Publication Information

{'id': 'https://openalex.org/W2110747905', 'doi': 'https://doi.org/10.1126/science.1156609', 'title': "Efficient Inhibition of the Alzheimer's Disease β-Secretase by Membrane Targeting", 'display_name': "Efficient Inhibition of the Alzheimer's Disease β-Secretase by Membrane Targeting", 'publication_year': 2008, 'publication_date': '2008-04-24', 'ids': {'openalex': 'https://openalex.org/W2110747905', 'doi': 'https://doi.org/10.1126/science.1156609', 'mag': '2110747905', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18436784'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.1156609', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5015618876', 'display_name': 'Lawrence Rajendran', 'orcid': 'https://orcid.org/0000-0002-6390-1821'}, 'institutions': [{'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}, {'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}, {'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Lawrence Rajendran', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}, {'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076331208', 'display_name': 'Anja Schneider', 'orcid': 'https://orcid.org/0000-0001-9540-8700'}, 'institutions': [{'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}, {'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Anja Schneider', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}, {'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019377042', 'display_name': 'Georg Schlechtingen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}, {'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Georg Schlechtingen', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}, {'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}, {'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035752466', 'display_name': 'Sebastian Weidlich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}, {'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Sebastian Weidlich', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}, {'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}, {'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028735345', 'display_name': 'Jonas Ries', 'orcid': 'https://orcid.org/0000-0002-6640-9250'}, 'institutions': [{'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}, {'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jonas Ries', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}, {'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091742190', 'display_name': 'Tobias Braxmeier', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}, {'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Tobias Braxmeier', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}, {'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086296055', 'display_name': 'Petra Schwille', 'orcid': 'https://orcid.org/0000-0002-6106-4847'}, 'institutions': [{'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}, {'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Petra Schwille', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}, {'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033794504', 'display_name': 'Jörg B. Schulz', 'orcid': 'https://orcid.org/0000-0002-8903-0593'}, 'institutions': [{'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}, {'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jörg B. Schulz', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}, {'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}, {'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103426169', 'display_name': 'Cornelia Schroeder', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}, {'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Cornelia Schroeder', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079565983', 'display_name': 'Mikael Simons', 'orcid': 'https://orcid.org/0000-0001-5329-192X'}, 'institutions': [{'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}, {'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Mikael Simons', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}, {'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018373393', 'display_name': 'Gary Jennings', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}, {'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Gary Jennings', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}, {'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026290431', 'display_name': 'Hans‐Joachim Knölker', 'orcid': 'https://orcid.org/0000-0002-9631-5239'}, 'institutions': [{'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}, {'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hans-Joachim Knölker', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}, {'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000708652', 'display_name': 'Kai Simons', 'orcid': 'https://orcid.org/0000-0002-9231-9996'}, 'institutions': [{'id': 'https://openalex.org/I4210137682', 'display_name': 'Max Planck Institute of Experimental Medicine', 'ror': 'https://ror.org/04a7f6w43', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210137682']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}, {'id': 'https://openalex.org/I4210159854', 'display_name': 'Max Planck Institute of Molecular Cell Biology and Genetics', 'ror': 'https://ror.org/05b8d3w18', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210159854']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Kai Simons', 'raw_affiliation_strings': ['Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.'], 'affiliations': [{'raw_affiliation_string': 'JADO Technologies GmbH, Tatzberg 47-51, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.', 'institution_ids': ['https://openalex.org/I4210137682']}, {'raw_affiliation_string': 'Department of Chemistry, Technical University of Dresden, Bergstr. 66, 01069 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I78650965']}, {'raw_affiliation_string': 'Biotec, Biotechnologisches Zentrum, Tatzberg 47/49, 01307 Dresden, Germany.', 'institution_ids': []}, {'raw_affiliation_string': 'Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.', 'institution_ids': ['https://openalex.org/I4210159854']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 17.497, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 258, 'citation_normalized_percentile': {'value': 0.999939, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '320', 'issue': '5875', 'first_page': '520', 'last_page': '523'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11419', 'display_name': 'Supramolecular Self-Assembly in Materials', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C36103677', 'wikidata': 'https://www.wikidata.org/wiki/Q4749551', 'display_name': 'Amyloid precursor protein secretase', 'level': 5, 'score': 0.6454855}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.5954427}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.55510247}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.5344113}, {'id': 'https://openalex.org/C2776879804', 'wikidata': 'https://www.wikidata.org/wiki/Q7630919', 'display_name': 'Subcellular localization', 'level': 3, 'score': 0.50966716}, {'id': 'https://openalex.org/C31705614', 'wikidata': 'https://www.wikidata.org/wiki/Q423510', 'display_name': 'Amyloid precursor protein', 'level': 4, 'score': 0.4730372}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46617508}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.4627976}, {'id': 'https://openalex.org/C74187038', 'wikidata': 'https://www.wikidata.org/wiki/Q1418791', 'display_name': 'Drug discovery', 'level': 2, 'score': 0.4621957}, {'id': 'https://openalex.org/C41183919', 'wikidata': 'https://www.wikidata.org/wiki/Q423026', 'display_name': 'Active site', 'level': 3, 'score': 0.4410057}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.43789417}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.41830656}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.357864}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2692421}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.20025569}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.16589695}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.09360862}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D053829', 'descriptor_name': 'Amyloid Precursor Protein Secretases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011992', 'descriptor_name': 'Endosomes', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D013261', 'descriptor_name': 'Sterols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053829', 'descriptor_name': 'Amyloid Precursor Protein Secretases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053829', 'descriptor_name': 'Amyloid Precursor Protein Secretases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030801', 'descriptor_name': 'Animals, Genetically Modified', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004330', 'descriptor_name': 'Drosophila', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004330', 'descriptor_name': 'Drosophila', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016503', 'descriptor_name': 'Drug Delivery Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004705', 'descriptor_name': 'Endocytosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011992', 'descriptor_name': 'Endosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021962', 'descriptor_name': 'Membrane Microdomains', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D021962', 'descriptor_name': 'Membrane Microdomains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.1156609', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18436784', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.59, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1559606020', 'https://openalex.org/W1585690852', 'https://openalex.org/W1588478093', 'https://openalex.org/W1675488686', 'https://openalex.org/W176147796', 'https://openalex.org/W1778767804', 'https://openalex.org/W1854324009', 'https://openalex.org/W1964369443', 'https://openalex.org/W1977169750', 'https://openalex.org/W1977570151', 'https://openalex.org/W1980825524', 'https://openalex.org/W1983417600', 'https://openalex.org/W2004883429', 'https://openalex.org/W2009956378', 'https://openalex.org/W2049632243', 'https://openalex.org/W2054648295', 'https://openalex.org/W2070596032', 'https://openalex.org/W2123941817', 'https://openalex.org/W2147268537', 'https://openalex.org/W2147958725', 'https://openalex.org/W2156281143', 'https://openalex.org/W2156788921', 'https://openalex.org/W2163240161', 'https://openalex.org/W2402272843'], 'related_works': ['https://openalex.org/W3216557857', 'https://openalex.org/W2766320206', 'https://openalex.org/W2743792264', 'https://openalex.org/W2349155146', 'https://openalex.org/W2325221887', 'https://openalex.org/W2101940205', 'https://openalex.org/W2028218135', 'https://openalex.org/W2015798402', 'https://openalex.org/W1971023308', 'https://openalex.org/W1533573354'], 'abstract_inverted_index': {'beta-Secretase': [0], 'plays': [1], 'a': [2, 11, 39, 43, 51], 'critical': [3], 'role': [4], 'in': [5, 63, 91, 95, 109], 'beta-amyloid': [6], 'formation': [7], 'and': [8, 65, 94], 'thus': [9], 'provides': [10], 'therapeutic': [12], 'target': [13], 'for': [14], "Alzheimer's": [15], 'disease.': [16], 'Inhibitor': [17], 'design': [18], 'has': [19], 'usually': [20], 'focused': [21], 'on': [22], 'active-site': [23], 'binding,': [24], 'neglecting': [25], 'the': [26, 57, 68, 71, 88], 'subcellular': [27], 'localization': [28], 'of': [29, 42, 70], 'active': [30, 60], 'enzyme.': [31], 'We': [32], 'have': [33], 'addressed': [34], 'this': [35, 103], 'issue': [36], 'by': [37, 47], 'synthesizing': [38], 'membrane-anchored': [40], 'version': [41], 'beta-secretase': [44, 61], 'transition-state': [45], 'inhibitor': [46, 58, 79, 90], 'linking': [48], 'it': [49], 'to': [50, 59, 99], 'sterol': [52], 'moiety.': [53], 'Thus,': [54], 'we': [55], 'targeted': [56], 'found': [62], 'endosomes': [64], 'also': [66, 106], 'reduced': [67, 80], 'dimensionality': [69], 'inhibitor,': [72], 'increasing': [73], 'its': [74], 'local': [75], 'membrane': [76, 115], 'concentration.': [77], 'This': [78], 'enzyme': [81], 'activity': [82], 'much': [83], 'more': [84], 'efficiently': [85], 'than': [86], 'did': [87], 'free': [89], 'cultured': [92], 'cells': [93], 'vivo.': [96], 'In': [97], 'addition': [98], 'effectively': [100], 'targeting': [101], 'beta-secretase,': [102], 'strategy': [104], 'could': [105], 'be': [107], 'used': [108], 'designing': [110], 'potent': [111], 'drugs': [112], 'against': [113], 'other': [114], 'protein': [116], 'targets.': [117]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2110747905', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 26}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 27}], 'updated_date': '2024-12-21T02:10:00.528372', 'created_date': '2016-06-24'}