Publication Information

{'id': 'https://openalex.org/W2109593516', 'doi': 'https://doi.org/10.4049/jimmunol.181.3.2220', 'title': 'Human Anti-Inflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells, Which Suppress via Membrane-Bound TGFβ-1', 'display_name': 'Human Anti-Inflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells, Which Suppress via Membrane-Bound TGFβ-1', 'publication_year': 2008, 'publication_date': '2008-08-01', 'ids': {'openalex': 'https://openalex.org/W2109593516', 'doi': 'https://doi.org/10.4049/jimmunol.181.3.2220', 'mag': '2109593516', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18641362'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.181.3.2220', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/181/3/2220/1256351/zim01508002220.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.aai.org/jimmunol/article-pdf/181/3/2220/1256351/zim01508002220.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029055010', 'display_name': 'Nigel D. L. Savage', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}, {'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['CZ', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Nigel D. L. Savage', 'raw_affiliation_strings': ['*Department of Immunohematology and Blood Transfusion and', '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunohematology and Blood Transfusion and', 'institution_ids': ['https://openalex.org/I4210096318']}, {'raw_affiliation_string': '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110234137', 'display_name': 'Tjitske de Boer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}, {'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['CZ', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Tjitske de Boer', 'raw_affiliation_strings': ['*Department of Immunohematology and Blood Transfusion and', '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunohematology and Blood Transfusion and', 'institution_ids': ['https://openalex.org/I4210096318']}, {'raw_affiliation_string': '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111153739', 'display_name': 'Kimberley V. Walburg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Kimberley V. Walburg', 'raw_affiliation_strings': ['†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016521148', 'display_name': 'Simone A. Joosten', 'orcid': 'https://orcid.org/0000-0002-9878-0863'}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}, {'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['CZ', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Simone A. Joosten', 'raw_affiliation_strings': ['*Department of Immunohematology and Blood Transfusion and', '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunohematology and Blood Transfusion and', 'institution_ids': ['https://openalex.org/I4210096318']}, {'raw_affiliation_string': '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074035245', 'display_name': 'Krista E. van Meijgaarden', 'orcid': 'https://orcid.org/0000-0003-2818-9805'}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}, {'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['CZ', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Krista van Meijgaarden', 'raw_affiliation_strings': ['*Department of Immunohematology and Blood Transfusion and', '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunohematology and Blood Transfusion and', 'institution_ids': ['https://openalex.org/I4210096318']}, {'raw_affiliation_string': '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003866582', 'display_name': 'Annemieke Geluk', 'orcid': 'https://orcid.org/0000-0001-8555-2872'}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}, {'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['CZ', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Annemiek Geluk', 'raw_affiliation_strings': ['*Department of Immunohematology and Blood Transfusion and', '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunohematology and Blood Transfusion and', 'institution_ids': ['https://openalex.org/I4210096318']}, {'raw_affiliation_string': '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5004201118', 'display_name': 'Tom H. M. Ottenhoff', 'orcid': 'https://orcid.org/0000-0003-3706-3403'}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}, {'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['CZ', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Tom H. M. Ottenhoff', 'raw_affiliation_strings': ['*Department of Immunohematology and Blood Transfusion and', '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunohematology and Blood Transfusion and', 'institution_ids': ['https://openalex.org/I4210096318']}, {'raw_affiliation_string': '†Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.533, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 233, 'citation_normalized_percentile': {'value': 0.999911, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '181', 'issue': '3', 'first_page': '2220', 'last_page': '2226'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11313', 'display_name': 'Immune cells in cancer', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11313', 'display_name': 'Immune cells in cancer', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12387', 'display_name': 'Galectins and Cancer Biology', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/regulatory-t-cell', 'display_name': 'Regulatory T cell', 'score': 0.4326729}], 'concepts': [{'id': 'https://openalex.org/C2779727006', 'wikidata': 'https://www.wikidata.org/wiki/Q426188', 'display_name': 'FOXP3', 'level': 3, 'score': 0.8195269}, {'id': 'https://openalex.org/C79484868', 'wikidata': 'https://www.wikidata.org/wiki/Q5971673', 'display_name': 'IL-2 receptor', 'level': 4, 'score': 0.6199136}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5830304}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.55969316}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5005851}, {'id': 'https://openalex.org/C2778296632', 'wikidata': 'https://www.wikidata.org/wiki/Q1550619', 'display_name': 'Regulatory T cell', 'level': 5, 'score': 0.4326729}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.33865124}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.24130967}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22482753}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.13556054}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.12885576}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11921272}], 'mesh': [{'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053645', 'descriptor_name': 'Interleukin-2 Receptor alpha Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017475', 'descriptor_name': 'Receptors, Nerve Growth Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053773', 'descriptor_name': 'Transforming Growth Factor beta1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002450', 'descriptor_name': 'Cell Communication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002450', 'descriptor_name': 'Cell Communication', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053450', 'descriptor_name': 'Glucocorticoid-Induced TNFR-Related Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D053645', 'descriptor_name': 'Interleukin-2 Receptor alpha Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053645', 'descriptor_name': 'Interleukin-2 Receptor alpha Subunit', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007519', 'descriptor_name': 'Isoantigens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007519', 'descriptor_name': 'Isoantigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017475', 'descriptor_name': 'Receptors, Nerve Growth Factor', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D017475', 'descriptor_name': 'Receptors, Nerve Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D053773', 'descriptor_name': 'Transforming Growth Factor beta1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.181.3.2220', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/181/3/2220/1256351/zim01508002220.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18641362', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.181.3.2220', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/181/3/2220/1256351/zim01508002220.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.5, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1745273943', 'https://openalex.org/W1898102248', 'https://openalex.org/W1942388905', 'https://openalex.org/W1967577988', 'https://openalex.org/W1967603837', 'https://openalex.org/W1984451487', 'https://openalex.org/W1988474688', 'https://openalex.org/W1990899950', 'https://openalex.org/W1997398245', 'https://openalex.org/W2002726823', 'https://openalex.org/W2024483802', 'https://openalex.org/W2026426963', 'https://openalex.org/W2026836824', 'https://openalex.org/W2070443202', 'https://openalex.org/W2071734372', 'https://openalex.org/W2081771448', 'https://openalex.org/W2094663408', 'https://openalex.org/W2095764253', 'https://openalex.org/W2097811455', 'https://openalex.org/W2117493229', 'https://openalex.org/W2119194984', 'https://openalex.org/W2122738080', 'https://openalex.org/W2123518168', 'https://openalex.org/W2136245823', 'https://openalex.org/W2141324432', 'https://openalex.org/W2147291647', 'https://openalex.org/W2151948277', 'https://openalex.org/W2156626338', 'https://openalex.org/W2158092720', 'https://openalex.org/W2161545566', 'https://openalex.org/W2164872587', 'https://openalex.org/W2172116560', 'https://openalex.org/W4234615218'], 'related_works': ['https://openalex.org/W4295086901', 'https://openalex.org/W4200177251', 'https://openalex.org/W2524538250', 'https://openalex.org/W2474797438', 'https://openalex.org/W2389761496', 'https://openalex.org/W2375617839', 'https://openalex.org/W2354113403', 'https://openalex.org/W1997185845', 'https://openalex.org/W1990002777', 'https://openalex.org/W1585751203'], 'abstract_inverted_index': {'CD4(+)': [0], 'T': [1, 35, 68, 127, 152], 'cell': [2, 36, 69, 95, 153], 'differentiation': [3], 'and': [4, 14, 33, 48, 56, 62, 84, 88, 99, 188, 190, 246], 'function': [5, 70], 'are': [6, 40, 191], 'critically': [7], 'dependent': [8], 'on': [9, 31, 67, 149], 'the': [10, 15, 26, 41, 46, 150, 165, 224], 'type': [11], 'of': [12, 28, 60, 80, 138, 158, 212, 217], 'APC': [13, 209], 'microenvironment': [16], 'in': [17, 45, 52, 63, 161, 170, 223, 233, 242], 'which': [18], 'Ag': [19, 97], 'presentation': [20], 'occurs.': [21], 'Most': [22], 'studies': [23], 'have': [24], 'documented': [25], 'effect': [27, 59], 'dendritic': [29], 'cells': [30, 128, 163, 205], 'effector': [32], 'regulatory': [34, 126, 151, 166], 'differentiation;': [37], 'however,': [38], 'macrophages': [39, 82, 219, 237], 'most': [42], 'abundant': [43], 'APCs': [44], 'periphery': [47, 225], 'can': [49], 'be': [50], 'found': [51], 'virtually': [53], 'all': [54], 'organs': [55], 'tissues.': [57], 'The': [58, 215], 'macrophages,': [61], 'particular': [64], 'their': [65], 'subsets,': [66], 'has': [71, 226], 'received': [72], 'little': [73], 'attention.': [74], 'Previously,': [75], 'we': [76, 116], 'described': [77], 'distinct': [78], 'subsets': [79], 'human': [81, 105], '(pro-': [83], 'anti-inflammatory,': [85], 'm': [86, 89, 106, 110, 119, 123, 195, 203], 'phi1': [87, 107], 'phi2,': [90, 120], 'respectively)': [91], 'with': [92, 129], 'highly': [93], 'divergent': [94], 'surface': [96], 'expression': [98], 'cytokine/chemokine': [100], 'production.': [101], 'We': [102], 'reported': [103], 'that': [104, 118], 'promote,': [108], 'whereas': [109], 'phi2': [111, 196, 204], 'decrease,': [112], 'Th1': [113], 'activation.': [114], 'Here,': [115], 'demonstrate': [117], 'but': [121], 'not': [122], 'phi1,': [124], 'induce': [125, 221], 'a': [130, 207, 239], 'strong': [131], 'suppressive': [132], 'phenotype': [133], '(T(m': [134], 'phi2)).': [135], 'Their': [136], 'mechanism': [137], 'suppression': [139], 'is': [140], 'cell-cell': [141, 174], 'contact': [142], 'dependent,': [143], 'mediated': [144], 'by': [145, 194], 'membrane-bound': [146], 'TGFbeta-1': [147, 159], 'expressed': [148], '(Treg)': [154], 'population': [155], 'since': [156], 'inhibition': [157], 'signaling': [160], 'target': [162], 'blocks': [164], 'phenotype.': [167], 'T(m': [168], 'phi2),': [169], 'addition': [171], 'to': [172, 220], 'mediating': [173], 'contact-dependent': [175], 'suppression,': [176], 'express': [177], 'typical': [178], 'Treg': [179, 231], 'markers': [180], 'such': [181], 'as': [182, 206], 'CD25,': [183], 'glucocorticoid-induced': [184], 'TNF': [185], 'receptor': [186], '(GITR),': [187], 'Foxp3': [189], 'actively': [192], 'induced': [193], 'from': [197], 'CD25-depleted': [198], 'cells.': [199], 'These': [200], 'data': [201], 'identify': [202], 'novel': [208], 'subset': [210], 'capable': [211], 'inducing': [213], 'Tregs.': [214], 'ability': [216], 'anti-inflammatory': [218], 'Tregs': [222], 'important': [227], 'implications': [228], 'for': [229], 'understanding': [230], 'dynamics': [232], 'pathological': [234], 'conditions': [235], 'where': [236], 'play': [238], 'key': [240], 'role': [241], 'inflammatory': [243], 'disease': [244], 'control': [245], 'exacerbation.': [247]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2109593516', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 18}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 22}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2025-01-08T03:55:32.465589', 'created_date': '2016-06-24'}