Publication Information

{'id': 'https://openalex.org/W2110143191', 'doi': 'https://doi.org/10.1158/1078-0432.ccr-09-1677', 'title': 'Methylation Induced Gene Silencing of HtrA3 in Smoking-Related Lung Cancer', 'display_name': 'Methylation Induced Gene Silencing of HtrA3 in Smoking-Related Lung Cancer', 'publication_year': 2010, 'publication_date': '2010-01-13', 'ids': {'openalex': 'https://openalex.org/W2110143191', 'doi': 'https://doi.org/10.1158/1078-0432.ccr-09-1677', 'mag': '2110143191', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20068077'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.ccr-09-1677', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_from_Methylation_Induced_Gene_Silencing_of_HtrA3_in_Smoking-Related_Lung_Cancer/22440148/1/files/39891007.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078873196', 'display_name': 'Daniah Beleford', 'orcid': 'https://orcid.org/0000-0003-1766-1094'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}, {'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniah Beleford', 'raw_affiliation_strings': ["Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy", 'institution_ids': ['https://openalex.org/I1330342723', 'https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021842480', 'display_name': 'Zhixue Liu', 'orcid': 'https://orcid.org/0000-0001-7597-5337'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhixue Liu', 'raw_affiliation_strings': ["Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy", 'institution_ids': ['https://openalex.org/I150468666', 'https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074885471', 'display_name': 'Ramandeep Rattan', 'orcid': 'https://orcid.org/0000-0002-3532-6057'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ramandeep Rattan', 'raw_affiliation_strings': ["Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy", 'institution_ids': ['https://openalex.org/I150468666', 'https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015950669', 'display_name': 'Lucio Quagliuolo', 'orcid': 'https://orcid.org/0000-0003-0651-3264'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lucio Quagliuolo', 'raw_affiliation_strings': ["Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy", 'institution_ids': ['https://openalex.org/I150468666', 'https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027752331', 'display_name': 'Mariarosaria Boccellino', 'orcid': 'https://orcid.org/0000-0001-6989-010X'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mariarosaria Boccellino', 'raw_affiliation_strings': ["Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy", 'institution_ids': ['https://openalex.org/I150468666', 'https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020924323', 'display_name': 'Alfonso Baldi', 'orcid': 'https://orcid.org/0000-0002-8693-3842'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alfonso Baldi', 'raw_affiliation_strings': ["Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy", 'institution_ids': ['https://openalex.org/I150468666', 'https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014339455', 'display_name': 'Jacie Maguire', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jacie Maguire', 'raw_affiliation_strings': ["Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy", 'institution_ids': ['https://openalex.org/I150468666', 'https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069570379', 'display_name': 'Julie Staub', 'orcid': 'https://orcid.org/0000-0002-7939-6882'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julie Staub', 'raw_affiliation_strings': ["Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy", 'institution_ids': ['https://openalex.org/I150468666', 'https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038755935', 'display_name': 'Julian R. Molina', 'orcid': 'https://orcid.org/0000-0002-9962-4635'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julian Molina', 'raw_affiliation_strings': ["Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy", 'institution_ids': ['https://openalex.org/I150468666', 'https://openalex.org/I1330342723']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103279653', 'display_name': 'Viji Shridhar', 'orcid': 'https://orcid.org/0000-0001-7232-0802'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Viji Shridhar', 'raw_affiliation_strings': ["Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations: Departments of 1Experimental Pathology and 2Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 3Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; and 4Department of Biochemistry, Second University of Naples, Naples, Italy", 'institution_ids': ['https://openalex.org/I150468666', 'https://openalex.org/I1330342723']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.266, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 50, 'citation_normalized_percentile': {'value': 0.912218, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '16', 'issue': '2', 'first_page': '398', 'last_page': '409'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13648', 'display_name': 'Cerebrovascular and genetic disorders', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.6227475}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.57485956}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5638199}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.50419915}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.48831224}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.35651428}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23381293}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.13576159}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08376619}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002283', 'descriptor_name': 'Carcinoma, Bronchogenic', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D020868', 'descriptor_name': 'Gene Silencing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012907', 'descriptor_name': 'Smoking', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002283', 'descriptor_name': 'Carcinoma, Bronchogenic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D002283', 'descriptor_name': 'Carcinoma, Bronchogenic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002283', 'descriptor_name': 'Carcinoma, Bronchogenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018287', 'descriptor_name': 'Carcinoma, Large Cell', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D018287', 'descriptor_name': 'Carcinoma, Large Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018287', 'descriptor_name': 'Carcinoma, Large Cell', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005047', 'descriptor_name': 'Etoposide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005047', 'descriptor_name': 'Etoposide', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D020868', 'descriptor_name': 'Gene Silencing', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009602', 'descriptor_name': 'Nitrosamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009602', 'descriptor_name': 'Nitrosamines', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012907', 'descriptor_name': 'Smoking', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.ccr-09-1677', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.22440148', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_from_Methylation_Induced_Gene_Silencing_of_HtrA3_in_Smoking-Related_Lung_Cancer/22440148/1/files/39891007.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20068077', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1078-0432.22440148', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_from_Methylation_Induced_Gene_Silencing_of_HtrA3_in_Smoking-Related_Lung_Cancer/22440148/1/files/39891007.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.89, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W139728060', 'https://openalex.org/W1492521210', 'https://openalex.org/W1605353467', 'https://openalex.org/W1965153645', 'https://openalex.org/W1977706798', 'https://openalex.org/W1997828131', 'https://openalex.org/W2011167367', 'https://openalex.org/W2016455125', 'https://openalex.org/W2018744320', 'https://openalex.org/W2025004154', 'https://openalex.org/W2027789251', 'https://openalex.org/W2031138807', 'https://openalex.org/W2042612293', 'https://openalex.org/W2043103956', 'https://openalex.org/W2049249200', 'https://openalex.org/W2050068580', 'https://openalex.org/W2050425919', 'https://openalex.org/W2051955621', 'https://openalex.org/W2056923697', 'https://openalex.org/W2063222562', 'https://openalex.org/W2064722602', 'https://openalex.org/W2068881045', 'https://openalex.org/W2070611230', 'https://openalex.org/W2072725722', 'https://openalex.org/W2075763186', 'https://openalex.org/W2078028724', 'https://openalex.org/W2085947779', 'https://openalex.org/W2101324933', 'https://openalex.org/W2106695119', 'https://openalex.org/W2110511887', 'https://openalex.org/W2117612500', 'https://openalex.org/W2119825626', 'https://openalex.org/W2127267778', 'https://openalex.org/W2132234428', 'https://openalex.org/W2137680076', 'https://openalex.org/W2141410747', 'https://openalex.org/W2142373051', 'https://openalex.org/W2143474295', 'https://openalex.org/W2152974369', 'https://openalex.org/W2168948582', 'https://openalex.org/W2566863750', 'https://openalex.org/W3145246212'], 'related_works': ['https://openalex.org/W3131850249', 'https://openalex.org/W3031103608', 'https://openalex.org/W2618185066', 'https://openalex.org/W2390152934', 'https://openalex.org/W2375344515', 'https://openalex.org/W2372561159', 'https://openalex.org/W2032912323', 'https://openalex.org/W1983633124', 'https://openalex.org/W1967103478', 'https://openalex.org/W1576675950'], 'abstract_inverted_index': {'Abstract': [0], 'Purpose:': [1], 'Some': [2], '85%': [3], 'of': [4, 15, 66, 84, 107, 120, 137, 154, 160, 166, 206, 212, 237, 244], 'lung': [5, 21, 46, 53, 108, 114, 141, 148, 214, 249], 'cancers': [6], 'are': [7], 'smoking': [8, 226], 'related.': [9], 'Here,': [10], 'we': [11], 'investigate': [12], 'the': [13, 34, 64, 81, 93, 157, 178, 242], 'role': [14], 'serine': [16], 'protease': [17], 'HtrA3': [18, 27, 67, 85, 97, 132, 161, 167, 185, 207, 222, 238], 'in': [19, 33, 45, 51, 104, 127, 131, 170, 184, 191, 247], 'smoking-related': [20, 248], 'cancer.': [22, 250], 'Experimental': [23], 'Design:': [24], 'We': [25, 61, 90], 'assess': [26], 'methylation': [28, 155, 236], 'and': [29, 50, 58, 72, 77, 80, 112, 145, 199, 224], 'its': [30], 'corresponding': [31, 82, 164, 189], 'expression': [32, 98, 223], 'human': [35], 'bronchial': [36], 'cell': [37, 48, 110, 122, 143], 'line': [38], 'BEAS-2B': [39], 'following': [40], 'cigarette': [41, 179, 234], 'smoke': [42, 180], 'carcinogen': [43, 181], 'treatment,': [44], 'cancer': [47, 109, 142], 'lines': [49, 111, 123, 144], 'primary': [52, 113, 147, 213], 'tumors': [54, 115, 149, 171, 215], 'from': [55, 116, 140, 146, 172], 'light,': [56], 'moderate,': [57], 'heavy': [59, 117, 225], 'smokers.': [60, 118, 173], 'also': [62], 'show': [63, 91], 'effects': [65, 83], 'downregulation': [68, 186], 'on': [69], 'MTT': [70], 'reduction': [71], 'clonogenic': [73], 'survival': [74], 'with': [75, 124, 162, 177, 187], 'etoposide': [76, 198], 'cisplatin': [78, 200], 'treatment': [79, 176], 're-expression': [86], 'during': [87], 'treatment.': [88], 'Results:': [89], 'for': [92], 'first': [94, 158], 'time': [95], 'that': [96, 233], 'is': [99], 'reduced': [100], 'or': [101], 'completely': [102], 'lost': [103], 'over': [105], '50%': [106], 'Treatment': [119], 'HtrA3-deficient': [121], '5-aza-2′-deoxycytidine': [125], 'resulted': [126, 183], 'a': [128, 163, 188, 203, 217], 'dose-dependent': [129], 'increase': [130, 190], 'transcription.': [133], 'Further,': [134], 'sequence': [135], 'analysis': [136, 211], 'bisulfite-modified': [138], 'DNA': [139], 'showed': [150], 'an': [151], 'increased': [152], 'frequency': [153], 'within': [156], 'exon': [159], 'loss': [165], 'expression,': [168], 'particularly': [169], 'In': [174], 'BEAS-2B,': [175], '4-(methylnitrosamino)-I-(3-pyridyl)-1-butanone': [182], 'methylation.': [192], 'Additional': [193], 'studies': [194], 'indicate': [195], 'resistance': [196], 'to': [197, 241], 'cytotoxicity': [201], 'as': [202], 'functional': [204], 'consequence': [205], 'loss.': [208], 'Finally,': [209], 'immunohistochemical': [210], 'revealed': [216], 'strong': [218], 'correlation': [219], 'between': [220], 'low': [221], 'history.': [227], 'Conclusions:': [228], 'Collectively,': [229], 'these': [230], 'results': [231], 'suggest': [232], 'smoke–induced': [235], 'could': [239], 'contribute': [240], 'etiology': [243], 'chemoresistant': [245], 'disease': [246], 'Clin': [251], 'Cancer': [252], 'Res;': [253], '16(2);': [254], '398–409': [255]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2110143191', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-24T14:12:39.081613', 'created_date': '2016-06-24'}