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'major': [239, 872, 1277, 1396, 1562, 1609], 'role.': [240], 'few': [244], 'decades,': [245], 'each': [246, 1122, 1211], 'successive': [247], 'national': [248, 565, 704, 720, 734, 760, 2116], 'survey': [250], 'recorded': [252], 'systolic': [256, 266, 286, 305, 346, 1282, 1321, 1368], 'hypertension': [260, 362, 1870], 'control.': [261], 'For': [262, 336, 627, 905], 'example,': [263, 628, 906, 956], 'median': [265, 285, 304], 'among': [269, 321, 2432], 'aged': [270], '60': [271], '74': [273], 'years': [274, 674, 1604], '1960–1962': [276], 'was': [277], '≈150': [278], 'mm': [279, 312, 352, 356], 'Hg.6': [280, 357], 'In': [281, 816, 928, 950, 1174, 1352, 1549], 'subsequent': [282], 'surveys,': [283, 1881], 'consistently': [290], 'declined': [291], 'by': [293, 434, 545, 549, 1155, 1478, 1481, 1999, 2616, 3005, 3273, 3688], '1988–1991': [295], 'National': [296, 1774, 1781, 1793, 1807, 1985, 2960], 'Health': [297, 1970, 1982, 2007, 2050, 2161], 'Nutrition': [299], 'Examination': [300], 'Survey': [301], 'III,': [302], 'had': [308], 'decreased': [309, 349], '130': [311], 'Hg.6Improvements': [313], 'particularly': [319, 596, 710, 1569], 'pronounced': [320], 'those': [322], 'with': [323, 474, 488, 609, 640, 759, 764, 780, 967, 1016, 1075, 1109, 1202, 1215, 2321, 2647, 3227, 3356], 'very': [324], 'high': [325, 597, 1069, 1346, 2435], 'pressure,': [327, 1284, 1323, 1370], 'which': [328, 372, 853], 'confers': [329], 'disproportionately': [331], 'higher': [332, 512, 725, 914, 935, 1196], 'risk': [333, 739, 874, 1233, 1279, 1398, 1471, 1586, 1934, 2071, 2143, 2436], 'stroke.': [335], 'instance,': [337], 'during': [338, 382, 835, 1249, 1347, 3404], 'same': [340, 837], 'period,': [341], '90th': [343], 'percentile': [344], '>190': [351], 'Hg': [353], '<160': [355], 'This': [358, 469, 976, 1188], 'pattern': [359, 653, 841, 1151, 1189], 'improved': [361], 'demonstrated': [367], 'other': [369], 'high-income': [370, 500], 'countries,': [371], 'experienced': [374], '42%': [376], 'decrease': [377], 'overall': [381, 507, 666, 766], 'past': [384, 1349], 'years.7The': [386], 'Ongoing': [387], 'StrokeFrom': [391], 'global': [393, 570, 1033, 1454, 1552, 2063], 'prospective,': [394], 'outlook': [396], 'quite': [400, 655, 701], 'distinct.': [401], 'The': [402, 591, 652, 716, 754, 1007, 1079, 1137, 1801, 1972, 1994, 2037, 2281, 2310, 2970, 3626, 3638, 3750], 'conventional': [403], 'wisdom': [404], 'that': [406, 491, 552, 573, 669, 836, 858, 990, 1152, 1590], 'heart': [407, 776, 850, 881, 908, 938, 974, 1018, 1077, 1145, 1203, 2091, 2150, 3793], 'disease': [408, 429, 508, 667, 777, 795, 851, 864, 868, 882, 889, 899, 909, 939, 1134, 1146, 1204, 1268, 1599, 1668, 1932, 2137, 2151], 'primarily': [412], 'diseases': [413, 770], 'developed': [416], 'world,': [417], 'although': [418, 879, 1374], 'point': [420], 'fact': [422], 'most': [423, 499, 555, 621], 'burden': [426, 471, 509, 544, 581, 592, 668, 696, 726, 847, 890, 980, 1058, 1071, 1198, 1303, 1597, 1930, 2022, 2064, 2086], 'cardiovascular': [428, 454, 738, 823, 1555, 2066, 2136, 2366], 'borne': [433], 'countries': [435, 487, 533, 983], 'developing': [438, 515, 999, 1572], 'world.8,9': [439], 'second': [445, 1543], 'worldwide': [450, 852], '(second': [451], 'only': [452, 504, 1046], 'disease)': [455], 'accounts': [457, 520], '≈1': [459], '10': [461, 1218, 2276, 2759, 2797], 'or': [463, 1480], '5.7': [464], 'million': [465, 1113, 1118], 'year.10': [468], 'come': [473], 'more': [476], 'than': [477, 915, 936], 'doubling': [478], 'low-': [484, 530, 1157], 'middle-income': [486, 532, 1159], 'rates': [490, 496, 618, 911, 918, 932, 941], 'commonly': [492], 'surpass': [493], 'seen': [497, 844, 1360], 'countries.7': [501], 'So': [502], 'not': [503, 855, 1463], 'world': [516, 1000, 1573], 'but': [517, 803, 1059], 'greater': [523, 1596], 'relative': [524, 1070, 1197, 2085], 'proportion': [525, 819, 1168, 1298], 'well.There': [535], 'substantial': [537, 1055, 1207, 1297], 'variation': [538, 693, 2019, 2082], 'distribution': [541, 1469], 'region': [547, 1479], 'country—the': [550], 'may': [553, 1001, 1485], 'relevant': [556], 'policy': [558, 1537, 2152], 'program': [560], 'development.': [561], 'These': [562], 'regional': [563, 1929], 'hot': [566], 'spots': [567], 'constitute': [568], 'belt': [572, 585], 'parallels': [574], 'well-documented': [576], 'variations': [578], 'within': [582, 3730], 'southeastern': [588], 'States.11': [590], 'Eastern': [599], 'Europe,': [600, 925, 3594], 'North': [601, 920, 3568], 'Asia,': [602], 'Central': [603, 2294], 'Africa,': [604], 'South': [607, 951], 'Pacific': [608], '10-fold': [611], 'difference': [612], 'morbidity': [617], 'between': [619, 718, 3225], 'affected': [622, 625], 'least': [624], 'countries.12': [626], "Russia's": [629], 'standardized': [630], '251': [635], 'per': [636, 645, 722], '100': [637, 646], '000': [638, 647], 'compared': [639, 966, 1015, 1074, 1201], '32': [644], 'States.10': [651], 'similar': [656, 839], 'disability': [658, 684], 'adjusted': [659], 'life': [660, 677], 'year': [661], 'loss': [662], 'rates—a': [663], 'measure': [664], 'takes': [670], 'into': [671, 1465], 'account': [672, 807, 1258, 1294, 1466], 'both': [673], 'potential': [676], 'lost': [678], 'premature': [680], 'long-term': [683], 'stroke.12Once': [686], 'again,': [687], 'reasons': [689], 'globally': [699], 'complex.': [702], 'income': [705, 721, 761, 782, 903], 'emerged': [707, 1559], 'strong': [711, 755], 'predictor': [712], 'burden.12': [715], 'association': [717, 756, 2311], 'lower': [719, 902], 'capita': [723], 'persists': [729], 'even': [730, 1595], 'after': [731, 2610, 3267], 'adjustment': [732], 'measures': [735, 1365], 'typical': [737], 'factors,': [740, 1280, 1935], 'such': [741, 774], 'physical': [743], 'inactivity,': [744], 'hypertension,': [745], 'diabetes': [746, 1286], 'mellitus,': [747, 1287], 'tobacco': [748], 'use,': [749, 751], 'alcohol': [750], 'dyslipidemia.12': [753], 'consistent': [763], 'an': [765, 1049, 1063, 1110, 1240, 1448, 1493, 1594], 'shift': [767], 'communicable': [769], 'noncommunicable': [772], 'diseases,': [773, 824, 2649], 'stroke,': [779, 826, 2693, 3019], 'rising': [781], 'what': [784], 'termed': [787], 'epidemiological': [789, 1432], 'transition.13': [790], 'Infection,': [791], 'nutrition,': [792], 'perinatal': [794], 'accounted': [796], '34%': [798, 834], '1990': [802], 'just': [809, 968], '15%': [810], '2020.14': [815], 'contrast,': [817, 929, 1353], 'including': [825, 1281], '28%': [832], 'period.14A': [838], 'ischemic': [849, 880, 907, 937, 973, 1017, 1076, 1144, 1751, 2090, 2612, 2692, 3683], 'surprising': [856], 'given': [857], 'these': [859, 1425], '2': [860], 'forms': [861], 'vascular': [863, 888, 898, 1133, 1232, 1278, 1397, 1581, 1585, 2643], 'overlapping': [866], 'atherosclerotic': [867, 2365], 'mechanisms': [869], 'modifiable': [873], 'common.': [877], 'But': [878], 'predominant': [885, 895, 1130, 1578], 'form': [886, 896, 1131], 'overall,': [891], 'many': [901, 1156], 'countries.15': [904, 1160], 'slightly': [913], 'America,': [921], 'Western': [922], 'Northern': [924], 'Australia.15': [927], 'substantially': [934], 'much': [943], 'Africa': [945, 988], 'Asia': [947, 986], '(Figure': [948, 1336], '1).': [949], 'Korea': [952], 'China,': [954, 1408, 3071, 3235, 3738], '17%': [957], '18%': [959], 'all': [961, 1275], '6%': [969], '8%': [971], 'disease.': [975, 1582], 'concentration': [977], 'low-income': [982], 'suggests': [989], 'targeted': [992], 'approach': [993], 'addressing': [995, 1098], 'warranted.10Download': [1003], 'figureDownload': [1004, 1391], 'PowerPointFigure': [1005, 1392], '1.': [1006], 'Stroke-Belt.': [1009], 'Relative': [1010], 'disease,': [1019, 1556, 2367, 3450], '2004': [1020, 1977], '(based': [1021, 1412], 'on': [1022, 1413, 1434, 1703, 1707, 1712, 1783, 1809, 2199, 2239, 2506, 2789, 3630], 'WHO': [1023, 1414, 2163], 'Disease': [1027, 1418], 'data).15The': [1028], 'Case': [1029], 'ChinaIn': [1031], 'epidemic,': [1034], 'recent': [1036], 'experience': [1037], 'China': [1039, 1048, 1061, 1108, 1248, 2959], 'deserving': [1041], 'special': [1043], 'attention.': [1044], 'Not': [1045], 'outlier': [1050, 1064], 'terms': [1052, 1066], 'absolute': [1056], 'disease.15': [1078], 'sobering': [1080], 'projections': [1081, 1237, 1747, 2146], 'provide': [1089, 1517], 'case': [1091, 1903], 'study': [1092], 'current': [1095, 1228, 1236], 'challenges': [1096], 'epidemic.Stroke': [1100], 'estimated': [1111], '2.5': [1112], 'incident': [1114, 1170], 'strokes': [1115, 1162, 1171], '1.6': [1117], 'year.16': [1123], 'As': [1124], 'previously': [1125], 'described,': [1126], 'China.': [1136], 'far': [1141], 'exceeds': [1142, 1182], 'shared': [1154], 'Hemorrhagic': [1161], 'make': [1164, 1447], 'up': [1165], 'larger': [1167], 'well.17': [1173], 'fact,': [1175], 'hemorrhagic': [1179], 'alone': [1181], 'myocardial': [1186, 1223], 'infarction.': [1187], 'hemorrhage': [1191], 'subtypes': [1193], 'contributes': [1205], 'societal': [1208], 'costs': [1209], 'since': [1210, 1332], 'associated': [1214], 'upward': [1216], 'times': [1219], 'cost': [1221], 'infarction.16On': [1224], 'basis': [1226], 'demographic': [1229, 1255], 'population-level': [1231, 1364], 'factor': [1234, 1587, 2144, 2315], 'trends,': [1235], 'unprecedented': [1241], '50%': [1242], 'next': [1251], '20': [1252, 1350], 'years.17': [1253], 'Although': [1254], 'changes': [1256], 'do': [1257, 1462, 1516], 'some': [1260], 'expected': [1263, 1301], 'increases': [1264], 'coronary': [1266, 2149], 'artery': [1267, 3155], 'incidence,': [1271], 'trends': [1272, 1588], 'virtually': [1274], 'cholesterol,': [1285, 1319, 1367], 'smoking,': [1289], 'unfavorable': [1291], 'will': [1293, 1444, 1529, 1592, 1606], 'excess': [1302], 'moving': [1306, 1539, 1613], 'forward.17': [1307], 'Mean': [1308], 'body': [1310, 1378, 3590], 'mass': [1311, 1379, 3591], 'index': [1312, 2644, 3592], 'increasing': [1315, 1331], 'decades;': [1317], 'mean': [1318, 1320, 1325, 1377, 1384], 'glucose': [1327, 1386], 'steadily': [1330], 'early': [1334, 1902], '1990s': [1335], '2);': [1337], 'prevalence': [1340], 'smoking': [1342, 1372], 'persistently': [1345], 'years.18': [1351], 'States': [1356], 'Japan': [1358], 'steady': [1361], 'prevalence,': [1373, 1864], 'obesity': [1375], 'index,': [1380], 'well': [1382], 'serum': [1385], 'continue': [1387, 1445], 'trend': [1389], 'upward.18Download': [1390], '2.': [1393], 'States,': [1407], 'Japan,': [1410], '1980–2008': [1411], 'data).LimitationsAs': [1419], 'we': [1420], 'move': [1421], 'forward': [1422], 'meet': [1424], 'challenges,': [1426], 'limited': [1428], 'availability': [1429], 'high-quality': [1431], 'data': [1433, 1442, 1515, 1838], 'integrating': [1440], 'heterogeneous': [1441], 'sources': [1443], 'accurate': [1449], 'transnational': [1450], 'picture': [1451], 'epidemic': [1456, 1553], 'challenging': [1458], 'task.': [1459], 'Country-level': [1460], 'analyses': [1461, 2600], 'take': [1464], 'joint': [1468], 'important': [1474], 'subnational': [1475], 'groupings': [1476], '(e.g.,': [1477], 'urban/rural': [1482], 'area)': [1483], 'subject': [1487], 'ecological': [1490], 'fallacy,': [1491], 'whereby': [1492], 'inference': [1494], 'made': [1495], 'falsely': [1501], 'assumed': [1502], 'apply': [1504], 'individual': [1507], 'level.': [1508], 'together': [1510], 'whole,': [1513], 'available': [1514], 'hint': [1519], 'magnitude': [1522], 'scope': [1524], 'inform': [1532], 'priorities': [1535], 'planning': [1538], 'forward.ConclusionsStroke': [1540], 'worldwide.': [1548], 'ongoing': [1551], 'preventable': [1565], 'morbidity,': [1568], 'where': [1574], 'subtype': [1579], 'Demographic': [1583], 'suggest': [1589], 'represent': [1607], 'forward.Sources': [1614], 'FundingNone.DisclosuresNone.FootnotesCorrespondence': [1616], 'MAS,': [1622], 'Department': [1623, 2005], 'Neurology,': [1625, 2490, 2519, 2757, 2795], '675': [1631], 'Nelson': [1632], 'Rising': [1633], 'Lane,': [1634], 'Room': [1635], '411B,': [1636], 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'Outcome': [2510], 'Potential': [2513, 2779], 'Benefits': [2514], 'Supplementation,': [2516], '10.3389/fneur.2020.00384,': [2520], 'Salwi': [2522], 'Cutting': [2524], 'Salgado': [2526], 'Espaillat': [2528], 'Fusco': [2530], 'Froehler': [2532], 'Chitale': [2534], 'Kirshner': [2536], 'H,': [2537, 2674, 2991, 3036, 3046, 3209, 3339, 3658], 'Schrag': [2538], 'Jasne': [2540], 'Burton': [2542], 'MacGrory': [2544], 'B,': [2545, 2704, 3044, 3203, 3421, 3517], 'Saad': [2546], 'Jayaraman': [2548], 'Madsen': [2550], 'Dakay': [2552], 'McTaggart': [2554], 'Yaghi': [2556], 'Khatri': [2558], 'Mistry': [2560, 2563], 'E': [2564, 2939], 'Mechanical': [2566], 'Thrombectomy': [2567], 'Patients': [2569], 'With': [2570, 2573, 2786, 2969], 'Prestroke': [2574], 'Stroke,': [2576, 2754, 2792, 2815, 2864, 3132, 3168, 3758], '51:5,': [2577], '(1539-1545),': [2578], '1-May-2020.': [2582], 'X,': [2584, 2716, 2718, 2987, 3032, 3038, 3052, 3201, 3207, 3250, 3419, 3456, 3660, 3706, 3708], 'Qing': [2585], ',': [2587, 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3650], 'Gao': [2661], 'Raza': [2663], 'Ramesha': [2665], 'Nwabueze': [2667], 'Tomkins': [2669], 'Cheng': [2671, 3053, 3651], 'Yepes': [2675], 'Rangaraju': [2678], '(2019)': [2680, 2724, 2746, 2773, 2809], 'Temporal': [2681], 'profiling': [2682], 'Kv1.3': [2684], 'channel': [2685], 'expression': [2686], 'brain': [2688, 2893, 3684], 'mononuclear': [2689], 'phagocytes': [2690], 'following': [2691], 'Neuroinflammation,': [2696], '10.1186/s12974-019-1510-8,': [2697], '16:1,': [2698], '1-Dec-2019.': [2702], 'Zhang': [2705, 3049, 3285, 3291, 3653, 3655, 3659], 'Ke': [2707], 'Xia': [2709], 'Luo': [2711], 'Guan': [2715], 'Cao': [2717], 'Ginseng-Angelica-Sansheng-Pulvis': [2725], 'Boosts': [2726], 'Neurogenesis': [2727], 'Against': [2728], 'Focal': [2729], 'Ischemia-Induced': [2731], 'Deficiency,': [2733], '10.3389/fnins.2019.00515,': [2737], '13': [2738], 'Lucchese': [2739], 'Flöel': [2741], 'Stahl': [2744], 'B': [2745, 3621, 3624], 'Cross-Reactivity': [2747], 'Mechanism': [2750], 'Linking': [2751], 'Infections': [2752], '10.3389/fneur.2019.00469,': [2758], 'Darsalia': [2760], 'Johansen': [2762], 'Lietzau': [2764], 'Nyström': [2766], 'Klein': [2768], 'Patrone': [2771], 'Dipeptidyl': [2774], 'Peptidase-4': [2775], 'Inhibitors': [2776], 'Brain': [2782, 3692], 'Disorders;': [2783], 'Mini-Review': [2785], 'Special': [2787], 'Focus': [2788], 'Linagliptin': [2790], '10.3389/fneur.2019.00493,': [2796], 'Davis': [2798], 'Jain': [2800], 'Bae': [2802], 'Majid': [2804], 'Rajanikant': [2807], 'Hypoxia': [2810], 'Mimetic': [2811], 'Agents': [2812], 'Developmental': [2820], 'Biology,': [2821], '10.3389/fcell.2018.00175,': [2822], '6': [2823], 'Ravina': [2824], 'Briggs': [2826], 'Kislal': [2828], 'Warraich': [2830], 'Nguyen': [2832], 'Lam': [2834], 'Zarembinski': [2836], 'Shamloo': [2839], '(2018)': [2841, 2884, 2943, 3001, 3058, 3124, 3146, 3167, 3185], 'Intracerebral': [2842], 'Delivery': [2843], 'Brain-Derived': [2845], 'Neurotrophic': [2846], 'Factor': [2847], 'Using': [2848], 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[2947], 'Characteristics': [2948], 'Analysis': [2956, 3259], 'Registry': [2962], 'Get': [2968], 'Guidelines––Stroke': [2971], 'Program,': [2972], 'Association,': [2978, 3777], '7:20,': [2979], '16-Oct-2018.': [2983], 'Ding': [2992], 'Han': [2994, 3324], 'Shi': [2996, 3293], 'PR-957': [3002], 'mediates': [3003], 'neuroprotection': [3004], 'inhibiting': [3006], 'Th17': [3007], 'differentiation': [3008, 3586], 'modulating': [3010], 'cytokine': [3011], 'production': [3012], 'mouse': [3015, 3687], 'ischaemic': [3018], 'Clinical': [3020], 'Experimental': [3022], 'Immunology,': [3023], '10.1111/cei.13132,': [3024], '193:2,': [3025], '(194-206),': [3026], '15-Jul-2018.': [3030], 'Kong': [3033], 'Lian': [3035], 'Peng': [3043, 3303], 'Fang': [3047], 'Jin': [3051, 3433], 'K': [3054, 3120, 3434], 'Fan': [3056], 'Distribution': [3059], 'predictors': [3061], 'hospital': [3063, 3220], 'charges': [3064, 3221], 'haemorrhagic': [3066], 'Beijing,': [3070, 3234], 'March': [3072], '2012': [3073], 'February': [3075], '2015:': [3076], 'retrospective': [3078], 'BMJ': [3080], 'Open,': [3081], '10.1136/bmjopen-2017-017693,': [3082], '8:3,': [3083], '(e017693),': [3084], '1-Mar-2018.': [3088], 'Tsivgoulis': [3089], 'Patousi': [3091], 'Pikilidou': [3093], 'Birbilis': [3095], 'Katsanos': [3097], 'Mantatzis': [3099], 'Asimis': [3101], 'Papanas': [3103], 'Skendros': [3105], 'Terzoudi': [3107], 'Karamanli': [3109], 'Kouroumichakis': [3111], 'I,': [3112], 'Zebekakis': [3113], 'Maltezos': [3115], 'Piperidou': [3117], 'Vadikolias': [3119], 'Heliopoulos': [3122], 'I': [3123, 3395], 'Incidence': [3126], 'Northeastern': [3130], 'Greece,': [3131], '49:2,': [3133], '(288-295),': [3134], '1-Feb-2018.': [3138], 'Gavrilenko': [3139], 'Kuklin': [3141], 'Fomina': [3144], 'V': [3145, 3166, 3398], 'Conventional': [3147], 'eversion': [3149], 'carotid': [3150, 3154, 3405], 'endarterectomy': [3151], 'internal': [3153], 'stenosis,': [3156], 'Khirurgiya.': [3157], 'N.I.': [3160], 'Pirogova,': [3161], 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