Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk

Name: Work Video:
Duration: 3 min 30 s
Riikka Kivelä; Mika Silvennoinen; Maarit Lehti; Rita Rinnankoski‐Tuikka; Tatja Purhonen; Tarmo Ketola; Katri Pullinen; M Vuento; Niina Mutanen; Maureen A. Sartor; Hilkka Reunanen; Lauren G. Koch; Steven L. Britton; Heikki Kainulainen
{'id': 'https://openalex.org/W2109549845', 'doi': 'https://doi.org/10.1096/fj.10-157313', 'title': 'Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk', 'display_name': 'Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk', 'publication_year': 2010, 'publication_date': '2010-07-19', 'ids': {'openalex': 'https://openalex.org/W2109549845', 'doi': 'https://doi.org/10.1096/fj.10-157313', 'mag': '2109549845', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20643908', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2974413'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fj.10-157313', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.10-157313', 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.10-157313', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026249203', 'display_name': 'Riikka Kivelä', 'orcid': 'https://orcid.org/0000-0002-2686-8890'}, 'institutions': [{'id': 'https://openalex.org/I94722563', 'display_name': 'University of Jyväskylä', 'ror': 'https://ror.org/05n3dz165', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I94722563']}, {'id': 'https://openalex.org/I4210148053', 'display_name': 'LIKES – Foundation for Sport and Health Sciences', 'ror': 'https://ror.org/03mahcv92', 'country_code': 'FI', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210148053']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Riikka Kivela', 'raw_affiliation_strings': ['Liikunnan ja Kansaterveyden Edistämissäätiö (LIKES)Research Center for Sport and Health Sciences Jyväskylä Finland', 'Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland'], 'affiliations': [{'raw_affiliation_string': 'Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I94722563']}, {'raw_affiliation_string': 'Liikunnan ja Kansaterveyden Edistämissäätiö (LIKES)Research Center for Sport and Health Sciences Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I4210148053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058069617', 'display_name': 'Mika Silvennoinen', 'orcid': 'https://orcid.org/0000-0002-5389-8251'}, 'institutions': [{'id': 'https://openalex.org/I94722563', 'display_name': 'University of Jyväskylä', 'ror': 'https://ror.org/05n3dz165', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I94722563']}, {'id': 'https://openalex.org/I4210148053', 'display_name': 'LIKES – Foundation for Sport and Health Sciences', 'ror': 'https://ror.org/03mahcv92', 'country_code': 'FI', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210148053']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Mika Silvennoinen', 'raw_affiliation_strings': ['Liikunnan ja Kansaterveyden Edistämissäätiö (LIKES)Research Center for Sport and Health Sciences Jyväskylä Finland', 'Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland'], 'affiliations': [{'raw_affiliation_string': 'Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I94722563']}, {'raw_affiliation_string': 'Liikunnan ja Kansaterveyden Edistämissäätiö (LIKES)Research Center for Sport and Health Sciences Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I4210148053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087514509', 'display_name': 'Maarit Lehti', 'orcid': 'https://orcid.org/0000-0002-9063-6541'}, 'institutions': [{'id': 'https://openalex.org/I4210148053', 'display_name': 'LIKES – Foundation for Sport and Health Sciences', 'ror': 'https://ror.org/03mahcv92', 'country_code': 'FI', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210148053']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Maarit Lehti', 'raw_affiliation_strings': ['Liikunnan ja Kansaterveyden Edistämissäätiö (LIKES)Research Center for Sport and Health Sciences Jyväskylä Finland'], 'affiliations': [{'raw_affiliation_string': 'Liikunnan ja Kansaterveyden Edistämissäätiö (LIKES)Research Center for Sport and Health Sciences Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I4210148053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079480912', 'display_name': 'Rita Rinnankoski‐Tuikka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I94722563', 'display_name': 'University of Jyväskylä', 'ror': 'https://ror.org/05n3dz165', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I94722563']}, {'id': 'https://openalex.org/I4210148053', 'display_name': 'LIKES – Foundation for Sport and Health Sciences', 'ror': 'https://ror.org/03mahcv92', 'country_code': 'FI', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210148053']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Rita Rinnankoski‐Tuikka', 'raw_affiliation_strings': ['Liikunnan ja Kansaterveyden Edistämissäätiö (LIKES)Research Center for Sport and Health Sciences Jyväskylä Finland', 'Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland'], 'affiliations': [{'raw_affiliation_string': 'Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I94722563']}, {'raw_affiliation_string': 'Liikunnan ja Kansaterveyden Edistämissäätiö (LIKES)Research Center for Sport and Health Sciences Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I4210148053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028830157', 'display_name': 'Tatja Purhonen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I94722563', 'display_name': 'University of Jyväskylä', 'ror': 'https://ror.org/05n3dz165', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I94722563']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Tatja Purhonen', 'raw_affiliation_strings': ['Department of Biological and Environmental SciencesUniversity of Jyväskykä Jyväskylä Finland'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological and Environmental SciencesUniversity of Jyväskykä Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I94722563']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000355400', 'display_name': 'Tarmo Ketola', 'orcid': 'https://orcid.org/0000-0001-5151-7980'}, 'institutions': [{'id': 'https://openalex.org/I94722563', 'display_name': 'University of Jyväskylä', 'ror': 'https://ror.org/05n3dz165', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I94722563']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Tarmo Ketola', 'raw_affiliation_strings': ['Department of Biological and Environmental SciencesUniversity of Jyväskykä Jyväskylä Finland'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological and Environmental SciencesUniversity of Jyväskykä Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I94722563']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066046843', 'display_name': 'Katri Pullinen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I94722563', 'display_name': 'University of Jyväskylä', 'ror': 'https://ror.org/05n3dz165', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I94722563']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Katri Pullinen', 'raw_affiliation_strings': ['Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland'], 'affiliations': [{'raw_affiliation_string': 'Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I94722563']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113735707', 'display_name': 'M Vuento', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I94722563', 'display_name': 'University of Jyväskylä', 'ror': 'https://ror.org/05n3dz165', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I94722563']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Meri Vuento', 'raw_affiliation_strings': ['Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland'], 'affiliations': [{'raw_affiliation_string': 'Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I94722563']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054933561', 'display_name': 'Niina Mutanen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I94722563', 'display_name': 'University of Jyväskylä', 'ror': 'https://ror.org/05n3dz165', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I94722563']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Niina Mutanen', 'raw_affiliation_strings': ['Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland'], 'affiliations': [{'raw_affiliation_string': 'Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I94722563']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028712728', 'display_name': 'Maureen A. Sartor', 'orcid': 'https://orcid.org/0000-0001-6155-5702'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maureen A. Sartor', 'raw_affiliation_strings': ['Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003902925', 'display_name': 'Hilkka Reunanen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I94722563', 'display_name': 'University of Jyväskylä', 'ror': 'https://ror.org/05n3dz165', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I94722563']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Hilkka Reunanen', 'raw_affiliation_strings': ['Department of Biological and Environmental SciencesUniversity of Jyväskykä Jyväskylä Finland'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological and Environmental SciencesUniversity of Jyväskykä Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I94722563']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075341016', 'display_name': 'Lauren G. Koch', 'orcid': 'https://orcid.org/0000-0002-2019-5939'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lauren G. Koch', 'raw_affiliation_strings': ['Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090417116', 'display_name': 'Steven L. Britton', 'orcid': 'https://orcid.org/0000-0002-7372-8671'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven L. Britton', 'raw_affiliation_strings': ['Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062099550', 'display_name': 'Heikki Kainulainen', 'orcid': 'https://orcid.org/0000-0001-5102-4350'}, 'institutions': [{'id': 'https://openalex.org/I94722563', 'display_name': 'University of Jyväskylä', 'ror': 'https://ror.org/05n3dz165', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I94722563']}, {'id': 'https://openalex.org/I4210148053', 'display_name': 'LIKES – Foundation for Sport and Health Sciences', 'ror': 'https://ror.org/03mahcv92', 'country_code': 'FI', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210148053']}], 'countries': ['FI'], 'is_corresponding': True, 'raw_author_name': 'Heikki Kainulainen', 'raw_affiliation_strings': ['Liikunnan ja Kansaterveyden Edistämissäätiö (LIKES)Research Center for Sport and Health Sciences Jyväskylä Finland', 'Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland'], 'affiliations': [{'raw_affiliation_string': 'Neuromuscular Research CenterDepartment of Biology of Physical ActivityUniversity of Jyväskykä Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I94722563']}, {'raw_affiliation_string': 'Liikunnan ja Kansaterveyden Edistämissäätiö (LIKES)Research Center for Sport and Health Sciences Jyväskylä Finland', 'institution_ids': ['https://openalex.org/I4210148053']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5062099550'], 'corresponding_institution_ids': ['https://openalex.org/I94722563', 'https://openalex.org/I4210148053'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.561, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 64, 'citation_normalized_percentile': {'value': 0.999951, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '24', 'issue': '11', 'first_page': '4565', 'last_page': '4574'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13354', 'display_name': 'Genetics and Physical Performance', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13354', 'display_name': 'Genetics and Physical Performance', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11399', 'display_name': 'Muscle metabolism and nutrition', 'score': 0.9732, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aerobic-capacity', 'display_name': 'Aerobic capacity', 'score': 0.6972656}, {'id': 'https://openalex.org/keywords/link', 'display_name': 'Link (geometry)', 'score': 0.50665575}, {'id': 'https://openalex.org/keywords/expression', 'display_name': 'Expression (computer science)', 'score': 0.4678377}, {'id': 'https://openalex.org/keywords/aerobic-exercise', 'display_name': 'Aerobic Exercise', 'score': 0.44609526}], 'concepts': [{'id': 'https://openalex.org/C2992361435', 'wikidata': 'https://www.wikidata.org/wiki/Q60354', 'display_name': 'Aerobic capacity', 'level': 2, 'score': 0.6972656}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.5838481}, {'id': 'https://openalex.org/C2778753846', 'wikidata': 'https://www.wikidata.org/wiki/Q6554239', 'display_name': 'Link (geometry)', 'level': 2, 'score': 0.50665575}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.47680566}, {'id': 'https://openalex.org/C90559484', 'wikidata': 'https://www.wikidata.org/wiki/Q778379', 'display_name': 'Expression (computer science)', 'level': 2, 'score': 0.4678377}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.45341572}, {'id': 'https://openalex.org/C103038586', 'wikidata': 'https://www.wikidata.org/wiki/Q1152037', 'display_name': 'Aerobic exercise', 'level': 2, 'score': 0.44609526}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.30822077}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.30494064}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26886415}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26023835}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.15218943}, {'id': 'https://openalex.org/C31258907', 'wikidata': 'https://www.wikidata.org/wiki/Q1301371', 'display_name': 'Computer network', 'level': 1, 'score': 0.06812245}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017079', 'descriptor_name': 'Exercise Tolerance', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008659', 'descriptor_name': 'Metabolic Diseases', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D018995', 'descriptor_name': 'Myosin Heavy Chains', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010805', 'descriptor_name': 'Physical Conditioning, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004734', 'descriptor_name': 'Energy Metabolism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004734', 'descriptor_name': 'Energy Metabolism', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017079', 'descriptor_name': 'Exercise Tolerance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008659', 'descriptor_name': 'Metabolic Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008659', 'descriptor_name': 'Metabolic Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018995', 'descriptor_name': 'Myosin Heavy Chains', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018995', 'descriptor_name': 'Myosin Heavy Chains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010101', 'descriptor_name': 'Oxygen Consumption', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010101', 'descriptor_name': 'Oxygen Consumption', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fj.10-157313', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.10-157313', 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/2027.42/154281', 'pdf_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/154281/1/fsb2fj10157313.pdf', 'source': {'id': 'https://openalex.org/S4306400393', 'display_name': 'Deep Blue (University of Michigan)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I27837315', 'host_organization_name': 'University of Michigan–Ann Arbor', 'host_organization_lineage': ['https://openalex.org/I27837315'], 'host_organization_lineage_names': ['University of Michigan–Ann Arbor'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2974413', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974413', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20643908', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fj.10-157313', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.10-157313', 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.55, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320306085', 'funder_display_name': 'U.S. Department of Health and Human Services', 'award_id': None}, {'funder': 'https://openalex.org/F4320321108', 'funder_display_name': 'Academy of Finland', 'award_id': None}, {'funder': 'https://openalex.org/F4320321727', 'funder_display_name': 'Opetus- ja Kulttuuriministeriö', 'award_id': None}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': '1R01DK077200'}, {'funder': 'https://openalex.org/F4320337375', 'funder_display_name': 'National Center for Research Resources', 'award_id': 'RR17718'}], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1573372314', 'https://openalex.org/W1905920866', 'https://openalex.org/W1974997159', 'https://openalex.org/W1980446844', 'https://openalex.org/W1980733995', 'https://openalex.org/W1982372490', 'https://openalex.org/W1990498742', 'https://openalex.org/W2002487158', 'https://openalex.org/W2004739732', 'https://openalex.org/W2005032160', 'https://openalex.org/W2017602541', 'https://openalex.org/W2028068170', 'https://openalex.org/W2034342958', 'https://openalex.org/W2042515074', 'https://openalex.org/W2042726264', 'https://openalex.org/W2045691659', 'https://openalex.org/W2087408740', 'https://openalex.org/W2097400458', 'https://openalex.org/W2113723055', 'https://openalex.org/W2116404316', 'https://openalex.org/W2116634113', 'https://openalex.org/W2122683221', 'https://openalex.org/W2123106337', 'https://openalex.org/W2130410032', 'https://openalex.org/W2130661160', 'https://openalex.org/W2131492087', 'https://openalex.org/W2132329816', 'https://openalex.org/W2138553207', 'https://openalex.org/W2143060519', 'https://openalex.org/W2144885342', 'https://openalex.org/W2144887170', 'https://openalex.org/W2152227081', 'https://openalex.org/W2156831368', 'https://openalex.org/W2158217645', 'https://openalex.org/W2159428568', 'https://openalex.org/W2165816035', 'https://openalex.org/W3103786587', 'https://openalex.org/W4251690959'], 'related_works': ['https://openalex.org/W4387307307', 'https://openalex.org/W4224211697', 'https://openalex.org/W3097327920', 'https://openalex.org/W2622595842', 'https://openalex.org/W2580960414', 'https://openalex.org/W2155596831', 'https://openalex.org/W2151313540', 'https://openalex.org/W2039029095', 'https://openalex.org/W2001506585', 'https://openalex.org/W1972939203'], 'abstract_inverted_index': {'A': [0], 'strong': [1], 'link': [2, 225], 'exists': [3], 'between': [4], 'low': [5, 22, 66, 227], 'aerobic': [6, 26, 48, 185, 229], 'exercise': [7, 156, 230], 'capacity': [8, 29, 50, 61, 67, 157, 186, 231], 'and': [9, 23, 64, 90, 96, 116, 148, 158, 171, 232], 'complex': [10, 233], 'metabolic': [11, 37, 52, 106], 'diseases.': [12], 'To': [13], 'probe': [14], 'this': [15], 'linkage,': [16], 'we': [17], 'utilized': [18], 'rat': [19], 'models': [20], 'of': [21, 73, 121], 'high': [24, 60, 111], 'intrinsic': [25, 184, 228], 'endurance': [27, 49, 82], 'running': [28, 83], 'that': [30, 46, 75, 128, 181, 224], 'differ': [31], 'also': [32], 'in': [33, 41, 132, 174], 'the': [34, 178], 'risk': [35, 54, 160], 'for': [36, 79, 104], 'syndrome.': [38], 'We': [39], 'investigated': [40], 'skeletal': [42, 122, 168], 'muscle': [43, 114, 123, 169], 'gene-phenotype': [44], 'relationships': [45], 'connect': [47], 'with': [51, 99, 154, 166, 226], 'disease': [53, 159, 189, 234], 'factors.': [55], 'The': [56], 'study': [57], 'compared': [58, 98], '12': [59, 65], 'runners': [62, 68], '(HCRs)': [63], '(LCRs)': [69], 'from': [70], 'generation': [71], '18': [72], 'selection': [74], 'differed': [76], 'by': [77], '615%': [78], 'maximal': [80], 'treadmill': [81], 'capacity.': [84], 'On': [85], 'average,': [86], 'LCRs': [87], 'were': [88, 102, 134], 'heavier': [89], 'had': [91], 'increased': [92], 'blood': [93], 'glucose,': [94], 'insulin,': [95], 'triglycerides': [97], 'HCRs.': [100], 'HCRs': [101, 133], 'higher': [103], 'resting': [105], 'rate,': [107], 'voluntary': [108], 'activity,': [109], 'serum': [110], 'density': [112], 'lipoproteins,': [113], 'capillarity,': [115], 'mitochondrial': [117, 172], 'area.': [118], 'Bioinformatic': [119], 'analysis': [120], 'gene': [124], 'expression': [125, 143, 222], 'data': [126], 'revealed': [127], 'many': [129], 'genes': [130], 'up-regulated': [131], 'related': [135], 'to': [136], 'oxidative': [137, 146], 'energy': [138], 'metabolism.': [139], 'Seven': [140], 'mean': [141], 'mRNA': [142], 'centroids,': [144], 'including': [145], 'phosphorylation': [147], 'fatty': [149], 'acid': [150], 'metabolism,': [151], 'correlated': [152], 'significantly': [153], 'several': [155], 'phenotypes.': [161], 'These': [162], 'expression-phenotype': [163], 'correlations,': [164], 'together': [165], 'diminished': [167], 'capillarity': [170], 'area': [173], 'LCR': [175], 'rats,': [176], 'support': [177], 'general': [179], 'hypothesis': [180], 'an': [182], 'inherited': [183], 'can': [187], 'underlie': [188], 'risks.—Kivelä,': [190], 'R.,': [191, 197], 'Silvennoinen,': [192], 'M.,': [193, 195, 205], 'Lehti,': [194], 'Rinnankoski-Tuikka,': [196], 'Purhonen,': [198], 'T.,': [199, 201], 'Ketola,': [200], 'Pullinen,': [202], 'K.,': [203], 'Vuento,': [204], 'Mutanen,': [206], 'N.,': [207], 'Sartor,': [208], 'M.': [209], 'A.,': [210], 'Reunanen,': [211], 'H.,': [212], 'Koch,': [213], 'L.': [214], 'G.,': [215], 'Britton,': [216], 'S.': [217], 'L.,': [218], 'Kainulainen,': [219], 'H.': [220], 'Gene': [221], 'centroids': [223], 'risk.': [235], 'FASEB': [236], 'J.': [237], '24,': [238], '4565–4574': [239], '(2010).': [240], 'www.fasebj.org': [241]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2109549845', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-12-16T07:57:48.740682', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
