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'leading': [20], 'cause': [21], 'death': [23], 'in': [24, 38, 55, 128, 135, 159, 198], 'VHL': [25, 36, 59, 108, 191], 'patients': [26], 'due': [27], 'to': [28, 173, 182], 'deleterious': [30], 'effects': [31, 144], 'metastatic': [34], 'tumor(s).': [35], 'functions': [37], 'destruction': [40, 82], 'alpha': [43], 'subunits': [44], 'heterodimeric': [47], 'transcription': [48, 147], 'factor,': [49], 'hypoxia-inducible': [50, 69], 'factor': [51], '(HIF-1α': [52], 'and': [53, 67, 78, 112, 122, 150, 181, 195, 201], 'HIF-2α),': [54], 'normoxic': [56], 'conditions.': [57], 'When': [58], 'function': [60, 111, 194], 'lost,': [62], 'HIF-α': [63], 'protein': [64, 202], 'stabilized,': [66], 'target': [68], 'genes': [70], 'are': [71], 'transcribed.': [72], 'The': [73], 'process': [74], 'invasion': [77], 'metastasis': [79], 'involves': [80], 'extracellular': [85], 'matrix,': [86], 'which': [87, 138], 'accomplished': [89], 'primarily': [90], 'by': [91, 141, 179], 'matrix': [93], 'metalloproteinase': 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