Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2111358509', 'doi': 'https://doi.org/10.1158/1535-7163.mct-12-1162', 'title': 'Regorafenib Inhibits Growth, Angiogenesis, and Metastasis in a Highly Aggressive, Orthotopic Colon Cancer Model', 'display_name': 'Regorafenib Inhibits Growth, Angiogenesis, and Metastasis in a Highly Aggressive, Orthotopic Colon Cancer Model', 'publication_year': 2013, 'publication_date': '2013-04-26', 'ids': {'openalex': 'https://openalex.org/W2111358509', 'doi': 'https://doi.org/10.1158/1535-7163.mct-12-1162', 'mag': '2111358509', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23619301'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-12-1162', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5009596615', 'display_name': 'Lotfi Abou‐Elkacem', 'orcid': 'https://orcid.org/0000-0001-8657-9030'}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}, {'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}, {'id': 'https://openalex.org/I4210137840', 'display_name': 'Federal Office for Radiation Protection', 'ror': 'https://ror.org/02yvd4j36', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I4210137840']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Lotfi Abou-Elkacem', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany", 'institution_ids': ['https://openalex.org/I887968799', 'https://openalex.org/I67348948', 'https://openalex.org/I4210137840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008142398', 'display_name': 'Susanne Arns', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}, {'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}, {'id': 'https://openalex.org/I4210137840', 'display_name': 'Federal Office for Radiation Protection', 'ror': 'https://ror.org/02yvd4j36', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I4210137840']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Susanne Arns', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany", 'institution_ids': ['https://openalex.org/I887968799', 'https://openalex.org/I67348948', 'https://openalex.org/I4210137840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028261654', 'display_name': 'Gunnar Brix', 'orcid': 'https://orcid.org/0000-0002-5023-1830'}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}, {'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}, {'id': 'https://openalex.org/I4210137840', 'display_name': 'Federal Office for Radiation Protection', 'ror': 'https://ror.org/02yvd4j36', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I4210137840']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Gunnar Brix', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany", 'institution_ids': ['https://openalex.org/I887968799', 'https://openalex.org/I67348948', 'https://openalex.org/I4210137840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069679489', 'display_name': 'Felix Gremse', 'orcid': 'https://orcid.org/0000-0002-6522-9004'}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}, {'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}, {'id': 'https://openalex.org/I4210137840', 'display_name': 'Federal Office for Radiation Protection', 'ror': 'https://ror.org/02yvd4j36', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I4210137840']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Felix Gremse', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany", 'institution_ids': ['https://openalex.org/I887968799', 'https://openalex.org/I67348948', 'https://openalex.org/I4210137840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034373024', 'display_name': 'Dieter Zopf', 'orcid': 'https://orcid.org/0000-0001-9251-7792'}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}, {'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}, {'id': 'https://openalex.org/I4210137840', 'display_name': 'Federal Office for Radiation Protection', 'ror': 'https://ror.org/02yvd4j36', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I4210137840']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Dieter Zopf', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany", 'institution_ids': ['https://openalex.org/I887968799', 'https://openalex.org/I67348948', 'https://openalex.org/I4210137840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028314781', 'display_name': 'Fabian Kießling', 'orcid': 'https://orcid.org/0000-0002-7341-0399'}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}, {'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}, {'id': 'https://openalex.org/I4210137840', 'display_name': 'Federal Office for Radiation Protection', 'ror': 'https://ror.org/02yvd4j36', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I4210137840']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Fabian Kiessling', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany", 'institution_ids': ['https://openalex.org/I887968799', 'https://openalex.org/I67348948', 'https://openalex.org/I4210137840']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085724871', 'display_name': 'Wiltrud Lederle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}, {'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}, {'id': 'https://openalex.org/I4210137840', 'display_name': 'Federal Office for Radiation Protection', 'ror': 'https://ror.org/02yvd4j36', 'country_code': 'DE', 'type': 'government', 'lineage': ['https://openalex.org/I4210137840']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Wiltrud Lederle', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen; 2Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Neuherberg; and 3Global Drug Discovery, Bayer Pharma AG, Berlin, Germany", 'institution_ids': ['https://openalex.org/I887968799', 'https://openalex.org/I67348948', 'https://openalex.org/I4210137840']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.281, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 244, 'citation_normalized_percentile': {'value': 0.999952, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '12', 'issue': '7', 'first_page': '1322', 'last_page': '1331'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10073', 'display_name': 'Hepatocellular Carcinoma Treatment and Prognosis', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/regorafenib', 'display_name': 'Regorafenib', 'score': 0.99232733}], 'concepts': [{'id': 'https://openalex.org/C2776248978', 'wikidata': 'https://www.wikidata.org/wiki/Q3891664', 'display_name': 'Regorafenib', 'level': 4, 'score': 0.99232733}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8222814}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.72005427}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.6919793}, {'id': 'https://openalex.org/C2777802072', 'wikidata': 'https://www.wikidata.org/wiki/Q413299', 'display_name': 'Bevacizumab', 'level': 3, 'score': 0.58641}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.57892436}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.45984805}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.45377997}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.43721586}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.42039973}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.41818288}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.402947}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.28710252}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.10574475}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D010671', 'descriptor_name': 'Phenylurea Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008137', 'descriptor_name': 'Longitudinal Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D010671', 'descriptor_name': 'Phenylurea Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-12-1162', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23619301', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.7, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 65, 'referenced_works': ['https://openalex.org/W1226199980', 'https://openalex.org/W1518520618', 'https://openalex.org/W1636670860', 'https://openalex.org/W1664817186', 'https://openalex.org/W1756949381', 'https://openalex.org/W1950724735', 'https://openalex.org/W1967587727', 'https://openalex.org/W1968209756', 'https://openalex.org/W1970730148', 'https://openalex.org/W1977587080', 'https://openalex.org/W1977999028', 'https://openalex.org/W1984373489', 'https://openalex.org/W1996859043', 'https://openalex.org/W1997062296', 'https://openalex.org/W2002226820', 'https://openalex.org/W2011158867', 'https://openalex.org/W2012708129', 'https://openalex.org/W2021596330', 'https://openalex.org/W2026351725', 'https://openalex.org/W2027607692', 'https://openalex.org/W2030188889', 'https://openalex.org/W2036913456', 'https://openalex.org/W2045604912', 'https://openalex.org/W2048388966', 'https://openalex.org/W2049972026', 'https://openalex.org/W2055220513', 'https://openalex.org/W2058648826', 'https://openalex.org/W2059702427', 'https://openalex.org/W2067863614', 'https://openalex.org/W2074195384', 'https://openalex.org/W2077910135', 'https://openalex.org/W2080162976', 'https://openalex.org/W2080860848', 'https://openalex.org/W2091065076', 'https://openalex.org/W2092932188', 'https://openalex.org/W2105623649', 'https://openalex.org/W2107019084', 'https://openalex.org/W2108180348', 'https://openalex.org/W2110643890', 'https://openalex.org/W2114165294', 'https://openalex.org/W2114545185', 'https://openalex.org/W2115518353', 'https://openalex.org/W2115735904', 'https://openalex.org/W2120621109', 'https://openalex.org/W2124109795', 'https://openalex.org/W2125763124', 'https://openalex.org/W2126922455', 'https://openalex.org/W2128059540', 'https://openalex.org/W2132190370', 'https://openalex.org/W2140088548', 'https://openalex.org/W2140207145', 'https://openalex.org/W2141674582', 'https://openalex.org/W2143743735', 'https://openalex.org/W2144026118', 'https://openalex.org/W2154458783', 'https://openalex.org/W2158734599', 'https://openalex.org/W2165132869', 'https://openalex.org/W2166715150', 'https://openalex.org/W2247003217', 'https://openalex.org/W2414560449', 'https://openalex.org/W2414639108', 'https://openalex.org/W2589339679', 'https://openalex.org/W3141441736', 'https://openalex.org/W4245981633', 'https://openalex.org/W4251087695'], 'related_works': ['https://openalex.org/W4380224996', 'https://openalex.org/W4293577346', 'https://openalex.org/W3032784534', 'https://openalex.org/W2811168026', 'https://openalex.org/W2624771607', 'https://openalex.org/W2566344969', 'https://openalex.org/W2319024198', 'https://openalex.org/W2314601331', 'https://openalex.org/W2190778458', 'https://openalex.org/W2054301472'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'combination': [2], 'of': [3, 23, 62, 76, 109, 133, 186, 213, 245], 'target-specific': [4], 'drugs': [5, 31], 'like': [6], 'bevacizumab': [7], 'with': [8, 35, 42, 64, 82, 103, 120, 202], 'chemotherapeutics': [9], 'has': [10, 55], 'improved': [11], 'treatment': [12, 99, 244], 'efficacy': [13], 'in': [14, 40, 80, 87, 142, 148, 190, 242], 'advanced': [15, 246], 'colorectal': [16], 'cancer': [17, 95], '(CRC).': [18], 'However,': [19], 'the': [20, 49, 71, 74, 83, 88, 163, 184, 193, 203, 211, 220, 243], 'clinical': [21], 'prognosis': [22], 'metastatic': [24, 93, 194], 'CRCs': [25, 65], 'is': [26], 'still': [27], 'poor,': [28], 'and': [29, 155, 168, 228], 'novel': [30], 'are': [32], 'currently': [33], 'assessed': [34, 147], 'respect': [36], 'to': [37, 59], 'their': [38], 'efficacies': [39], 'patients': [41, 63], 'CRCs.': [43, 247], 'In': [44, 70, 159, 206], 'a': [45, 98, 107, 129, 139, 170], 'phase': [46], 'III': [47], 'study,': [48, 73], 'multikinase': [50, 221], 'inhibitor': [51, 85, 222], 'regorafenib': [52, 77, 123, 161, 181, 208, 223], '(BAY': [53], '73-4506)': [54], 'recently': [56], 'been': [57], 'shown': [58], 'prolong': [60], 'survival': [61], 'after': [66], 'standard': [67], 'therapies': [68], 'failed.': [69], 'present': [72], 'activity': [75, 165], 'was': [78, 196], 'investigated': [79], 'comparison': [81], 'angiogenesis': [84], 'DC101': [86, 104], 'highly': [89, 233], 'aggressive,': [90], 'murine': [91], 'CT26': [92], 'colon': [94, 235], 'model.': [96], 'While': [97], 'for': [100, 238], '10': [101], 'days': [102], 'given': [105], 'at': [106, 128], 'dose': [108, 132], '34': [110], 'mg/kg': [111], 'every': [112], 'third': [113], 'day': [114], 'significantly': [115, 209], 'delayed': [116], 'tumor': [117, 126, 143], 'growth': [118, 127], 'compared': [119, 201], 'vehicle-treated': [121], 'animals,': [122, 192], 'completely': [124, 182], 'suppressed': [125], 'daily': [130], 'oral': [131], '30': [134], 'mg/kg.': [135], 'Regorafenib': [136], 'also': [137], 'induced': [138, 169], 'stronger': [140], 'reduction': [141], 'vascularization,': [144], 'as': [145], 'longitudinally': [146], 'vivo': [149], 'by': [150, 157, 199], 'dynamic': [151], 'contrast-enhanced': [152], 'MRI': [153], '(DCE-MRI)': [154], 'confirmed': [156], 'immunohistochemistry.': [158], 'addition,': [160, 207], 'inhibited': [162], 'angiogenic': [164], 'more': [166, 179], 'strongly': [167], 'three': [171], 'times': [172], 'higher': [173], 'apoptosis': [174], 'rate': [175, 195], 'than': [176], 'DC101.': [177], 'Even': [178], 'important,': [180], 'prevented': [183], 'formation': [185], 'liver': [187], 'metastases,': [188], 'whereas': [189], 'DC101-treated': [191], 'only': [197], 'reduced': [198, 210], '33%': [200], 'vehicle': [204], 'group.': [205], 'amount': [212], 'infiltrating': [214], 'macrophages.': [215], 'These': [216], 'data': [217], 'show': [218], 'that': [219], 'exerts': [224], 'strong': [225], 'antiangiogenic,': [226], 'antitumorigenic,': [227], 'even': [229], 'antimetastatic': [230], 'effects': [231], 'on': [232], 'aggressive': [234], 'carcinomas': [236], 'indicative': [237], 'its': [239], 'high': [240], 'potential': [241], 'Mol': [248], 'Cancer': [249], 'Ther;': [250], '12(7);': [251], '1322–31.': [252], '©2013': [253], 'AACR.': [254]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2111358509', 'counts_by_year': [{'year': 2024, 'cited_by_count': 15}, {'year': 2023, 'cited_by_count': 30}, {'year': 2022, 'cited_by_count': 37}, {'year': 2021, 'cited_by_count': 31}, {'year': 2020, 'cited_by_count': 33}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 18}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 4}], 'updated_date': '2024-12-19T07:44:53.945713', 'created_date': '2016-06-24'}