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'recombinant': [392], 'conjugated': [395], 'horseradish': [397, 404], 'peroxidase': [398, 405], 'combination': [400], 'luminol-enhanced': [403], 'substrate': [406], 'for': [407, 767, 1007], 'chemiluminescence': [408], 'detection,': [409], 'previously': [411], 'described.7': [412], 'preapheresis': [414], 'cholesterol': [419, 497, 530, 560, 603, 1108], 'significantly': [422], 'inversely': [423], 'correlated': [424, 901], '(r=−0.74;': [425], 'r2=0.55;': [426], 'P=0.017),': [427], 'postapheresis': [430], 'unrelated': [433, 769], '(r=0.09;': [434], 'P=0.53),': [435], 'which': [436], 'may': [437, 801], 'reflection': [440], 'pool': [443], '≈60%': [445], 'unbound': [452], 'LDL3': [454], 'less': [457], 'apheresis.': [462], '3': [464], 'subjects': [465, 587], 'received': [467, 519], 'full': [469], 'treatment,': [472, 525], 'concentration': [476, 531, 543], 'decreased': [477, 544], 'mean': [479], '52±9%': [481], '(from': [482, 498, 535, 547], '161±98': [483], '76±50': [485], 'ng/mL;': [486], 'P=0.1)': [487], 'parallel': [489], '74±5%': [492], 'reduction': [493, 554, 591, 600], '200±38': [499], '53±15': [501], 'mg/dL;': [502], 'P=0.01).': [503], 'These': [504], 'results': [505, 583, 605], 'are': [506, 606, 662], 'comparable': [507], 'reported': [511], 'Tavori': [513, 612, 854, 1088, 1119, 1161], 'et': [514, 613, 1174], 'al.3': [515], 'fourth': [517], 'subject': [518, 803], 'only': [520, 533], 'partial': [522, 563], 'lowering': [526], '15%': [534], '212': [536], '181': [538], 'mg/dL),': [539], '37%': [546], '155': [548], '98).': [550], '2-fold': [552], 'greater': [553], 'compared': [557], 'treatment': [565], 'raises': [566], 'possibility': [568], 'PCSK9-containing': [570], 'might': [573], 'preferentially': [575], 'bound': [576, 634], 'column.': [580], 'pooled': [582], 'our': [585], '48±11%': [590], '(P=0.038)': [594], 'association': [596], '59±30%': [599], '(P=0.03).Our': [604], 'concordant': [607], 'al3': [614], 'provide': [616], 'further': [617], 'evidence': [618], 'support': [620], 'notion': [623], 'large': [626], 'proportion': [627], '(≈40%)': [628], 'B–containing': [637], '(primarily': [639], 'LDL)': [640], 'majority': [644], 'can': [648], 'removed': [650], 'adsorption.': [659], 'Additional': [660], 'needed': [663], 'elucidate': [665], 'physiological': [667], 'clinical': [669, 1013], 'implications': [670], 'observations.P.B.': [673], 'DuellOregon': [674], 'UniversityPortlandGenevieve': [678], 'DubucLaval': [679], 'UniversityQuebec': [680], 'CityQuebec,': [681], 'CanadaNabil': [682], 'SeidahJean': [684], 'DavignonUniversity': [685], 'MontréalMontreal,': [694], 'CanadaSources': [696], 'FundingThis': [698], 'work': [699], 'supported': [701], 'Foundation,': [709], 'first': [711], 'Pfizer': [712], 'Distinguished': [715], 'Cardiovascular': [716, 1110], 'Metabolic': [718], 'Award,': [720], 'Canadian': [721], 'Institutes': [722], '(CIHR)': [726], 'grant': [727, 734], 'MOP-36496,': [728], 'CTP-82946,': [729], 'chair': [731], '20652,': [732], 'CIHR': [733], '102741,': [735], 'Fondation': [738], 'Leducq': [739], 'grant.': [740], 'recipient': [746], 'doctoral': [749], 'award': [750], 'Fonds': [752], 'la': [754], 'Recherche': [755], 'en': [756], 'Santé': [757], 'du': [758], 'Québec.DisclosuresP.B.': [759], 'served': [761], 'consultant': [764], 'Kaneka': [766], 'purposes': [768], 'this': [771], 'study.': [772], 'other': [774], 'authors': [775], 'report': [776], 'no': [777], 'conflicts.FootnotesLetters': [778], 'Editor': [781], 'will': [782], 'published,': [784], 'if': [785], 'suitable,': [786], 'space': [788], 'permits.': [789], 'They': [790], 'should': [791], 'not': [792], 'exceed': [793], '1000': [794], 'words': [795], '(typed': [796], 'double-spaced)': [797], 'length': [799], 'editing': [805], 'or': [806], 'abridgment.References1.': [807], 'Horton': [808], 'JD,': [809], 'Cohen': [810], 'JC,': [811], 'Hobbs': [812], 'HH.': [813], 'Molecular': [814, 1043], 'biology': [815], 'PCSK9:': [817, 1012, 1133], 'its': [818, 848], 'metabolism.Trends': [822], 'Biochem': [823], 'Sci.': [824], '2007;': [825, 908], '32:71–77.CrossrefMedlineGoogle': [826], 'Scholar2.': [827], 'Fan': [828], 'D,': [829], 'Yancey': [830], 'PG,': [831], 'Qiu': [832], 'S,': [833, 956, 993], 'Ding': [834], 'L,': [835, 995, 999], 'Weeber': [836], 'EJ,': [837], 'Linton': [838, 858, 1165], 'MF,': [839, 859], 'Fazio': [840, 860, 1092, 1124, 1168], 'S.': [841, 861], 'Self-association': [842], 'correlates': [846], 'LDLR-degrading': [849], 'activity.Biochemistry.': [850], '2008;': [851], '47:1631–1639.CrossrefMedlineGoogle': [852], 'Scholar3.': [853], 'H,': [855, 948, 989, 1089, 1120, 1162], 'Giunzioni': [856, 1163], 'I,': [857, 1164], 'Loss': [862], 'proprotein': [865, 894, 926, 1100], 'after': [870], 'apheresis.Circ': [872], 'Res.': [873, 1016], '2013;': [874, 944], '113:1290–1295.LinkGoogle': [875], 'Scholar4.': [876], 'Alborn': [877], 'WE,': [878], 'Cao': [879], 'G,': [880, 916, 983, 987, 1087], 'Careskey': [881], 'HE,': [882], 'Qian': [883], 'YW,': [884], 'Subramaniam': [885], 'DR,': [886], 'Davies': [887], 'J,': [888, 950, 991, 997], 'Conner': [889], 'EM,': [890], 'Konrad': [891], 'RJ.': [892], 'Serum': [893], 'subtilisin': [896, 1102], 'kexin': [897, 1103], 'type': [898], 'directly': [902], 'serum': [904], 'cholesterol.Clin': [906], 'Chem.': [907, 943], '53:1814–1819.CrossrefMedlineGoogle': [909], 'Scholar5.': [910], 'Kosenko': [911], 'T,': [912], 'Golder': [913], 'M,': [914, 952, 985, 1057, 1059], 'Leblond': [915], 'Weng': [917], 'W,': [918], 'Lagace': [919], 'TA.': [920], 'Low': [921], 'binds': [924], 'type-9': [929], 'inhibits': [935], 'PCSK9-mediated': [936], 'low': [937], 'degradation.J': [941], 'Biol': [942], '288:8279–8288.CrossrefMedlineGoogle': [945], 'Scholar6.': [946], 'Mabuchi': [947], 'Koizumi': [949], 'Shimizu': [951], 'Kajinami': [953], 'K,': [954, 958, 1055], 'Miyamoto': [955], 'Ueda': [957], 'Takegoshi': [959], 'T.': [960], 'Long-term': [961], 'on': [967], 'coronary': [968], 'heart': [969], 'disease': [970], 'hypercholesterolemia.': [973], 'Hokuriku-FH-LDL-Apheresis': [974], 'Study': [975], 'Group.Am': [976], 'J': [977, 1064], 'Cardiol.': [978], '1998;': [979], '82:1489–1495.CrossrefMedlineGoogle': [980], 'Scholar7.': [981], 'Tremblay': [984], 'Paré': [986], 'Jacques': [988], 'Hamelin': [990], 'Benjannet': [992], 'Boulet': [994], 'Genest': [996], 'Bernier': [998], 'NG,': [1001], 'J.': [1003], 'A': [1004, 1096], 'new': [1005], 'method': [1006], 'measurement': [1008], 'applications.J': [1014], 'Lipid': [1015], '2010;': [1017], '51:140–149.CrossrefMedlineGoogle': [1018], 'Scholar': [1019], 'Previous': [1020], 'Back': [1021], 'top': [1023], 'Next': [1024], 'FiguresReferencesRelatedDetailsCited': [1025], 'By': [1026], 'Burnap': [1027], 'S': [1028, 1093, 1122, 1125, 1169], 'Mayr': [1030], 'M': [1031, 1166], '(2021)': [1032], 'compartmentalisation': [1034], 'regulator': [1037], 'activity,': [1040], 'Journal': [1041], 'Cellular': [1045], 'Cardiology,': [1046], '10.1016/j.yjmcc.2021.02.004,': [1047], '155,': [1048], '(21-24),': [1049], 'Online': [1050, 1115, 1146, 1180], 'publication': [1051, 1116, 1147, 1181], 'date:': [1052, 1117, 1148, 1182], '1-Jun-2021.': [1053], 'Hathorn': [1054], 'Luskin': [1056], 'Caton': [1058], 'DeAngelo': [1060], 'D': [1061], 'Saltzman': [1063], '(2019)(2019)': [1065], 'Colonic': [1066], 'Wall': [1067], 'Thickening': [1068], 'First': [1071], 'Indicator': [1072], 'Relapse': [1074], 'Acute': [1076], 'Lymphoblastic': [1077], 'Leukemia,': [1078], 'ACG': [1079], 'Case': [1080], 'Reports': [1081], 'Journal,': [1082], '10.14309/crj.0000000000000207,': [1083], '6:8,': [1084], '(e00207)': [1085], 'Norata': [1086], 'Pirillo': [1090], 'A,': [1091], 'Catapano': [1095], '(2016)': [1097], 'Biology': [1098], '9:': [1104], 'beyond': [1105], 'lowering,': [1109], 'Research,': [1111, 1177], '10.1093/cvr/cvw194,': [1112], '112:1,': [1113], '(429-442),': [1114], '1-Oct-2016.': [1118], 'Rashid': [1121], '(2015)': [1126, 1152], 'On': [1127], 'function': [1129], 'homeostasis': [1131], 'Reciprocal': [1134], 'interaction': [1135], 'LDLR': [1137], 'additional': [1139], 'lipid': [1140], 'Atherosclerosis,': [1142], '10.1016/j.atherosclerosis.2014.12.017,': [1143], '238:2,': [1144], '(264-270),': [1145], '1-Feb-2015.': [1149], 'P': [1151], 'Dyslipidemias,': [1157], '10.1007/978-1-60761-424-1_29,': [1158], '(483-497),': [1159], '.': [1160], '(2014)': [1170], 'Response': [1171], 'al,': [1175], '115:1,': [1178], '(e5-e5),': [1179], '20-Jun-2014.': [1183], 'June': [1184], '20,': [1185, 1202], '2014Vol': [1186], 'Issue': [1188], '1': [1189], 'Advertisement': [1190, 1206], 'Article': [1191], 'InformationMetrics': [1192], '©': [1193], '2014': [1194, 1203], 'American': [1195], 'Heart': [1196], 'Association,': [1197], 'Inc.https://doi.org/10.1161/CIRCRESAHA.114.304163PMID:': [1198], '24951769': [1199], 'publishedJune': [1201], 'PDF': [1204], 'download': [1205], 'SubjectsEpidemiologyLipids': [1207], 'CholesterolMetabolism': [1209]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2112129124', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-08-13T17:54:36.729876', 'created_date': '2016-06-24'}