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1617, 1933, 2005, 2837, 2962, 2973, 3002, 3062, 3121, 3244, 3255, 3272, 3306, 3617, 3641, 3740, 3758, 3798, 3865, 3933, 3973, 3984, 4134, 4172, 4198, 4236, 4320, 4368], 'with': [591, 665, 746, 778, 941, 1046, 1147, 1170, 1187, 1220, 1259, 1264, 1287, 1366, 1373, 1427, 1437, 1513, 1531, 1703, 1730, 1899, 2006, 2053, 2163, 2180, 2188, 2438, 2455, 2516, 2553, 2704, 2725, 2739, 2775, 2780, 2827, 2868, 2912, 2934, 2963, 2982, 2988, 3016, 3024, 3049, 3063, 3089, 3100, 3122, 3126, 3140, 3207, 3245, 3262, 3273, 3307, 3314, 3351, 3430, 3455, 3460, 3540, 3571, 3618, 3642, 3662, 3699, 3706, 3775, 3778, 3789, 3799, 3806, 3866, 3937, 3948, 3974, 3985, 3995, 4237, 4266, 4333, 4346, 4369, 4402], 'or': [592, 942, 1028, 1184, 1192, 1278, 1554, 1622, 1668, 1694, 1713, 1740, 1745, 1897, 1901, 2002, 2225, 2354, 2387, 2460, 2601, 2693, 2804, 2906, 3548, 3581, 3753, 4048, 4123, 4215, 4277, 4340, 4401], 'at': [593, 749, 943, 1178, 1403, 1505, 1776, 1832, 2065, 2171, 2195, 2431, 2711, 2795, 2809, 2908, 3083, 3519, 3955, 4269], 'risk': [594, 741, 751, 944, 1405, 1507, 1532, 1824, 1867, 2175, 2274, 2779, 2784, 2829, 3087, 3237, 3303, 3414, 3574, 3586, 3649, 3693, 3749, 3786, 3809, 3812, 3817, 4038, 4216, 4229], 'diabetes?': [596, 946], 'How': [597, 947], 'can': [598, 948, 1737, 1907, 4095], 'gaps': [599, 949], 'best': [603, 953], 'filled?': [605, 955], 'AcknowledgmentsReferencesCiting': [606], 'LiteraturePDF': [607], 'ToolsRequest': [608], 'permissionExport': [609], 'citationAdd': [610], 'favoritesTrack': [612], 'citation': [613], 'ShareShare': [614], 'Give': [615], 'accessShare': [616], 'full': [617], 'text': [618], 'accessClose': [619], 'modalShare': [620], 'full-text': [621, 636, 660], 'accessPlease': [622], 'review': [623], 'our': [624, 1959], 'Terms': [625, 648], 'Conditions': [627, 650], 'Use': [629], 'check': [631], 'box': [632], 'below': [633, 656], 'share': [635, 658], 'version': [637, 661], 'article.I': [639], 'have': [640, 781, 1174, 1289, 1314, 1338, 1352, 1477, 1522, 1722, 1782, 1918, 1978, 2405, 2625, 2966, 3065, 3226, 3311, 3379, 3634, 3885, 3934, 3944, 3961, 4117, 4180], 'read': [641], 'accept': [643], 'Wiley': [645], 'Online': [646], 'Library': [647], 'UseShareable': [652], 'LinkUse': [653], 'link': [655], 'your': [666], 'friends': [667], 'colleagues.': [669], 'Learn': [670], 'more.Copy': [671], 'URL': [672], 'Share': [673], 'linkShare': [675], 'onFacebookTwitterLinkedInRedditWechat': [676], 'More': [677, 3745], 'than': [678, 1243, 1262, 1317, 1362, 1789, 2176, 2442, 3143, 3404, 3736, 4406], '25%': [679], 'U.S.': [682, 979, 1068], 'population': [683, 702, 1365], 'aged': [684, 852, 981, 1123, 1310, 1319, 1347, 1536, 1772, 1828, 1893, 1998, 2061, 2587, 2672, 2743, 3004, 3051, 3179, 3216, 3368, 3685, 4151], '≥': [685, 853, 982, 1124, 1311, 1348, 1537, 1773, 1829, 1999, 2062, 2673, 2744, 2821, 3686], '65': [686, 854, 983, 1125, 1152, 1182, 2063, 2288, 3687], 'years': [687, 984, 1126, 1313, 1321, 1350, 1547, 1587, 1775, 1808, 1831, 1896, 2001, 2064, 2240, 2289, 2369, 2444, 2459, 2589, 2675, 2746, 2881, 2890, 3181, 3218, 3372, 3688, 4101, 4153], 'mellitus': [690], '(hereafter': [691], 'referred': [692, 2089], 'as': [694, 850, 1035, 1853, 1924, 2091, 2290, 2551, 2849, 3473, 3654, 3834, 3894, 4060, 4414], 'diabetes),1': [695], 'aging': [698, 1106, 3591], 'overall': [701, 4161], 'significant': [705, 1891, 2081, 2334, 2340, 2377, 2393, 3357, 3670, 4181, 4374], 'driver': [706], 'epidemic.': [710], 'Although': [711, 1247, 1368, 1869], 'burden': [713], 'often': [717, 782], 'described': [718], 'terms': [720], 'impact': [723, 1814, 1849], 'on': [724, 844, 991, 1017, 1563, 1619, 1631, 1931, 1968, 2019, 2047, 2383, 2610, 3337, 3674, 4132, 4165], 'working-age': [725], 'adults,': [726, 1851, 1885, 3720, 4257, 4290], 'linked': [732, 1058], 'higher': [734, 1315, 1332, 2173, 2463, 2794, 2808, 3084, 3541, 3728, 3785], 'mortality,': [735, 2703, 3516, 3542], 'reduced': [736], 'functional': [737, 1650, 1900, 4046, 4303], 'status,': [738], 'increased': [740, 2726, 2828, 3515, 3584, 3776], 'institutionalization.2': [743], 'substantial': [750, 1564, 2184], 'both': [753, 1156, 1509, 2084, 3174], 'acute': [754, 4218], 'chronic': [756, 3878, 3914], 'microvascular': [757, 1969, 2048, 3939], 'cardiovascular': [759, 1275, 1866, 1971, 2174, 2191, 2259, 2272, 2335, 2385, 2529, 2602, 2761, 2917, 2942, 3073, 3137, 3239, 3302, 3343, 3457, 3476, 3585, 3808, 3861, 4228], 'complications': [760, 1597, 1670, 2648, 3880, 3951, 4017, 4041, 4220, 4284, 4298], 'disease.': [763, 4025], 'Despite': [764], 'having': [765, 2182], 'highest': [767, 1291], 'prevalence': [768, 975, 1015, 1091, 1159, 1273], 'any': [772, 1307, 2800, 3148], 'age-group,': [773], 'persons': [775, 4150], 'and/or': [776, 3993], 'those': [777, 851, 1122, 1263, 1318, 1729, 1827, 1898, 2060, 2454, 2552, 2633, 2981, 3046, 3050, 3125, 3175, 3178, 3215, 3261, 3367, 3508, 3518, 3544, 3737, 3805, 3994, 4265, 4332, 4397], 'multiple': [779, 2831, 3996], 'excluded': [784], 'from': [785, 815, 986, 1326, 1785, 1798, 2531, 2658, 2684, 2839, 2944, 2969, 3250, 3265, 3283, 3907], 'randomized': [786, 1948, 2109, 2622, 3657], 'controlled': [787, 2110, 2623], 'trials': [788, 817, 1721, 1752, 1950, 1977, 2111, 2168, 2208, 2471, 2509, 2624, 2955, 2970, 2985, 3028, 3055, 3225, 3252, 3267, 3310], 'treatments—and': [790], 'targets—for': [792], 'associated': [796, 1436, 2724, 2826, 2911, 3454, 3539, 3774, 3938], 'conditions.': [797], 'Heterogeneity': [798], 'health': [800, 1991, 2008], 'status': [801, 4047], '(even': [805], 'within': [806], 'an': [807, 1550, 2712, 2901, 3765, 4322], 'age': [808, 1148, 1151, 1181, 1191, 1282, 2194, 2286, 2352, 2591, 2677, 2879, 2888, 3441], 'range)': [809], 'dearth': [812], 'present': [818, 1585], 'challenges': [819], 'determining': [821], 'standard': [822, 2421, 2581], 'intervention': [823, 1454, 1788, 1819, 1846, 1878, 2579], 'strategies': [824, 1905], 'that': [825, 1082, 1113, 1517, 1528, 1579, 1594, 1648, 1691, 1724, 1847, 1873, 1906, 2269, 2415, 2495, 2514, 2666, 2932, 2974, 3112, 3168, 3279, 3374, 3408, 3446, 3507, 4042, 4087, 4091, 4299], 'fit': [826], 'adults.': [829, 2489, 2996, 3420, 3911, 4126, 4193], 'To': [830], 'address': [831, 879], 'these': [832, 1199, 1870, 1935, 1976, 2207, 3820], 'issues,': [833], '(ADA)': [838], 'convened': [839], 'Development': [842], 'Conference': [843], 'Adults': [848], '(defined': [849], 'years)': [855, 1183, 2679, 3006], 'February': [857], '2012.': [858], 'Following': [859], 'series': [861], 'scientific': [863], 'presentations': [864], 'experts': [866], 'field,': [869], 'writing': [871], 'group': [872, 2280], 'independently': [873], 'developed': [874, 1920, 4118, 4190], 'report': [877, 3466], 'following': [881, 3978], 'questions:': [882], 'According': [967], 'most': [970, 1323, 1391], 'recent': [971], 'surveillance': [972, 1514], 'data,': [973], 'among': [978], 'varies': [985], '22': [987], '33%,': [989], 'depending': [990, 1016], 'diagnostic': [993, 1019, 1033], 'criteria': [994, 4203], 'used.': [995], 'Postprandial': [996], 'hyperglycemia': [997, 2486, 4211], 'prominent': [1000], 'characteristic': [1001], 'type': [1003, 1053, 1374, 1387, 1396, 1410, 1574, 1580, 1612, 1665, 1672, 1696, 1734, 1952, 2056, 2164, 2520, 2668, 2740, 2869, 3208], '2': [1004, 1054, 1344, 1388, 1411, 1575, 1581, 1613, 1666, 1673, 1697, 1717, 1735, 1953, 2057, 2165, 2521, 2669, 2741, 2870, 3209], 'adults,3,': [1008], '4': [1009], 'contributing': [1010], 'observed': [1012], 'differences': [1013, 2598], 'which': [1018, 1155, 1443, 1760, 2037, 3199, 3497], 'test': [1020, 4074], 'used.5': [1022], 'Using': [1023], 'hemoglobin': [1025], 'A1C': [1026, 1236, 2701, 2713, 2721, 2752, 2781, 2788, 2796, 2810, 2902, 4323, 4387], '(A1C)': [1027], 'fasting': [1029], 'plasma': [1030], 'glucose': [1031, 1556, 1732, 1966, 1994, 2020, 2218, 2228, 2248, 2320, 2381, 2947], '(FPG)': [1032], 'criteria,': [1034, 4209], 'currently': [1037], 'done': [1038], 'national': [1040], 'surveillance,': [1041], 'one-third': [1042], 'undiagnosed.1': [1049], 'epidemic': [1051], 'clearly': [1057], 'increasing': [1060, 1369, 1419], 'rates': [1061, 1087, 1292, 1316, 1337, 3726], 'overweight': [1063, 1529], 'obesity': [1065], 'population,': [1069, 4086], 'but': [1070, 1792, 1923, 2389, 2606, 2924, 2976, 2991, 3257, 3354, 3664, 3679, 3721, 3768, 4210, 4291, 4325], 'projections': [1071, 1111], 'Centers': [1074], 'Disease': [1076], 'Control': [1077, 1943, 2115, 3223], 'Prevention': [1079, 1461, 1712], '(CDC)': [1080], 'suggest': [1081, 1112, 1872, 2511, 3396, 3601], 'even': [1083], 'if': [1084], 'incidence': [1086, 1143, 1157, 2344, 2915, 3702], 'level': [1088, 1162], 'off,': [1089], 'will': [1094, 1127], 'double': [1095, 1353], 'next': [1098], '20': [1099, 2458], 'years,': [1100, 1153, 2356, 2596, 3444, 4408], 'part': [1102], 'due': [1103, 1413], 'population.5': [1109], 'Other': [1110, 4227], 'number': [1115, 1205, 1946, 2616], 'cases': [1117], 'diagnosed': [1119, 2055, 3946, 3963], 'increase': [1128], '4.5-fold': [1130], '(compared': [1131], '3-fold': [1133], 'total': [1136, 1838], 'population)': [1137], 'between': [1138, 2361, 2644, 2700, 2750, 2789], '2005': [1139], '2050.6': [1141], 'increases': [1146], 'until': [1149], 'about': [1150, 2584, 2715], 'after': [1154, 1180, 1809, 2237], 'seem': [1160], 'off': [1163], '(www.cdc.gov/diabetes/statistics).': [1164], 'As': [1165, 2765], 'result,': [1167], 'may': [1172, 1444, 2543, 2939, 3114, 3378, 3411, 3843, 4204, 4263], 'either': [1173, 1549], 'incident': [1175, 1393, 3919], 'disease': [1176, 1276, 1305, 3014, 3578], '(diagnosed': [1177], 'long-standing': [1185, 3935], 'onset': [1188, 2396], 'middle': [1190], 'earlier.': [1193], 'Demographic': [1194], 'characteristics': [1197], 'two': [1200], 'groups': [1201], 'differ': [1202], 'ways,': [1207], 'adding': [1208, 3158], 'complexity': [1211], 'making': [1213], 'generalized': [1214], 'patients': [1219, 1997, 2052, 2162, 2170, 2515, 2586, 2630, 2671, 2738, 2867, 2873, 2933, 3081, 3992], 'diabetes.': [1221, 1246, 2166, 2964, 3308, 3867], 'Older-age–onset': [1222], 'non-Hispanic': [1228], 'whites': [1229], 'characterized': [1232], 'lower': [1234, 1238, 2786, 2913, 3692], 'mean': [1235, 2193, 2720, 3440], 'likelihood': [1239], 'insulin': [1241, 1420, 1430], 'use': [1242, 3708, 3760, 3830], 'middle-age–onset': [1245, 1260], 'history': [1249, 2561, 3667], 'retinopathy': [1251], 'significantly': [1253, 1331, 2172, 2263, 2807, 3691], 'older-age': [1265], 'onset,': [1266], 'there': [1267, 1926, 2330, 2337, 2357, 2695, 4078], 'is,': [1268], 'interestingly,': [1269], 'no': [1270, 2013, 2332, 2359, 2375, 2597, 2953, 3155, 3212, 3335, 3397, 3665, 3669], 'difference': [1271, 2360], '(CVD)': [1277], 'peripheral': [1279], 'neuropathy': [1280], 'onset.7': [1284], 'major': [1294, 2108, 2384, 3041, 3136, 3751], 'lower-extremity': [1295], 'amputation,8': [1296], 'myocardial': [1297], 'infarction': [1298], '(MI),': [1299], 'visual': [1300, 4064], 'impairment,': [1301], 'end-stage': [1303, 4024], 'renal': [1304], 'age-group.': [1308, 3149], 'Those': [1309, 1346, 2437], '75': [1312, 1349, 2000], '65–74': [1320], 'complications.': [1324, 3942, 3968], 'Deaths': [1325], 'hyperglycemic': [1327, 4219], 'crises': [1328], 'also': [1329, 1351, 1689, 3066, 4071, 4421], '(although': [1336], 'declined': [1339], 'markedly': [1340], 'past': [1343], 'decades).': [1345], 'rate': [1355], 'emergency': [1357], 'department': [1358], 'visits': [1359], 'hypoglycemia': [1361, 2296], 'general': [1364, 2635, 2650], 'diabetes.9': [1367], 'numbers': [1370, 1892], 'individuals': [1372, 3570, 3661], '1': [1375], 'living': [1378], 'into': [1379, 2874], 'old': [1380, 3991], 'age,10': [1381], 'discussion': [1383], 'pathophysiology': [1385], 'concerns': [1386, 4379], 'diabetes—overwhelmingly': [1389], 'prevalent': [1395, 1599, 3921], 'age-groups.': [1399], 'high': [1404, 1506, 2719, 2877, 2928, 2935, 3285, 3807], 'development': [1408], 'combined': [1416, 2253], 'effects': [1417, 1964, 1992, 2300], 'resistance': [1421, 1431], 'impaired': [1423, 1731], 'pancreatic': [1424, 1468], 'islet': [1425, 1469, 1473], 'function': [1426], 'aging.': [1428], 'Age-related': [1429], 'appears': [1432], 'primarily': [1435, 1753], 'adiposity,': [1438], 'sarcopenia,': [1439], 'physical': [1441], 'inactivity,11': [1442], 'partially': [1445], 'explain': [1446], 'disproportionate': [1448, 2271], 'success': [1449], 'intensive': [1452, 2212, 2247, 2277, 2319, 2380, 2419, 2451, 2467, 2483, 2532, 2540, 2945], 'lifestyle': [1453, 1743, 1787, 1818, 1845, 1877], 'participants': [1457, 1770, 1779, 1822, 2187, 2283, 3429], 'Program': [1462], '(DPP).12': [1463], 'However,': [1464, 2295, 3623, 3893], 'age-related': [1465], 'declines': [1466], 'function4,': [1470], '13': [1471], 'proliferative': [1474], 'capacity14,': [1475], '15': [1476, 2443], 'previously': [1478], 'described.': [1480], 'Screening': [1497, 3868, 4281], 'Prediabetes': [1501], 'prediabetes,': [1512], 'data': [1515, 1981, 2018], 'suggesting': [1516, 2931, 3111], 'half': [1518], 'latter.1': [1524], 'ADA': [1526, 2491, 3884, 4128, 4306, 4348], 'recommends': [1527], 'factors—and': [1533], '45': [1538], 'years—be': [1539], 'screened': [1540], 'setting': [1544], 'every': [1545, 4099], '1–3': [1546], 'using': [1548, 2893, 4188, 4207], 'FPG': [1551], 'test,': [1552], 'A1C,': [1553], 'oral': [1555, 2685, 2691], 'tolerance': [1557], 'test.': [1558], 'based': [1562, 4164], 'indirect': [1565], 'benefits': [1569, 1605, 1842, 2043, 2072, 2478, 2546, 3595, 3625], 'early': [1571, 1695, 2096, 4014], 'diabetes,': [1576, 2058, 2559, 3210, 3558], 'fact': [1578], 'typically': [1584], 'before': [1588], 'diagnosis,': [1590], 'signs': [1595, 4015], '“newly': [1601], 'diagnosed”': [1602], 'patients.16': [1603], 'identification': [1607], 'prediabetes': [1609, 1693], 'asymptomatic': [1611], 'depend': [1618], 'whether': [1620, 2850], 'primary': [1621, 2252, 2365, 3033, 3339, 3629, 3677, 3696, 3858, 4276], 'secondary': [1623, 3057, 3103, 3362, 3599, 4278], 'preventive': [1624], 'interventions': [1625, 1639, 1662, 1744, 2958, 3876], 'would': [1626, 1646, 1675, 1688, 1706, 2854, 3092, 4300], 'likely': [1627, 1676, 3480, 3802], 'effective': [1629], 'anticipated': [1633], 'timeframe': [1634, 4241, 4274], 'benefit': [1637, 1797, 2448, 2530, 2943, 3156, 3202, 3213, 3313, 3336, 3377, 3398, 3562, 3671, 3792, 4009, 4243, 4264], 'versus': [1640, 2420, 2580, 3370, 3718, 3920], "patient's": [1642], 'life': [1643, 3129, 3976, 4000, 4051, 4182, 4267, 4335, 4403], 'expectancy.': [1644, 3130], 'Most': [1645, 1687], 'agree': [1647, 1690], 'generally': [1652, 2814, 3905], 'healthy': [1653, 1883, 3971, 4393], '66-year-old': [1654], 'individual': [1655, 1702, 4246], 'should': [1656, 3610, 4032, 4070, 4184, 4221, 4231, 4285, 4294], 'offered': [1658, 3612], 'screening': [1660, 3874, 3953, 3980, 4036], 'since': [1661], 'prevent': [1664, 4021], 'beneficial': [1678], 'given': [1679], 'presumption': [1681], 'decades': [1683], 'remaining': [1685], 'life.': [1686], 'finding': [1692], '95-year-old': [1701], 'advanced': [1704, 2565, 2568, 4337], 'dementia': [1705], 'unlikely': [1708], 'provide': [1710], 'benefit.': [1711], 'Delay': [1714], 'Type': [1716], 'Numerous': [1719], 'shown': [1723, 3312], 'high-risk': [1726], 'subjects': [1727, 3482, 3684], '(particularly': [1728], 'tolerance),': [1733], 'prevented': [1739], 'delayed': [1741], 'various': [1747], 'classes': [1748], 'medications.': [1750], 'These': [1751, 1778, 2469], 'enrolled': [1754, 2050, 2169], 'middle-aged': [1755, 2051, 2159, 3719, 3739], 'participants.': [1756, 2294], 'In': [1757, 2347, 3555, 3780, 4344], 'DPP,': [1759], 'largest': [1763], 'trial': [1764, 2017, 2234, 2311, 2402, 2573, 3153, 3333, 3394], 'date,': [1766], '~': [1767], '20%': [1768, 3037], 'were': [1771, 1985, 2144, 2303, 2331, 2604, 2723, 2813, 3478, 3538, 3551, 3727], '60': [1774, 1830, 2745], 'enrollment.': [1777, 2436], 'seemed': [1780], 'efficacy': [1784], 'younger': [1790, 3910, 4192], 'participants,': 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