Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

Name: Work Video:
Duration: 3 min 30 s
Carl‐Henrik Heldin; Bengt Westermark
{'id': 'https://openalex.org/W2110121929', 'doi': 'https://doi.org/10.1152/physrev.1999.79.4.1283', 'title': 'Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor', 'display_name': 'Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor', 'publication_year': 1999, 'publication_date': '1999-01-10', 'ids': {'openalex': 'https://openalex.org/W2110121929', 'doi': 'https://doi.org/10.1152/physrev.1999.79.4.1283', 'mag': '2110121929', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10508235'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/physrev.1999.79.4.1283', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203035050', 'display_name': 'Physiological Reviews', 'issn_l': '0031-9333', 'issn': ['0031-9333', '1522-1210'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5084535456', 'display_name': 'Carl‐Henrik Heldin', 'orcid': 'https://orcid.org/0000-0002-9508-896X'}, 'institutions': [{'id': 'https://openalex.org/I196064397', 'display_name': 'Ludwig Cancer Research', 'ror': 'https://ror.org/05923xh51', 'country_code': 'BE', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I196064397', 'https://openalex.org/I4210150094']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Carl-Henrik Heldin', 'raw_affiliation_strings': ['Ludwig Institute for Cancer Research, Biomedical Center, and Department of Pathology, University Hospital, Uppsala, Sweden.'], 'affiliations': [{'raw_affiliation_string': 'Ludwig Institute for Cancer Research, Biomedical Center, and Department of Pathology, University Hospital, Uppsala, Sweden.', 'institution_ids': ['https://openalex.org/I196064397']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5090354704', 'display_name': 'Bengt Westermark', 'orcid': 'https://orcid.org/0000-0001-7153-5545'}, 'institutions': [{'id': 'https://openalex.org/I196064397', 'display_name': 'Ludwig Cancer Research', 'ror': 'https://ror.org/05923xh51', 'country_code': 'BE', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I196064397', 'https://openalex.org/I4210150094']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Bengt Westermark', 'raw_affiliation_strings': ['Ludwig Institute for Cancer Research, Biomedical Center, and Department of Pathology, University Hospital, Uppsala, Sweden.'], 'affiliations': [{'raw_affiliation_string': 'Ludwig Institute for Cancer Research, Biomedical Center, and Department of Pathology, University Hospital, Uppsala, Sweden.', 'institution_ids': ['https://openalex.org/I196064397']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 13.996, 'has_fulltext': False, 'cited_by_count': 2387, 'citation_normalized_percentile': {'value': 0.912442, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '79', 'issue': '4', 'first_page': '1283', 'last_page': '1316'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12600', 'display_name': 'Eosinophilic Disorders and Syndromes', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12600', 'display_name': 'Eosinophilic Disorders and Syndromes', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11346', 'display_name': 'Mast cells and histamine', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/platelet-derived-growth-factor', 'display_name': 'Platelet-derived growth factor', 'score': 0.6124932}], 'concepts': [{'id': 'https://openalex.org/C180361614', 'wikidata': 'https://www.wikidata.org/wiki/Q7202242', 'display_name': 'Platelet-derived growth factor receptor', 'level': 4, 'score': 0.8856176}, {'id': 'https://openalex.org/C128240485', 'wikidata': 'https://www.wikidata.org/wiki/Q786998', 'display_name': 'Autocrine signalling', 'level': 3, 'score': 0.79621243}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.70794785}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.6577583}, {'id': 'https://openalex.org/C2781294074', 'wikidata': 'https://www.wikidata.org/wiki/Q22327352', 'display_name': 'Platelet-derived growth factor', 'level': 5, 'score': 0.6124932}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5712528}, {'id': 'https://openalex.org/C7876069', 'wikidata': 'https://www.wikidata.org/wiki/Q14873666', 'display_name': 'Paracrine signalling', 'level': 3, 'score': 0.56995666}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4366237}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.4334006}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.3572716}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19784689}], 'mesh': [{'descriptor_ui': 'D010982', 'descriptor_name': 'Platelet-Derived Growth Factor', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D017479', 'descriptor_name': 'Receptors, Platelet-Derived Growth Factor', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004194', 'descriptor_name': 'Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005314', 'descriptor_name': 'Embryonic and Fetal Development', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010982', 'descriptor_name': 'Platelet-Derived Growth Factor', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010982', 'descriptor_name': 'Platelet-Derived Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010982', 'descriptor_name': 'Platelet-Derived Growth Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017479', 'descriptor_name': 'Receptors, Platelet-Derived Growth Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017479', 'descriptor_name': 'Receptors, Platelet-Derived Growth Factor', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D017479', 'descriptor_name': 'Receptors, Platelet-Derived Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/physrev.1999.79.4.1283', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203035050', 'display_name': 'Physiological Reviews', 'issn_l': '0031-9333', 'issn': ['0031-9333', '1522-1210'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10508235', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.51}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 519, 'referenced_works': ['https://openalex.org/W109074058', 'https://openalex.org/W112957796', 'https://openalex.org/W114547043', 'https://openalex.org/W115929065', 'https://openalex.org/W1251519535', 'https://openalex.org/W142697010', 'https://openalex.org/W1486484681', 'https://openalex.org/W1489423942', 'https://openalex.org/W1493414055', 'https://openalex.org/W1494589518', 'https://openalex.org/W1495524665', 'https://openalex.org/W1495712810', 'https://openalex.org/W1495847993', 'https://openalex.org/W1496067662', 'https://openalex.org/W1499373702', 'https://openalex.org/W1501425607', 'https://openalex.org/W1503656739', 'https://openalex.org/W1507764267', 'https://openalex.org/W1507887565', 'https://openalex.org/W1509096292', 'https://openalex.org/W1515935875', 'https://openalex.org/W1519494647', 'https://openalex.org/W1521785861', 'https://openalex.org/W15225809', 'https://openalex.org/W1530530071', 'https://openalex.org/W1531755510', 'https://openalex.org/W1532726328', 'https://openalex.org/W1532741774', 'https://openalex.org/W1534461206', 'https://openalex.org/W1534734027', 'https://openalex.org/W1537958640', 'https://openalex.org/W1543283875', 'https://openalex.org/W1543752796', 'https://openalex.org/W1547402512', 'https://openalex.org/W1548006851', 'https://openalex.org/W1548798005', 'https://openalex.org/W1551210345', 'https://openalex.org/W1554167856', 'https://openalex.org/W1556778240', 'https://openalex.org/W1557003501', 'https://openalex.org/W1560709577', 'https://openalex.org/W1561335619', 'https://openalex.org/W1564495345', 'https://openalex.org/W1565685840', 'https://openalex.org/W1567131741', 'https://openalex.org/W1567495621', 'https://openalex.org/W1568057583', 'https://openalex.org/W1571113921', 'https://openalex.org/W1572087673', 'https://openalex.org/W1575595760', 'https://openalex.org/W1575914838', 'https://openalex.org/W1578564433', 'https://openalex.org/W1584248977', 'https://openalex.org/W1585517331', 'https://openalex.org/W1585685121', 'https://openalex.org/W1586111947', 'https://openalex.org/W1591328192', 'https://openalex.org/W1593468710', 'https://openalex.org/W1593791623', 'https://openalex.org/W1594156122', 'https://openalex.org/W1595723592', 'https://openalex.org/W1596796609', 'https://openalex.org/W1597241698', 'https://openalex.org/W1602103287', 'https://openalex.org/W1605041458', 'https://openalex.org/W1608077902', 'https://openalex.org/W1612998887', 'https://openalex.org/W1615015314', 'https://openalex.org/W1624505911', 'https://openalex.org/W1634344740', 'https://openalex.org/W16918793', 'https://openalex.org/W1720796911', 'https://openalex.org/W1725436419', 'https://openalex.org/W1752312133', 'https://openalex.org/W1785951391', 'https://openalex.org/W1796832639', 'https://openalex.org/W1799254473', 'https://openalex.org/W1801102136', 'https://openalex.org/W1808322538', 'https://openalex.org/W1823941928', 'https://openalex.org/W182887844', 'https://openalex.org/W1836215938', 'https://openalex.org/W1843891279', 'https://openalex.org/W1848995687', 'https://openalex.org/W1854163794', 'https://openalex.org/W1857978595', 'https://openalex.org/W1871201802', 'https://openalex.org/W1883414954', 'https://openalex.org/W1898814725', 'https://openalex.org/W1899513052', 'https://openalex.org/W1915295247', 'https://openalex.org/W1921828865', 'https://openalex.org/W1927693030', 'https://openalex.org/W1932371007', 'https://openalex.org/W1937671642', 'https://openalex.org/W1942976947', 'https://openalex.org/W1947540857', 'https://openalex.org/W1948282121', 'https://openalex.org/W1955795615', 'https://openalex.org/W1963669837', 'https://openalex.org/W1964082310', 'https://openalex.org/W1964822816', 'https://openalex.org/W1965380392', 'https://openalex.org/W1965526093', 'https://openalex.org/W1965718220', 'https://openalex.org/W1966551570', 'https://openalex.org/W1967168361', 'https://openalex.org/W1968275604', 'https://openalex.org/W1968427251', 'https://openalex.org/W1968432271', 'https://openalex.org/W1969086189', 'https://openalex.org/W1969586367', 'https://openalex.org/W1969735397', 'https://openalex.org/W1969921590', 'https://openalex.org/W1969966792', 'https://openalex.org/W1970575648', 'https://openalex.org/W1970709922', 'https://openalex.org/W1971972894', 'https://openalex.org/W1972172786', 'https://openalex.org/W1972638248', 'https://openalex.org/W1972785471', 'https://openalex.org/W1973052569', 'https://openalex.org/W1973418567', 'https://openalex.org/W1973631902', 'https://openalex.org/W1974625164', 'https://openalex.org/W1974790290', 'https://openalex.org/W1974926778', 'https://openalex.org/W1974967725', 'https://openalex.org/W1975408686', 'https://openalex.org/W1975729483', 'https://openalex.org/W1975730239', 'https://openalex.org/W1975735851', 'https://openalex.org/W1976569872', 'https://openalex.org/W1976937182', 'https://openalex.org/W1976964404', 'https://openalex.org/W1977024142', 'https://openalex.org/W1977701732', 'https://openalex.org/W1978271705', 'https://openalex.org/W1978634509', 'https://openalex.org/W1978857678', 'https://openalex.org/W1979271028', 'https://openalex.org/W1979286083', 'https://openalex.org/W1979356105', 'https://openalex.org/W1979965517', 'https://openalex.org/W1980166477', 'https://openalex.org/W1980478927', 'https://openalex.org/W1981330583', 'https://openalex.org/W1981393628', 'https://openalex.org/W1982014509', 'https://openalex.org/W1982130940', 'https://openalex.org/W1983051282', 'https://openalex.org/W1983512588', 'https://openalex.org/W1983688599', 'https://openalex.org/W1984797080', 'https://openalex.org/W1985258446', 'https://openalex.org/W1985355924', 'https://openalex.org/W1986126704', 'https://openalex.org/W1986263030', 'https://openalex.org/W1987885030', 'https://openalex.org/W1988017194', 'https://openalex.org/W1988028144', 'https://openalex.org/W1988532979', 'https://openalex.org/W1989163220', 'https://openalex.org/W1989783897', 'https://openalex.org/W1989987282', 'https://openalex.org/W1990809270', 'https://openalex.org/W1990833751', 'https://openalex.org/W1991074555', 'https://openalex.org/W1991577267', 'https://openalex.org/W1991767106', 'https://openalex.org/W1991779158', 'https://openalex.org/W1992245559', 'https://openalex.org/W1992410932', 'https://openalex.org/W1992425534', 'https://openalex.org/W1992894005', 'https://openalex.org/W1993036672', 'https://openalex.org/W1993255165', 'https://openalex.org/W1993487598', 'https://openalex.org/W1993851092', 'https://openalex.org/W1994060872', 'https://openalex.org/W1994926193', 'https://openalex.org/W1995482236', 'https://openalex.org/W1995700570', 'https://openalex.org/W1996017770', 'https://openalex.org/W1996385798', 'https://openalex.org/W1996728737', 'https://openalex.org/W1998109615', 'https://openalex.org/W1998155351', 'https://openalex.org/W1998371307', 'https://openalex.org/W1998499591', 'https://openalex.org/W1998650818', 'https://openalex.org/W1999012962', 'https://openalex.org/W2000269495', 'https://openalex.org/W2000626160', 'https://openalex.org/W2001381510', 'https://openalex.org/W2001423488', 'https://openalex.org/W2001574571', 'https://openalex.org/W2001922490', 'https://openalex.org/W2002250340', 'https://openalex.org/W2002320883', 'https://openalex.org/W2002513158', 'https://openalex.org/W2003196630', 'https://openalex.org/W2003248867', 'https://openalex.org/W2004106252', 'https://openalex.org/W2004876902', 'https://openalex.org/W2004894290', 'https://openalex.org/W2005328009', 'https://openalex.org/W2005697934', 'https://openalex.org/W2007075196', 'https://openalex.org/W2007380070', 'https://openalex.org/W2007463241', 'https://openalex.org/W2008014785', 'https://openalex.org/W2008468198', 'https://openalex.org/W2008641061', 'https://openalex.org/W2009310010', 'https://openalex.org/W2009416998', 'https://openalex.org/W2009639116', 'https://openalex.org/W2009877560', 'https://openalex.org/W2009946441', 'https://openalex.org/W2010389170', 'https://openalex.org/W2010959859', 'https://openalex.org/W2011347121', 'https://openalex.org/W2011672211', 'https://openalex.org/W2011918999', 'https://openalex.org/W2011957331', 'https://openalex.org/W2012335876', 'https://openalex.org/W2013012981', 'https://openalex.org/W2013106706', 'https://openalex.org/W2013628458', 'https://openalex.org/W2013862214', 'https://openalex.org/W2013906072', 'https://openalex.org/W2014456898', 'https://openalex.org/W2014623103', 'https://openalex.org/W2015182207', 'https://openalex.org/W2015219342', 'https://openalex.org/W2015313106', 'https://openalex.org/W2016718666', 'https://openalex.org/W2016826417', 'https://openalex.org/W2017072501', 'https://openalex.org/W2017205210', 'https://openalex.org/W2017999418', 'https://openalex.org/W2018504080', 'https://openalex.org/W2019635705', 'https://openalex.org/W2019829774', 'https://openalex.org/W2019914700', 'https://openalex.org/W2020108005', 'https://openalex.org/W2020247376', 'https://openalex.org/W2020292310', 'https://openalex.org/W2020374796', 'https://openalex.org/W2021890356', 'https://openalex.org/W2021949056', 'https://openalex.org/W2023090301', 'https://openalex.org/W2023412289', 'https://openalex.org/W2023744959', 'https://openalex.org/W2024675846', 'https://openalex.org/W2026107691', 'https://openalex.org/W2026578815', 'https://openalex.org/W2028140587', 'https://openalex.org/W2028245130', 'https://openalex.org/W2029462030', 'https://openalex.org/W2029521699', 'https://openalex.org/W2029634948', 'https://openalex.org/W2029737371', 'https://openalex.org/W2029804108', 'https://openalex.org/W2033027298', 'https://openalex.org/W2033480740', 'https://openalex.org/W2033655249', 'https://openalex.org/W2033669335', 'https://openalex.org/W2033846139', 'https://openalex.org/W2035140776', 'https://openalex.org/W2036180570', 'https://openalex.org/W2036502382', 'https://openalex.org/W2037434894', 'https://openalex.org/W2037674971', 'https://openalex.org/W2037904160', 'https://openalex.org/W2038443483', 'https://openalex.org/W2038706023', 'https://openalex.org/W2038900950', 'https://openalex.org/W2040047797', 'https://openalex.org/W2040493554', 'https://openalex.org/W2042038421', 'https://openalex.org/W2042817005', 'https://openalex.org/W2043395027', 'https://openalex.org/W2044167739', 'https://openalex.org/W2044461115', 'https://openalex.org/W2045188943', 'https://openalex.org/W2045679498', 'https://openalex.org/W2046352223', 'https://openalex.org/W2046459907', 'https://openalex.org/W2046733107', 'https://openalex.org/W2046841776', 'https://openalex.org/W2047258893', 'https://openalex.org/W2048121649', 'https://openalex.org/W2048258133', 'https://openalex.org/W2048587624', 'https://openalex.org/W2049128935', 'https://openalex.org/W2049227276', 'https://openalex.org/W2049503539', 'https://openalex.org/W2049770167', 'https://openalex.org/W2049906092', 'https://openalex.org/W2050596106', 'https://openalex.org/W2050601632', 'https://openalex.org/W2051396176', 'https://openalex.org/W2051398414', 'https://openalex.org/W2051864488', 'https://openalex.org/W2051946942', 'https://openalex.org/W2052026152', 'https://openalex.org/W2053645332', 'https://openalex.org/W2053806341', 'https://openalex.org/W2054154416', 'https://openalex.org/W2054362092', 'https://openalex.org/W2054760273', 'https://openalex.org/W2054867605', 'https://openalex.org/W2055259320', 'https://openalex.org/W2055420944', 'https://openalex.org/W2056354630', 'https://openalex.org/W2056477723', 'https://openalex.org/W2057866456', 'https://openalex.org/W2058460635', 'https://openalex.org/W2058488557', 'https://openalex.org/W2058839845', 'https://openalex.org/W2059436482', 'https://openalex.org/W2059810045', 'https://openalex.org/W2059897006', 'https://openalex.org/W2061013276', 'https://openalex.org/W2061078864', 'https://openalex.org/W2061881061', 'https://openalex.org/W2061892936', 'https://openalex.org/W2062216081', 'https://openalex.org/W2062264213', 'https://openalex.org/W2063277519', 'https://openalex.org/W2063422026', 'https://openalex.org/W2063453094', 'https://openalex.org/W2064769526', 'https://openalex.org/W2065260396', 'https://openalex.org/W2065758306', 'https://openalex.org/W2066367871', 'https://openalex.org/W2066642014', 'https://openalex.org/W2067885827', 'https://openalex.org/W2068953892', 'https://openalex.org/W2069269360', 'https://openalex.org/W2070276514', 'https://openalex.org/W2070351900', 'https://openalex.org/W2072486984', 'https://openalex.org/W2072634958', 'https://openalex.org/W2073323729', 'https://openalex.org/W2073545087', 'https://openalex.org/W2073725672', 'https://openalex.org/W2074358065', 'https://openalex.org/W2074644169', 'https://openalex.org/W2076105533', 'https://openalex.org/W2076832562', 'https://openalex.org/W2077488103', 'https://openalex.org/W2077673188', 'https://openalex.org/W2078345708', 'https://openalex.org/W2078349330', 'https://openalex.org/W2079235460', 'https://openalex.org/W2080003284', 'https://openalex.org/W2080033658', 'https://openalex.org/W2080177806', 'https://openalex.org/W2081203911', 'https://openalex.org/W2081560586', 'https://openalex.org/W2081712966', 'https://openalex.org/W2083290361', 'https://openalex.org/W2083398588', 'https://openalex.org/W2083802827', 'https://openalex.org/W2083991453', 'https://openalex.org/W2085081729', 'https://openalex.org/W2085295620', 'https://openalex.org/W2085895135', 'https://openalex.org/W2086080576', 'https://openalex.org/W2086214867', 'https://openalex.org/W2086222728', 'https://openalex.org/W2086555107', 'https://openalex.org/W2086732757', 'https://openalex.org/W2087171927', 'https://openalex.org/W2087525053', 'https://openalex.org/W2087890016', 'https://openalex.org/W2088204809', 'https://openalex.org/W2088637264', 'https://openalex.org/W2089083607', 'https://openalex.org/W2089294536', 'https://openalex.org/W2089639142', 'https://openalex.org/W2090584224', 'https://openalex.org/W2090634323', 'https://openalex.org/W2091664620', 'https://openalex.org/W2091920637', 'https://openalex.org/W2093101342', 'https://openalex.org/W2094249300', 'https://openalex.org/W2094672991', 'https://openalex.org/W2094891357', 'https://openalex.org/W2096395306', 'https://openalex.org/W2097716740', 'https://openalex.org/W2098916975', 'https://openalex.org/W2100088344', 'https://openalex.org/W2100278794', 'https://openalex.org/W2100285612', 'https://openalex.org/W2100453456', 'https://openalex.org/W2101283727', 'https://openalex.org/W2106797092', 'https://openalex.org/W2106931330', 'https://openalex.org/W2110153861', 'https://openalex.org/W2110928083', 'https://openalex.org/W2111059239', 'https://openalex.org/W2111334443', 'https://openalex.org/W2112356144', 'https://openalex.org/W2112569801', 'https://openalex.org/W2115874784', 'https://openalex.org/W2116887336', 'https://openalex.org/W2116911322', 'https://openalex.org/W2117066001', 'https://openalex.org/W2117563665', 'https://openalex.org/W2118961710', 'https://openalex.org/W2119521625', 'https://openalex.org/W2120500721', 'https://openalex.org/W2122260580', 'https://openalex.org/W2122530058', 'https://openalex.org/W2122847223', 'https://openalex.org/W2123340693', 'https://openalex.org/W2124273066', 'https://openalex.org/W2124977745', 'https://openalex.org/W2125393205', 'https://openalex.org/W2126933366', 'https://openalex.org/W2127208829', 'https://openalex.org/W2127227377', 'https://openalex.org/W2128048856', 'https://openalex.org/W2128539657', 'https://openalex.org/W2128781299', 'https://openalex.org/W2129906075', 'https://openalex.org/W2130091743', 'https://openalex.org/W2131419480', 'https://openalex.org/W2131651845', 'https://openalex.org/W2132237061', 'https://openalex.org/W2132246987', 'https://openalex.org/W2133323445', 'https://openalex.org/W2133733828', 'https://openalex.org/W2136137790', 'https://openalex.org/W2136390877', 'https://openalex.org/W2136459448', 'https://openalex.org/W2137570167', 'https://openalex.org/W2137577023', 'https://openalex.org/W2139352577', 'https://openalex.org/W2140606960', 'https://openalex.org/W2141676073', 'https://openalex.org/W2141904364', 'https://openalex.org/W2144238090', 'https://openalex.org/W2149153953', 'https://openalex.org/W2150696320', 'https://openalex.org/W2151489147', 'https://openalex.org/W2154015205', 'https://openalex.org/W2154083290', 'https://openalex.org/W2154172993', 'https://openalex.org/W2154636701', 'https://openalex.org/W2155815716', 'https://openalex.org/W2156905839', 'https://openalex.org/W2157065140', 'https://openalex.org/W2158464481', 'https://openalex.org/W2159620641', 'https://openalex.org/W2159634847', 'https://openalex.org/W2160628654', 'https://openalex.org/W2160992446', 'https://openalex.org/W2161162677', 'https://openalex.org/W2161972167', 'https://openalex.org/W2163380244', 'https://openalex.org/W2163887788', 'https://openalex.org/W2164965551', 'https://openalex.org/W2165970948', 'https://openalex.org/W2166578267', 'https://openalex.org/W2168427813', 'https://openalex.org/W2169007182', 'https://openalex.org/W2170346765', 'https://openalex.org/W2170429308', 'https://openalex.org/W2171027815', 'https://openalex.org/W2171046456', 'https://openalex.org/W2171754317', 'https://openalex.org/W2178320031', 'https://openalex.org/W2183343968', 'https://openalex.org/W2186753081', 'https://openalex.org/W2210114785', 'https://openalex.org/W2211393669', 'https://openalex.org/W2227416752', 'https://openalex.org/W2245482469', 'https://openalex.org/W2249984074', 'https://openalex.org/W225562129', 'https://openalex.org/W2286568283', 'https://openalex.org/W2292523598', 'https://openalex.org/W2302980047', 'https://openalex.org/W2303155598', 'https://openalex.org/W2314886992', 'https://openalex.org/W233869125', 'https://openalex.org/W2339212275', 'https://openalex.org/W2341350186', 'https://openalex.org/W2368817160', 'https://openalex.org/W2376219091', 'https://openalex.org/W2399042156', 'https://openalex.org/W2405720985', 'https://openalex.org/W2409349087', 'https://openalex.org/W2416432770', 'https://openalex.org/W2419596270', 'https://openalex.org/W2433649018', 'https://openalex.org/W2438351295', 'https://openalex.org/W2438645951', 'https://openalex.org/W2442530891', 'https://openalex.org/W2465406787', 'https://openalex.org/W2469409012', 'https://openalex.org/W250791542', 'https://openalex.org/W261406519', 'https://openalex.org/W263572369', 'https://openalex.org/W284870166', 'https://openalex.org/W3134071211', 'https://openalex.org/W321995181', 'https://openalex.org/W32471076', 'https://openalex.org/W355272', 'https://openalex.org/W41707389', 'https://openalex.org/W4241814063', 'https://openalex.org/W4255080146', 'https://openalex.org/W4285719527', 'https://openalex.org/W58289801', 'https://openalex.org/W957639277'], 'related_works': ['https://openalex.org/W3004047898', 'https://openalex.org/W2367035282', 'https://openalex.org/W2099619041', 'https://openalex.org/W2091727603', 'https://openalex.org/W2085869617', 'https://openalex.org/W2059527338', 'https://openalex.org/W2025842270', 'https://openalex.org/W2023442141', 'https://openalex.org/W2015867957', 'https://openalex.org/W1963652002'], 'abstract_inverted_index': {'Platelet-derived': [0], 'growth': [1, 165], 'factor': [2], '(PDGF)': [3], 'is': [4, 18, 137], 'a': [5, 19, 93, 98, 151], 'major': [6], 'mitogen': [7], 'for': [8], 'connective': [9], 'tissue': [10], 'cells': [11], 'and': [12, 28, 35, 47, 59, 79, 89, 144, 163, 190, 197, 202, 213, 220], 'certain': [13], 'other': [14], 'cell': [15, 70, 77, 95, 185], 'types.': [16], 'It': [17], 'dimeric': [20], 'molecule': [21], 'consisting': [22], 'of': [23, 63, 69, 84, 100, 120, 132, 142, 156, 167, 171, 200, 216], 'disulfide-bonded,': [24], 'structurally': [25, 50], 'similar': [26], 'A-': [27], 'B-polypeptide': [29], 'chains,': [30], 'which': [31], 'combine': [32], 'to': [33, 46, 67, 74, 139], 'homo-': [34], 'heterodimers.': [36], 'The': [37, 129], 'PDGF': [38, 64, 81, 104, 121, 157, 172, 201, 203, 208, 217], 'isoforms': [39], 'exert': [40], 'their': [41], 'cellular': [42, 211], 'effects': [43], 'by': [44, 150, 182], 'binding': [45], 'activating': [48], 'two': [49], 'related': [51, 138], 'protein': [52], 'tyrosine': [53], 'kinase': [54], 'receptors,': [55, 204], 'denoted': [56], 'the': [57, 60, 85, 109, 140, 205, 214], 'α-receptor': [58], 'β-receptor.': [61], 'Activation': [62], 'receptors': [65], 'leads': [66], 'stimulation': [68, 149, 166], 'growth,': [71], 'but': [72], 'also': [73], 'changes': [75], 'in': [76, 125, 161, 174, 178, 218], 'shape': [78], 'motility;': [80], 'induces': [82], 'reorganization': [83], 'actin': [86], 'filament': [87], 'system': [88], 'stimulates': [90], 'chemotaxis,': [91], 'i.e.,': [92], 'directed': [94], 'movement': [96], 'toward': [97], 'gradient': [99], 'PDGF.': [101], 'In': [102], 'vivo,': [103], 'has': [105, 122], 'important': [106], 'roles': [107], 'during': [108, 115], 'embryonic': [110], 'development': [111], 'as': [112, 114, 188], 'well': [113], 'wound': [116], 'healing.': [117], 'Moreover,': [118], 'overactivity': [119], 'been': [123, 176], 'implicated': [124, 177], 'several': [126], 'pathological': [127], 'conditions.': [128, 192], 'sis': [130], 'oncogene': [131], 'simian': [133], 'sarcoma': [134], 'virus': [135], '(SSV)': [136], 'B-chain': [141], 'PDGF,': [143], 'SSV': [145], 'transformation': [146], 'involves': [147], 'autocrine': [148, 162], 'PDGF-like': [152], 'molecule.': [153], 'Similarly,': [154], 'overproduction': [155], 'may': [158], 'be': [159], 'involved': [160], 'paracrine': [164], 'human': [168], 'tumors.': [169], 'Overactivity': [170], 'has,': [173], 'addition,': [175], 'nonmalignant': [179], 'conditions': [180], 'characterized': [181], 'an': [183], 'increased': [184], 'proliferation,': [186], 'such': [187], 'atherosclerosis': [189], 'fibrotic': [191], 'This': [193], 'review': [194], 'discusses': [195], 'structural': [196], 'functional': [198], 'properties': [199], 'mechanism': [206], 'whereby': [207], 'exerts': [209], 'its': [210], 'effects,': [212], 'role': [215], 'normal': [219], 'diseased': [221], 'tissues.': [222]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2110121929', 'counts_by_year': [{'year': 2024, 'cited_by_count': 71}, {'year': 2023, 'cited_by_count': 83}, {'year': 2022, 'cited_by_count': 81}, {'year': 2021, 'cited_by_count': 63}, {'year': 2020, 'cited_by_count': 82}, {'year': 2019, 'cited_by_count': 65}, {'year': 2018, 'cited_by_count': 83}, {'year': 2017, 'cited_by_count': 95}, {'year': 2016, 'cited_by_count': 87}, {'year': 2015, 'cited_by_count': 103}, {'year': 2014, 'cited_by_count': 102}, {'year': 2013, 'cited_by_count': 132}, {'year': 2012, 'cited_by_count': 110}], 'updated_date': '2025-01-09T12:43:43.322809', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
