Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2109994599', 'doi': 'https://doi.org/10.1158/0008-5472.can-10-4463', 'title': 'Mutationally Activated BRAFV600E Elicits Papillary Thyroid Cancer in the Adult Mouse', 'display_name': 'Mutationally Activated BRAFV600E Elicits Papillary Thyroid Cancer in the Adult Mouse', 'publication_year': 2011, 'publication_date': '2011-04-22', 'ids': {'openalex': 'https://openalex.org/W2109994599', 'doi': 'https://doi.org/10.1158/0008-5472.can-10-4463', 'mag': '2109994599', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21512141', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3107361'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-10-4463', 'pdf_url': 'https://cancerres.aacrjournals.org/content/canres/71/11/3863.full.pdf', 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://cancerres.aacrjournals.org/content/canres/71/11/3863.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040548392', 'display_name': 'Roch‐Philippe Charles', 'orcid': 'https://orcid.org/0000-0002-5243-3866'}, 'institutions': [{'id': 'https://openalex.org/I4210115745', 'display_name': 'Biogem', 'ror': 'https://ror.org/01ymr5447', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801626668', 'https://openalex.org/I4210115745']}, {'id': 'https://openalex.org/I4210167126', 'display_name': 'UCSF Helen Diller Family Comprehensive Cancer Center', 'ror': 'https://ror.org/05yndxy10', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I180670191', 'https://openalex.org/I4210110664', 'https://openalex.org/I4210167126']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['IT', 'US'], 'is_corresponding': False, 'raw_author_name': 'Roch-Philippe Charles', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081UCSF Helen Diller Family Comprehensive Cancer Center; Departments of 2Cell and Molecular Pharmacology and 3Pathology, University of California, San Francisco, California; and 4L'Istituto di Ricerche Genetiche, Gaetano Salvatore, Biogem s.c.ar.l., Ariano Irpino, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081UCSF Helen Diller Family Comprehensive Cancer Center; Departments of 2Cell and Molecular Pharmacology and 3Pathology, University of California, San Francisco, California; and 4L'Istituto di Ricerche Genetiche, Gaetano Salvatore, Biogem s.c.ar.l., Ariano Irpino, Italy", 'institution_ids': ['https://openalex.org/I4210115745', 'https://openalex.org/I4210167126', 'https://openalex.org/I180670191', 'https://openalex.org/I4210115745', 'https://openalex.org/I4210167126', 'https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002092324', 'display_name': 'Gioia Iezza', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115745', 'display_name': 'Biogem', 'ror': 'https://ror.org/01ymr5447', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801626668', 'https://openalex.org/I4210115745']}, {'id': 'https://openalex.org/I4210167126', 'display_name': 'UCSF Helen Diller Family Comprehensive Cancer Center', 'ror': 'https://ror.org/05yndxy10', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I180670191', 'https://openalex.org/I4210110664', 'https://openalex.org/I4210167126']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['IT', 'US'], 'is_corresponding': False, 'raw_author_name': 'Gioia Iezza', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081UCSF Helen Diller Family Comprehensive Cancer Center; Departments of 2Cell and Molecular Pharmacology and 3Pathology, University of California, San Francisco, California; and 4L'Istituto di Ricerche Genetiche, Gaetano Salvatore, Biogem s.c.ar.l., Ariano Irpino, Italy", 'Departments of Cell and Molecular Pharmacology and Pathology, University of California, San Francisco, California'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081UCSF Helen Diller Family Comprehensive Cancer Center; Departments of 2Cell and Molecular Pharmacology and 3Pathology, University of California, San Francisco, California; and 4L'Istituto di Ricerche Genetiche, Gaetano Salvatore, Biogem s.c.ar.l., Ariano Irpino, Italy", 'institution_ids': ['https://openalex.org/I4210115745', 'https://openalex.org/I4210167126', 'https://openalex.org/I180670191']}, {'raw_affiliation_string': 'Departments of Cell and Molecular Pharmacology and Pathology, University of California, San Francisco, California', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028185001', 'display_name': 'Elena Amendola', 'orcid': 'https://orcid.org/0000-0001-5545-3048'}, 'institutions': [{'id': 'https://openalex.org/I4210115745', 'display_name': 'Biogem', 'ror': 'https://ror.org/01ymr5447', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801626668', 'https://openalex.org/I4210115745']}, {'id': 'https://openalex.org/I4210167126', 'display_name': 'UCSF Helen Diller Family Comprehensive Cancer Center', 'ror': 'https://ror.org/05yndxy10', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I180670191', 'https://openalex.org/I4210110664', 'https://openalex.org/I4210167126']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['IT', 'US'], 'is_corresponding': False, 'raw_author_name': 'Elena Amendola', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081UCSF Helen Diller Family Comprehensive Cancer Center; Departments of 2Cell and Molecular Pharmacology and 3Pathology, University of California, San Francisco, California; and 4L'Istituto di Ricerche Genetiche, Gaetano Salvatore, Biogem s.c.ar.l., Ariano Irpino, Italy", 'Departments of Cell and Molecular Pharmacology and Pathology, University of California, San Francisco, California'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081UCSF Helen Diller Family Comprehensive Cancer Center; Departments of 2Cell and Molecular Pharmacology and 3Pathology, University of California, San Francisco, California; and 4L'Istituto di Ricerche Genetiche, Gaetano Salvatore, Biogem s.c.ar.l., Ariano Irpino, Italy", 'institution_ids': ['https://openalex.org/I4210115745', 'https://openalex.org/I4210167126', 'https://openalex.org/I180670191']}, {'raw_affiliation_string': 'Departments of Cell and Molecular Pharmacology and Pathology, University of California, San Francisco, California', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040249960', 'display_name': 'David Dankort', 'orcid': 'https://orcid.org/0000-0002-5862-6829'}, 'institutions': [{'id': 'https://openalex.org/I4210115745', 'display_name': 'Biogem', 'ror': 'https://ror.org/01ymr5447', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801626668', 'https://openalex.org/I4210115745']}, {'id': 'https://openalex.org/I4210167126', 'display_name': 'UCSF Helen Diller Family Comprehensive Cancer Center', 'ror': 'https://ror.org/05yndxy10', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I180670191', 'https://openalex.org/I4210110664', 'https://openalex.org/I4210167126']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['IT', 'US'], 'is_corresponding': False, 'raw_author_name': 'David Dankort', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081UCSF Helen Diller Family Comprehensive Cancer Center; Departments of 2Cell and Molecular Pharmacology and 3Pathology, University of California, San Francisco, California; and 4L'Istituto di Ricerche Genetiche, Gaetano Salvatore, Biogem s.c.ar.l., Ariano Irpino, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081UCSF Helen Diller Family Comprehensive Cancer Center; Departments of 2Cell and Molecular Pharmacology and 3Pathology, University of California, San Francisco, California; and 4L'Istituto di Ricerche Genetiche, Gaetano Salvatore, Biogem s.c.ar.l., Ariano Irpino, Italy", 'institution_ids': ['https://openalex.org/I4210115745', 'https://openalex.org/I4210167126', 'https://openalex.org/I180670191', 'https://openalex.org/I4210115745', 'https://openalex.org/I4210167126', 'https://openalex.org/I180670191']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5003652463', 'display_name': 'Martin McMahon', 'orcid': 'https://orcid.org/0000-0003-2812-1042'}, 'institutions': [{'id': 'https://openalex.org/I4210115745', 'display_name': 'Biogem', 'ror': 'https://ror.org/01ymr5447', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801626668', 'https://openalex.org/I4210115745']}, {'id': 'https://openalex.org/I4210167126', 'display_name': 'UCSF Helen Diller Family Comprehensive Cancer Center', 'ror': 'https://ror.org/05yndxy10', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I180670191', 'https://openalex.org/I4210110664', 'https://openalex.org/I4210167126']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['IT', 'US'], 'is_corresponding': False, 'raw_author_name': 'Martin McMahon', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081UCSF Helen Diller Family Comprehensive Cancer Center; Departments of 2Cell and Molecular Pharmacology and 3Pathology, University of California, San Francisco, California; and 4L'Istituto di Ricerche Genetiche, Gaetano Salvatore, Biogem s.c.ar.l., Ariano Irpino, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081UCSF Helen Diller Family Comprehensive Cancer Center; Departments of 2Cell and Molecular Pharmacology and 3Pathology, University of California, San Francisco, California; and 4L'Istituto di Ricerche Genetiche, Gaetano Salvatore, Biogem s.c.ar.l., Ariano Irpino, Italy", 'institution_ids': ['https://openalex.org/I4210115745', 'https://openalex.org/I4210167126', 'https://openalex.org/I180670191', 'https://openalex.org/I4210115745', 'https://openalex.org/I4210167126', 'https://openalex.org/I180670191']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.464, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 98, 'citation_normalized_percentile': {'value': 0.999911, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '71', 'issue': '11', 'first_page': '3863', 'last_page': '3871'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10329', 'display_name': 'Thyroid Cancer Diagnosis and Treatment', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10329', 'display_name': 'Thyroid Cancer Diagnosis and Treatment', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12030', 'display_name': 'S100 Proteins and Annexins', 'score': 0.9808, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2781461381', 'wikidata': 'https://www.wikidata.org/wiki/Q2292945', 'display_name': 'Papillary thyroid cancer', 'level': 4, 'score': 0.7239768}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6379527}, {'id': 'https://openalex.org/C2779761222', 'wikidata': 'https://www.wikidata.org/wiki/Q826522', 'display_name': 'Thyroid cancer', 'level': 3, 'score': 0.6327592}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.6198459}, {'id': 'https://openalex.org/C2993294228', 'wikidata': 'https://www.wikidata.org/wiki/Q13632630', 'display_name': 'Thyroid carcinoma', 'level': 3, 'score': 0.5971835}, {'id': 'https://openalex.org/C526584372', 'wikidata': 'https://www.wikidata.org/wiki/Q16399', 'display_name': 'Thyroid', 'level': 2, 'score': 0.59290695}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5308082}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.47395396}, {'id': 'https://openalex.org/C179185449', 'wikidata': 'https://www.wikidata.org/wiki/Q219699', 'display_name': 'Suppressor', 'level': 3, 'score': 0.43175733}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.39002404}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3629073}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.345425}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.33817405}], 'mesh': [{'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D048493', 'descriptor_name': 'Proto-Oncogene Proteins B-raf', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002277', 'descriptor_name': 'Carcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002291', 'descriptor_name': 'Carcinoma, Papillary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048493', 'descriptor_name': 'Proto-Oncogene Proteins B-raf', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048493', 'descriptor_name': 'Proto-Oncogene Proteins B-raf', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077273', 'descriptor_name': 'Thyroid Cancer, Papillary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-10-4463', 'pdf_url': 'https://cancerres.aacrjournals.org/content/canres/71/11/3863.full.pdf', 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3107361', 'pdf_url': 'https://europepmc.org/articles/pmc3107361?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107361', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21512141', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-10-4463', 'pdf_url': 'https://cancerres.aacrjournals.org/content/canres/71/11/3863.full.pdf', 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.69}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1496124518', 'https://openalex.org/W1968516446', 'https://openalex.org/W1970195561', 'https://openalex.org/W1994772304', 'https://openalex.org/W1995223428', 'https://openalex.org/W2026866722', 'https://openalex.org/W2033882181', 'https://openalex.org/W2055996927', 'https://openalex.org/W2093924594', 'https://openalex.org/W2106543129', 'https://openalex.org/W2109544257', 'https://openalex.org/W2113259149', 'https://openalex.org/W2113549577', 'https://openalex.org/W2113896257', 'https://openalex.org/W2118986295', 'https://openalex.org/W2124705154', 'https://openalex.org/W2137792649', 'https://openalex.org/W2140690632', 'https://openalex.org/W2142020978', 'https://openalex.org/W2163188200', 'https://openalex.org/W2166568854', 'https://openalex.org/W2231156824'], 'related_works': ['https://openalex.org/W4391057618', 'https://openalex.org/W4389691350', 'https://openalex.org/W4206801750', 'https://openalex.org/W3022228189', 'https://openalex.org/W2603577764', 'https://openalex.org/W2520425266', 'https://openalex.org/W25001789', 'https://openalex.org/W2433485935', 'https://openalex.org/W2067336395', 'https://openalex.org/W2017000262'], 'abstract_inverted_index': {'Abstract': [0], 'Mutated': [1], 'BRAF': [2, 111], 'is': [3], 'detected': [4], 'in': [5, 37], 'approximately': [6], '45%': [7], 'of': [8, 23, 50, 65, 71, 79, 86, 107, 109], 'papillary': [9], 'thyroid': [10, 33, 38, 76, 80, 99], 'carcinomas': [11], '(PTC).': [12], 'To': [13], 'model': [14], 'PTC,': [15], 'we': [16], 'bred': [17], 'mice': [18, 30, 55], 'with': [19, 89], 'adult-onset,': [20], 'thyrocyte-specific': [21], 'expression': [22, 63], 'BRAFV600E.': [24], 'One': [25], 'month': [26], 'following': [27], 'BRAFV600E': [28], 'expression,': [29], 'displayed': [31], 'increased': [32], 'size,': [34, 77], 'widespread': [35], 'alterations': [36], 'architecture,': [39], 'and': [40, 61, 82, 84, 102, 104], 'dramatic': [41], 'hypothyroidism.': [42], 'Over': [43], '1': [44], 'year,': [45], 'without': [46], 'any': [47], 'deliberate': [48], 'manipulation': [49], 'tumor': [51, 100], 'suppressor': [52], 'genes,': [53], 'all': [54], 'developed': [56], 'PTC': [57, 91], 'displaying': [58], 'nuclear': [59], 'atypia': [60], 'marker': [62], 'characteristic': [64], 'the': [66, 105], 'human': [67], 'disease.': [68], 'Pharmacologic': [69], 'inhibition': [70, 85], 'MEK1/2': [72], 'led': [73], 'to': [74, 97], 'decreased': [75], 'restoration': [78], 'form': [81], 'function,': [83], 'tumorigenesis.': [87], 'Mice': [88], 'BRAFV600E-induced': [90], 'will': [92], 'provide': [93], 'an': [94], 'excellent': [95], 'system': [96], 'study': [98], 'initiation': [101], 'progression': [103], 'evaluation': [106], 'inhibitors': [108], 'oncogenic': [110], 'signaling.': [112], 'Cancer': [113], 'Res;': [114], '71(11);': [115], '3863–71.': [116], '©2011': [117], 'AACR.': [118]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2109994599', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-10T04:39:59.592074', 'created_date': '2016-06-24'}