Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2110949863', 'doi': 'https://doi.org/10.1016/j.bbrc.2005.02.038', 'title': 'Characterisation of Tat protein transport complexes carrying inactivating mutations', 'display_name': 'Characterisation of Tat protein transport complexes carrying inactivating mutations', 'publication_year': 2005, 'publication_date': '2005-04-01', 'ids': {'openalex': 'https://openalex.org/W2110949863', 'doi': 'https://doi.org/10.1016/j.bbrc.2005.02.038', 'mag': '2110949863', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15737641'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbrc.2005.02.038', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5066853094', 'display_name': 'Christopher A. McDevitt', 'orcid': 'https://orcid.org/0000-0003-1596-4841'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Christopher A. McDevitt', 'raw_affiliation_strings': ['Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049336574', 'display_name': 'Matthew G. Hicks', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1118541', 'display_name': 'University of East Anglia', 'ror': 'https://ror.org/026k5mg93', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I1118541']}, {'id': 'https://openalex.org/I100288624', 'display_name': 'John Innes Centre', 'ror': 'https://ror.org/055zmrh94', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I100288624', 'https://openalex.org/I2799693246', 'https://openalex.org/I4210087105']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Matthew G. Hicks', 'raw_affiliation_strings': ['Department of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK', 'School of Biological Sciences University of East Anglia Norwich NR4 7TJ UK'], 'affiliations': [{'raw_affiliation_string': 'School of Biological Sciences University of East Anglia Norwich NR4 7TJ UK', 'institution_ids': ['https://openalex.org/I1118541']}, {'raw_affiliation_string': 'Department of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK', 'institution_ids': ['https://openalex.org/I100288624']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090196992', 'display_name': 'Tracy Palmer', 'orcid': 'https://orcid.org/0000-0001-9043-2592'}, 'institutions': [{'id': 'https://openalex.org/I1118541', 'display_name': 'University of East Anglia', 'ror': 'https://ror.org/026k5mg93', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I1118541']}, {'id': 'https://openalex.org/I100288624', 'display_name': 'John Innes Centre', 'ror': 'https://ror.org/055zmrh94', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I100288624', 'https://openalex.org/I2799693246', 'https://openalex.org/I4210087105']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Tracy Palmer', 'raw_affiliation_strings': ['Department of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK', 'School of Biological Sciences University of East Anglia Norwich NR4 7TJ UK'], 'affiliations': [{'raw_affiliation_string': 'School of Biological Sciences University of East Anglia Norwich NR4 7TJ UK', 'institution_ids': ['https://openalex.org/I1118541']}, {'raw_affiliation_string': 'Department of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK', 'institution_ids': ['https://openalex.org/I100288624']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048730287', 'display_name': 'Ben C. Berks', 'orcid': 'https://orcid.org/0000-0001-9685-4067'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ben C. Berks', 'raw_affiliation_strings': ['Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.', 'institution_ids': ['https://openalex.org/I40120149']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2770, 'currency': 'USD', 'value_usd': 2770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.592, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 33, 'citation_normalized_percentile': {'value': 0.747111, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '329', 'issue': '2', 'first_page': '693', 'last_page': '698'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10303', 'display_name': 'Molecular Mechanisms of Photosynthesis and Photoprotection', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10303', 'display_name': 'Molecular Mechanisms of Photosynthesis and Photoprotection', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10015', 'display_name': 'RNA Sequencing Data Analysis', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/twin-arginine-translocation-pathway', 'display_name': 'Twin-arginine translocation pathway', 'score': 0.98400235}, {'id': 'https://openalex.org/keywords/transport-protein', 'display_name': 'Transport protein', 'score': 0.69333124}, {'id': 'https://openalex.org/keywords/translocase', 'display_name': 'Translocase', 'score': 0.55578583}, {'id': 'https://openalex.org/keywords/metabolite-binding', 'display_name': 'Metabolite Binding', 'score': 0.421952}], 'concepts': [{'id': 'https://openalex.org/C33292294', 'wikidata': 'https://www.wikidata.org/wiki/Q21760416', 'display_name': 'Twin-arginine translocation pathway', 'level': 5, 'score': 0.98400235}, {'id': 'https://openalex.org/C57581600', 'wikidata': 'https://www.wikidata.org/wiki/Q2449730', 'display_name': 'Transport protein', 'level': 2, 'score': 0.69333124}, {'id': 'https://openalex.org/C115335371', 'wikidata': 'https://www.wikidata.org/wiki/Q142943', 'display_name': 'Membrane transport protein', 'level': 4, 'score': 0.6355801}, {'id': 'https://openalex.org/C138626823', 'wikidata': 'https://www.wikidata.org/wiki/Q916504', 'display_name': 'Chromosomal translocation', 'level': 3, 'score': 0.6208378}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.5823709}, {'id': 'https://openalex.org/C101692577', 'wikidata': 'https://www.wikidata.org/wiki/Q337889', 'display_name': 'Thylakoid', 'level': 4, 'score': 0.5811299}, {'id': 'https://openalex.org/C113035283', 'wikidata': 'https://www.wikidata.org/wiki/Q909555', 'display_name': 'Translocase', 'level': 4, 'score': 0.55578583}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5185205}, {'id': 'https://openalex.org/C199229279', 'wikidata': 'https://www.wikidata.org/wiki/Q610647', 'display_name': 'Translocon', 'level': 4, 'score': 0.4768575}, {'id': 'https://openalex.org/C57947595', 'wikidata': 'https://www.wikidata.org/wiki/Q7886088', 'display_name': 'Membrane transport', 'level': 3, 'score': 0.4562413}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45331126}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42557773}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.37093857}, {'id': 'https://openalex.org/C144647389', 'wikidata': 'https://www.wikidata.org/wiki/Q423042', 'display_name': 'Membrane protein', 'level': 3, 'score': 0.35270154}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.3488431}, {'id': 'https://openalex.org/C69305403', 'wikidata': 'https://www.wikidata.org/wiki/Q47263', 'display_name': 'Chloroplast', 'level': 3, 'score': 0.2738036}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.13374236}], 'mesh': [{'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D029968', 'descriptor_name': 'Escherichia coli Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D026901', 'descriptor_name': 'Membrane Transport Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029968', 'descriptor_name': 'Escherichia coli Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D029968', 'descriptor_name': 'Escherichia coli Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026901', 'descriptor_name': 'Membrane Transport Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D026901', 'descriptor_name': 'Membrane Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008970', 'descriptor_name': 'Molecular Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbrc.2005.02.038', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15737641', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Life below water', 'score': 0.41, 'id': 'https://metadata.un.org/sdg/14'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1949275432', 'https://openalex.org/W1985205346', 'https://openalex.org/W1999207123', 'https://openalex.org/W2006175108', 'https://openalex.org/W2006421795', 'https://openalex.org/W2008293899', 'https://openalex.org/W2024693081', 'https://openalex.org/W2037067254', 'https://openalex.org/W2045985595', 'https://openalex.org/W2052470499', 'https://openalex.org/W2066848052', 'https://openalex.org/W2078787129', 'https://openalex.org/W2083021096', 'https://openalex.org/W2085614442', 'https://openalex.org/W2089016671', 'https://openalex.org/W2097634886', 'https://openalex.org/W2100837269', 'https://openalex.org/W2101108802', 'https://openalex.org/W2108575112', 'https://openalex.org/W2115115305', 'https://openalex.org/W2117847784', 'https://openalex.org/W2118785817', 'https://openalex.org/W2121828948', 'https://openalex.org/W2122598117', 'https://openalex.org/W2133542385', 'https://openalex.org/W2136767810', 'https://openalex.org/W2139198526', 'https://openalex.org/W2143599839', 'https://openalex.org/W2145727150', 'https://openalex.org/W2149781820'], 'related_works': ['https://openalex.org/W4210651271', 'https://openalex.org/W2748683110', 'https://openalex.org/W2597957413', 'https://openalex.org/W2476287278', 'https://openalex.org/W2163603099', 'https://openalex.org/W2157655379', 'https://openalex.org/W2125031052', 'https://openalex.org/W2071373642', 'https://openalex.org/W1992003720', 'https://openalex.org/W1979649414'], 'abstract_inverted_index': {'The': [0], 'Tat': [1, 20, 74], 'system': [2], 'functions': [3], 'to': [4, 42, 128], 'transport': [5, 21, 75], 'folded': [6], 'proteins': [7], 'across': [8], 'the': [9, 14, 49, 65, 89, 99, 105, 108, 115, 122, 132, 137], 'bacterial': [10], 'cytoplasmic': [11], 'membrane': [12, 16], 'and': [13, 67, 85], 'thylakoid': [15], 'of': [17, 52, 64, 82, 88, 107, 114, 136], 'plant': [18], 'chloroplasts.': [19], 'involves': [22], 'a': [23, 44], 'high': [24], 'molecular': [25, 46], 'weight': [26], 'TatBC-containing': [27], 'complex': [28, 51, 110], 'that': [29, 58, 72, 98], 'transiently': [30], 'associates': [31], 'with': [32], 'TatA': [33, 123], 'during': [34], 'protein': [35, 124], 'translocation.': [36], 'Sedimentation': [37], 'equilibrium': [38], 'experiments': [39], 'were': [40], 'used': [41], 'determine': [43], 'protein-only': [45], 'mass': [47], 'for': [48, 131], 'TatBC': [50, 90, 109, 138], '630': [53], '±': [54], '30': [55], 'kDa,': [56], 'suggesting': [57], 'it': [59], 'contains': [60], 'approximately': [61], '13': [62], 'copies': [63], 'TatB': [66], 'TatC': [68], 'protomers.': [69], 'Point': [70], 'mutations': [71], 'inactivate': [73], 'have': [76], 'previously': [77], 'been': [78], 'identified': [79], 'in': [80], 'each': [81], 'TatA,': [83], 'TatB,': [84], 'TatC.': [86], 'Analysis': [87], 'complexes': [91], 'formed': [92], 'by': [93], 'these': [94], 'inactive': [95], 'variants': [96], 'demonstrates': [97], 'amino': [100], 'acid': [101], 'substitutions': [102], 'neither': [103], 'affect': [104], 'composition': [106], 'nor': [111], 'cause': [112], 'accumulation': [113], 'assembled': [116], 'TatABC': [117], 'translocation': [118], 'site.': [119], 'In': [120], 'addition,': [121], 'is': [125], 'shown': [126], 'not': [127], 'be': [129], 'required': [130], 'assembly': [133], 'or': [134], 'stability': [135], 'complex.': [139]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2110949863', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-08-13T17:49:35.090556', 'created_date': '2016-06-24'}