The First Entry to Complex Bakkanes: A Highly Effective Retroaldol–Aldol-Based Approach to (−)-Bakkenolides III, B, C, and H

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Duration: 3 min 30 s
Description: A novel SmI2-promoted chemoselective double reduction of an epoxy ketone and a thermodynamically governed retroaldol–aldol reaction have allowed the first successful entry to enantiopure (−)-bakkenolide III (1) to be realized. This compound has been used as a platform for accessing representative bioactive C1,C9-diacyloxybakkenolides.
Olivier Hamelin; Yanyun Wang; Jean‐Pierre Deprés; Andrew E. Greene
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