Title: A double-blind, randomized, placebo-controlled,cross-over study on the pharmacokinetics and effects of cannabis
Abstract: Systematic measurements of the concentration of the psycho-active
substance delta-9- tetrahydrocannabinol (THC) in 'netherweed' cannabis
obtained from coffeeshops in the Netherlands have revealed that the mean
THC concentrations have steadily increased from circa 8.6% in December
1999-January 2000 to 17.7% in December 2004-January 2005. Smoking
cannabis with higher THC contents (external exposure: 9.75 to 23.12%
THC) was associated with a dose-related increase of the serum
concentrations of THC (internal exposure).
Smoking cannabis with higher THC contents was also associated with a
dose-related increase of physical effects (such as increase of heart
rate, and decrease of blood pressure) and psychomotor effects (such as
reacting more slowly, being less concentrated, making more mistakes
during testing, having decreased functioning of motor control, and having
more drowsiness). Results as mentioned above were derived from a
clinical study with 24 cannabis users.
Publication Year: 2006
Publication Date: 2006-05-23
Language: en
Type: article
Access and Citation
Cited By Count: 12
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