Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2112147962', 'doi': 'https://doi.org/10.1128/jvi.00311-08', 'title': 'Varicella-Zoster Virus Open Reading Frame 66 Protein Kinase Is Required for Efficient Viral Growth in Primary Human Corneal Stromal Fibroblast Cells', 'display_name': 'Varicella-Zoster Virus Open Reading Frame 66 Protein Kinase Is Required for Efficient Viral Growth in Primary Human Corneal Stromal Fibroblast Cells', 'publication_year': 2008, 'publication_date': '2008-05-22', 'ids': {'openalex': 'https://openalex.org/W2112147962', 'doi': 'https://doi.org/10.1128/jvi.00311-08', 'mag': '2112147962', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18495764', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2493351'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.00311-08', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1128/jvi.00311-08', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5032595225', 'display_name': 'Angela Erazo', 'orcid': 'https://orcid.org/0000-0003-2182-4423'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Angela Erazo', 'raw_affiliation_strings': ['Departments of Ophthalmology', 'Graduate Program in Molecular Virology and Microbiology'], 'affiliations': [{'raw_affiliation_string': 'Graduate Program in Molecular Virology and Microbiology', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of Ophthalmology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082588881', 'display_name': 'Michael B. Yee', 'orcid': 'https://orcid.org/0000-0002-6296-7757'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Michael B. Yee', 'raw_affiliation_strings': ['Departments of Ophthalmology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Ophthalmology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033773848', 'display_name': 'Nikolaus Osterrieder', 'orcid': 'https://orcid.org/0000-0002-5313-2176'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nikolaus Osterrieder', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Cornell University, Ithaca, New York'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Cornell University, Ithaca, New York', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5046119962', 'display_name': 'Paul R. Kinchington', 'orcid': 'https://orcid.org/0000-0002-1901-9970'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Paul R. Kinchington', 'raw_affiliation_strings': ['Departments of Ophthalmology', 'Molecular Microbiology and Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Departments of Ophthalmology', 'institution_ids': []}, {'raw_affiliation_string': 'Molecular Microbiology and Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania', 'institution_ids': ['https://openalex.org/I170201317']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5046119962'], 'corresponding_institution_ids': ['https://openalex.org/I170201317'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.984, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 32, 'citation_normalized_percentile': {'value': 0.813187, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '82', 'issue': '15', 'first_page': '7653', 'last_page': '7665'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10625', 'display_name': 'Herpesvirus Infections and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10625', 'display_name': 'Herpesvirus Infections and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11495', 'display_name': 'Animal Virus Infections Studies', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1103', 'display_name': 'Animal Science and Zoology'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/varicella-zoster-virus', 'display_name': 'Varicella zoster virus', 'score': 0.58708286}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.93556756}, {'id': 'https://openalex.org/C2776159415', 'wikidata': 'https://www.wikidata.org/wiki/Q6868', 'display_name': 'Varicella zoster virus', 'level': 3, 'score': 0.58708286}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.54977304}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.46926066}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.41969487}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.40342844}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.38446927}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.349829}], 'mesh': [{'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': True}, {'descriptor_ui': 'D014645', 'descriptor_name': 'Herpesvirus 3, Human', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D014645', 'descriptor_name': 'Herpesvirus 3, Human', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017361', 'descriptor_name': 'Viral Nonstructural Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017930', 'descriptor_name': 'Genes, Reporter', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014645', 'descriptor_name': 'Herpesvirus 3, Human', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D014645', 'descriptor_name': 'Herpesvirus 3, Human', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017874', 'descriptor_name': 'Immediate-Early Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017874', 'descriptor_name': 'Immediate-Early Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017874', 'descriptor_name': 'Immediate-Early Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017384', 'descriptor_name': 'Sequence Deletion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013194', 'descriptor_name': 'Staining and Labeling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014759', 'descriptor_name': 'Viral Envelope Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014759', 'descriptor_name': 'Viral Envelope Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014759', 'descriptor_name': 'Viral Envelope Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017361', 'descriptor_name': 'Viral Nonstructural Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017361', 'descriptor_name': 'Viral Nonstructural Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014771', 'descriptor_name': 'Virion', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014771', 'descriptor_name': 'Virion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.00311-08', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2493351', 'pdf_url': 'https://europepmc.org/articles/pmc2493351?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493351', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18495764', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.00311-08', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 69, 'referenced_works': ['https://openalex.org/W1488101841', 'https://openalex.org/W1567183023', 'https://openalex.org/W1590213056', 'https://openalex.org/W1636940737', 'https://openalex.org/W1736186603', 'https://openalex.org/W1907539319', 'https://openalex.org/W1925481846', 'https://openalex.org/W1925839757', 'https://openalex.org/W1926597794', 'https://openalex.org/W1969883219', 'https://openalex.org/W1971663674', 'https://openalex.org/W1980363093', 'https://openalex.org/W1984431177', 'https://openalex.org/W1988639907', 'https://openalex.org/W1993744179', 'https://openalex.org/W1994882633', 'https://openalex.org/W1996235334', 'https://openalex.org/W1998704297', 'https://openalex.org/W2002296591', 'https://openalex.org/W2010905723', 'https://openalex.org/W2024303292', 'https://openalex.org/W2028634883', 'https://openalex.org/W2029689060', 'https://openalex.org/W2035109828', 'https://openalex.org/W2039667276', 'https://openalex.org/W2040569736', 'https://openalex.org/W2041303063', 'https://openalex.org/W2041655864', 'https://openalex.org/W2042343633', 'https://openalex.org/W2043039839', 'https://openalex.org/W2052267129', 'https://openalex.org/W2054022085', 'https://openalex.org/W2069191615', 'https://openalex.org/W2081900413', 'https://openalex.org/W2082779452', 'https://openalex.org/W2095356884', 'https://openalex.org/W2096464703', 'https://openalex.org/W2096538271', 'https://openalex.org/W2101116346', 'https://openalex.org/W2101328506', 'https://openalex.org/W2101557510', 'https://openalex.org/W2109863815', 'https://openalex.org/W2111973961', 'https://openalex.org/W2114958692', 'https://openalex.org/W2118329333', 'https://openalex.org/W2120055283', 'https://openalex.org/W2123788475', 'https://openalex.org/W2126202137', 'https://openalex.org/W2127758278', 'https://openalex.org/W2131820144', 'https://openalex.org/W2135342726', 'https://openalex.org/W2135433503', 'https://openalex.org/W2135550325', 'https://openalex.org/W2137200318', 'https://openalex.org/W2138395245', 'https://openalex.org/W2138696295', 'https://openalex.org/W2141270853', 'https://openalex.org/W2142280321', 'https://openalex.org/W2142483675', 'https://openalex.org/W2146141017', 'https://openalex.org/W2146470087', 'https://openalex.org/W2153824014', 'https://openalex.org/W2161838452', 'https://openalex.org/W2161923121', 'https://openalex.org/W2162149154', 'https://openalex.org/W2163294020', 'https://openalex.org/W2167466700', 'https://openalex.org/W2255201724', 'https://openalex.org/W646955379'], 'related_works': ['https://openalex.org/W4386371748', 'https://openalex.org/W292004825', 'https://openalex.org/W2188759708', 'https://openalex.org/W2153434009', 'https://openalex.org/W2147145791', 'https://openalex.org/W2138564085', 'https://openalex.org/W2123163123', 'https://openalex.org/W2111970140', 'https://openalex.org/W2016551366', 'https://openalex.org/W1874513932'], 'abstract_inverted_index': {'Varicella-zoster': [0], 'virus': [1, 171], '(VZV)': [2], 'open': [3], 'reading': [4], 'frame': [5], '66': [6], '(ORF66)': [7], 'encodes': [8], 'a': [9], 'serine/threonine': [10], 'protein': [11, 71, 85], 'kinase': [12, 35, 122, 144, 186, 217], 'that': [13, 130, 181, 222], 'is': [14, 25, 49], 'not': [15, 164, 200], 'required': [16], 'for': [17, 27, 89, 203], 'VZV': [18, 66, 78, 156, 216], 'growth': [19, 29, 90, 100, 116, 206], 'in': [20, 30, 54, 94, 104, 175, 188, 195], 'most': [21], 'cell': [22], 'types': [23], 'but': [24, 97], 'needed': [26], 'efficient': [28], 'T': [31, 55], 'cells.': [32, 56, 177], 'The': [33], 'ORF66': [34, 64, 76, 84, 121, 143, 185, 209], 'affects': [36], 'nuclear': [37, 126, 147, 159], 'import': [38], 'and': [39, 48, 74, 91, 101, 162, 229], 'virion': [40], 'packaging': [41], 'of': [42, 63, 124, 183, 193, 208], 'IE62,': [43], 'the': [44, 61, 115, 138, 155, 169, 184, 204, 212], 'major': [45], 'regulatory': [46], 'protein,': [47], 'known': [50], 'to': [51, 120], 'regulate': [52], 'apoptosis': [53, 194], 'Here,': [57], 'we': [58], 'further': [59], 'examined': [60], 'importance': [62], 'using': [65], 'recombinants': [67], 'expressing': [68], 'green': [69], 'fluorescent': [70], '(GFP)-tagged': [72], 'functional': [73], 'kinase-negative': [75], 'proteins.': [77], 'virions': [79], 'with': [80, 133], 'truncated': [81], 'or': [82], 'kinase-inactivated': [83], 'were': [86, 98, 149], 'marginally': [87, 190], 'reduced': [88], 'progeny': [92], 'yields': [93], 'MRC-5': [95], 'fibroblasts': [96, 110], 'severely': [99], 'replication': [102], 'impaired': [103], 'low-passage': [105], 'primary': [106], 'human': [107], 'corneal': [108], 'stromal': [109], '(PCF).': [111], 'To': [112], 'determine': [113], 'if': [114], 'impairment': [117], 'was': [118, 163], 'due': [119], 'regulation': [123], 'IE62': [125, 132, 146, 151, 228], 'import,': [127, 148], 'recombinant': [128, 157], 'VZVs': [129], 'expressed': [131, 153], 'alanine': [134], 'residues': [135], 'at': [136], 'S686,': [137], 'suspected': [139], 'target': [140], 'by': [141, 154], 'which': [142, 198], 'blocks': [145], 'made.': [150], 'S686A': [152], 'remained': [158], 'throughout': [160], 'infection': [161], 'packaged': [165], 'into': [166], 'virions.': [167], 'However,': [168], 'mutant': [170], 'still': [172], 'replicated': [173], 'efficiently': [174], 'PCF': [176, 196], 'We': [178], 'also': [179], 'show': [180], 'inactivation': [182], 'resulted': [187], 'only': [189], 'increased': [191], 'levels': [192], 'cells,': [197], 'could': [199], 'fully': [201], 'account': [202], 'cell-specific': [205], 'requirement': [207], 'kinase.': [210], 'Thus,': [211], 'unique': [213], 'short': [214], 'region': [215], 'has': [218], 'important': [219], 'cell-type-specific': [220], 'functions': [221], 'are': [223], 'separate': [224], 'from': [225], 'those': [226], 'affecting': [227], 'apoptosis.': [230]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2112147962', 'counts_by_year': [{'year': 2022, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2025-01-09T14:57:34.224668', 'created_date': '2016-06-24'}