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[46], 'recent': [47], 'evidence': [48], 'suggests': [49], 'that': [50, 82, 90, 100, 166], 'additional': [51], 'downstream': [52, 133], 'effectors': [53], 'contribute': [54], 'We': [59, 88, 110], 'previously': [60], 'identified': [61], 'cultured': [65], 'human': [66], 'cells': [67], 'which': [69, 214], 'APC,': [70], 'acting': [71], 'through': [72], 'glycogen': [73], 'synthase': [74], 'kinase-3': [75], '(GSK-3),': [76], 'suppresses': [77], 'mTORC1,': [78], 'nutrient': [80], 'sensor': [81], 'regulates': [83], 'cell': [84], 'growth': [85], 'proliferation.': [87], 'hypothesized': [89], 'truncating': [91], 'should': [94], 'activate': [95], 'mTORC1': [96, 101, 112, 129, 137, 154, 179, 195, 215], 'vivo': [98], 'plays': [102], 'an': [103], 'important': [104], 'role': [105], 'find': [111], 'activated': [115, 217], 'apc': [117], 'zebrafish': [119], 'intestinal': [122], 'polyps': [123], 'mice.': [127], 'Furthermore,': [128], 'essential': [132], 'as': [136, 180], 'inhibition': [138, 157, 171], 'partially': [139], 'rescues': [140, 158], 'phenotypes': [143], 'including': [144], 'early': [145], 'lethality,': [146], 'reduced': [147], 'circulation': [148], 'liver': [150], 'hyperplasia.': [151], 'Importantly,': [152], 'combining': [153], 'defects': [159], 'morphogenesis': [161], 'anterior-posterior': [164], 'axis': [165], 'not': [168], 'rescued': [169], 'either': [173], 'alone.': [175], 'These': [176], 'data': [177], 'establish': [178], 'crucial,': [182], 'β-catenin': [183], 'independent': [184], 'effector': [185], 'oncogenic': [187], 'highlight': [191], 'importance': [193], 'regulation': [196], 'during': [199], 'embryonic': [200], 'development.': [201], 'Our': [202], 'findings': [203], 'also': [204], 'suggest': [205], 'new': [207], 'model': [208], 'cancer': [211], 'pathogenesis': [212], 'parallel': [219], 'with': [220], 'Wnt/β-catenin': [221], 'signaling.': [222]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2110676924', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}], 'updated_date': '2024-09-11T15:11:31.374212', 'created_date': '2016-06-24'}