Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2111214065', 'doi': 'https://doi.org/10.1242/dev.070763', 'title': 'Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells', 'display_name': 'Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells', 'publication_year': 2011, 'publication_date': '2011-12-22', 'ids': {'openalex': 'https://openalex.org/W2111214065', 'doi': 'https://doi.org/10.1242/dev.070763', 'mag': '2111214065', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22190634', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3252352'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dev.070763', 'pdf_url': 'https://dev.biologists.org/content/develop/139/3/488.full.pdf', 'source': {'id': 'https://openalex.org/S86558740', 'display_name': 'Development', 'issn_l': '0950-1991', 'issn': ['0950-1991', '1477-9129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://dev.biologists.org/content/develop/139/3/488.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003270106', 'display_name': 'Kelli L. VanDussen', 'orcid': 'https://orcid.org/0000-0002-5810-0720'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kelli L. VanDussen', 'raw_affiliation_strings': ['Department of Molecular & Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular & Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051452566', 'display_name': 'Alexis J. Carulli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexis J. Carulli', 'raw_affiliation_strings': ['Department of Molecular & Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular & Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090813037', 'display_name': 'Theresa M. Keeley', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Theresa M. Keeley', 'raw_affiliation_strings': ['Department of Molecular & Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular & Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070887046', 'display_name': 'Sanjeevkumar R. Patel', 'orcid': 'https://orcid.org/0000-0002-6715-6064'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sanjeevkumar R. Patel', 'raw_affiliation_strings': ['Department of Internal Medicine, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054738968', 'display_name': 'Brent J. Puthoff', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brent J. Puthoff', 'raw_affiliation_strings': ['Departments of Medicine and Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicine and Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014274257', 'display_name': 'Scott T. Magness', 'orcid': 'https://orcid.org/0000-0002-2746-1224'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Scott T. Magness', 'raw_affiliation_strings': ['Departments of Medicine and Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicine and Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040611280', 'display_name': 'Ivy Tran', 'orcid': 'https://orcid.org/0000-0003-4300-7379'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ivy T. Tran', 'raw_affiliation_strings': ['Department of The Life Sciences Institute, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of The Life Sciences Institute, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048706550', 'display_name': 'Ivan Maillard', 'orcid': 'https://orcid.org/0000-0003-1312-6748'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ivan Maillard', 'raw_affiliation_strings': ['Department of Cell & Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.', 'Department of Internal Medicine, The University of Michigan, Ann Arbor, MI 48109, USA.', 'Department of The Life Sciences Institute, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Department of The Life Sciences Institute, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Department of Cell & Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082522262', 'display_name': 'Christian W. Siebel', 'orcid': 'https://orcid.org/0000-0003-4333-3756'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christian Siebel', 'raw_affiliation_strings': ['Department of Molecular Biology, Genentech, San Francisco, CA 94080, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, Genentech, San Francisco, CA 94080, USA.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069016468', 'display_name': 'Åsa Kolterud', 'orcid': 'https://orcid.org/0000-0002-6924-3524'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Åsa Kolterud', 'raw_affiliation_strings': ['Department of Cell & Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell & Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091623135', 'display_name': 'Ann S. Grosse', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ann S. Grosse', 'raw_affiliation_strings': ['Department of Cell & Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell & Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068046209', 'display_name': 'Deborah L. Gumucio', 'orcid': 'https://orcid.org/0000-0001-8883-383X'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Deborah L. Gumucio', 'raw_affiliation_strings': ['Department of Cell & Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell & Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109567473', 'display_name': 'Stephen A. Ernst', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen A. Ernst', 'raw_affiliation_strings': ['Department of Cell & Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell & Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109218250', 'display_name': 'Yu-Hwai Tsai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yu-Hwai Tsai', 'raw_affiliation_strings': ['Department of Pediatrics & Communicable Diseases, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatrics & Communicable Diseases, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033492600', 'display_name': 'Peter J. Dempsey', 'orcid': 'https://orcid.org/0000-0003-4151-799X'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter J. Dempsey', 'raw_affiliation_strings': ['Department of Molecular & Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA.', 'Department of Pediatrics & Communicable Diseases, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular & Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Department of Pediatrics & Communicable Diseases, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066686042', 'display_name': 'Linda C. Samuelson', 'orcid': 'https://orcid.org/0000-0002-0898-2243'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Linda C. Samuelson', 'raw_affiliation_strings': ['Department of Internal Medicine, The University of Michigan, Ann Arbor, MI 48109, USA.', 'Department of Molecular & Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Department of Molecular & Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 10.725, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 508, 'citation_normalized_percentile': {'value': 0.924466, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '139', 'issue': '3', 'first_page': '488', 'last_page': '497'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13199', 'display_name': 'Digestive system and related health', 'score': 0.9835, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10966', 'display_name': 'Liver physiology and pathology', 'score': 0.9626, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hes1', 'display_name': 'HES1', 'score': 0.5504037}, {'id': 'https://openalex.org/keywords/cell-fate-determination', 'display_name': 'Cell fate determination', 'score': 0.5067583}, {'id': 'https://openalex.org/keywords/paneth-cell', 'display_name': 'Paneth cell', 'score': 0.4453371}, {'id': 'https://openalex.org/keywords/notch-proteins', 'display_name': 'Notch proteins', 'score': 0.43375495}], 'concepts': [{'id': 'https://openalex.org/C161879069', 'wikidata': 'https://www.wikidata.org/wiki/Q904082', 'display_name': 'Notch signaling pathway', 'level': 3, 'score': 0.9127319}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.88931286}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.80760413}, {'id': 'https://openalex.org/C201750760', 'wikidata': 'https://www.wikidata.org/wiki/Q1896218', 'display_name': 'Progenitor cell', 'level': 3, 'score': 0.7536701}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.7215451}, {'id': 'https://openalex.org/C148738053', 'wikidata': 'https://www.wikidata.org/wiki/Q210861', 'display_name': 'Cellular differentiation', 'level': 3, 'score': 0.6495291}, {'id': 'https://openalex.org/C2780283210', 'wikidata': 'https://www.wikidata.org/wiki/Q18027301', 'display_name': 'HES1', 'level': 4, 'score': 0.5504037}, {'id': 'https://openalex.org/C163952510', 'wikidata': 'https://www.wikidata.org/wiki/Q5058196', 'display_name': 'Cell fate determination', 'level': 4, 'score': 0.5067583}, {'id': 'https://openalex.org/C2776145723', 'wikidata': 'https://www.wikidata.org/wiki/Q2004084', 'display_name': 'Paneth cell', 'level': 3, 'score': 0.4453371}, {'id': 'https://openalex.org/C66090201', 'wikidata': 'https://www.wikidata.org/wiki/Q15995009', 'display_name': 'Crypt', 'level': 2, 'score': 0.4364351}, {'id': 'https://openalex.org/C202769670', 'wikidata': 'https://www.wikidata.org/wiki/Q4045508', 'display_name': 'Notch proteins', 'level': 4, 'score': 0.43375495}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.41668236}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.3673064}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.11141631}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.11060354}, {'id': 'https://openalex.org/C2777882243', 'wikidata': 'https://www.wikidata.org/wiki/Q11090', 'display_name': 'Small intestine', 'level': 2, 'score': 0.1081768}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0630818}], 'mesh': [{'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D051881', 'descriptor_name': 'Receptor, Notch1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051883', 'descriptor_name': 'Receptor, Notch2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051792', 'descriptor_name': 'Basic Helix-Loop-Helix Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051792', 'descriptor_name': 'Basic Helix-Loop-Helix Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020397', 'descriptor_name': 'Goblet Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020397', 'descriptor_name': 'Goblet Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051819', 'descriptor_name': 'Immunoglobulin J Recombination Signal Sequence-Binding Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051819', 'descriptor_name': 'Immunoglobulin J Recombination Signal Sequence-Binding Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007421', 'descriptor_name': 'Intestine, Small', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009924', 'descriptor_name': 'Organ Culture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019879', 'descriptor_name': 'Paneth Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019879', 'descriptor_name': 'Paneth Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051881', 'descriptor_name': 'Receptor, Notch1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051881', 'descriptor_name': 'Receptor, Notch1', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D051883', 'descriptor_name': 'Receptor, Notch2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051883', 'descriptor_name': 'Receptor, Notch2', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dev.070763', 'pdf_url': 'https://dev.biologists.org/content/develop/139/3/488.full.pdf', 'source': {'id': 'https://openalex.org/S86558740', 'display_name': 'Development', 'issn_l': '0950-1991', 'issn': ['0950-1991', '1477-9129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://cdr.lib.unc.edu/downloads/2v23w391z', 'pdf_url': 'https://cdr.lib.unc.edu/downloads/2v23w391z', 'source': {'id': 'https://openalex.org/S4306401075', 'display_name': 'Carolina Digital Repository (University of North Carolina at Chapel Hill)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I114027177', 'host_organization_name': 'University of North Carolina at Chapel Hill', 'host_organization_lineage': ['https://openalex.org/I114027177'], 'host_organization_lineage_names': ['University of North Carolina at Chapel Hill'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252352', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3252352', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22190634', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dev.070763', 'pdf_url': 'https://dev.biologists.org/content/develop/139/3/488.full.pdf', 'source': {'id': 'https://openalex.org/S86558740', 'display_name': 'Development', 'issn_l': '0950-1991', 'issn': ['0950-1991', '1477-9129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.53, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 64, 'referenced_works': ['https://openalex.org/W1568038787', 'https://openalex.org/W1965567319', 'https://openalex.org/W1968833346', 'https://openalex.org/W1969335165', 'https://openalex.org/W1978232052', 'https://openalex.org/W1978810631', 'https://openalex.org/W1982603620', 'https://openalex.org/W1990442683', 'https://openalex.org/W1991493591', 'https://openalex.org/W1995632399', 'https://openalex.org/W1996543394', 'https://openalex.org/W2003424014', 'https://openalex.org/W2013351311', 'https://openalex.org/W2014209146', 'https://openalex.org/W2015477868', 'https://openalex.org/W2021370278', 'https://openalex.org/W2023649138', 'https://openalex.org/W2024121049', 'https://openalex.org/W2029358883', 'https://openalex.org/W2031735410', 'https://openalex.org/W2032208533', 'https://openalex.org/W2033016500', 'https://openalex.org/W2033167307', 'https://openalex.org/W2037245332', 'https://openalex.org/W2042082068', 'https://openalex.org/W2049792810', 'https://openalex.org/W2050610306', 'https://openalex.org/W2051244361', 'https://openalex.org/W2053735133', 'https://openalex.org/W2058797249', 'https://openalex.org/W2068037194', 'https://openalex.org/W2068423301', 'https://openalex.org/W2073274892', 'https://openalex.org/W2076562605', 'https://openalex.org/W2081471404', 'https://openalex.org/W2082867256', 'https://openalex.org/W2084323335', 'https://openalex.org/W2084745919', 'https://openalex.org/W2090279335', 'https://openalex.org/W2095397411', 'https://openalex.org/W2097705657', 'https://openalex.org/W2097845265', 'https://openalex.org/W2100413191', 'https://openalex.org/W2102394111', 'https://openalex.org/W2103750856', 'https://openalex.org/W2111164352', 'https://openalex.org/W2113337076', 'https://openalex.org/W2117374458', 'https://openalex.org/W2120207971', 'https://openalex.org/W2129828870', 'https://openalex.org/W2133024684', 'https://openalex.org/W2133899877', 'https://openalex.org/W2142661486', 'https://openalex.org/W2142755832', 'https://openalex.org/W2144228956', 'https://openalex.org/W2145639699', 'https://openalex.org/W2146883005', 'https://openalex.org/W2152501601', 'https://openalex.org/W2154144191', 'https://openalex.org/W2157010562', 'https://openalex.org/W2168901267', 'https://openalex.org/W2765275788', 'https://openalex.org/W4243390175', 'https://openalex.org/W4247382314'], 'related_works': ['https://openalex.org/W4243390175', 'https://openalex.org/W4205584353', 'https://openalex.org/W2164479709', 'https://openalex.org/W2131748018', 'https://openalex.org/W2124407730', 'https://openalex.org/W2102270036', 'https://openalex.org/W1997151227', 'https://openalex.org/W1974246469', 'https://openalex.org/W1971602200', 'https://openalex.org/W1073061956'], 'abstract_inverted_index': {'Notch': [0, 24, 36, 50, 82, 94, 123, 138, 151], 'signaling': [1], 'is': [2], 'known': [3], 'to': [4, 45, 98, 157, 164, 169], 'regulate': [5, 165], 'the': [6, 39, 72, 92, 130], 'proliferation': [7], 'and': [8, 13, 20, 63, 117, 163], 'differentiation': [9, 100], 'of': [10, 23, 66, 71, 101, 111, 122, 140], 'intestinal': [11, 160], 'stem': [12, 47, 74, 161], 'progenitor': [14, 154], 'cells;': [15], 'however,': [16], 'direct': [17], 'cellular': [18, 131], 'targets': [19, 38, 152], 'specific': [21], 'functions': [22], 'signals': [25], 'had': [26], 'not': [27], 'been': [28], 'identified.': [29], 'We': [30], 'show': [31], 'here': [32], 'in': [33, 91, 125], 'mice': [34], 'that': [35, 113, 129, 150], 'directly': [37, 79], 'crypt': [40], 'base': [41], 'columnar': [42], '(CBC)': [43], 'cell': [44, 48, 55, 61, 106, 119, 155, 166, 172], 'maintain': [46, 158], 'activity.': [49], 'inhibition': [51, 95], 'induced': [52], 'rapid': [53], 'CBC': [54, 73], 'loss,': [56], 'with': [57, 84], 'reduced': [58, 64], 'proliferation,': [59], 'apoptotic': [60], 'death': [62], 'efficiency': [65], 'organoid': [67], 'initiation.': [68], 'Furthermore,': [69], 'expression': [70, 143], 'cell-specific': [75], 'marker': [76], 'Olfm4': [77, 141], 'was': [78, 144], 'dependent': [80, 134], 'on': [81, 135], 'signaling,': [83], 'transcription': [85], 'activated': [86], 'through': [87], 'RBP-Jκ': [88], 'binding': [89], 'sites': [90], 'promoter.': [93], 'also': [96], 'led': [97], 'precocious': [99], 'epithelial': [102, 171], 'progenitors': [103], 'into': [104], 'secretory': [105], 'types,': [107], 'including': [108], 'large': [109], 'numbers': [110], 'cells': [112, 162], 'expressed': [114], 'both': [115], 'Paneth': [116], 'goblet': [118], 'markers.': [120], 'Analysis': [121], 'function': [124], 'Atoh1-deficient': [126], 'intestine': [127], 'demonstrated': [128], 'changes': [132], 'were': [133], 'Atoh1,': [136], 'whereas': [137], 'regulation': [139], 'gene': [142], 'Atoh1': [145], 'independent.': [146], 'Our': [147], 'findings': [148], 'suggest': [149], 'distinct': [153], 'populations': [156], 'adult': [159], 'fate': [167], 'choice': [168], 'control': [170], 'homeostasis.': [173]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2111214065', 'counts_by_year': [{'year': 2024, 'cited_by_count': 42}, {'year': 2023, 'cited_by_count': 31}, {'year': 2022, 'cited_by_count': 30}, {'year': 2021, 'cited_by_count': 63}, {'year': 2020, 'cited_by_count': 49}, {'year': 2019, 'cited_by_count': 32}, {'year': 2018, 'cited_by_count': 64}, {'year': 2017, 'cited_by_count': 53}, {'year': 2016, 'cited_by_count': 34}, {'year': 2015, 'cited_by_count': 39}, {'year': 2014, 'cited_by_count': 36}, {'year': 2013, 'cited_by_count': 22}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-31T06:02:07.442528', 'created_date': '2016-06-24'}