Title: In vivo effects and therapeutic potential of VEGF-C
Abstract: 7 REVIEW OF THE LITERATURE 8 The formation of blood and lymphatic vessel networks during embryonic development 8 Vasculogenesis and angiogenesis 8 Endothelial cell differentiation 8 Lymphangiogenesis 10 Characteristics of lymphatic vessels 11 Molecular regulation of the blood and lymphatic vessel growth 14 VEGF and its receptors 14 VEGF-B and PlGF 16 VEGF-C, VEGF–D and their receptors 18 Angiopoietins and their Tie-receptors 19 Ephrins 20 Lymphatic vessel markers 20 Diseases associated with lymphatic vessel function 23 Lymphedema 23 Tumorigenesis and metastasis 26 AIMS OF THE STUDY 30 MATERIALS AND METHODS 31 RESULTS AND DISCUSSION 34 I Expression of VEGF-C and its receptor VEGFR-3 in nasal mucosa and in nasopharyngeal tumors 34 II Expression of VEGF-C, VEGF-D and VEGFR-3 in normal human tissues 34 III In vivo effect of VEGF-C on blood and lymphatic vessels 35 IV Characterization of the VEGFR-3 specific mutant form of VEGF-C (VEGF-C156S) as a lymphangiogenic factor 38 CONCLUSIONS 42 ACKNOWLEDGEMENTS 44 REFERENCES 45
Publication Year: 2002
Publication Date: 2002-08-01
Language: en
Type: article
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