Publication Information

{'id': 'https://openalex.org/W2109188407', 'doi': 'https://doi.org/10.1111/j.1474-9726.2009.00459.x', 'title': 'Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in <i>C. elegans</i>', 'display_name': 'Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in <i>C. elegans</i>', 'publication_year': 2009, 'publication_date': '2009-02-23', 'ids': {'openalex': 'https://openalex.org/W2109188407', 'doi': 'https://doi.org/10.1111/j.1474-9726.2009.00459.x', 'mag': '2109188407', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19239417', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2680339'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1474-9726.2009.00459.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2009.00459.x', 'source': {'id': 'https://openalex.org/S174672550', 'display_name': 'Aging Cell', 'issn_l': '1474-9718', 'issn': ['1474-9718', '1474-9728', '1474-9726'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2009.00459.x', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003759640', 'display_name': 'Eric Lieberman Greer', 'orcid': 'https://orcid.org/0000-0002-7501-7371'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Eric L. Greer', 'raw_affiliation_strings': ['Cancer Biology Program, and', 'Department of Genetics,'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics,', 'institution_ids': []}, {'raw_affiliation_string': 'Cancer Biology Program, and', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088357328', 'display_name': 'Anne Brunet', 'orcid': 'https://orcid.org/0000-0002-4608-6845'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anne Brunet', 'raw_affiliation_strings': ['Cancer Biology Program, and', 'Department of Genetics,', 'Neurosciences Program, 300 Pasteur Drive, Stanford University, Stanford CA 94305, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics,', 'institution_ids': []}, {'raw_affiliation_string': 'Neurosciences Program, 300 Pasteur Drive, Stanford University, Stanford CA 94305, USA', 'institution_ids': ['https://openalex.org/I97018004']}, {'raw_affiliation_string': 'Cancer Biology Program, and', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'fwci': 10.966, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 553, 'citation_normalized_percentile': {'value': 0.997947, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '8', 'issue': '2', 'first_page': '113', 'last_page': '127'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10676', 'display_name': 'Genetics, Aging, and Longevity in Model Organisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1302', 'display_name': 'Aging'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10676', 'display_name': 'Genetics, Aging, and Longevity in Model Organisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1302', 'display_name': 'Aging'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10342', 'display_name': 'Circadian rhythm and melatonin', 'score': 0.9619, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12745', 'display_name': 'Dietary Effects on Health', 'score': 0.9469, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/calorie-restriction', 'display_name': 'Calorie Restriction', 'score': 0.67459875}], 'concepts': [{'id': 'https://openalex.org/C2776759703', 'wikidata': 'https://www.wikidata.org/wiki/Q1066907', 'display_name': 'Longevity', 'level': 2, 'score': 0.95084786}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.9081551}, {'id': 'https://openalex.org/C2778944004', 'wikidata': 'https://www.wikidata.org/wiki/Q91703', 'display_name': 'Caenorhabditis elegans', 'level': 3, 'score': 0.8535592}, {'id': 'https://openalex.org/C2778707264', 'wikidata': 'https://www.wikidata.org/wiki/Q1332886', 'display_name': 'Calorie restriction', 'level': 2, 'score': 0.67459875}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.57557493}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5688612}, {'id': 'https://openalex.org/C2780124434', 'wikidata': 'https://www.wikidata.org/wiki/Q12357464', 'display_name': 'AMPK', 'level': 4, 'score': 0.52070266}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.52066076}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.25262725}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.22343382}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.08703026}], 'mesh': [{'descriptor_ui': 'D017173', 'descriptor_name': 'Caenorhabditis elegans', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D017173', 'descriptor_name': 'Caenorhabditis elegans', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D031204', 'descriptor_name': 'Caloric Restriction', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D005508', 'descriptor_name': 'Food Deprivation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D005526', 'descriptor_name': 'Food, Formulated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008136', 'descriptor_name': 'Longevity', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D017173', 'descriptor_name': 'Caenorhabditis elegans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029742', 'descriptor_name': 'Caenorhabditis elegans Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029742', 'descriptor_name': 'Caenorhabditis elegans Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D031204', 'descriptor_name': 'Caloric Restriction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005508', 'descriptor_name': 'Food Deprivation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008136', 'descriptor_name': 'Longevity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008136', 'descriptor_name': 'Longevity', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000077185', 'descriptor_name': 'Resveratrol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D037761', 'descriptor_name': 'Sirtuins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037761', 'descriptor_name': 'Sirtuins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013267', 'descriptor_name': 'Stilbenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013267', 'descriptor_name': 'Stilbenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1474-9726.2009.00459.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2009.00459.x', 'source': {'id': 'https://openalex.org/S174672550', 'display_name': 'Aging Cell', 'issn_l': '1474-9718', 'issn': ['1474-9718', '1474-9728', '1474-9726'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2680339', 'pdf_url': 'https://europepmc.org/articles/pmc2680339?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680339', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19239417', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1474-9726.2009.00459.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2009.00459.x', 'source': {'id': 'https://openalex.org/S174672550', 'display_name': 'Aging Cell', 'issn_l': '1474-9718', 'issn': ['1474-9718', '1474-9728', '1474-9726'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.46, 'id': 'https://metadata.un.org/sdg/12', 'display_name': 'Responsible consumption and production'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 89, 'referenced_works': ['https://openalex.org/W1892721446', 'https://openalex.org/W1924615382', 'https://openalex.org/W1933788686', 'https://openalex.org/W1965060083', 'https://openalex.org/W1966262847', 'https://openalex.org/W1969084204', 'https://openalex.org/W1970023517', 'https://openalex.org/W1978383432', 'https://openalex.org/W1978792924', 'https://openalex.org/W1979203107', 'https://openalex.org/W1982134676', 'https://openalex.org/W1985308585', 'https://openalex.org/W1985645688', 'https://openalex.org/W1987738803', 'https://openalex.org/W1991080848', 'https://openalex.org/W1991087616', 'https://openalex.org/W1991096049', 'https://openalex.org/W1996914636', 'https://openalex.org/W1997145913', 'https://openalex.org/W2002741326', 'https://openalex.org/W2004923406', 'https://openalex.org/W2005381354', 'https://openalex.org/W2006022142', 'https://openalex.org/W2007711341', 'https://openalex.org/W2009971361', 'https://openalex.org/W2011169717', 'https://openalex.org/W2013749723', 'https://openalex.org/W2013894349', 'https://openalex.org/W2023431124', 'https://openalex.org/W2026226511', 'https://openalex.org/W2027271710', 'https://openalex.org/W2030031350', 'https://openalex.org/W2030732918', 'https://openalex.org/W2030907978', 'https://openalex.org/W2031477980', 'https://openalex.org/W2032195707', 'https://openalex.org/W2032462953', 'https://openalex.org/W2032502888', 'https://openalex.org/W2034103943', 'https://openalex.org/W2034661709', 'https://openalex.org/W2040805319', 'https://openalex.org/W2042986568', 'https://openalex.org/W2043738446', 'https://openalex.org/W2051509673', 'https://openalex.org/W2056673369', 'https://openalex.org/W2057141021', 'https://openalex.org/W2060814375', 'https://openalex.org/W2061756062', 'https://openalex.org/W2063330578', 'https://openalex.org/W2064609969', 'https://openalex.org/W2071206597', 'https://openalex.org/W2073701988', 'https://openalex.org/W2074997034', 'https://openalex.org/W2077612844', 'https://openalex.org/W2081638148', 'https://openalex.org/W2085772485', 'https://openalex.org/W2088381487', 'https://openalex.org/W2092395757', 'https://openalex.org/W2092581835', 'https://openalex.org/W2096361448', 'https://openalex.org/W2103450921', 'https://openalex.org/W2103743923', 'https://openalex.org/W2104177210', 'https://openalex.org/W2105537673', 'https://openalex.org/W2110928985', 'https://openalex.org/W2111092938', 'https://openalex.org/W2114008231', 'https://openalex.org/W2121945497', 'https://openalex.org/W2122073743', 'https://openalex.org/W2123754932', 'https://openalex.org/W2125121177', 'https://openalex.org/W2125508726', 'https://openalex.org/W2130016073', 'https://openalex.org/W2134622083', 'https://openalex.org/W2138416557', 'https://openalex.org/W2148242921', 'https://openalex.org/W2148581106', 'https://openalex.org/W2151160060', 'https://openalex.org/W2156934560', 'https://openalex.org/W2158016476', 'https://openalex.org/W2158124286', 'https://openalex.org/W2161463238', 'https://openalex.org/W2161774043', 'https://openalex.org/W2161842981', 'https://openalex.org/W2169799458', 'https://openalex.org/W2170147877', 'https://openalex.org/W2170979056', 'https://openalex.org/W2314858243', 'https://openalex.org/W2409016876'], 'related_works': ['https://openalex.org/W4315797749', 'https://openalex.org/W2747212715', 'https://openalex.org/W2623190716', 'https://openalex.org/W2393707090', 'https://openalex.org/W2188080485', 'https://openalex.org/W2165718079', 'https://openalex.org/W2035376627', 'https://openalex.org/W2025901141', 'https://openalex.org/W1987610681', 'https://openalex.org/W1585830474'], 'abstract_inverted_index': {'Dietary': [0], 'restriction': [1], '(DR)': [2], 'has': [3, 237], 'the': [4, 48, 66, 74, 112, 127, 199, 215, 227, 242], 'remarkable': [5], 'ability': [6], 'to': [7, 25, 149], 'extend': [8, 32, 205, 235], 'lifespan': [9, 33, 113, 128, 176, 206, 218, 236, 248], 'and': [10, 73, 97, 187, 249], 'healthspan.': [11, 250], 'A': [12], 'variety': [13, 154], 'of': [14, 140, 155, 219, 245], 'DR': [15, 30, 56, 86, 106, 119, 156, 203, 222, 233, 246], 'regimens': [16, 31, 57, 223, 234], 'have': [17, 62], 'been': [18], 'described': [19], 'in': [20, 58, 168], 'species': [21], 'ranging': [22], 'from': [23], 'yeast': [24], 'mammals.': [26], 'However,': [27], 'whether': [28], 'different': [29, 55, 118, 202, 221, 232], 'via': [34], 'universal,': [35], 'distinct,': [36], 'or': [37], 'overlapping': [38], 'pathways': [39, 50], 'is': [40, 123, 171], 'still': [41], 'an': [42], 'open': [43], 'question.': [44], 'Here': [45, 92], 'we': [46, 89, 93, 143, 178, 212], 'examine': [47], 'genetic': [49, 210, 228], 'that': [51, 65, 88, 95, 136, 180, 201, 214], 'mediate': [52, 150], 'longevity': [53, 82, 102, 151, 193], 'by': [54, 84, 104, 116, 131, 152, 195, 207, 230], 'Caenorhabditis': [59], 'elegans.': [60], 'We': [61], 'previously': [63, 147], 'shown': [64], 'low-energy': [67], 'sensing': [68], 'AMP-activated': [69], 'protein': [70], 'kinase': [71], 'AMPK/aak-2': [72], 'Forkhead': [75], 'transcription': [76], 'factor': [77], 'FoxO/daf-16': [78], 'are': [79, 99, 109, 158, 189, 224], 'necessary': [80, 100, 125, 159], 'for': [81, 101, 111, 126, 160, 174, 192, 240], 'induced': [83, 103, 115, 194], 'a': [85, 133, 153, 165], 'regimen': [87], 'developed': [90], '(sDR).': [91], 'find': [94, 179, 213], 'AMPK': [96, 122], 'FoxO': [98], 'another': [105], 'regimen,': [107], 'but': [108], 'dispensable': [110, 191], 'extension': [114, 129], 'two': [117, 220], 'methods.': [120], 'Intriguingly,': [121], 'also': [124, 172], 'elicited': [130], 'resveratrol,': [132], 'natural': [134], 'polyphenol': [135], 'mimics': [137], 'some': [138], 'aspects': [139], 'DR.': [141], 'Conversely,': [142], 'test': [144], 'if': [145], 'genes': [146, 183], 'reported': [148], 'methods': [157, 204], 'sDR-induced': [161, 175], 'longevity.': [162], 'Although': [163], 'clk-1,': [164], 'gene': [166], 'involved': [167], 'ubiquinone': [169], 'biosynthesis,': [170], 'required': [173], 'extension,': [177], 'four': [181], 'other': [182], '(sir-2.1,': [184], 'FoxA/pha-4,': [185], 'skn-1,': [186], 'hsf-1)': [188], 'all': [190], 'sDR.': [196], 'Consistent': [197], 'with': [198], 'observation': [200], 'mostly': [208], 'independent': [209], 'mechanisms,': [211], 'effects': [216], 'on': [217, 247], 'additive.': [225], 'Understanding': [226], 'network': [229], 'which': [231], 'important': [238], 'implications': [239], 'harnessing': [241], 'full': [243], 'benefits': [244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2109188407', 'counts_by_year': [{'year': 2024, 'cited_by_count': 25}, {'year': 2023, 'cited_by_count': 28}, {'year': 2022, 'cited_by_count': 29}, {'year': 2021, 'cited_by_count': 36}, {'year': 2020, 'cited_by_count': 33}, {'year': 2019, 'cited_by_count': 37}, {'year': 2018, 'cited_by_count': 33}, {'year': 2017, 'cited_by_count': 40}, {'year': 2016, 'cited_by_count': 41}, {'year': 2015, 'cited_by_count': 35}, {'year': 2014, 'cited_by_count': 42}, {'year': 2013, 'cited_by_count': 29}, {'year': 2012, 'cited_by_count': 42}], 'updated_date': '2025-01-08T03:02:48.594756', 'created_date': '2016-06-24'}