Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2112125281', 'doi': 'https://doi.org/10.1158/1055-9965.epi-05-0320', 'title': 'Molecular Profiling of Computed Tomography Screen-Detected Lung Nodules Shows Multiple Malignant Features', 'display_name': 'Molecular Profiling of Computed Tomography Screen-Detected Lung Nodules Shows Multiple Malignant Features', 'publication_year': 2006, 'publication_date': '2006-02-01', 'ids': {'openalex': 'https://openalex.org/W2112125281', 'doi': 'https://doi.org/10.1158/1055-9965.epi-05-0320', 'mag': '2112125281', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16492931'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1055-9965.epi-05-0320', 'pdf_url': 'https://cebp.aacrjournals.org/content/cebp/15/2/373.full.pdf', 'source': {'id': 'https://openalex.org/S8391440', 'display_name': 'Cancer Epidemiology Biomarkers & Prevention', 'issn_l': '1055-9965', 'issn': ['1055-9965', '1538-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://cebp.aacrjournals.org/content/cebp/15/2/373.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027132856', 'display_name': 'María J. Pajares', 'orcid': 'https://orcid.org/0000-0003-3149-8959'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'María J. Pajares', 'raw_affiliation_strings': ['1Oncology Division, Center for Applied Medical Research; Departments of', '6Histology and Pathology,', 'Departments of'], 'affiliations': [{'raw_affiliation_string': '1Oncology Division, Center for Applied Medical Research; Departments of', 'institution_ids': []}, {'raw_affiliation_string': '6Histology and Pathology,', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037224467', 'display_name': 'Isabel Zudaire', 'orcid': 'https://orcid.org/0000-0003-2297-7106'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Isabel Zudaire', 'raw_affiliation_strings': ['1Oncology Division, Center for Applied Medical Research; Departments of', '7Genetics and', 'Departments of', 'Genetics and'], 'affiliations': [{'raw_affiliation_string': '1Oncology Division, Center for Applied Medical Research; Departments of', 'institution_ids': []}, {'raw_affiliation_string': '7Genetics and', 'institution_ids': []}, {'raw_affiliation_string': 'Genetics and', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029140865', 'display_name': 'María D. Lozano', 'orcid': 'https://orcid.org/0000-0002-6796-9380'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'María D. Lozano', 'raw_affiliation_strings': ['2Pathology,', 'Pathology,'], 'affiliations': [{'raw_affiliation_string': '2Pathology,', 'institution_ids': []}, {'raw_affiliation_string': 'Pathology,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078154524', 'display_name': 'Jackeline Agorreta', 'orcid': 'https://orcid.org/0000-0003-4503-9884'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jackeline Agorreta', 'raw_affiliation_strings': ['1Oncology Division, Center for Applied Medical Research; Departments of', '6Histology and Pathology,', 'Departments of'], 'affiliations': [{'raw_affiliation_string': '1Oncology Division, Center for Applied Medical Research; Departments of', 'institution_ids': []}, {'raw_affiliation_string': '6Histology and Pathology,', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030603009', 'display_name': 'Gorka Bastarrika', 'orcid': 'https://orcid.org/0000-0001-9493-6907'}, 'institutions': [{'id': 'https://openalex.org/I4210150674', 'display_name': 'University Radiology', 'ror': 'https://ror.org/058fx5466', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210150674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gorka Bastarrika', 'raw_affiliation_strings': ['3Radiology,', 'Radiology,'], 'affiliations': [{'raw_affiliation_string': '3Radiology,', 'institution_ids': []}, {'raw_affiliation_string': 'Radiology,', 'institution_ids': ['https://openalex.org/I4210150674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017866765', 'display_name': 'W. Torre', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wenceslao Torre', 'raw_affiliation_strings': ['4Thoracic Surgery, and'], 'affiliations': [{'raw_affiliation_string': '4Thoracic Surgery, and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078835951', 'display_name': 'Ana Remírez', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ana Remírez', 'raw_affiliation_strings': ['1Oncology Division, Center for Applied Medical Research; Departments of', 'Departments of'], 'affiliations': [{'raw_affiliation_string': '1Oncology Division, Center for Applied Medical Research; Departments of', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051024704', 'display_name': 'Rubén Pı́o', 'orcid': 'https://orcid.org/0000-0002-6831-6111'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Ruben Pio', 'raw_affiliation_strings': ['1Oncology Division, Center for Applied Medical Research; Departments of', '8Biochemistry, Schools of Medicine and Sciences, University of Navarra, Pamplona, Spain', 'Departments of'], 'affiliations': [{'raw_affiliation_string': '1Oncology Division, Center for Applied Medical Research; Departments of', 'institution_ids': []}, {'raw_affiliation_string': '8Biochemistry, Schools of Medicine and Sciences, University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}, {'raw_affiliation_string': 'Departments of', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051485828', 'display_name': 'Javier J. Zulueta', 'orcid': 'https://orcid.org/0000-0003-3182-3555'}, 'institutions': [{'id': 'https://openalex.org/I4210135003', 'display_name': 'Clinica Universidad de Navarra', 'ror': 'https://ror.org/03phm3r45', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210135003']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Javier J. Zulueta', 'raw_affiliation_strings': ['5Pulmonary Medicine, Clínica Universitaria de Navarra; and Departments of'], 'affiliations': [{'raw_affiliation_string': '5Pulmonary Medicine, Clínica Universitaria de Navarra; and Departments of', 'institution_ids': ['https://openalex.org/I4210135003']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5004034328', 'display_name': 'Luis M. Montuenga', 'orcid': 'https://orcid.org/0000-0002-8739-1387'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Luis M. Montuenga', 'raw_affiliation_strings': ['1Oncology Division, Center for Applied Medical Research; Departments of', '6Histology and Pathology,', 'Departments of'], 'affiliations': [{'raw_affiliation_string': '1Oncology Division, Center for Applied Medical Research; Departments of', 'institution_ids': []}, {'raw_affiliation_string': '6Histology and Pathology,', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.13, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.770932, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '15', 'issue': '2', 'first_page': '373', 'last_page': '380'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10202', 'display_name': 'Lung Cancer Diagnosis and Treatment', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10202', 'display_name': 'Lung Cancer Diagnosis and Treatment', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12422', 'display_name': 'Radiomics and Machine Learning in Medical Imaging', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/overdiagnosis', 'display_name': 'Overdiagnosis', 'score': 0.67561495}, {'id': 'https://openalex.org/keywords/spiral-computed-tomography', 'display_name': 'Spiral computed tomography', 'score': 0.6398426}, {'id': 'https://openalex.org/keywords/histology', 'display_name': 'Histology', 'score': 0.41682887}], 'concepts': [{'id': 'https://openalex.org/C2777405583', 'wikidata': 'https://www.wikidata.org/wiki/Q6704277', 'display_name': 'Lung cancer screening', 'level': 3, 'score': 0.81739616}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.7229268}, {'id': 'https://openalex.org/C2779399171', 'wikidata': 'https://www.wikidata.org/wiki/Q1483951', 'display_name': 'Malignancy', 'level': 2, 'score': 0.6859815}, {'id': 'https://openalex.org/C2779377019', 'wikidata': 'https://www.wikidata.org/wiki/Q956131', 'display_name': 'Overdiagnosis', 'level': 2, 'score': 0.67561495}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.650616}, {'id': 'https://openalex.org/C2778398297', 'wikidata': 'https://www.wikidata.org/wiki/Q30673015', 'display_name': 'Spiral computed tomography', 'level': 3, 'score': 0.6398426}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.63641864}, {'id': 'https://openalex.org/C146357865', 'wikidata': 'https://www.wikidata.org/wiki/Q1123245', 'display_name': 'Stage (stratigraphy)', 'level': 2, 'score': 0.5750654}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.5127893}, {'id': 'https://openalex.org/C2778321237', 'wikidata': 'https://www.wikidata.org/wiki/Q17125886', 'display_name': 'National Lung Screening Trial', 'level': 4, 'score': 0.47355902}, {'id': 'https://openalex.org/C57742111', 'wikidata': 'https://www.wikidata.org/wiki/Q7168', 'display_name': 'Histology', 'level': 2, 'score': 0.41682887}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.41035193}, {'id': 'https://openalex.org/C126838900', 'wikidata': 'https://www.wikidata.org/wiki/Q77604', 'display_name': 'Radiology', 'level': 1, 'score': 0.35093302}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.27031898}, {'id': 'https://openalex.org/C544519230', 'wikidata': 'https://www.wikidata.org/wiki/Q32566', 'display_name': 'Computed tomography', 'level': 2, 'score': 0.20144218}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20056823}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D036542', 'descriptor_name': 'Tomography, Spiral Computed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D042241', 'descriptor_name': 'Early Diagnosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017404', 'descriptor_name': 'In Situ Hybridization, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D008403', 'descriptor_name': 'Mass Screening', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009367', 'descriptor_name': 'Neoplasm Staging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012680', 'descriptor_name': 'Sensitivity and Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012907', 'descriptor_name': 'Smoking', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1055-9965.epi-05-0320', 'pdf_url': 'https://cebp.aacrjournals.org/content/cebp/15/2/373.full.pdf', 'source': {'id': 'https://openalex.org/S8391440', 'display_name': 'Cancer Epidemiology Biomarkers & Prevention', 'issn_l': '1055-9965', 'issn': ['1055-9965', '1538-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10171/16768', 'pdf_url': 'https://dadun.unav.edu/bitstream/10171/16768/1/agorretamolecularprofilingofcomputed.pdf', 'source': {'id': 'https://openalex.org/S4306401513', 'display_name': 'Deposito Adademico Digital Universidad De Navarra (University of Navarra)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I88155538', 'host_organization_name': 'Universidad de Navarra', 'host_organization_lineage': ['https://openalex.org/I88155538'], 'host_organization_lineage_names': ['Universidad de Navarra'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16492931', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1055-9965.epi-05-0320', 'pdf_url': 'https://cebp.aacrjournals.org/content/cebp/15/2/373.full.pdf', 'source': {'id': 'https://openalex.org/S8391440', 'display_name': 'Cancer Epidemiology Biomarkers & Prevention', 'issn_l': '1055-9965', 'issn': ['1055-9965', '1538-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.77, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1482267503', 'https://openalex.org/W1514053247', 'https://openalex.org/W1522392444', 'https://openalex.org/W1967005016', 'https://openalex.org/W1967947451', 'https://openalex.org/W1972311492', 'https://openalex.org/W1980006285', 'https://openalex.org/W1984050410', 'https://openalex.org/W1993312546', 'https://openalex.org/W1995007106', 'https://openalex.org/W2000631042', 'https://openalex.org/W2004567377', 'https://openalex.org/W2009551160', 'https://openalex.org/W2022806640', 'https://openalex.org/W2031827337', 'https://openalex.org/W2031881519', 'https://openalex.org/W2034269086', 'https://openalex.org/W2040479532', 'https://openalex.org/W2040972520', 'https://openalex.org/W2043003885', 'https://openalex.org/W2044294160', 'https://openalex.org/W2045186848', 'https://openalex.org/W2045518196', 'https://openalex.org/W2049610541', 'https://openalex.org/W2050105240', 'https://openalex.org/W2054315710', 'https://openalex.org/W2058680827', 'https://openalex.org/W2059604723', 'https://openalex.org/W2070207712', 'https://openalex.org/W2072363520', 'https://openalex.org/W2100828885', 'https://openalex.org/W2102770896', 'https://openalex.org/W2107043994', 'https://openalex.org/W2107854589', 'https://openalex.org/W2108320285', 'https://openalex.org/W2110544196', 'https://openalex.org/W2117346638', 'https://openalex.org/W2125579284', 'https://openalex.org/W2128012941', 'https://openalex.org/W2134881779', 'https://openalex.org/W2137583207', 'https://openalex.org/W2138449953', 'https://openalex.org/W2143555928', 'https://openalex.org/W2147149806', 'https://openalex.org/W2170034446', 'https://openalex.org/W2171616701', 'https://openalex.org/W3093133154', 'https://openalex.org/W4242182325'], 'related_works': ['https://openalex.org/W2898433158', 'https://openalex.org/W2518090021', 'https://openalex.org/W2325395784', 'https://openalex.org/W2165276713', 'https://openalex.org/W2158158233', 'https://openalex.org/W2103348420', 'https://openalex.org/W2089804822', 'https://openalex.org/W2034952766', 'https://openalex.org/W2016169004', 'https://openalex.org/W1790528337'], 'abstract_inverted_index': {'Abstract': [0], 'Rationale': [1], 'and': [2, 57, 82, 131, 144, 162, 175], 'Purpose:': [3], 'Low-dose': [4], 'spiral': [5, 43, 78, 217], 'computerized': [6], 'axial': [7], 'tomography': [8], '(spiral': [9], 'CT)': [10], 'is': [11], 'effective': [12], 'for': [13, 202], 'the': [14, 35, 40, 49, 55, 61, 69, 121, 163, 184, 188, 236], 'detection': [15, 67, 214], 'of': [16, 32, 37, 42, 48, 71, 94, 106, 113, 140, 165, 183], 'small': [17, 62], 'early': [18], 'lung': [19, 96, 107, 146, 177, 205, 210, 232], 'cancers.': [20], 'Although': [21], 'published': [22], 'data': [23], 'seem': [24], 'promising,': [25], 'there': [26], 'has': [27, 198], 'been': [28, 199], 'a': [29, 111, 216], 'significant': [30], 'degree': [31], 'discussion': [33], 'concerning': [34], 'potential': [36], 'overdiagnosis': [38], 'in': [39, 60, 68, 110, 133, 187, 215, 229], 'context': [41], 'CT–based': [44], 'screening.': [45], 'The': [46, 159], 'objective': [47], 'current': [50], 'study': [51, 193], 'was': [52, 154], 'to': [53, 83, 92, 226], 'analyze': [54], 'phenotypic': [56, 166], 'genetic': [58, 168], 'alterations': [59, 161, 185], 'pulmonary': [63], 'malignancies': [64], 'resected': [65, 95, 116, 212], 'after': [66, 213], 'University': [70], 'Navarra/International': [72], 'Early': [73], 'Lung': [74], 'Cancer': [75], 'Action': [76], 'Project': [77], 'CT': [79], 'screening': [80, 153, 219], 'trial': [81, 220], 'determine': [84], 'whether': [85], 'their': [86], 'malignant': [87, 222], 'molecular': [88, 160, 223], 'features': [89, 224], 'are': [90, 239], 'similar': [91, 172, 225], 'those': [93, 227], 'tumors': [97, 115], 'diagnosed': [98, 148, 231], 'conventionally.': [99], 'Experimental': [100], 'Design:': [101], 'We': [102], 'analyzed': [103], '17': [104], 'biomarkers': [105], 'epithelial': [108], 'malignancy': [109], 'series': [112, 139], '11': [114, 141], 'at': [117], 'our': [118], 'institution': [119], 'during': [120], 'last': [122], '4': [123], 'years': [124], '(1,004': [125], 'high-risk': [126], 'individuals': [127], 'screened),': [128], 'using': [129], 'immunohistochemistry': [130], 'fluorescence': [132], 'situ': [134], 'hybridization': [135], '(FISH).': [136], 'A': [137], 'parallel': [138], 'gender-,': [142], 'stage-,': [143], 'histology-matched': [145], 'cancers': [147, 178, 190, 211, 238], 'by': [149], 'other': [150], 'means': [151], 'except': [152], 'used': [155], 'as': [156], 'control.': [157], 'Results:': [158], 'frequency': [164], 'or': [167], 'aberrations': [169], 'were': [170, 179, 194], 'very': [171], 'when': [173], 'screen-detected': [174, 189, 237], 'nonscreen-detected': [176], 'compared.': [180], 'Furthermore,': [181], 'most': [182], 'found': [186, 228], 'from': [191], 'this': [192], 'concordant': [195], 'with': [196], 'what': [197], 'described': [200], 'previously': [201], 'stage': [203], 'I-II': [204], 'cancer.': [206], 'Conclusions:': [207], 'Small': [208], 'early-stage': [209], 'CT-based': [218], 'reveal': [221], 'conventionally': [230], 'cancers,': [233], 'suggesting': [234], 'that': [235], 'not': [240], 'overdiagnosed.': [241], '(Cancer': [242], 'Epidemiol': [243], 'Biomarkers': [244], 'Prev': [245], '2006;15(2):373–80)': [246]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2112125281', 'counts_by_year': [{'year': 2016, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-15T11:40:17.331429', 'created_date': '2016-06-24'}