Title: Short-range compositional correlation in the yeast genome depends on transcriptional orientation
Abstract: This article reports an analysis of composition of about 5000 intergenic regions and neighboring ORFs in the nuclear genome of Saccharomyces cerevisiae, and their correlation. Intergenic regions flanked by divergently transcribed ORFs are GC richer (36%) than those separating convergent ORFs (29%). This difference in GC content cannot be fully attributed to its location upstream or downstream the ORFs, since no such strong compositional bias is found within 3′ and 5′ segments of intergenic regions between ORFs transcribed in the same direction. We have also found that the GC content of intergenic regions is positively correlated to that of its flanking ORFs in tandem and divergent orientations, but not in convergent orientations, and that the correlation coefficient between the GC content of nearby ORFs is higher for divergent pairs. Our observations are discussed in the light of recent work stressing the relationships between base composition, chromatin structure and meiotic recombination.
Publication Year: 2004
Publication Date: 2004-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 12
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