Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2109033354', 'doi': 'https://doi.org/10.1016/s0022-5347(05)00017-0', 'title': 'Human Muscarinic Receptor Binding Characteristics of Antimuscarinic Agents to Treat Overactive Bladder', 'display_name': 'Human Muscarinic Receptor Binding Characteristics of Antimuscarinic Agents to Treat Overactive Bladder', 'publication_year': 2006, 'publication_date': '2006-01-01', 'ids': {'openalex': 'https://openalex.org/W2109033354', 'doi': 'https://doi.org/10.1016/s0022-5347(05)00017-0', 'mag': '2109033354', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16406943'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0022-5347(05)00017-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5031651623', 'display_name': 'Shuji Maruyama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150240954', 'display_name': 'University of Shizuoka', 'ror': 'https://ror.org/04rvw0k47', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I150240954']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shuji Maruyama', 'raw_affiliation_strings': ['Department of Pharmacokinetics and Pharmacodynamics and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacokinetics and Pharmacodynamics and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka', 'institution_ids': ['https://openalex.org/I150240954']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082929696', 'display_name': 'Tomomi Oki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150240954', 'display_name': 'University of Shizuoka', 'ror': 'https://ror.org/04rvw0k47', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I150240954']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tomomi Oki', 'raw_affiliation_strings': ['Department of Pharmacokinetics and Pharmacodynamics and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacokinetics and Pharmacodynamics and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka', 'institution_ids': ['https://openalex.org/I150240954']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063182256', 'display_name': 'Atsushi Otsuka', 'orcid': 'https://orcid.org/0000-0001-6472-0988'}, 'institutions': [{'id': 'https://openalex.org/I3123035732', 'display_name': 'Hamamatsu University School of Medicine', 'ror': 'https://ror.org/00ndx3g44', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I3123035732']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Atsushi Otsuka', 'raw_affiliation_strings': ['Department of Urology, Hamamatsu University School of Medicine, Hamamatsu'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Hamamatsu University School of Medicine, Hamamatsu', 'institution_ids': ['https://openalex.org/I3123035732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005302264', 'display_name': 'Hitoshi Shinbo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3123035732', 'display_name': 'Hamamatsu University School of Medicine', 'ror': 'https://ror.org/00ndx3g44', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I3123035732']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hitoshi Shinbo', 'raw_affiliation_strings': ['Department of Urology, Hamamatsu University School of Medicine, Hamamatsu'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Hamamatsu University School of Medicine, Hamamatsu', 'institution_ids': ['https://openalex.org/I3123035732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004687590', 'display_name': 'Seiichiro Ozono', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3123035732', 'display_name': 'Hamamatsu University School of Medicine', 'ror': 'https://ror.org/00ndx3g44', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I3123035732']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Seiichiro Ozono', 'raw_affiliation_strings': ['Department of Urology, Hamamatsu University School of Medicine, Hamamatsu'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Hamamatsu University School of Medicine, Hamamatsu', 'institution_ids': ['https://openalex.org/I3123035732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102705376', 'display_name': 'Shinji Kageyama', 'orcid': 'https://orcid.org/0000-0002-7573-1284'}, 'institutions': [{'id': 'https://openalex.org/I1298590031', 'display_name': 'Shizuoka University', 'ror': 'https://ror.org/01w6wtk13', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I1298590031']}, {'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shinji Kageyama', 'raw_affiliation_strings': ['Shio Urologic Clinic, Shizuoka, University of Yamanashi, Tamaho, Japan'], 'affiliations': [{'raw_affiliation_string': 'Shio Urologic Clinic, Shizuoka, University of Yamanashi, Tamaho, Japan', 'institution_ids': ['https://openalex.org/I1298590031', 'https://openalex.org/I66906201']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012367050', 'display_name': 'Yuuki Mikami', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuuki Mikami', 'raw_affiliation_strings': ['Department of Urology, School of Medicine, University of Yamanashi, Tamaho, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, School of Medicine, University of Yamanashi, Tamaho, Japan', 'institution_ids': ['https://openalex.org/I66906201']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004648641', 'display_name': 'Isao Araki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Isao Araki', 'raw_affiliation_strings': ['Department of Urology, School of Medicine, University of Yamanashi, Tamaho, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, School of Medicine, University of Yamanashi, Tamaho, Japan', 'institution_ids': ['https://openalex.org/I66906201']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084498556', 'display_name': 'Masayuki Takeda', 'orcid': 'https://orcid.org/0000-0002-2950-0960'}, 'institutions': [{'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masayuki Takeda', 'raw_affiliation_strings': ['Department of Urology, School of Medicine, University of Yamanashi, Tamaho, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, School of Medicine, University of Yamanashi, Tamaho, Japan', 'institution_ids': ['https://openalex.org/I66906201']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087150619', 'display_name': 'Keisuke Masuyama', 'orcid': 'https://orcid.org/0000-0001-7104-835X'}, 'institutions': [{'id': 'https://openalex.org/I66906201', 'display_name': 'University of Yamanashi', 'ror': 'https://ror.org/059x21724', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I66906201']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Keisuke Masuyama', 'raw_affiliation_strings': ['Department of Orolaryngology, School of Medicine, University of Yamanashi, Tamaho, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Orolaryngology, School of Medicine, University of Yamanashi, Tamaho, Japan', 'institution_ids': ['https://openalex.org/I66906201']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051609821', 'display_name': 'Shizuo Yamada', 'orcid': 'https://orcid.org/0000-0002-5915-9863'}, 'institutions': [{'id': 'https://openalex.org/I150240954', 'display_name': 'University of Shizuoka', 'ror': 'https://ror.org/04rvw0k47', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I150240954']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shizuo Yamada', 'raw_affiliation_strings': ['Department of Pharmacokinetics and Pharmacodynamics and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacokinetics and Pharmacodynamics and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka', 'institution_ids': ['https://openalex.org/I150240954']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.351, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 53, 'citation_normalized_percentile': {'value': 0.893299, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '175', 'issue': '1', 'first_page': '365', 'last_page': '369'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10279', 'display_name': 'Standardisation of Lower Urinary Tract Function', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2748', 'display_name': 'Urology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10279', 'display_name': 'Standardisation of Lower Urinary Tract Function', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2748', 'display_name': 'Urology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11142', 'display_name': 'Biochemistry of Diabetic Complications', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10342', 'display_name': 'Mammalian Circadian Rhythms and Physiology', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/toll-like-receptors', 'display_name': 'Toll-like Receptors', 'score': 0.510529}, {'id': 'https://openalex.org/keywords/overactive-bladder', 'display_name': 'Overactive Bladder', 'score': 0.503651}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9039128}, {'id': 'https://openalex.org/C2778941218', 'wikidata': 'https://www.wikidata.org/wiki/Q331231', 'display_name': 'Overactive bladder', 'level': 3, 'score': 0.8667666}, {'id': 'https://openalex.org/C33789571', 'wikidata': 'https://www.wikidata.org/wiki/Q410959', 'display_name': 'Muscarinic acetylcholine receptor', 'level': 3, 'score': 0.7777982}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.5964141}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.37171197}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3700282}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.28688514}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.060210675}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018727', 'descriptor_name': 'Muscarinic Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018727', 'descriptor_name': 'Muscarinic Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D010306', 'descriptor_name': 'Parotid Gland', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D011976', 'descriptor_name': 'Receptors, Muscarinic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001743', 'descriptor_name': 'Urinary Bladder', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014549', 'descriptor_name': 'Urinary Incontinence', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018727', 'descriptor_name': 'Muscarinic Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010306', 'descriptor_name': 'Parotid Gland', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011976', 'descriptor_name': 'Receptors, Muscarinic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001743', 'descriptor_name': 'Urinary Bladder', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014549', 'descriptor_name': 'Urinary Incontinence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0022-5347(05)00017-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16406943', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1775749144', 'https://openalex.org/W1965672986', 'https://openalex.org/W1969195277', 'https://openalex.org/W2010470645', 'https://openalex.org/W2023676739', 'https://openalex.org/W2033470362', 'https://openalex.org/W2033947916', 'https://openalex.org/W2040008446', 'https://openalex.org/W2064430566', 'https://openalex.org/W2073149905', 'https://openalex.org/W2088679190', 'https://openalex.org/W2092079022', 'https://openalex.org/W2098709306', 'https://openalex.org/W2104254261', 'https://openalex.org/W2106607972', 'https://openalex.org/W2127252378', 'https://openalex.org/W2169527010', 'https://openalex.org/W2225473745', 'https://openalex.org/W2516345462', 'https://openalex.org/W63727678'], 'related_works': ['https://openalex.org/W2965204637', 'https://openalex.org/W2750698829', 'https://openalex.org/W2743658275', 'https://openalex.org/W2738454591', 'https://openalex.org/W2324466213', 'https://openalex.org/W2322824728', 'https://openalex.org/W2020443535', 'https://openalex.org/W2018940414', 'https://openalex.org/W2003638941', 'https://openalex.org/W1583592967'], 'abstract_inverted_index': {'No': [0], 'AccessJournal': [1], 'of': [2, 11, 45, 57, 61, 69, 81, 85, 93, 98, 106, 111, 119, 124, 136, 145, 148, 151, 160, 163, 166, 175, 178, 181, 190, 193, 196, 206, 218, 222, 244, 258, 310, 322, 342, 365, 488, 492, 507, 528, 581, 618, 637, 663, 668, 679, 703, 744, 754, 770, 793, 827, 832, 848, 872, 878, 884, 898, 966, 990, 1006, 1088, 1100, 1104, 1115, 1127, 1131, 1142, 1147, 1158, 1163, 1174, 1179, 1194, 1206, 1209, 1212, 1224, 1227, 1230, 1242, 1245, 1248, 1260, 1263, 1266, 1278, 1290, 1294], 'UrologyInvestigative': [3], 'urology1': [4], 'Jan': [5], '2006Human': [6], 'Muscarinic': [7, 547, 917, 992], 'Receptor': [8, 993], 'Binding': [9, 994], 'Characteristics': [10], 'Antimuscarinic': [12, 658], 'Agents': [13], 'to': [14, 231, 330, 349, 373, 395, 398, 403, 446, 451, 455, 471, 557, 712, 804, 1002], 'Treat': [15, 1003], 'Overactive': [16, 1004], 'Bladder': [17], 'Shuji': [18, 41, 1085], 'Maruyama,': [19], 'Tomomi': [20, 65, 1112], 'Oki,': [21], 'Atsushi': [22, 89, 1139], 'Otsuka,': [23], 'Hitoshi': [24, 102, 1155], 'Shinbo,': [25], 'Seiichiro': [26, 115, 1171], 'Ozono,': [27], 'Shinji': [28, 128, 1187], 'Kageyama,': [29], 'Yuuki': [30, 141, 1203], 'Mikami,': [31], 'Isao': [32, 156, 1221], 'Araki,': [33], 'Masayuki': [34, 171, 1239], 'Takeda,': [35], 'Keisuke': [36, 186, 1257], 'Masuyama,': [37], 'and': [38, 47, 49, 71, 73, 201, 208, 210, 253, 277, 296, 298, 314, 345, 369, 384, 391, 416, 442, 465, 514, 534, 555, 579, 583, 589, 624, 640, 660, 681, 690, 768, 779, 795, 801, 810, 825, 928, 932, 956, 984, 999, 1036, 1051, 1064, 1090, 1092, 1117, 1119, 1280, 1282], 'Shizuo': [39, 202, 1275], 'Yamada': [40, 204, 985, 1276], 'MaruyamaShuji': [42], 'Maruyama': [43, 1086], 'Department': [44, 68, 92, 105, 118, 144, 159, 174, 189, 205, 1087, 1114, 1141, 1157, 1173, 1205, 1223, 1241, 1259, 1277], 'Pharmacokinetics': [46, 70, 207, 1089, 1116, 1279], 'Pharmacodynamics': [48, 72, 209, 1091, 1118, 1281], 'COE': [50, 74, 211, 1093, 1120, 1283], 'Program': [51, 75, 212, 1094, 1121, 1284], 'in': [52, 76, 213, 248, 273, 278, 301, 308, 320, 353, 357, 377, 406, 411, 474, 479, 512, 585, 686, 748, 774, 799, 807, 829, 904, 921, 1095, 1122, 1285], 'the': [53, 77, 214, 241, 291, 311, 339, 354, 358, 362, 378, 407, 412, 431, 434, 452, 456, 475, 480, 577, 687, 728, 749, 775, 830, 870, 1096, 1123, 1286], '21st': [54, 78, 215, 1097, 1124, 1287], 'Century,': [55, 79, 216, 1098, 1125, 1288], 'School': [56, 80, 97, 110, 123, 147, 162, 177, 192, 217, 1099, 1126, 1146, 1162, 1178, 1208, 1226, 1244, 1262, 1289], 'Pharmaceutical': [58, 82, 219, 1057, 1101, 1128, 1291], 'Sciences,': [59, 83, 220, 267, 1102, 1129, 1292], 'University': [60, 84, 96, 109, 122, 135, 150, 165, 180, 195, 221, 1103, 1130, 1145, 1161, 1177, 1193, 1211, 1229, 1247, 1265, 1293], 'Shizuoka,': [62, 86, 134, 223, 1105, 1132, 1192, 1295], 'Shizuoka': [63, 87, 224, 1106, 1133, 1296], ',': [64, 88, 101, 114, 127, 140, 155, 170, 185, 200], 'OkiTomomi': [66], 'Oki': [67, 1113], 'OtsukaAtsushi': [90], 'Otsuka': [91, 1140], 'Urology,': [94, 107, 120, 146, 161, 176, 838, 967, 1007, 1143, 1159, 1175, 1207, 1225, 1243], 'Hamamatsu': [95, 100, 108, 113, 121, 126, 1144, 1149, 1160, 1165, 1176, 1181], 'Medicine,': [99, 112, 125, 149, 164, 179, 194, 1148, 1164, 1180, 1210, 1228, 1246, 1264], 'ShinboHitoshi': [103], 'Shinbo': [104, 1156], 'OzonoSeiichiro': [116], 'Ozono': [117, 1172], 'KageyamaShinji': [129], 'Kageyama': [130, 978, 1188], 'Shio': [131, 1189], 'Urologic': [132, 1190], 'Clinic,': [133, 1191], 'Yamanashi,': [137, 152, 167, 182, 197, 1195, 1213, 1231, 1249, 1267], 'Tamaho,': [138, 153, 168, 183, 198, 1196, 1214, 1232, 1250, 1268], 'Japan': [139, 154, 169, 184, 199, 1197, 1215, 1233, 1251, 1269], 'MikamiYuuki': [142], 'Mikami': [143, 1204], 'ArakiIsao': [157], 'Araki': [158, 1222], 'TakedaMasayuki': [172], 'Takeda': [173, 1240], 'MasuyamaKeisuke': [187], 'Masuyama': [188, 1258], 'Orolaryngology,': [191, 1261], 'YamadaShizuo': [203], 'View': [225], 'All': [226, 1303], 'Author': [227], 'Informationhttps://doi.org/10.1016/S0022-5347(05)00017-0AboutFull': [228], 'TextPDF': [229], 'ToolsAdd': [230], 'favoritesDownload': [232], 'CitationsTrack': [233], 'CitationsPermissionsReprints': [234], 'ShareFacebookLinked': [235], 'InTwitterEmail': [236], 'Abstract': [237], 'Purpose:': [238], 'We': [239], 'characterized': [240], 'binding': [242, 270, 307, 426, 559, 708], 'affinities': [243], 'several': [245], 'antimuscarinic': [246, 259, 605], 'agents': [247, 260], 'human': [249, 274, 283, 312, 327, 408, 476, 517, 688, 776, 851, 905, 922], 'muscarinic': [250, 284, 328, 404, 472, 493, 509, 706, 771, 901], 'receptors.': [251, 495], 'Materials': [252], 'Methods:': [254], 'Competitive': [255], 'inhibitory': [256, 340, 363], 'effects': [257, 341, 364, 847], 'on': [261, 335, 622, 626, 643, 850], 'specific': [262, 305, 424], 'NMS': [263], '[3H]': [264], '(PerkinElmer': [265], 'Life': [266], 'Boston,': [268], 'Massachusetts)': [269], 'were': [271, 347, 371, 393, 418, 1039, 1053, 1066], 'examined': [272], 'tissue': [275], 'homogenates': [276, 309], 'CHO-K1': [279, 323], 'cell': [280, 324, 428], 'membranes': [281, 321, 429], 'expressing': [282, 326, 430], 'receptor': [285, 332, 510, 549, 707, 902, 919], 'subtypes.': [286, 333], 'Results:': [287], 'Oxybutynin,': [288, 997], 'propiverine,': [289, 440], 'tolterodine,': [290, 343, 382, 463], 'respective': [292], 'metabolites': [293, 642], 'DEOB,': [294, 367, 389, 439], 'DPr-P-4(N→O)': [295, 346, 385, 441, 466, 1052], '5-HM,': [297], 'darifenacin': [299, 370, 392, 443], 'inhibited': [300], 'concentration': [302], 'dependent': [303, 621], 'fashion': [304], '[3H]NMS': [306, 425], 'bladder': [313, 355, 409, 477, 553, 661, 704, 778], 'parotid': [315, 359, 379, 413, 481, 691, 780], 'gland': [316], 'as': [317, 319], 'well': [318], 'lines': [325], 'M1': [329], 'M5': [331], 'Based': [334], 'inhibition': [336], 'constant': [337], 'values': [338], '5-HM': [344, 383, 417, 464, 1065], '1.4': [348], '1.7': [350], 'times': [351, 375, 400, 448], 'greater': [352, 376, 401], 'than': [356, 410, 454, 478], 'gland,': [360], 'whereas': [361], 'oxybutynin,': [366, 388, 438, 462], 'propiverine': [368, 390, 582, 638], '2': [372, 445, 502], '10': [374, 676], 'gland.': [380, 414, 482, 692, 781], 'Consequently': [381], 'compared': [386], 'with': [387, 461, 587, 727, 886], 'found': [394], 'show': [396], '3': [397, 525], '4': [399, 545], 'affinity': [402, 450], 'receptors': [405, 473, 747, 773], 'Tolterodine': [415, 998, 1062], '2-fold': [419], 'more': [420, 469], 'potent': [421], 'for': [422, 880], 'inhibiting': [423], 'at': [427], 'M2': [432, 457], 'vs': [433], 'M3': [435, 453], 'subtype.': [436, 458], 'Conversely': [437], 'showed': [444], '22': [447], 'higher': [449], 'Conclusions:': [459], 'Compared': [460], 'may': [467], 'bind': [468], 'selectively': [470], 'References': [483], '1': [484], ':': [485, 503, 526, 546, 571, 601, 615, 635, 657, 677, 701, 724, 742, 766, 791, 822, 845, 865, 896, 916], 'International': [486], 'Union': [487], 'Pharmacology.': [489], 'XVII.': [490], 'Classification': [491], 'acetylcholine': [494, 548], 'Pharmacol': [496, 538, 562, 670, 758], 'Rev1998;': [497], '50:': [498, 630, 840], '279.': [499], 'Google': [500, 523, 543, 568, 598, 612, 632, 654, 674, 698, 721, 739, 763, 788, 819, 842, 862, 893, 913, 938], 'Scholar': [501, 524, 544, 569, 599, 613, 633, 655, 675, 699, 722, 740, 764, 789, 820, 843, 863, 894, 914, 939], 'Differential': [504], 'gene': [505], 'expression': [506], 'cholinergic': [508, 772, 918], 'subtypes': [511, 550, 903, 920], 'male': [513], 'female': [515], 'normal': [516], 'urinary': [518, 530, 552, 647, 777, 853], 'bladder.': [519, 648, 715, 854, 888], 'Urology2002;': [520], '60:': [521], '719.': [522], 'Pharmacology': [527], 'lower': [529], 'tract': [531], 'smooth': [532], 'muscles': [533], 'penile': [535], 'erectile': [536], 'tissues.': [537], 'Rev1993;': [539], '45:': [540], '253.': [541], 'Medline,': [542, 567, 597, 738, 818, 861], 'mediating': [551], 'contractility': [554], 'coupling': [556], 'GTP': [558], 'proteins.': [560], 'J': [561, 608, 693, 716, 732, 757, 782, 856, 908], 'Exp': [563, 759], 'Ther1995;': [564], '273:': [565], '959.': [566], '5': [570], 'A': [572, 963], 'placebo-controlled,': [573], 'multicentre': [574], 'study': [575], 'comparing': [576], 'tolerability': [578], 'efficacy': [580, 824], 'oxybutynin': [584, 619, 680, 711, 794], 'patients': [586, 885], 'urgency': [588], 'urge': [590], 'incontinence.': [591], 'BJU': [592], 'Int1999;': [593], '84:': [594], '646.': [595], 'Crossref,': [596, 737, 817, 860], '6': [600], 'Tolterodine—a': [602], 'new': [603, 874], 'bladder-selective': [604], 'agent.': [606], 'Eur': [607, 855], 'Pharmacol1997;': [609], '327:': [610], '195.': [611], '7': [614], 'The': [616], 'metabolism': [617], 'is': [620], 'CYP3A': [623], 'not': [625, 868], 'CYP2D6.': [627], 'Therapie,': [628], 'suppl.1995;': [629], '67.': [631], '8': [634], 'Effects': [636], 'hydrochloride': [639, 1035, 1038, 1050], 'its': [641, 682, 796, 802], 'isolated': [644, 852], 'guinea': [645], 'pig': [646], 'Nippon': [649], 'Yakurigaku': [650], 'Zasshi1989;': [651], '94:': [652], '145.': [653], '9': [656], 'potency': [659], 'selectivity': [662], 'PNU-200577,': [664], 'a': [665, 835, 873], 'major': [666], 'metabolite': [667, 798], 'tolterodine.': [669], 'Toxicol1997;': [671], '81:': [672], '169.': [673], 'Comparison': [678], 'active': [683], 'metabolite,': [684], 'N-desethyl-oxybutynin,': [685], 'detrusor': [689, 906, 923], 'Urol1997;': [694], '157:': [695], '1093.': [696], 'Link,': [697, 912], '11': [700], 'Demonstration': [702], 'selective': [705], 'by': [709, 926, 942, 996, 1027, 1041, 1055, 1068, 1078, 1109, 1136, 1152, 1168, 1184, 1200, 1218, 1236, 1254, 1272, 1299], 'intravesical': [710], 'treat': [713], 'overactive': [714, 833, 887], 'Urol2004;': [717], '172:': [718], '2059.': [719], 'Abstract,': [720], '12': [723], 'Protein': [725], 'measurement': [726], 'Folin': [729], 'phenol': [730], 'reagent.': [731], 'Biol': [733], 'Chem1951;': [734], '193:': [735], '265.': [736], '13': [741], 'Characterization': [743], 'alpha-1': [745], 'adrenergic': [746], 'heart': [750], 'using': [751], '[3H]WB4101:': [752], 'effect': [753], '6-hydroxydopamine': [755], 'treatment.': [756], 'Ther1980;': [760], '215:': [761], '176.': [762], '14': [765], 'Identification': [767], 'characterization': [769], 'Auton': [783], 'Nerv': [784], 'Syst1987;': [785], '20:': [786], '129.': [787], '15': [790], 'Measurement': [792], 'N-desethyl': [797], 'plasma,': [800], 'application': [803], 'pharmacokinetic': [805], 'studies': [806], 'young,': [808], 'elderly': [809, 812], 'frail': [811], 'volunteers.': [813], 'Xenobiotica1992;': [814], '22:': [815], '859.': [816], '16': [821], 'Clinical': [823], 'safety': [826], 'tolterodine': [828, 849, 879], 'treatment': [831, 883], 'bladder:': [834], 'pooled': [836], 'analysis.': [837], 'suppl.1997;': [839], '90.': [841], '17': [844], 'Pharmacological': [846], 'Pharmacol1999;': [857], '368:': [858], '223.': [859], '18': [864], 'Food': [866], 'does': [867], 'influence': [869], 'pharmacokinetics': [871], 'extended': [875], 'release': [876], 'formulation': [877], 'once': [881], 'daily': [882], 'Clin': [889], 'Pharmacokinet2001;': [890], '40:': [891], '135.': [892], '19': [895], 'Evaluation': [897, 989], 'mRNAs': [899], 'encoding': [900], 'muscle.': [907], 'Urol1996;': [909], '156:': [910], '1208.': [911], '20': [915], 'muscle': [924], 'studied': [925], 'labeled': [927], 'nonlabeled': [929], 'pirenzepine,': [930], 'AFDX-116': [931], '4DAMP.': [933], 'Urol': [934], 'Int1995;': [935], '54:': [936], '150.': [937], '©': [940], '2006': [941, 1026], 'American': [943, 1028], 'Urological': [944, 1029], 'AssociationFiguresReferencesRelatedDetailsCited': [945], 'byGriebling': [946], 'T': [947], '(2014)': [948], 'Re:': [949], 'Anticholinergic': [950, 954], 'Drug': [951, 958], 'Use,': [952], 'Serum': [953], 'Activity,': [955], 'Adverse': [957], 'Events': [959], 'among': [960], 'Older': [961], 'People:': [962], 'Population-Based': [964], 'StudyJournal': [965], 'VOL.': [968, 1008], '192,': [969], 'NO.': [970, 1010], '2,': [971, 1011], '(490-491),': [972], 'Online': [973, 1013], 'publication': [974, 1014], 'date:': [975, 1015], '1-Aug-2014.Oki': [976], 'T,': [977], 'A,': [979], 'Takagi': [980], 'Y,': [981], 'Uchida': [982], 'S': [983, 986], '(2018)': [987], 'Comparative': [988], 'Central': [991], 'Activity': [995], 'Darifenacin': [1000, 1074], 'Used': [1001], 'BladderJournal': [1005], '177,': [1009], '(766-770),': [1012], '1-Feb-2007.': [1016], 'Volume': [1017], '175Issue': [1018], '1January': [1019], '2006Page:': [1020], '365-369': [1021], 'Advertisement': [1022, 1304], 'Copyright': [1023], '&': [1024], 'Permissions©': [1025], 'AssociationKeywordsmuscarinic': [1030], 'antagonistsurination': [1031], 'disordersparotid': [1032], 'glandreceptors,': [1033], 'muscarinicbladderAcknowledgmentOxybutynin': [1034], 'DEOB': [1037], 'provided': [1040, 1054, 1067, 1077], 'Meiji': [1042], 'Milk': [1043], 'Products': [1044], 'Co.': [1045, 1058, 1070, 1080], 'Ltd.,': [1046, 1059, 1071, 1081], 'Odawara,': [1047], 'Japan.': [1048, 1061, 1073], 'Propiverine': [1049], 'Taiho': [1056], 'Tokushima,': [1060], 'L-tartrate': [1063], 'Pharmacia': [1069], 'Tokyo,': [1072, 1082], 'hydrobromide': [1075], 'was': [1076], 'Pfizer': [1079], 'Japan.MetricsAuthor': [1083], 'Information': [1084], 'More': [1107, 1134, 1150, 1166, 1182, 1198, 1216, 1234, 1252, 1270, 1297], 'articles': [1108, 1135, 1151, 1167, 1183, 1199, 1217, 1235, 1253, 1271, 1298], 'this': [1110, 1137, 1153, 1169, 1185, 1201, 1219, 1237, 1255, 1273, 1300], 'author': [1111, 1138, 1154, 1170, 1186, 1202, 1220, 1238, 1256, 1274, 1301], 'Expand': [1302], 'PDF': [1305], 'downloadLoading': [1306], '...': [1307]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2109033354', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-10T00:17:58.766720', 'created_date': '2016-06-24'}