dev.': [470, 632, 688, 1142, 1199, 1215, 1294, 1330, 1346, 1624, 1669], 'Biol.': [471, 1107, 1143, 1157, 1347, 2364, 2477], '2000;': [472, 889, 955, 1158, 1188, 1237, 1260, 1625, 2349, 2462], '16:': [473], '191-220Crossref': [474], '(794)': [477], '3Aubin': [480], 'J.E.': [481], 'Endocr.': [483], 'Metab.': [484, 2348, 2461], 'Disord.': [485], '2001;': [486, 702, 1144, 1727, 1915, 3299], '2:': [487], '81-94Crossref': [488], '(411)': [491], 'Scholar).': [493, 617, 671, 706, 731, 848, 901, 967, 1020, 1121, 1165, 1267, 1302, 1355, 1630, 1702, 1751, 1927, 2060, 2133, 2431, 2544, 2753, 2919, 3028, 3111, 3306, 3969], 'Although': [494], 'understood,': [497], '1The': [502], 'abbreviations': [503], 'used': [504, 2988, 3044, 3192, 3321, 3357, 3512, 3585, 3595, 3836], 'are:': [505], 'BMP,': [506], 'proteins;': [509], 'CTGF,': [510, 2314, 3601], 'factor;': [514], 'RNAi,': [515], 'interference;': [517], 'TGFβ,': [518], 'transforming': [519], 'factor-β;': [521], 'FCS,': [522, 2801, 3146], 'fetal': [523, 2765, 3748, 3762], 'calf': [524, 2766, 3749, 3763], 'serum;': [525], 'GFP,': [526, 3633], 'green': [527], 'fluorescent': [528], 'protein;': [529], 'qPCR,': [530], 'quantitative': [531], 'real': [532], 'time': [533, 3165], 'PCR;': [534], 'GAPDH,': [535], 'glyceraldehyde-3-phosphate': [536], 'dehydrogenase;': [537], 'PBS,': [538], 'phosphate-buffered': [539], 'saline;': [540], 'siRNA,': [541], 'small': [542], 'interfering': [543], 'RNA;': [544], 'DMEM,': [545, 4186, 4220, 4235], "Dulbecco's": [546], 'modified': [547], "Eagle's": [548], 'medium;': [549], 'BSA,': [550], 'bovine': [551], 'serum': [552, 2767, 3750, 3764], 'albumin;': [553], 'ECM,': [554], 'extracellular': [555], 'matrix;': [556], 'ALP,': [557], 'alkaline': [558, 2244, 4527], 'phosphatase.': [559], 'play': [560, 679, 1041, 1707, 2633], 'an': [561, 680, 1638, 1708, 2634, 2955, 3045, 3270], 'important': [562, 681, 1639, 1709, 2203, 2635], 'role': [563, 682, 1043, 1131, 1641, 1710, 2554, 2636], 'subsequent': [569], 'formation': [571], '(4Urist': [572], 'M.R.': [573], 'Nilsson': [574], 'O.': [575, 1517], 'Rasmussen': [576, 2113], 'J.': [577, 796, 832, 874, 940, 1010, 1069, 1099, 1106, 1135, 1138, 1284, 1532, 1569, 1571, 1681, 1687, 1741, 1811, 1823, 1945, 1947, 1962, 1980, 2045, 2124, 2184, 2422, 2535, 2879, 2900, 3009, 3092, 3886, 3922, 3959, 4437, 4473], 'Hirota': [578], 'Lovell': [580], 'T.': [581, 583, 1719, 1801, 1856, 1874, 1907, 2168, 2176], 'Schmalzreid': [582], 'Finerman': [584], 'G.A.': [585], 'Clin.': [586], 'Orthop.': [587], '1987;': [588], '214:': [589], '295-304PubMed': [590], '5Wozney': [593], 'J.M.': [594], 'Rosen': [595], 'V.': [596, 642], 'Celeste': [597], 'A.J.': [598, 1597, 1622, 2032], 'Mitsock': [599], 'L.M.': [600, 1835, 1943], 'Whitters': [601], 'M.J.': [602, 1288, 1896], 'Kriz': [603], 'R.W.': [604], 'Hewick': [605], 'R.M.': [606, 1213], 'E.A.': [608], '1988;': [610], '242:': [611], '1528-1534Crossref': [612], '(3438)': [615], 'At': [618, 3162, 3989, 4038, 4090, 4103, 4168], 'least': [619], '15': [620, 3728, 3990, 4091], 'types': [621, 743, 4247, 4404], 'BMPs': [623, 672, 710, 849, 986, 989, 1026, 1172, 2270], 'have': [624, 711, 748, 969, 1176, 2135], 'been': [625, 1177, 1757], 'humans': [628], '(6Hogan': [629, 685], 'B.L.': [630, 686], 'Genes': [631, 687, 1214, 1293, 1329, 1623, 1668], '1996;': [633, 689], '10:': [634, 690], '1580-1594Crossref': [635, 691], '(1737)': [638, 694], '7Rosen': [641], 'Thies': [643], 'R.S.': [644, 1211, 1740, 1878], 'Trends': [645], 'Genet.': [646, 2047, 2347, 2460], '1992;': [647], '8:': [648, 665], '97-102Abstract': [649], 'Full': [650, 892, 894, 958, 960, 1112, 1114, 1506, 1508, 1918, 1920, 2051, 2053], 'Text': [651, 893, 895, 959, 961, 1113, 1115, 1507, 1509, 1919, 1921, 2052, 2054], 'PDF': [652, 896, 962, 1116, 1510, 1922, 2055], '(234)': [655], '8Reddi': [658], 'A.H.': [659], 'Cytokine': [660], 'Growth': [661], 'Factor': [662], '1997;': [664, 1331], '11-20Crossref': [666], '(256)': [669], 'belong': [673], 'TGF-β': [676], 'superfamily': [677], 'development': [684, 720, 1133, 1181], '9Kingsley': [697], 'D.M.': [698], 'Novartis': [699], 'Found.': [700], 'Symp.': [701], '232:': [703], '213-222PubMed': [704], 'Genetic': [707], 'disruptions': [708], 'resulted': [712], 'various': [714, 2268, 4036], 'skeletal': [715], 'extraskeletal': [717], 'abnormalities': [718], 'during': [719, 1179, 2655], '(10Zhao': [721], 'G.Q.': [722], 'Genesis.': [723], '2003;': [724, 801, 1013, 1072, 2126, 2397, 2412, 2424, 2510, 2525, 2537, 2884, 3891, 3962, 4442], '35:': [725], '43-56Crossref': [726], '(308)': [729], 'Through': [732], 'comprehensive': [734, 4395], 'analysis': [735, 2260, 2279, 3278, 3369, 3400, 3494, 4396], 'activity': [739, 853, 2201, 2242, 2650, 3846, 4400], '14': [742, 4403], 'human': [745, 2144, 2839, 2960, 3383, 4406], 'recently': [749, 970], 'BMP-2,': [752, 1028, 2840, 4491], 'BMP-6,': [753, 1029, 4492], 'most': [758, 2147, 2277, 2285], 'potent': [759], 'inducers': [760], 'vitro': [766, 3555, 3676, 4508], 'vivo': [769], '(11Cheng': [770, 2853, 3860, 4411], 'H.': [771, 814, 995, 1054, 1256, 1290, 1473, 1799, 1860, 1882, 2172, 2394, 2507, 2854, 3063, 3861, 3904, 3944, 4412, 4455], 'Jiang': [772, 821, 1000, 1059, 1086, 2163, 2855, 3862, 3911, 3949, 4413, 4462], 'Phillips': [774, 2857, 3864, 4415], 'F.M.': [775, 2858, 3865, 4416], 'Haydon': [776, 835, 1006, 1065, 1102, 2859, 3866, 3925, 3955, 4417, 4476], 'R.C.': [777, 836, 1007, 1066, 1103, 1854, 2156, 2860, 3867, 3926, 3956, 4418, 4477], 'Peng': [778, 815, 2861, 3868, 3905, 4419, 4456], 'Y.': [779, 816, 834, 991, 1050, 1081, 1787, 2002, 2116, 2862, 3869, 3906, 3924, 3940, 4420, 4457, 4475], 'Zhou': [780, 2165, 2863, 2894, 3003, 3086, 3870, 4421], 'L.': [781, 1229, 1475, 1614, 1736, 1876, 1949, 1996, 2008, 2166, 2864, 3065, 3871, 4422], 'Luu': [782, 823, 1002, 1061, 1092, 2865, 3872, 3913, 3951, 4423, 4464], 'H.H.': [783, 824, 1003, 1062, 1093, 2866, 3873, 3914, 3952, 4424, 4465], 'An': [784, 2257, 2867, 2951, 3874, 4425], 'N.': [785, 1254, 1791, 1960, 2016, 2122, 2406, 2519, 2868, 3875, 4426], 'Breyer': [786, 2173, 2869, 3876, 4427], 'B.': [787, 1482, 1499, 1575, 1843, 1848, 1852, 1886, 1888, 1905, 1992, 2020, 2118, 2174, 2388, 2390, 2408, 2501, 2503, 2521, 2736, 2870, 2904, 3013, 3072, 3096, 3877, 4428], 'Vanichakarn': [788, 827, 2871, 3878, 3917, 4429, 4468], 'P.': [789, 828, 1587, 1829, 2039, 2872, 3879, 3918, 4430, 4469], 'Szatkowski': [790, 825, 2873, 3880, 3915, 4431, 4466], 'J.P.': [791, 826, 1975, 2874, 3881, 3916, 4432, 4467], 'Park': [792, 829, 1004, 1063, 1094, 2875, 3882, 3919, 3953, 4433, 4470], 'J.Y.': [793, 830, 1005, 1064, 2876, 3883, 3920, 3954, 4434, 4471], 'He': [794, 837, 1008, 1067, 1104, 2181, 2877, 3884, 3927, 3957, 4435, 4478], 'T.C.': [795, 1009, 1068, 1105, 1467, 1495, 2182, 2878, 2893, 3002, 3057, 3085, 3885, 3958, 4436], 'Bone': [797, 2880, 3887, 4438], 'Jt.': [798, 2881, 3888, 4439], 'Surg.': [799, 2882, 3889, 4440], 'Am.': [800, 2044, 2883, 3890, 4441], '85:': [802, 2885, 3892, 4443], '1544-1552Crossref': [803, 2886, 3893, 4444], '(837)': [806, 2889, 3896, 4447], '12Kang': [809, 3899, 4450], 'Q.': [810, 993, 1052, 1083, 1085, 3900, 3942, 4451], 'Sun': [811, 998, 1057, 3901, 3947, 4452], 'M.H.': [812, 999, 1058, 3902, 3948, 4453], 'Cheng': [813, 994, 1053, 2171, 3903, 3943, 4454], 'Montag': [817, 1100, 2179, 3907, 4458], 'A.G.': [818, 1101, 2180, 3908, 4459], 'Deyrup': [819, 2157, 3909, 4460], 'A.T.': [820, 3910, 4461], 'Luo': [831, 1084, 1098, 3921, 4472], 'Li': [833, 996, 1055, 1096, 3923, 3945, 4474], 'T.-C.': [838, 3928, 4479], 'Gene': [839, 3546, 3929, 4480], 'Ther.': [840, 3930, 4481], '2004;': [841, 1109, 1448, 3931, 4482], '11:': [842, 1332, 3932, 4483], '1312-1320Crossref': [843, 3933, 4484], '(521)': [846, 3936, 4487], 'fulfill': [850], 'their': [851], 'interacting': [855], 'heterodimeric': [858, 920], 'complex': [859, 921], 'two': [861], 'transmembrane': [862], 'serine/threonine': [863], 'kinase': [864, 1395], 'receptors,': [865], 'BMPR': [866, 870], 'type': [867, 871], 'I': [868, 4248], 'II': [872, 3343], '(13Massague': [873, 939], 'Biochem.': [877, 943, 1012, 1071, 1743, 3961], '1998;': [878, 944, 1200, 1348, 1486, 1605, 1695, 2912, 3021, 3076, 3104], '67:': [879, 945], '753-791Crossref': [880, 946], '(4040)': [883, 949], '14Wrana': [886, 952], 'J.L.': [887, 953, 1153], 'Cell.': [888, 954, 1011, 1070, 1502, 1742, 1914, 3960], '100:': [890, 956], '189-192Abstract': [891, 957], '(366)': [899, 965], 'The': [902, 1303, 1356, 2208, 2432, 2717, 2969, 3212, 3231, 3276, 3330, 3347, 3396, 3416, 3484, 3592, 3665, 3679, 3736, 3813, 4256, 4273, 4288, 4327, 4343, 4362], 'activated': [903, 2142], 'receptor': [904], 'kinases': [905], 'phosphorylate': [906], 'transcription': [908, 1434, 3677], 'factors': [909, 1435], 'Smads': [910], '1,': [911, 4105], '5,': [912], 'or': [913, 2563, 2625, 2824, 3160, 3382, 3590, 3831, 3987, 4021, 4088, 4162], '8,': [914], 'turn': [917], 'form': [918, 2149], 'Smad4': [923], 'nucleus': [926], 'activate': [928, 1438], 'genes': [933, 1442, 1647, 2288, 3209, 3253, 3267], 'concert': [935], 'other': [937], 'co-activators': [938], 'gene': [973, 1772, 2672, 3203], 'pre-osteoblast': [978], 'precursor': [979], 'were': [982, 2693, 2708, 2724, 2757, 2787, 2820, 2848, 2987, 3035, 3130, 3191, 3220, 3236, 3320, 3352, 3526, 3534, 3669, 3683, 3720, 3739, 3784, 3835, 3975, 3998, 4008, 4017, 4028, 4069, 4079, 4098, 4141, 4156, 4174, 4214, 4238, 4258, 4280, 4293, 4315, 4349, 4368], 'versus': [987], 'non-osteogenic': [988], '(15Peng': [990, 1049], 'Kang': [992, 1051, 1082, 3941], 'X.': [997, 1056, 1097, 2004, 2024, 3946], '90:': [1014, 1073, 3963], '1149-1165Crossref': [1015, 1074, 3964], '(169)': [1018, 1077, 3967], 'results': [1022, 4059, 4130, 4374], '(e.g.': [1027, 1648], 'BMP-9)': [1031], 'distinct': [1034], 'set': [1035, 4205], 'downstream': [1037, 1441], 'targets': [1038, 2212], 'BMP-induced': [1046], '16Peng': [1080], 'Si': [1088], 'Liu': [1090], 'B.A.': [1091], 'J.K.': [1095], 'Chem.': [1108], '279:': [1110], '32941-32949Abstract': [1111], '(195)': [1119], 'Cross-talk': [1122], 'between': [1123], 'plays': [1128, 1637], 'critical': [1130, 2070], '(17Capdevila': [1134], 'Izpisua': [1136], 'Belmonte': [1137, 1690], '17:': [1145], '87-132Crossref': [1146], '(351)': [1149], '18Christian': [1152], 'Curr.': [1154], 'Opin.': [1155], '12:': [1159], '244-249Crossref': [1160], '(69)': [1163], 'synergistic': [1167], 'antagonistic': [1169], 'roles': [1170], 'observed': [1178], 'embryonic': [1180, 1318], '(19Hartmann': [1182], 'C.': [1183, 1471, 1536, 1579, 1683, 1717, 1837, 1984, 2012, 2386, 2499, 3061, 3289], 'Tabin': [1184, 1692], 'C.J.': [1185, 1693], 'Development': [1186], '(Camb.).': [1187], '127:': [1189], '3141-3159Crossref': [1190], '20Hoppler': [1194], 'Moon': [1196], 'R.T.': [1197], 'Mech.': [1198], '71:': [1201, 2350, 2463], '119-129Crossref': [1202], '(145)': [1205], '21Baker': [1208], 'J.C.': [1209, 1691], 'Beddington': [1210], 'Harland': [1212], '13:': [1217, 1296], '3149-3159Crossref': [1218], '(279)': [1221], '22Labbe': [1224], 'E.': [1225, 1872, 1884, 2108, 2114], 'Letamendia': [1226], 'A.': [1227, 1236, 1340, 1542, 1549, 1604, 1721, 1846, 1858, 1866, 1890, 1951, 2014, 2018, 2030, 2158, 2160, 2362, 2475, 2745, 2911, 3020, 3103, 3298], 'Attisano': [1228], 'Proc.': [1230, 1543, 1598, 2739, 2905, 3014, 3097, 3292], 'Natl.': [1231, 1544, 1599, 2740, 2906, 3015, 3098, 3293], 'Acad.': [1232, 1545, 1600, 2741, 2907, 3016, 3099, 3294], 'Sci.': [1233, 1546, 1601, 2742, 2908, 3017, 3100, 3295], 'U.': [1234, 1547, 1602, 2743, 2909, 3018, 3101, 3296], '97:': [1238], '8358-8363Crossref': [1239], '(388)': [1242], '23Nishita': [1245], 'M.': [1246, 1530, 1538, 1577, 1679, 1807, 1825, 1870, 1880, 1901, 1903, 1982, 2392, 2505], 'Hashimoto': [1247], 'M.K.': [1248], 'Ogata': [1249], 'Laurent': [1251], 'M.N.': [1252], 'Ueno': [1253], 'Shibuya': [1255], 'Cho': [1257], 'K.W.': [1258, 1484, 1501, 2738, 2902, 3011, 3074, 3094], 'Nature.': [1259, 1520], '403:': [1261], '781-785Crossref': [1262], '(405)': [1265, 1300], 'For': [1268, 2920, 3040], 'example,': [1269], 'LEF1-deficient': [1272], 'mice': [1273], 'display': [1274], 'similar': [1275], 'phenotypes': [1276], 'latter': [1279], 'developing': [1280, 1654], 'limb': [1281, 1655], 'deformities': [1282], '(24Galceran': [1283], 'Farinas': [1285], 'I.': [1286, 1534], 'Depew': [1287], 'Clevers': [1289], 'Grosschedl': [1291], '709-717Crossref': [1297], 'family': [1305, 2317], 'consists': [1306], 'large': [1309], 'number': [1310], 'secreted': [1312, 2436], 'glycoproteins': [1313], 'involved': [1316], 'development,': [1319], 'induction,': [1321], 'axis': [1323], 'polarity': [1324], '(25Cadigan': [1325], 'K.M.': [1326, 2028], 'Nusse': [1327, 1341, 1445, 2938], '3286-3305Crossref': [1333], '(2249)': [1336], '26Wodarz': [1339], '14:': [1349, 1626], '59-88Crossref': [1350], '(1758)': [1353], 'ligands': [1358], 'initiate': [1359], 'pathway': [1362], 'binding': [1364, 1406], 'frizzled': [1367], 'receptors': [1368], 'co-receptors': [1370], 'LRP5/6,': [1371], 'leading': [1372], 'phosphorylation': [1374], 'disheveled': [1377], 'protein,': [1378], 'which,': [1379], 'through': [1380], 'its': [1381, 2649, 2704], 'association': [1382], 'axin': [1384], 'adenomatous': [1387], 'polyposis': [1388], 'coil': [1389], 'tumor': [1390], 'suppressor,': [1391], 'prevents': [1392], 'glycogen': [1393], 'synthase': [1394], '3β': [1396], 'phosphorylating': [1398], 'β-catenin.': [1399], 'Antagonist': [1400], 'Dkk1': [1401, 2092], 'competes': [1402], 'LRP5/6.': [1408], 'Unphosphorylated': [1409], 'β-catenin': [1410, 1426, 2961], 'stabilized': [1412], 'escaping': [1414], 'recognition': [1415], 'β-TrCP,': [1417], 'component': [1419], 'ubiquitin-protein': [1422], 'isopeptide': [1423], 'ligase.': [1424], 'Free': [1425], 'translocates': [1427], 'nucleus,': [1430], 'where': [1431], 'it': [1432], 'engages': [1433], 'LEF/Tcf-4': [1436], '(27Nelson': [1443], 'W.J.': [1444], '303:': [1449], '1483-1487Crossref': [1450], '(2273)': [1453], 'Scholar),': [1455, 2193], 'such': [1456], 'c-Myc,': [1458], 'peroxisome': [1459], 'proliferator-activated': [1460], 'receptor-δ,': [1461], 'cyclin': [1462], 'D1,': [1463], 'WISPs': [1465], '(28He': [1466, 3056], 'Sparks': [1468, 3058], 'A.B.': [1469, 3059], 'Rago': [1470, 3060], 'Hermeking': [1472, 3062], 'Zawel': [1474, 3064], 'da': [1476, 2896, 3005, 3066, 3088], 'Costa': [1477, 2897, 3006, 3067, 3089], 'L.T.': [1478, 2898, 3007, 3068, 3090], 'Morin': [1479, 3069], 'P.J.': [1480, 3070], 'Vogelstein': [1481, 1498, 2715, 2735, 2903, 3012, 3071, 3095], 'Kinzler': [1483, 1500, 2712, 2737, 2901, 3010, 3073, 3093], '281:': [1487, 3077], '1509-1512Crossref': [1488, 3078], '(4121)': [1491, 3081], '29He': [1494], 'Chan': [1496], 'T.A.': [1497, 1561, 2730], '99:': [1504, 2747], '335-345Abstract': [1505], '(1040)': [1513], '30Tetsu': [1516], 'McCormick': [1518], 'F.': [1519, 2110], '398:': [1522], '422-426Crossref': [1523], '(3291)': [1526], '31Shtutman': [1529], 'Zhurinsky': [1531], 'Simcha': [1533], 'Albanese': [1535], "D'Amico": [1537], 'Pestell': [1539], "Ben-Ze'ev": [1541], '96:': [1551], '5522-5527Crossref': [1552], '(1948)': [1555], '32Pennica': [1558], 'D.': [1559, 1595, 1620, 1805, 1868, 1955, 2170], 'Swanson': [1560], 'Welsh': [1562, 1617], 'J.W.': [1563, 1618], 'Roy': [1564], 'Lawrence': [1566], 'D.A.': [1567], 'Lee': [1568], 'Brush': [1570], 'Taneyhill': [1572], 'L.A.': [1573], 'Deuel': [1574], 'Lew': [1576], 'Watanabe': [1578], 'Cohen': [1580], 'R.L.': [1581, 1689], 'Melhem': [1582], 'Finley': [1584], 'G.G.': [1585], 'Quirke': [1586], 'Goddard': [1588], 'A.D.': [1589], 'Hillan': [1590], 'K.J.': [1591], 'Gurney': [1592], 'A.L.': [1593], 'Botstein': [1594], 'Levine': [1596, 1621], '95:': [1606, 2913, 3022, 3105], '14717-14722Crossref': [1607], '(469)': [1610], '33Xu': [1613], 'Corcoran': [1615], 'R.B.': [1616, 1789], 'Pennica': [1619], '585-595Crossref': [1627], 'Increasing': [1631], 'evidence': [1632], 'suggests': [1633], 'regulatory': [1640], 'Several': [1645], 'Wnt3A)': [1649], 'expressed': [1651], 'chondrogenesis': [1661], '(34Gavin': [1662], 'B.J.': [1663], 'McMahon': [1664, 1666], 'J.A.': [1665, 1827], 'A.P.': [1667], '1990;': [1670], '4:': [1671], '2319-2332Crossref': [1672], '(433)': [1675], '35Kengaku': [1678], 'Capdevila': [1680], 'Rodriguez-Esteban': [1682], 'De': [1684, 1844], 'La': [1685], 'Pena': [1686], 'Johnson': [1688, 2042], '280:': [1696], '1274-1277Crossref': [1697], '(368)': [1700], 'Some': [1703], 'osteogenesis': [1715], '(36Bergwitz': [1716], 'Wendlandt': [1718], 'Kispert': [1720], 'Brabant': [1722], 'G.': [1723, 1738, 1793, 1817, 2026], 'Biochim.': [1724], 'Biophys.': [1725], 'Acta.': [1726], '1538:': [1728], '129-140Crossref': [1729], '(47)': [1732], '37Fischer': [1735], 'Boland': [1737], 'Tuan': [1739], '2002;': [1744, 1964, 2048, 2186, 2365, 2478, 2746], '84:': [1745], '816-831Crossref': [1746], '(104)': [1749], 'Recently,': [1752], 'co-receptor': [1754], 'LRP5': [1755, 1771, 1932, 2068], 'has': [1756, 2651], 'participate': [1760], 'mass': [1763, 1777], 'accrual': [1764], 'loss-of-function': [1767], 'mutations': [1768, 1930], 'cause': [1773], 'low': [1775], 'phenotype': [1778], 'autosomal': [1781, 1936], 'recessive': [1782], 'disorder': [1783], 'osteoporosis-pseudoglioma': [1784], 'syndrome': [1785], '(38Gong': [1786], 'Slee': [1788], 'Fukai': [1790], 'Rawadi': [1792], 'Roman-Roman': [1794], 'Cundy': [1800], 'Glorieux': [1802], 'F.H.': [1803], 'Lev': [1804], 'Zacharin': [1806], 'Oexle': [1808], 'K.': [1809, 1864, 1957, 2000, 2384, 2497], 'Marcelino': [1810], 'Suwairi': [1812], 'Heeger': [1814], 'Sabatakos': [1816], 'Apte': [1818], 'Adkins': [1820], 'W.N.': [1821], 'Allgrove': [1822], 'Arslan-Kirchner': [1824], 'Batch': [1826], 'Beighton': [1828], 'Black': [1830], 'G.C.': [1831], 'Boles': [1832], 'R.G.': [1833, 1978], 'Boon': [1834], 'Borrone': [1836], 'Brunner': [1838], 'H.G.': [1839], 'Carle': [1840], 'G.F.': [1841], 'Dallapiccola': [1842], 'Paepe': [1845], 'Floege': [1847], 'Halfhide': [1849], 'M.L.': [1850, 1913, 2043], 'Hall': [1851], 'Hennekam': [1853], 'Hirose': [1855], 'Jans': [1857], 'Juppner': [1859], 'Kim': [1861], 'C.A.': [1862], 'Keppler-Noreuil': [1863], 'Kohlschuetter': [1865], 'LaCombe': [1867], 'Lambert': [1869], 'Lemyre': [1871], 'Letteboer': [1873], 'Peltonen': [1875], 'Ramesar': [1877], 'Romanengo': [1879], 'Somer': [1881], 'Steichen-Gersdorf': [1883], 'Steinmann': [1885], 'Sullivan': [1887], 'Superti-Furga': [1889], 'Swoboda': [1891], 'van': [1893], 'den': [1894], 'Boogaard': [1895], 'Van': [1897, 2037], 'Hul': [1898], 'Vikkula': [1900], 'Votruba': [1902], 'Zabel': [1904], 'Garcia': [1906], 'Baron': [1908], 'Olsen': [1910], 'Warman': [1912], '107:': [1916], '513-523Abstract': [1917], '(1899)': [1925], 'Conversely,': [1928], 'activating': [1929], 'result': [1933], 'dominant': [1937], 'high': [1938, 4358], 'density': [1940], 'trait': [1941], '(39Boyden': [1942], 'Mao': [1944], 'Belsky': [1946], 'Mitzner': [1948], 'Farhi': [1950], 'Mitnick': [1952], 'Wu': [1954], 'Insogna': [1956], 'Lifton': [1958], 'R.P.': [1959], 'Engl.': [1961, 2123], 'Med.': [1963, 2125], '346:': [1965], '1513-1521Crossref': [1966], '(1366)': [1969], '40Little': [1972], 'R.D.': [1973], 'Carulli': [1974], 'Del': [1976], 'Mastro': [1977], 'Dupuis': [1979], 'Osborne': [1981], 'Folz': [1983], 'Manning': [1985], 'S.P.': [1986], 'Swain': [1987], 'P.M.': [1988], 'Zhao': [1989], 'Eustace': [1991], 'Lappe': [1993], 'M.M.': [1994], 'Spitzer': [1995], 'Zweier': [1997], 'Braunschweiger': [1999], 'Benchekroun': [2001], 'Hu': [2003], 'Adair': [2005], 'Chee': [2007], 'FitzGerald': [2009], 'M.G.': [2010], 'Tulig': [2011], 'Caruso': [2013], 'Tzellas': [2015], 'Bawa': [2017], 'Franklin': [2019], 'McGuire': [2021], 'Nogues': [2023], 'Gong': [2025], 'Allen': [2027], 'Anisowicz': [2029], 'Morales': [2031], 'Lomedico': [2033], 'P.T.': [2034], 'Recker': [2035, 2040], 'S.M.': [2036], 'Eerdewegh': [2038], 'R.R.': [2041], 'Hum.': [2046], '70:': [2049], '11-19Abstract': [2050], '(1109)': [2058], 'These': [2061, 2984], 'suggest': [2063], 'balanced': [2065, 2667, 2795], 'function': [2066], 'oteoblastic': [2074], 'Consistent': [2078], 'this': [2080, 2231, 2546], 'notion': [2081], 'recent': [2084], 'report,': [2085, 2232], 'overexpression': [2088, 2614], 'antagonist': [2091], 'associated': [2094], 'presence': [2097, 3814], 'lytic': [2099], 'lesions': [2101], 'patients': [2103], 'multiple': [2105], 'myeloma': [2106], '(41Tian': [2107], 'Zhan': [2109], 'Walker': [2111], 'Ma': [2115], 'Barlogie': [2117], 'Shaughnessy': [2119], 'Jr.,': [2120], '349:': [2127], '2483-2494Crossref': [2128], '(1306)': [2131], 'Wnt/β-catenin': [2138, 2200], 'frequently': [2141], 'osteosarcoma,': [2145], 'common': [2148], 'primary': [2151, 3827], 'malignancy': [2152], '(42Haydon': [2155], 'Ishikawa': [2159], 'Heck': [2161], 'Feng': [2167], 'King': [2169], 'Peabody': [2175], 'Simon': [2177], 'Int.': [2183, 2411, 2524], 'Cancer.': [2185], '102:': [2187], '338-342Crossref': [2188], '(168)': [2191], 'identification': [2209], 'could': [2220], 'lend': [2221], 'insights': [2222], 'into': [2223, 2946, 2964, 2979, 4143, 4240], 'molecular': [2225], 'framework': [2226], 'osteogenesis.': [2229], 'In': [2230, 2545, 4010, 4202], 'induce': [2240, 4500], 'phosphatase': [2245, 3845, 4528], '(ALP),': [2246], 'established': [2249], 'marker,': [2252], 'profiling': [2259], 'C3H10T1/2': [2264, 2690, 2785, 3124, 4015, 4026, 4043, 4212], 'revealed': [2273], 'under': [2275, 3820, 4000, 4049, 4122], 'stringent': [2278], 'conditions': [2280], 'among': [2283], 'Wnt3A.': [2293, 2564, 2626], '(also': [2295, 2844], 'known': [2296, 2845, 3208], 'Fisp12,': [2298], 'Hcs24,': [2299], 'ecogenin,': [2300], 'βIG-M2,': [2301], 'IGFBP8,': [2302], 'CCN2)': [2304], 'member': [2307], 'CCN': [2310, 2433], '(acronym': [2311], 'Cyr61,': [2313], 'Nov)': [2316], 'includes': [2320], 'Cyr61/CCN1,': [2321], 'Nov/CCN3,': [2322], 'WISP1/CCN4,': [2323], 'WISP2/CCN5,': [2324], 'WISP3/CCN6': [2326], '(43Lau': [2327, 2440], 'L.F.': [2328, 2382, 2441, 2495], 'Lam': [2329, 2379, 2442, 2492], 'Exp.': [2331, 2444], 'Res.': [2333, 2446], '248:': [2335, 2448], '44-57Crossref': [2336, 2449], '(584)': [2339, 2452], '44Moussad': [2342, 2455], 'E.E.': [2343, 2456], 'Brigstock': [2344, 2457], 'Mol.': [2346, 2395, 2459, 2508], '276-292Crossref': [2351, 2464], '(447)': [2354, 2467], '45Blom': [2357, 2470], 'I.E.': [2358, 2471], 'Goldschmeding': [2359, 2375, 2472, 2488], 'Leask': [2361, 2474], 'Matrix': [2363, 2476], '21:': [2366, 2479], '473-482Crossref': [2367, 2480], '(332)': [2370, 2483], '46Brigstock': [2373, 2486], 'Katsube': [2377, 2490], 'K.I.': [2378, 2491], 'Lau': [2381, 2494], 'Lyons': [2383, 2496], 'Naus': [2385, 2498], 'Perbal': [2387, 2407, 2500, 2520], 'Riser': [2389, 2502], 'Takigawa': [2391, 2504], 'Yeger': [2393, 2506], 'Pathol.': [2396, 2509], '56:': [2398, 2511], '127-128Crossref': [2399, 2512], '(208)': [2402, 2515], '47Planque': [2405, 2518], 'Cancer': [2409, 2522], '3:': [2413, 2526], '1-15Crossref': [2414, 2527], '(143)': [2417, 2530], '48Brigstock': [2420, 2533], 'Endocrinol.': [2423, 2536], '178:': [2425, 2538], '169-175Crossref': [2426, 2539], '(452)': [2429, 2542], 'cysteine-rich': [2437], 'multimodular': [2438], 'study,': [2547], 'sought': [2549], 'determine': [2551, 4013], 'functional': [2553], 'induced': [2560, 2573, 4522], 'stimulation': [2582], 'returned': [2584], 'basal': [2586, 2790], 'levels': [2587], '5': [2588, 4225], 'days': [2589], 'after': [2590, 3166, 3992, 4041, 4093, 4110, 4171], 'stimulation.': [2591], 'Most': [2592], 'interestingly,': [2593], 'RNAi-mediated': [2594, 3542], 'progenitor': [2609, 2645, 4505], 'inhibited': [2617], 'initiated': [2622], 'promoting': [2638], 'cells,': [2646, 4024, 4044], 'terminal': [2657], 'osteoblasts.': [2662], 'This': [2663], 'indicates': [2664], 'Culture': [2685], 'Chemicals—HEK': [2687], '293': [2688, 2755], 'lines': [2692, 3129], 'obtained': [2694], 'ATCC': [2697], '(Manassas,': [2698], 'VA).': [2699], 'HCT116': [2700, 3127, 3996, 4006, 4023, 4033], 'parental': [2701], 'line': [2702], 'CTNNB1': [2705], 'knockout': [2706], 'derivatives': [2707], 'provided': [2709, 2935], 'Ken': [2711], 'Bert': [2714], 'Johns': [2718], 'Hopkins': [2719], 'Medical': [2720], 'Institutions,': [2721], 'Baltimore,': [2722], 'maintained': [2725, 2758, 2788], 'described': [2727, 2851, 2999, 3054, 3858], 'previously': [2728, 2852, 3000, 3055, 3859, 4410], '(49Chan': [2729], 'Z.': [2732], 'Dang': [2733], 'L.H.': [2734], '8265-8270Crossref': [2748], '(116)': [2751], 'HEK': [2754], 'complete': [2760, 3141, 3387], 'DMEM': [2761, 4178], 'supplemented': [2762, 2798, 3143], '10%': [2764, 2800, 4296], '(FCS,': [2768], 'Mediatech,': [2769], 'Herndon,': [2770], 'VA),': [2771], '100': [2772, 2776, 2802, 2806], 'units/ml': [2773, 2803], 'penicillin,': [2774, 2804], 'μg/ml': [2777, 2807], 'streptomycin': [2778, 2808], '37': [2780, 2810, 4195, 4270], '°C': [2781, 2811, 3423, 3434, 3439, 3445, 3459, 3464, 3470, 3481, 3726, 4271], '5%': [2783, 2813, 4197, 4268], 'CO2.': [2784, 2814], 'medium': [2791, 3142, 4189], 'Eagle': [2792], "Earle's": [2794], 'salt': [2796], 'solution,': [2797], 'Unless': [2815], 'indicated': [2816, 3164], 'otherwise,': [2817], 'all': [2818, 3258, 3274, 4005], 'chemicals': [2819], 'purchased': [2821], 'Sigma': [2823], 'Fisher.': [2825], 'Recombinant': [2826], 'Adenoviral': [2827], 'Vectors': [2828], 'Expressing': [2829], 'Wnt3A,': [2831, 2927], 'Oncogenic': [2832], 'β-Catenin,': [2833], 'CTGF—Recombinant': [2835], 'adenoviruses': [2836, 2992], '(AdBMPs)': [2837], 'expressing': [2838, 2926, 3048], '-6,': [2841], '-9': [2843], 'GDF-2)': [2847], 'generated': [2849], '50He': [2892, 3084], 'Yu': [2899, 3008, 3091], '2509-2514Crossref': [2914, 3023, 3106], '(3276)': [2917, 3026, 3109], 'construction': [2921, 3115], 'adenoviral': [2924], 'vectors': [2925, 2986], 'coding': [2929, 2970], 'region': [2930, 2971], 'mouse': [2932, 2973, 3202, 3381, 3588, 3600], '(kindly': [2934], 'Roel': [2937], 'Stanford': [2940], 'University)': [2941], 'PCR-amplified': [2943, 2976, 3030], 'subcloned': [2945, 2963, 2978], 'pAdTrack-CMV,': [2947, 2980], 'resulting': [2948, 2966, 2981], 'pAdTrack-Wnt3A.': [2950], 'cassette': [2953], 'containing': [2954, 3765, 4179], 'oncogenic': [2956], 'S33Y': [2957], 'mutation': [2958], 'pAdTrack,': [2965], 'pAdTrack-β-Cat*.': [2968], 'pAdTrack-CTGF.': [2983], 'shuttle': [2985], 'generate': [2990, 3323, 3548], 'recombinant': [2991, 3686], '(i.e.': [2993, 3051], 'AdWnt3A,': [2994, 3159], 'Adβ-Cat*,': [2995, 3158], 'AdCTGF)': [2997], '(50He': [3001], 'All': [3029, 3532], 'fragments': [3031], 'cloning': [3033], 'junctions': [3034], 'verified': [3036, 3490], 'DNA': [3038, 3408], 'sequencing.': [3039], 'control,': [3042], 'analogous': [3046], 'adenovirus': [3047], 'only': [3049], 'GFP': [3050], 'AdGFP)': [3052], 'Details': [3112], 'about': [3113], 'vector': [3114], 'available': [3117, 3393], 'upon': [3118], 'request.': [3119], 'Isolation': [3120], 'Total': [3122, 3174], 'RNA—Subconfluent': [3123], 'and/or': [3126, 3828, 3853], 'derivative': [3128], 'seeded': [3131, 3976, 4070], 'onto': [3132, 4332], '75-cm2': [3133], 'culture': [3135, 4076], 'flasks': [3136], '12': [3138, 4200], 'h': [3139, 3991, 4040, 4092, 4109, 4170, 4264], '0.5%': [3145, 4236], 'infected': [3148, 3984, 3995, 4080, 4157], 'pre-determined': [3151, 4083], 'optimal': [3152, 4084], 'titer': [3153, 4085], 'AdBMP-2,': [3155], 'AdBMP-6,': [3156], 'AdBMP-9,': [3157, 4161], 'AdGFP.': [3161, 3988], 'infection,': [3167, 3993, 4094, 4172], 'total': [3168, 3318], 'isolated': [3171], 'using': [3172, 3222, 3283, 3337, 3370, 3405, 3709], 'RNAgent': [3173], 'isolation': [3176], 'kit': [3177], '(Promega,': [3178], 'Madison,': [3179], 'WI)': [3180], 'according': [3181, 3712], "manufacturer's": [3184, 3699, 3715], 'instructions.': [3185, 3700, 3716], 'Microarray': [3186], 'Analysis—Fully': [3187], 'characterized': [3188], 'samples': [3190, 3259, 3533], 'preparation': [3195], 'subjected': [3197, 3670, 3684], 'hybridizations': [3199], 'Affymetrix': [3201, 3224], 'chips': [3204], '430A': [3205], '(containing': [3206], '∼22,000': [3207], 'ESTs).': [3211], 'acquisition': [3213], 'initial': [3215], 'quantitation': [3216], 'array': [3218], 'images': [3219], 'performed': [3221, 3336, 4369], 'MAS': [3225], '5.0': [3226], 'default': [3229], 'parameters.': [3230], 'acquired': [3232], 'raw': [3234], 'data': [3235], 'further': [3237, 3353, 3496], 'filtered': [3238], 'normalized': [3240, 3535], 'remove': [3242, 4285], 'noise,': [3243], 'although': [3244], 'retaining': [3245], 'true': [3246], 'biological': [3247], 'information': [3248], 'filtering': [3250], 'out': [3251, 3281, 3403, 3528, 3708], 'signal': [3255], 'intensity': [3256, 3261], '≥100': [3260], 'units,': [3262], 'removing': [3265], 'received': [3269], '“absent”': [3271], 'call': [3272], 'hybridizations.': [3275], 'clustering': [3277], 'carried': [3280, 3402, 3527, 3707], 'dChip': [3285], '1.3': [3286], 'software': [3287], '(51Li': [3288], 'Wong': [3290], 'W.H.': [3291], '98:': [3300], '31-36Crossref': [3301], '(2721)': [3304], 'Reverse': [3307], 'Transcription': [3308], 'Quantitative': [3310], 'Real': [3311], 'Time': [3312], 'PCR': [3313, 3501, 3570, 3593, 3667], '(qPCR)': [3314], 'Analysis—Ten': [3315], 'micrograms': [3316], 'cDNA': [3324, 3333, 3350], 'templates': [3325], 'reverse': [3327, 3344], 'transcriptase': [3328, 3345], 'PCR.': [3329], 'first': [3331, 3348], 'strand': [3332, 3349], 'synthesis': [3334], 'hexamer': [3339], '(Promega)': [3340], 'Superscript': [3342], '(Invitrogen).': [3346], 'products': [3351, 3502, 3668], 'diluted': [3354, 3509], '10-fold': [3355], 'qPCR': [3359, 3368, 3399, 3488], 'templates.': [3360], 'Expression': [3361, 4377], 'level': [3362, 3539], 'determined': [3366, 4350], 'oligonucleotides': [3371], '(18-mers)': [3372], 'amplify': [3374, 3587], '3′-end': [3376], '(∼120': [3377], 'bp)': [3378], 'gene.': [3385], 'A': [3386], 'list': [3388], 'primers': [3391, 3571, 3594], 'www.boneandcancer.org/ccngenes.htm.': [3395], 'SYBR': [3397], 'Green-based': [3398], 'Opticon': [3407], 'Engine': [3409], 'thermocycler': [3410], '(M': [3411], 'J': [3412], 'Research,': [3413], 'Waltham,': [3414], 'MA).': [3415], 'cycling': [3417], 'program': [3418], 'follows:': [3421, 3598], '94': [3422], '2': [3425], 'min': [3426, 3729, 3809, 4300], '1': [3428], 'cycle,': [3429], '4': [3430, 4108, 4169, 4263], 'cycles': [3431, 3456], '92': [3433, 3458], '20': [3436, 3447, 3461, 3472, 3808], 's,': [3437, 3442, 3462, 3467, 3473], '68': [3438], '30': [3441, 3455, 3466, 3755, 3793, 4306], '72': [3444, 3469], 's': [3448], 'decrease': [3451], '3°/cycle,': [3453], '57': [3463], 'followed': [3474, 3757, 3795], 'plate': [3477], 'read': [3478], '78': [3480], 'each': [3482, 3487, 3530, 3582, 4241, 4366], 'cycle.': [3483], 'specificity': [3485], 'melting': [3492], 'curve': [3493], 'resolving': [3499], 'on': [3503, 4290], '1.5%': [3504], 'agarose': [3505], 'gels.': [3506], '10-Fold': [3507], 'serially': [3508], 'pUC19': [3510], 'standard': [3515], '(ranging': [3516], '10': [3518, 4299, 4356], '0.001': [3520], 'pg': [3521], 'per': [3522, 4192], 'reaction).': [3523], 'Triplicate': [3524], 'reactions': [3525], 'sample.': [3531], 'GAPDH.': [3541], 'Silencing': [3543], 'Expression—To': [3547], 'siRNA': [3549, 3704], 'pools,': [3550], 'employed': [3552], 'dicer-mediated': [3556], 'digestions': [3557], 'double-stranded': [3559, 3681], 'derived': [3561], 'genes.': [3565], 'Briefly,': [3566], 'pair': [3568], '(anchored': [3572], 'T7': [3575, 3672], 'promoter': [3576], 'sequence': [3577], '5′-end': [3580], 'primer)': [3583], 'GFP.': [3591], '5′-GCG': [3602, 3617, 3634, 3650], 'TAA': [3603, 3610, 3618, 3635, 3651], 'TAC': [3604, 3619, 3636, 3652], 'GAC': [3605, 3620, 3628, 3637, 3644, 3646, 3653], 'TCA': [3606, 3621, 3638, 3654], 'CTA': [3607, 3622, 3639, 3655], 'TAG': [3608, 3623, 3640, 3656], 'GCG': [3609, 3657, 3658], 'AGC': [3611, 3663], 'CAG': [3612], 'GAA': [3613], 'GTA': [3614, 3647], 'AG-3′': [3615], 'GCT': [3624], 'CTG': [3625, 3643], 'ACT': [3626], 'CCT': [3627], 'AAG': [3629], 'TG-3′;': [3630], 'GTC': [3641, 3659], 'GAG': [3642], 'GGC': [3645], 'AAC-3′': [3648], 'ACG': [3660], 'AAC': [3661], 'TCC': [3662], 'AGG-3′.': [3664], 'purified': [3666], 'polymerase-mediated': [3674], '(Promega).': [3678], 'resultant': [3680], 'RNAs': [3682], 'dicer': [3687], '(or': [3688], 'RNase': [3689], 'III)': [3690], 'digestion': [3691], '(New': [3692], 'England': [3693], 'Biolabs,': [3694], 'Beverly,': [3695], 'MA)': [3696, 4154], 'following': [3697], 'Transfection': [3701], 'mixtures': [3705], 'Lipofectamine': [3710], '(Invitrogen)': [3711], 'Immunofluorescence': [3717], 'Staining—The': [3718], 'fixed': [3721, 3737, 4294], 'methanol': [3723], '-20': [3725], 'washed': [3731, 4175, 4217], 'PBS': [3733, 4283], '2-3': [3734], 'times.': [3735], 'permeabilized': [3740], '1%': [3742], 'Nonidet': [3743], 'P-40/PBS': [3744], 'blocked': [3746], 'room': [3752, 3811], 'temperature': [3753], 'min,': [3756, 3794], 'incubating': [3759, 3797], 'goat': [3767], 'anti-CTGF': [3768], 'antibody': [3769, 3791], '(Santa': [3770], 'Cruz': [3771], 'Biotechnology,': [3772], 'Santa': [3773], 'Cruz,': [3774], 'CA)': [3775], '60': [3777], 'min.': [3778, 4307], 'After': [3779], 'being': [3780], 'washed,': [3781], 'incubated': [3785, 4183], 'biotin-labeled': [3787], 'anti-goat': [3788], 'IgG': [3789], 'secondary': [3790, 3829], 'streptavidin-Alexa': [3801], 'Fluor-594': [3802], '(Molecular': [3803], 'Probes,': [3804], 'Eugene,': [3805], 'OR)': [3806], 'temperature.': [3812], 'protein': [3817], 'examined': [3819, 3999, 4048], 'fluorescence': [3822, 4002, 4054, 4127], 'microscope.': [3823], 'Stains': [3824], 'without': [3825], 'antibodies,': [3830], 'control': [3833], 'IgG,': [3834], 'negative': [3838], 'controls.': [3839], 'Determination': [3840], 'Alkaline': [3842], 'Phosphatase': [3843], 'Activity—Alkaline': [3844], 'assessed': [3848], 'colorimetric': [3851], 'assay': [3852, 3856], 'histochemical': [3854], 'staining': [3855], '15Peng': [3939], 'Mixed': [3970], 'Plating': [3972], 'Assay—HCT116': [3973, 4139], '12-well': [3978, 4074, 4149], 'plates': [3979, 4077, 4150], '10-20%': [3981], 'confluence': [3982], 'AdCTGF': [3986], 'microscope,': [4003], 'GFP-positive.': [4009], 'order': [4011, 4203], 'whether': [4014], 'attracted': [4018], 'AdCTGF-': [4020], 'AdGFP-infected': [4022], 'trypsinized': [4025, 4215], 'added': [4029, 4239], 'pre-infected': [4032], 'densities.': [4037], '3': [4039], 'plating': [4042], 'bright': [4051, 4124], 'field': [4052, 4125], 'microscopy': [4055], '(magnification,': [4056], '×300).': [4057], 'Representative': [4058, 4129], 'three': [4061, 4132], 'experiments': [4062, 4133], 'shown.': [4064, 4135, 4376], 'Wounding': [4066], 'Assay—C3H10T1/2': [4067], 'subconfluency': [4072], 'AdGFP': [4087], 'AdCTGF.': [4089], 'monolayer': [4096], 'wounded': [4099], 'pipette': [4101], 'tips.': [4102], '0,': [4104], '2,': [4106], 'wounding,': [4111], 'wound': [4113], 'healing': [4114], 'approximately': [4116], 'same': [4118], 'fields': [4119, 4360], 'recorded': [4121], 'microscopy.': [4128], 'Boyden': [4136], 'Chamber': [4137], 'Migration': [4138], 'plated': [4142], 'bottom': [4145], 'wells': [4146], 'Transwell': [4148, 4242, 4363], '(Corning': [4151], 'Costar,': [4152], 'Cambridge,': [4153], 'AdGFP,': [4159], 'AdCTGF,': [4160], 'AdWn3A': [4163], 'comparable': [4166], 'titer.': [4167], 'twice': [4176, 4218], '0.1%': [4180, 4187, 4221], 'BSA': [4181, 4188, 4222], '(2': [4190], 'ml': [4191, 4232], 'well)': [4193], '°C,': [4196], 'CO2,': [4198], 'h.': [4201], 'up': [4206], 'assays,': [4209], 'exponentially': [4210], 'growing': [4211], 'medium.': [4223], 'Approximately': [4224], '×': [4226], '104': [4227], '(resuspended': [4229], '1.0': [4231], 'pre-equilibrated': [4234], 'BSA)': [4237], 'insert,': [4243], 'consisted': [4245], 'III': [4250], 'collagen-coated': [4251], 'microporous': [4252], 'membrane': [4253, 4292, 4328], '(3.0': [4254], 'μm).': [4255], 'allowed': [4259, 4340], 'migrate': [4261], 'humidified': [4267], 'CO2': [4269], 'incubator.': [4272], 'apparatus': [4274], 'disassembled,': [4276], 'membranes': [4279], 'rinsed': [4281], 'unattached': [4286], 'formalin': [4297], 'stained': [4302], 'hematoxylin': [4304], 'Cells': [4308], 'attached': [4309], 'unmigrated': [4312], '(top)': [4313], 'side': [4314, 4321], 'removed': [4316], 'gently': [4318], 'wiping': [4319], 'damp': [4324], 'cotton': [4325], 'swab.': [4326], 'then': [4330], 'mounted': [4331], 'glass': [4334], 'slide': [4335], 'Permount': [4337], '(Fisher)': [4338], 'dry.': [4342], 'average': [4344], 'numbers': [4345], 'migrated': [4347], 'counting': [4352], 'random': [4357], 'power': [4359], '(×300).': [4361], 'assays': [4364], 'condition': [4367], 'duplicate,': [4371], 'representative': [4373], 'Profiling': [4378], 'Analysis': [4379], 'Early': [4382], 'Stage': [4383], 'Differentiation': [4389], 'Mesenchymal': [4391], 'Stem': [4392], 'Cells—Through': [4393], 'Scholar)': [4489], 'exhibit': [4495], 'greatest': [4497], 'ability': [4498], 'vivo.': [4513], 'As': [4514], 'Fig.': [4517], '1A,': [4518], 'drastic': [4524], 'increase': [4525], 'activ': [4529]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2112278084', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 19}, {'year': 2013, 'cited_by_count': 25}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2024-12-08T17:41:14.196916', 'created_date': '2016-06-24'}
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