Publication Information

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'2001https://doi.org/10.1161/hh1001.091869Circulation': [149], 'Research.': [150], '2001;88:981–983Once': [151], 'again,': [152], 'a': [153, 162, 253, 394, 418, 537, 545, 866, 926, 1051, 1267, 1279, 1284, 1294, 1744, 1749, 1833, 2693, 2701, 2842, 2922, 3087], 'MinK-related': [154, 1394, 1646, 1670, 2642, 3001], 'peptide': [155, 1395], '(MiRP)': [156], 'has': [157], 'been': [158, 242, 359, 413], 'implicated': [159], 'in': [160, 205, 214, 348, 381, 397, 423, 430, 439, 450, 531, 593, 601, 606, 613, 638, 655, 681, 748, 762, 776, 784, 803, 839, 859, 865, 906, 963, 994, 1015, 1048, 1072, 1081, 1107, 1174, 1266, 1301, 1616, 1777, 1861, 1911, 1977, 2163, 2231, 2274, 2301, 2483, 2534, 2764, 2769, 2806, 2846, 2926, 3008, 3111, 3153], 'allowing': [161], 'pore-forming,': [163], 'voltage-gated': [164, 1270, 1751, 3080], 'potassium': [165, 1271, 1438, 1553, 1590, 1614, 1638, 1662, 1703, 1731, 1752, 1917, 2032, 2052, 3113], 'channel': [166, 630, 1001, 1035, 1221, 1288, 1524, 1554, 1591, 1639, 1663, 1781, 1999, 2182, 2334, 2920, 3083, 3114], 'α': [167, 285, 309, 355, 528, 669, 1202, 1333, 1350], 'subunit': [168, 356, 627, 637, 670, 905, 1259, 1353, 1409], 'achieve': [170], 'its': [171, 266, 353, 914, 1402], 'potential.': [172], 'In': [173, 295, 341, 506, 1675], 'this': [174, 249, 507, 1290, 1302], 'issue': [175, 262], 'Circulation': [177], 'Research,': [178], 'Zhang': [179, 368, 1097, 1388, 2138], 'et': [180, 369, 1027, 1098], 'al1': [181, 370, 1028, 1099], 'show': [182, 598, 617, 805, 1257], 'that': [183, 220, 282, 333, 372, 390, 562, 642, 661, 757, 880, 937, 971, 1041, 1162, 1169, 1495, 1747, 1805], 'MiRP1': [184, 221, 323, 373, 1045, 1192, 1435, 2915], '(encoded': [185], 'by': [186, 274, 367, 483, 741, 827, 888, 1003, 1096, 1135, 1346, 1525, 1593, 1854, 1943, 2004, 2120, 2336, 2443, 2593, 3085], 'KCNE2': [188, 2873], 'gene)': [189], 'can': [190, 374, 584, 590, 933, 1883], 'alter': [191, 375], 'function': [193, 231, 377, 591, 1002, 1079, 1643], 'Kv4': [195, 379], 'family': [196, 2885], 'subunits': [197, 240, 281, 286, 310, 380, 392, 428, 467, 521, 529, 746, 1071, 1209, 1326, 1334, 2916, 3115], '(which': [198], 'contribute': [199], 'Ito,': [201], 'transient': [202, 1412], 'outward': [203, 1413], 'currents': [204, 555, 569, 576, 680, 693, 879, 3122], 'heart': [206], 'brain)': [208], 'when': [209, 448, 825, 955], 'they': [210], 'are': [211, 278, 426, 465, 570, 577, 1100, 1265, 1304], 'expressed': [212, 429, 530, 612, 956, 976, 1300], 'together': [213], 'Xenopus': [215, 639, 1774, 1862, 1889, 2484], 'oocytes.': [216, 1863, 1890], 'After': [217], 'recent': [218], 'reports': [219, 1129], 'affects': [222, 229], 'behavior': [224, 600], 'HERG23456': [226], 'MiRP2': [228, 893, 1612, 2730], 'KCNQ1,': [233], 'KCNQ4,': [234], 'HERG,': [235], 'Kv3.4,78': [237], 'MiRP': [239, 351, 391, 1241, 1285, 1325], 'have': [241, 358, 412, 951, 1147], 'accused': [243], 'widespread': [245], 'promiscuous': [246, 3118], 'partnering.': [247], 'Whether': [248], 'salacious': [250], 'charge': [251], 'is': [252, 259, 421, 480, 672, 739, 929, 1018, 1277, 1344, 1443, 1622, 1832, 2002], 'valid': [254], 'reflection': [255], 'natural': [257], 'physiology': [258, 1665], 'critical': [261], 'at': [263, 435, 443, 718, 1120, 1243], 'hand.MinK': [264], 'four': [267, 1349], 'recognized': [268], 'relations': [269], '(MiRP1': [270], 'through': [271, 276, 401, 949, 1197], 'MiRP4': [272], 'encoded': [273], 'KCNE1': [275], 'KCNE5)': [277], 'diminutive': [279], 'single-transmembrane': [280], 'coassemble': [283, 747], 'with': [284, 330, 471, 548, 665, 686, 694, 726, 797, 815, 897, 1199, 1210, 1214, 1398, 1440, 1445, 1476, 1501, 1557, 1619, 1624, 1801, 1923, 2480], 'during': [287], 'protein': [288, 445, 1746, 1830], 'translation': [289], 'form': [291, 755, 844, 1641, 1700, 1727], 'stable': [292], 'complexes910': [293], '(Figure).': [294], 'doing': [296], 'so,': [297], 'MinK': [298, 666, 699, 725, 958, 1014, 1493, 1696, 1803, 1924, 2051], 'alters': [299], 'gating': [301, 764, 1403, 1920], 'kinetics,': [302], 'permeation': [303, 766], 'attributes,': [304], 'pharmacology': [306, 460], 'KCNQ1': [308, 636, 950, 1594, 2201, 2330, 2441, 3049], 'yield': [312], 'attributes': [314, 458, 552, 619, 855], 'recorded': [315], 'native': [317, 433, 462, 488, 538, 554, 568, 575, 582, 780, 837, 863, 927, 1000, 1060, 1155, 1175, 1224, 1235], 'cardiac': [318, 338, 727, 759, 781, 1016, 1411, 1446, 1478, 1701, 1730, 1944, 2185], 'IKs': [319, 687, 730, 1796, 2277], 'channels.1112': [320], 'So,': [321], 'too,': [322], 'HERG': [325, 969, 1012, 1134, 1441, 1522, 1552, 1953, 1995, 2589, 2918], 'combine': [326], 'create': [328], 'complexes': [329, 440, 802, 1077, 1146, 1173, 1225, 1236, 1256, 1357, 2162], 'unique': [331, 1776], 'functions': [332], 'recapitulate': [334, 456, 536], 'properties': [336], 'IKr': [339, 760, 782, 1437], 'channels.23456': [340], 'each': [342], 'these': [344, 711, 821, 876, 1031, 1076], 'cases,': [345], 'inherited': [346, 892], 'mutations': [347, 948, 970, 1910, 3110], 'either': [349], 'or': [352, 475, 1013, 1311], 'associated': [354, 470, 896, 1444, 1475, 1623], 'partner': [357, 671, 1165], 'linked': [360], 'similar': [362, 1211], 'pathophysiology.': [363], 'The': [364, 675, 1321, 1352, 1658, 1829, 2028, 2367, 2400, 2412, 2641, 2658, 2809, 2932, 3128], 'present': [365], 'work': [366], 'indicates': [371], 'experimental': [382, 451, 533, 614, 829], 'cells': [383, 434, 595, 615, 660, 751, 778, 861, 912, 1176], 'demands': [385, 492, 1032], 'we': [386, 509, 1063, 1074], 'consider': [387, 510], 'possibility': [389, 1057], 'play': [393], 'central': [395, 1083, 1193, 1340], 'role': [396, 1406, 1974], 'determining': [398], 'cardiovascular': [399, 1195], 'excitability': [400, 1196], 'influence': [402, 735, 2882], 'over': [403], 'IKs,': [404], 'IKr,': [405], 'Ito': [407], 'channels.In': [408], 'general,': [409], 'three': [410, 1144], 'criteria': [411], 'used': [414], 'judge': [416], 'whether': [417], 'subunit-subunit': [419], 'complex': [420, 455], 'formed': [422, 1345, 1592, 1800], 'nature.': [424], 'First,': [425], 'same': [432, 437, 473, 603, 1141, 1245], 'time': [438], 'as': [441, 820, 991, 1151, 1407], 'assessed': [442, 482], 'level?': [446], 'Second,': [447], 'studied': [449], 'cells,': [452], 'does': [453], 'channels?': [463], 'Third,': [464], 'both': [468, 749, 840, 907, 918], 'genetically': [469], 'physiological': [474, 873], 'disease': [476, 1951], 'processes?The': [477], 'first': [478], 'criterion': [479], 'best': [481], 'coimmunoprecipitation': [484], 'coimmunolocalization': [486], 'using': [487], 'cells;': [489], 'third': [491], 'patient': [493], 'recruitment,': [494], 'careful': [495, 1038], 'clinical': [496], 'assessment,': [497], 'capacity': [500], 'perform': [502], 'molecular': [503, 722, 847, 1152, 2034], 'genetic': [504, 2368], 'analyses.': [505], 'discussion,': [508], 'second': [512], 'criterion,': [513], 'place': [515], 'where': [516], 'most': [517], 'studies': [518, 561], 'accessory': [520], 'begin': [522], 'culminate.': [524], 'Failure': [525], 'cloned': [527, 835], 'an': [532, 634, 668, 891], 'cell': [534, 604, 869, 2164], 'current': [539, 919, 962, 2442, 2875], 'often': [540], 'starts': [541], 'hunt': [543], 'missing': [546], 'subunit,': [547], 'correlation': [549, 685, 723, 874], 'new': [551], 'being': [556, 1037], 'desired': [558], 'outcome.': [559], 'However,': [560], 'seek': [563], 'correlate': [565], 'clones': [566, 611], 'difficult': [571, 941, 982], 'endeavors:': [572], 'recordings': [573], 'not': [578, 1232, 1305], 'always': [579], 'feasible,': [580], 'nonidentical': [581], 'channels': [583, 589, 756, 761, 775, 838, 858, 864, 1272, 1439, 1615, 1797, 1799, 1853, 1886, 1918], 'behave': [585], 'similarly,': [586], 'identical': [588], 'differently': [592], 'different': [594, 2337], 'even': [597], 'altered': [599, 622], 'type': [605, 1242, 2930], 'health': [607], 'disease.': [609], 'Similarly,': [610, 967], 'will': [616, 1078, 1177], 'variable': [618, 1258], 'because': [620, 900, 1102], 'gene': [623, 1945, 2448, 3042], 'expression,': [624], 'mRNA': [625], 'processing,': [626], 'composition,': [628], 'modulation.Thus,': [631], 'it': [632, 981], 'was': [633, 886], 'endogenous': [635, 1852, 1887], 'laevis': [640], 'oocytes': [641, 682, 753, 804, 1049, 1775], 'allowed': [643, 826], 'expression': [645, 737, 901, 932], 'cloning': [646], 'MinK1113': [648], '(and': [649, 779, 1261], 'apparent': [651], 'absence': [652], 'such': [654, 819], 'Chinese': [656, 2450], 'hamster': [657], 'ovary': [658], '[CHO]': [659], 'offers': [662], 'electrical': [663], 'silence': [664], 'until': [667], 'provided1415': [673], ').': [674], 'slow-activation': [676], 'kinetics': [677, 2879], 'MinK-induced': [679], 'suggested': [683, 871], 'their': [684, 763, 978, 1059, 1251, 1365], 'currents;': [688], 'however,': [689], 'induction': [690], 'chloride': [692], 'immoderate': [695], 'amounts': [696], 'injected': [698], 'cRNA16': [700], '(resulting': [701], 'from': [702, 1139, 2098], 'nonspecific': [703], 'calcium': [704], 'influx': [705], 'attributable': [706], 'profound': [708], 'overexpression': [709, 1005], 'transmembrane': [712, 1328, 1336], 'subunits1718': [713], ')': [714], 'confounded': [715], 'initial': [716], 'attempts': [717], 'characterization': [719, 852, 1021], 'eventual': [721], 'auditory': [729], 'channels.1112Another': [731], 'example': [732], 'environment': [738], 'offered': [740], 'MiRP1/HERG': [742, 774, 801, 995], 'complexes.23': [743], 'Whereas': [744], 'CHO': [750, 777, 860, 908], 'resemble': [758], 'properties,': [767], 'class': [769], 'III': [770], 'agent': [771], 'E-4031': [772], 'blocks': [773], 'channels)': [783], 'closed': [786], 'state,': [787], 'producing': [788], 'tonic': [789], 'blockade,': [790], 'additionally': [792], 'demonstrates': [793], 'ready': [794], 'use–dependent': [795], 'inhibition': [796, 814], 'cyclical': [798], 'stimulation.': [799], 'Conversely,': [800], 'no': [806, 1278], 'closed-state': [807], 'blockade': [808], 'slow': [810, 1750], 'relaxation': [811], 'equilibrium': [813], '≈200-fold': [816], 'lower': [817], 'sensitivity.Considerations': [818], 'support': [822, 1150], 'utility,': [824], 'favorable': [828], 'conditions,': [830], 'side-by-side': [832], 'comparisons': [833], 'wild-type': [841, 1007], 'mutant': [843, 904, 1009], 'establish': [846], 'identity.': [848], 'For': [849, 944, 1113], 'example,': [850, 945, 1114, 1217], 'simultaneous': [851], 'MiRP2/Kv3.4': [857], 'skeletal': [867, 910, 1617], 'muscle': [868, 911, 1618], 'line': [870], 'subthreshold': [877], 'activating': [878], 'set': [881], 'resting': [882, 924], 'membrane': [883, 1322, 1745, 1859, 1881], 'potential.8': [884], 'Identity': [885], 'supported': [887], 'isolation': [889], 'missense': [894], 'mutation': [895, 2374], 'periodic': [898, 1625], 'paralysis,': [899], 'revealed': [913, 1942], 'dominant': [915, 992], 'suppression': [916], 'density': [920], 'perturbation': [922, 998], 'potential.Once': [925], 'interaction': [928, 1068, 1198, 1922], 'supported,': [930], 'heterologous': [931, 1782, 1858], 'provide': [934, 1050], 'additional': [935], 'insights': [936], 'might': [938], 'otherwise': [939], 'be': [940, 1178, 1370], 'ascertain.': [943], 'some': [946, 1091, 1229], 'arrhythmia-associated': [947, 968], 'only': [952, 973], 'mild': [953, 974], 'effects': [954, 1043], 'without': [957], 'but': [959], 'markedly': [960], 'inhibit': [961], 'mixed': [964], 'MinK/KCNQ1': [965], 'complexes.19': [966], 'showed': [972], 'abnormalities': [975], 'on': [977, 1046, 2239, 2887], 'own': [979], '(making': [980], 'rationalize': [984], 'pathogenesis)': [986], 'were': [987, 1111], 'able': [988], 'act': [990], 'suppressors': [993], 'complexes.6': [996], 'Moreover,': [997], 'adenovirus-mediated': [1004], 'forms': [1010, 1436, 1613], 'myocytes': [1017], 'now': [1019], 'facilitating': [1020], 'gene-specific': [1023, 1938], 'mechanisms': [1024, 1939, 3145], 'arrhythmogenesis.20Zhang': [1026], 'fully': [1029], 'recognize': [1030], 'clone/native': [1034], 'identification,': [1036], 'stress': [1040], 'Kv4.2': [1047, 1399, 2410], 'starting': [1052], 'point': [1053], 'toward': [1054], 'addressing': [1055], 'association.': [1061], '(Although': [1062], 'also': [1064], 'observe': [1065], 'evidence': [1066, 2066], 'oocytes,21': [1073], 'suspect': [1075], 'primarily': [1080], 'nervous': [1084], 'system': [1085], 'rather': [1086], 'than': [1087, 1188, 1239], 'heart.)': [1089], 'Furthermore,': [1090], 'conclusions': [1094], 'drawn': [1095], 'questionable': [1101], 'unorthodox': [1105], 'manner': [1106], 'which': [1108], 'experiments': [1110], 'executed.': [1112], 'injection': [1115], 'cRNAs': [1117], 'asynchronously': [1118], 'unusual': [1121], 'levels': [1122, 1856], 'likely': [1123], 'explains': [1124], 'failure': [1125], 'repeat': [1127], 'earlier': [1128], 'functional': [1131, 1779], 'modulation': [1132, 1497, 1993, 2335], 'MiRP1,23456': [1136], 'including': [1137], 'one': [1138, 1240], 'laboratory.22Thus': [1142], 'far,': [1143], 'MiRP/α-subunit': [1145, 1255, 1356], 'garnered': [1148], 'considerable': [1149], 'correlates': [1153], 'currents:': [1156], 'MinK/KCNQ1,': [1157], 'MiRP1/HERG,': [1158], 'MiRP2/Kv3.4.': [1160], 'Hints': [1161], 'MiRPs': [1163, 1215, 1227, 1249, 1264, 1363], 'may': [1164], 'more': [1166, 1186, 1238], 'broadly': [1167], 'suggest': [1168], 'array': [1171], 'significantly': [1179], 'larger.': [1180], 'And': [1181], 'yet': [1182], 'questions': [1184], 'remain': [1185, 1368], 'numerous': [1187], 'answers.': [1190], 'Is': [1191], 'multiple': [1200, 1998, 2068, 3121], 'myocardial': [1201], 'subunits?': [1203], 'Will': [1204, 1223], 'other': [1205], 'types': [1206], 'pore-forming': [1208, 1252, 1332, 1366], 'topology': [1212, 1323], 'associate': [1213, 1725], '(for': [1216], 'pacemaker': [1218], 'cyclic-nucleotide–gated': [1220], 'subunits)?': [1222], 'contain': [1226, 1237], 'under': [1228], 'conditions': [1230], 'others?': [1233], 'Do': [1234, 1254, 2095], 'time?': [1246], 'Where': [1247, 2094], 'do': [1248], 'contact': [1250, 1361], 'partners?': [1253], 'stoichiometry': [1260, 1354], 'how': [1262], 'many': [1263], 'complex)?Do': [1268], 'all': [1269], 'use': [1273], 'Although': [1275], 'there': [1276], 'priori': [1280], 'reason': [1281], 'posit': [1283], 'every': [1287], 'complex,': [1289], 'irritating': [1291], 'notion': [1292], 'remains': [1293], 'viable': [1295], 'exciting': [1297], 'possibility.The': [1298], 'opinions': [1299], 'editorial': [1303], 'necessarily': [1306], 'those': [1307], 'editors': [1310], 'American': [1314, 3091, 3173], 'Heart': [1315, 3174], 'Association.Download': [1316], 'figureDownload': [1317], 'PowerPoint': [1318], 'Figure': [1319], '1.': [1320], '(1': [1327], 'segment)': [1329], '(left)': [1330], '(6': [1335], 'segments)': [1337], '(right).': [1338], 'A': [1339, 1472, 1587, 1634, 1973, 2293, 2324, 2373, 2502, 2587, 2660, 2689, 3072], 'ion-conduction': [1341], 'pore': [1342], '(P)': [1343], 'assembly': [1347], 'subunits.23': [1351], 'sites': [1359], 'between': [1362], 'partners': [1367], 'established.152425FootnotesCorrespondence': [1371], 'A.N.': [1374], 'Goldstein,': [1375], '295': [1376], 'Congress': [1377], 'Ave,': [1378], 'CT': [1381], '06536.': [1382], 'E-mail': [1383], '[email': [1384], 'protected]': [1385], 'References': [1386], '1': [1387, 1396], 'M,': [1389, 1391, 1426, 1580, 1715, 1717, 1770, 1826, 1898, 1989, 2254, 2315, 2393, 2581, 2823, 2829, 2907, 2948], 'Jiang': [1390, 1988], 'Tseng': [1392, 1990], 'G-N.': [1393], 'associates': [1397], 'modulates': [1401, 2874], 'function:': [1404], 'potential': [1405], 'β': [1408], 'channel?': [1414], 'Circ': [1415], 'Res.2001;': [1416], '88:1012–1019.CrossrefMedlineGoogle': [1417], 'Scholar2': [1418], 'GW,': [1420, 1454, 1601, 1631, 1655, 1968], 'F,': [1422, 1452, 1711, 1758, 1789, 1820, 2521, 2866], 'Splawski': [1423, 1901], 'I,': [1424, 1902], 'Buck': [1425], 'Lehmann': [1427], 'MH,': [1428, 1603, 1970], 'Timothy': [1429], 'KW,': [1430, 2045], 'Keating': [1431, 1690, 1903], 'MT,': [1432, 1904], 'SAN.': [1434, 1611, 1633, 1657, 1791, 1972, 2047], 'arrhythmia.': [1447, 1479], 'Cell.1999;': [1448], '97:175–187.CrossrefMedlineGoogle': [1449], 'Scholar3': [1450], 'Wei': [1455], 'J,': [1456, 1509, 1533, 1539, 1685, 1709, 1762, 1847, 1900, 2015, 2060, 2358, 2360, 2389, 2469, 2572, 2833, 2946], 'Murray': [1457], 'KT,': [1458], 'Saksena': [1459], 'S,': [1460, 1576, 1578, 1605, 2256, 2356, 2428, 2609, 2827, 3024, 3064], 'Schwartz': [1461], 'PJ,': [1462], 'Priori': [1463], 'SG,': [1464], 'Roden': [1465], 'DM,': [1466], 'George': [1467, 1491, 2323, 2501], 'AL': [1468], 'Jr,': [1469], 'SA.': [1471], 'common': [1473], 'polymorphism': [1474], 'antibiotic-induced': [1477], 'Proc': [1480, 1956], 'Natl': [1481, 1957], 'Acad': [1482, 1958], 'Sci': [1483, 1959], 'U': [1484, 1960], 'S': [1485, 1961, 2221, 2838, 3107], 'A.2000;': [1486], '97:10613–10618.CrossrefMedlineGoogle': [1487], 'Scholar4': [1488], 'Tapper': [1489, 2318], 'AR,': [1490], 'AL.': [1492], 'subdomains': [1494, 2327], 'mediate': [1496], 'association': [1500], 'KvLQT1.': [1502], 'J': [1503, 1559, 1810, 1926, 2075, 2437, 2550, 2753, 2912], 'Gen': [1504, 1811], 'Physiol.2000;': [1505], '116:379–389.CrossrefMedlineGoogle': [1506], 'Scholar5': [1507], 'Cui': [1508, 1532], 'Melman': [1510, 1540], 'Y,': [1511, 2137, 2139, 2386, 2430, 2905, 3028, 3068], 'Palma': [1512], 'E,': [1513, 1713, 1764, 1768, 1818, 1822, 1934, 2987], 'Fishman': [1514], 'GI,': [1515], 'McDonald': [1516, 1542], 'TV.': [1517, 1543], 'Cyclic': [1518], 'AMP': [1519], 'regulates': [1520], 'K+': [1523, 1837, 2037, 2181, 2919, 3005], 'dual': [1526, 1834], 'pathways.': [1527], 'Curr': [1528], 'Biol.2000;': [1529], '10:671–674.CrossrefMedlineGoogle': [1530], 'Scholar6': [1531], 'Kagan': [1534], 'A,': [1535, 1683, 2019, 2319, 2495, 2574, 2681, 2720, 2784, 2831, 2981, 2983], 'Qin': [1536], 'D,': [1537, 2260, 2790], 'Mathew': [1538], 'YF,': [1541], 'Analysis': [1544], 'cyclic': [1547], 'nucleotide-binding': [1548], 'domain': [1549], 'interactions': [1556], 'KCNE2.': [1558], 'Biol': [1560, 1927, 2076], 'Chem.': [1561], 'February': [1562], '26,': [1563], '2001;10.1074/jbc.M010904200.': [1564], 'Available': [1565], 'at:': [1566], 'http://www.jbc.org.': [1567], 'Accessed': [1568], 'April': [1569], '25,': [1570, 3163, 3179], '2001.Google': [1571], 'Scholar7': [1572], 'Schroeder': [1573], 'BC,': [1574], 'Waldegger': [1575], 'Fehr': [1577], 'Bleich': [1579], 'Warth': [1581], 'R,': [1582, 1584, 2258, 2313, 2467, 3032], 'Greger': [1583], 'Jentsch': [1585], 'TJ.': [1586], 'constitutively': [1588], 'open': [1589], 'KCNE3.': [1596], 'Nature.2000;': [1597], '403:196–199.CrossrefMedlineGoogle': [1598], 'Scholar8': [1599], 'Butler': [1602, 1969], 'Bendahhou': [1604], 'Dalakas': [1606], 'MC,': [1607, 1679], 'Ptacek': [1608], 'LJ,': [1609], 'Kv3.4': [1620], 'paralysis.': [1626], 'Cell.2001;': [1627], '104:217–231.CrossrefMedlineGoogle': [1628], 'Scholar9': [1629], 'superfamily': [1635, 1660], 'small': [1637, 1879], 'subunits:': [1640, 1664], 'peptides': [1647, 1671], '(MiRPs).': [1648, 1672], 'Q': [1649], 'Rev': [1650], 'Biophys.1998;': [1651], '31:357–398.CrossrefMedlineGoogle': [1652], 'Scholar10': [1653], 'KCNE': [1659, 2338, 2510, 2884, 3112], 'pathophysiology': [1667], 'Mol': [1673], 'Interventions.': [1674], 'press.Google': [1676], 'Scholar11': [1677], 'Sanguinetti': [1678, 1905], 'Curran': [1680], 'ME,': [1681], 'Zou': [1682], 'Shen': [1684, 1899], 'Spector': [1686], 'PS,': [1687], 'Atkinson': [1688], 'DL,': [1689, 1871], 'MT.': [1691], 'Coassembly': [1692, 2477], 'K(V)Lqt1': [1694], '(Isk)': [1697], 'proteins': [1698, 1724, 1860, 1882], 'I-Ks': [1702], 'channel.': [1704, 2074], 'Nature.1996;': [1705, 1733], '384:80–83.CrossrefMedlineGoogle': [1706], 'Scholar12': [1707], 'Barhanin': [1708, 1771, 1827], 'Lesage': [1710, 1757, 1819], 'Guillemare': [1712, 1817], 'Fink': [1714], 'Lazdunski': [1716, 1769, 1825], 'Romey': [1718, 1765, 1823], 'G.': [1719, 1991], 'K(V)LQT1': [1720], 'IsK': [1722, 1780, 1831, 2073], '(MinK)': [1723], 'I(Ks)': [1729], 'current.': [1732, 1753], '384:78–80.CrossrefMedlineGoogle': [1734], 'Scholar13': [1735], 'Takumi': [1736], 'T,': [1737, 1845, 2821], 'Ohkubo': [1738], 'H,': [1739, 3070], 'Nakanishi': [1740], 'S.': [1741], 'Cloning': [1742], 'induces': [1748], 'Science.1988;': [1754], '242:1042–1045.CrossrefMedlineGoogle': [1755], 'Scholar14': [1756], 'Attali': [1759, 1815, 2263], 'B,': [1760, 1816, 2579], 'Lakey': [1761], 'Honore': [1763, 1821], 'G,': [1766, 1824, 2463, 2570, 2611, 2786, 2985], 'Faurobert': [1767], 'J.': [1772, 1828], 'Are': [1773], 'displaying': [1778], 'expression?': [1783], 'Receptors': [1784], 'Channels.1993;': [1785], '1:143–52.MedlineGoogle': [1786], 'Scholar15': [1787], 'Single-channel': [1792], 'characteristics': [1793], 'wildtype': [1795], 'two': [1802, 1948], 'mutants': [1804], 'cause': [1806], 'long': [1807, 1949, 2927, 3148], 'QT': [1808, 1908, 1950, 2844, 2928, 2964, 3149], 'syndrome.': [1809], 'Physiol.1998;': [1812], '112:651–664.CrossrefMedlineGoogle': [1813], 'Scholar16': [1814], 'activator': [1835], 'Cl−': [1839], 'channels.': [1840, 2053], 'Nature.1993;': [1841], '365:850–852.CrossrefMedlineGoogle': [1842], 'Scholar17': [1843], 'Tzounopoulos': [1844], 'Maylie': [1846], 'Adelman': [1848], 'JP.': [1849], 'Induction': [1850], 'high': [1855], 'Biophys': [1864, 1891, 1981, 2006], 'J.1995;': [1865, 1892], '69:904–908.CrossrefMedlineGoogle': [1866], 'Scholar18': [1867], 'Shimbo': [1868], 'K,': [1869, 2262, 2424, 2683], 'Brassard': [1870], 'Lamb': [1872], 'RA,': [1873, 2017], 'Pinto': [1874], 'LH.': [1875], 'Viral': [1876], 'cellular': [1878], 'integral': [1880], 'modify': [1884, 1919], 'ion': [1885], '69:1819–1829.CrossrefMedlineGoogle': [1893], 'Scholar19': [1894], 'Franqueza': [1895], 'L,': [1896, 2135, 2216, 2317, 3026], 'Lin': [1897, 3029], 'MC.': [1906], 'Long': [1907, 2843], 'syndrome-associated': [1909], 'S4-S5': [1913], 'linker': [1914], 'KvLQT1': [1916], 'subunits.': [1925], 'Chem.1999;': [1928], '274:21063–21070.CrossrefMedlineGoogle': [1929], 'Scholar20': [1930], 'Hoppe': [1931], 'UC,': [1932], 'Marbán': [1933], 'Johns': [1935], 'DC.': [1936], 'Distinct': [1937, 2326], 'arrhythmia': [1941], 'transfer': [1946], 'genes,': [1952, 2511], 'KCNE1.': [1955], 'A.2001;': [1962], '98:5335–5340.CrossrefMedlineGoogle': [1963], 'Scholar21': [1964], 'Kim': [1965], 'LA,': [1966], 'MiRP1-Kv4.2': [1976], 'CNS': [1978], 'A-type': [1979, 2695], 'currents?': [1980], 'J.2001;': [1982], '80:437a.': [1983], 'Abstract.Google': [1984, 2009], 'Scholar22': [1985], 'Dun': [1986], 'W,': [1987, 2058, 3066], 'Ko': [1992], 'deactivation': [1996], 'involves': [1997], 'domains': [2000], 'affected': [2003], 'hMiRP1.': [2005], 'J.2000;': [2007], '78:341a.': [2008], 'Scholar23': [2010], 'Doyle': [2011], 'DA,': [2012], 'Morais': [2013], 'Cabral': [2014], 'Pfuetzner': [2016], 'Kuo': [2018], 'Gulbis': [2020], 'JM,': [2021], 'Cohen': [2022], 'SL,': [2023], 'Chait': [2024], 'BT,': [2025], 'MacKinnon': [2026], 'R.': [2027], 'structure': [2029], 'channel:': [2033], 'basis': [2035, 2369], 'conduction': [2038], 'selectivity.': [2040], 'Science.1998;': [2041], '280:69–77.CrossrefMedlineGoogle': [2042], 'Scholar24': [2043], 'Wang': [2044, 2057, 2615], 'Subunit': [2048], 'composition': [2049], 'Neuron.1995;': [2054], '14:1303–9.CrossrefMedlineGoogle': [2055], 'Scholar25': [2056], 'Xia': [2059], 'Kass': [2061, 2552, 2952], 'RS.': [2062], 'MinK-KvLQT1': [2063], 'fusion': [2064], 'proteins,': [2065], 'stoichiometries': [2069], 'assembled': [2072], 'Chem.1998;': [2077], '273:34069–34074.CrossrefMedlineGoogle': [2078], 'Scholar': [2079], 'Previous': [2080], 'Back': [2081], 'top': [2083], 'Next': [2084], 'FiguresReferencesRelatedDetailsCited': [2085], 'By': [2086], 'G': [2088, 2109, 2159, 2176, 2196, 2267, 2525, 2613, 2639, 2725, 2795, 2994, 3075, 3104], '(2022)': [2089], 'Kv': [2090], 'Channel': [2091, 2278, 2538, 2590, 2697, 2736, 2759, 2957, 3006], 'Ancillary': [2092, 2121], 'Subunits:': [2093], 'We': [2096], 'Go': [2097], 'Here?,': [2099], '10.1152/physiol.00005.2022,': [2101], '37:5,': [2102], '(225-241),': [2103], 'Online': [2104, 2171, 2191, 2211, 2247, 2306, 2347, 2381, 2419, 2456, 2516, 2545, 2565, 2604, 2631, 2648, 2674, 2715, 2745, 2777, 2816, 2859, 2900, 2939, 2976, 3019, 3059, 3099, 3134, 3158], 'publication': [2105, 2172, 2192, 2212, 2248, 2307, 2348, 2382, 2420, 2457, 2517, 2546, 2566, 2605, 2632, 2649, 2675, 2716, 2746, 2778, 2817, 2860, 2901, 2940, 2977, 3020, 3060, 3100, 3135, 3159], 'date:': [2106, 2173, 2193, 2213, 2249, 2308, 2349, 2383, 2421, 2458, 2518, 2547, 2567, 2606, 2633, 2650, 2676, 2717, 2747, 2779, 2818, 2861, 2902, 2941, 2978, 3021, 3061, 3101, 3136, 3160], '1-Sep-2022.': [2107], '(2021)': [2110], 'Control': [2111], 'Biophysical': [2113, 2599, 3053], 'Pharmacological': [2115, 2540], 'Properties': [2116], 'Subunits': [2122, 2482], 'Pharmacology': [2123, 2852, 2970], 'Channels,': [2126, 2411, 2625], '10.1007/164_2021_512,': [2127], '(445-480),': [2128], '.': [2129, 2493], 'Zhao': [2130], 'X,': [2131, 2141], 'Zhu': [2132], 'C,': [2133, 2311, 2391, 2497, 2944, 3030], 'Tian': [2134, 3063], 'Fu': [2136], 'Chen': [2140], 'Huang': [2142, 2908], 'Y': [2143, 2146], 'Li': [2145], '(2017)': [2147, 2160], 'Kv4.3': [2148], 'Modulates': [2149, 2800], 'Distribution': [2151], 'hERG,': [2153], 'Scientific': [2154], 'Reports,': [2155], '10.1038/s41598-017-17837-6,': [2156], '7:1': [2157], 'Chansporter': [2161], 'signaling,': [2165], 'FEBS': [2166], 'Letters,': [2167], '10.1002/1873-3468.12755,': [2168], '591:17,': [2169], '(2556-2576),': [2170], '1-Sep-2017.': [2174], '(2016)': [2177], 'KCNE4': [2178, 2446], 'KCNE5:': [2180], 'regulation': [2183], 'arrhythmogenesis,': [2186], 'Gene,': [2187], '10.1016/j.gene.2016.07.069,': [2188], '593:2,': [2189], '(249-260),': [2190], '1-Nov-2016.': [2194], '(2014)': [2197], 'Channel,': [2203], 'Journal': [2205, 2340, 2413, 2708, 2738, 2810, 2850, 2894, 2933, 3012, 3092], 'Science,': [2207], '10.1155/2014/237431,': [2208], '2014,': [2209], '(1-26),': [2210], '29-Jan-2014.': [2214], 'Millar': [2215], 'Sheikh': [2217], 'N': [2218], 'Sharma': [2220], '(2012)': [2222], 'Clinical': [2223], 'Genetic': [2225], 'Aspects': [2226], 'Sudden': [2228], 'Cardiac': [2229, 2276, 2558], 'Death': [2230], 'Practice': [2233], 'Sports': [2235], 'Colloquium': [2237], 'Series': [2238], 'Genomic': [2240], '10.4199/C00062ED1V01Y201206GMM002,': [2244], '1:2,': [2245], '(1-162),': [2246], '26-Jun-2012.': [2250], 'Strutz-Seebohm': [2251, 2460], 'N,': [2252, 2426, 2461, 2864], 'Pusch': [2253], 'Wolf': [2255], 'Stoll': [2257], 'Tapken': [2259], 'Gerwert': [2261], 'B': [2264, 2395], 'Seebohm': [2266, 2462], 'Structural': [2268], 'Basis': [2269], 'Slow': [2271], 'Activation': [2272], 'Gating': [2273], 'Complex,': [2279], 'Physiology': [2281, 2487, 2556], 'Biochemistry,': [2283, 2489], '10.1159/000329965,': [2284], '27:5,': [2285], '(443-452)': [2286], 'Campuzano': [2287], 'O,': [2288, 2465], 'Brugada': [2289, 2297, 2371], 'R': [2290, 2553, 2583, 2868, 2953, 3039, 3139], 'Iglesias': [2292], '(2010)': [2294, 2754], 'Genetics': [2295], 'syndrome,': [2298, 3150], 'Current': [2299, 3151], 'Opinion': [2300, 3152], 'Cardiology,': [2302, 3154], '10.1097/HCO.0b013e32833846ee,': [2303], '25:3,': [2304], '(210-215),': [2305], '1-May-2010.': [2309], 'Vanoye': [2310], 'Welch': [2312], 'Daniels': [2314], 'Manderfield': [2316], 'Sanders': [2320], 'C': [2321, 2909, 3142], '(2009)': [2325, 2366, 2399], 'S6': [2331], 'segment': [2332], 'determine': [2333], 'subunits,': [2339], 'General': [2342], '10.1085/jgp.200910234,': [2344], '134:3,': [2345], '(207-217),': [2346], '1-Sep-2009.': [2350, 2384], 'Hedley': [2351], 'P,': [2352, 2354, 2679, 2788], 'Jørgensen': [2353], 'Schlamowitz': [2355], 'Moolman-Smook': [2357], 'Kanters': [2359], 'Corfield': [2361], 'V': [2362], 'Christiansen': [2364], 'M': [2365, 2398, 2471], 'syndrome:': [2372], 'update,': [2375], 'Human': [2376, 2694], 'Mutation,': [2377], '10.1002/humu.21066,': [2378], '30:9,': [2379], '(1256-1266),': [2380], 'Kaulin': [2385], 'De': [2387], 'Santiago-Castillo': [2388], 'Rocha': [2390], 'Nadal': [2392], 'Rudy': [2394], 'Covarrubias': [2397], 'Dipeptidyl-Peptidase-Like': [2401], 'Protein': [2402, 2661, 2699], 'DPP6': [2403], 'Determines': [2404], 'Unitary': [2406], 'Conductance': [2407], 'Neuronal': [2409], 'Neuroscience,': [2415, 2812], '10.1523/JNEUROSCI.4767-08.2009,': [2416], '29:10,': [2417], '(3242-3251),': [2418], '11-Mar-2009.': [2422], 'MA': [2423], 'LI': [2425], 'TENG': [2427], 'ZHANG': [2429], 'SUN': [2431], 'Q,': [2432, 2825], 'GU': [2433], 'D': [2434, 2792, 2991], 'PU': [2436], '(2007)': [2438], 'Modulation': [2439], 'atrial': [2444], 'fibrillation-associated': [2445], '(145E/D)': [2447], 'polymorphism,': [2449], 'Medical': [2451], 'Journal,': [2452, 2600, 3130], '10.1097/00029330-200701020-00017,': [2453], '120:2,': [2454], '(150-154),': [2455], '1-Jan-2007.': [2459], 'Fedorenko': [2464], 'Baltaev': [2466], 'Engel': [2468], 'Knirsch': [2470], 'Lang': [2473], 'F': [2474, 2653], '(2006)': [2475, 2503], 'Functional': [2476], 'KCNQ4': [2479], 'KCNE-ß-': [2481], 'Oocytes,': [2485], '10.1159/000095158,': [2490], '18:1-3,': [2491], '(57-66),': [2492], 'Lundquist': [2494], 'Turner': [2496], 'Ballester': [2498], 'L': [2499], 'Expression': [2504, 2761, 3010], 'transcriptional': [2506], 'control': [2507], 'human': [2509], 'Genomics,': [2512], '10.1016/j.ygeno.2005.09.004,': [2513], '87:1,': [2514], '(119-128),': [2515], '1-Jan-2006.': [2519], 'Yu': [2520, 2652], 'Yarov-Yarovoy': [2522], 'V,': [2523, 3034], 'Gutman': [2524], 'Catterall': [2527, 2655], 'W': [2528, 2616, 2656], '(2005)': [2529, 2554, 2588, 2617], 'Overview': [2530], 'Relationships': [2533, 2959], 'Ion': [2537], 'Superfamily,': [2539], 'Reviews,': [2541, 2561, 2627], '10.1124/pr.57.4.13,': [2542], '57:4,': [2543], '(387-395),': [2544], '1-Dec-2005.': [2548], 'Nerbonne': [2549], 'Repolarization,': [2559], 'Physiological': [2560, 2626], '10.1152/physrev.00002.2005,': [2562], '85:4,': [2563], '(1205-1253),': [2564], '1-Oct-2005.': [2568], 'Berecki': [2569], 'Zegers': [2571], 'Verkerk': [2573], 'Bhuiyan': [2575], 'Z,': [2576, 2782, 2989], 'de': [2577], 'Jonge': [2578], 'Veldkamp': [2580], 'Wilders': [2582], 'van': [2585], 'Ginneken': [2586], '(Dys)function': [2591], 'Revealed': [2592], 'Dynamic': [2594], 'Action': [2595], 'Potential': [2596], 'Clamp': [2597], 'Technique,': [2598], '10.1529/biophysj.104.047290,': [2601], '88:1,': [2602], '(566-578),': [2603], '1-Jan-2005.': [2607, 2634], 'Hebert': [2608], 'Desir': [2610, 3074], 'Giebisch': [2612], 'Diversity': [2619], 'Regulation': [2621, 3077], 'Renal': [2623], '10.1152/physrev.00051.2003,': [2628], '85:1,': [2629], '(319-371),': [2630], 'McCrossan': [2635, 2721, 2781, 2988], 'Z': [2636, 2722], '(2004)': [2640, 2657, 2690, 2726], 'peptides,': [2643], 'Neuropharmacology,': [2644], '10.1016/j.neuropharm.2004.06.018,': [2645], '47:6,': [2646], '(787-821),': [2647], '1-Nov-2004.': [2651], 'VGL-Chanome:': [2659], 'Superfamily': [2662], 'Specialized': [2663], 'Electrical': [2665], 'Signaling': [2666], 'Ionic': [2668], 'Homeostasis,': [2669], "Science's": [2670], 'STKE,': [2671], '10.1126/stke.2532004re15,': [2672], '2004:253,': [2673], '5-Oct-2004.': [2677], 'Strop': [2678], 'Bankovich': [2680], 'Hansen': [2682], 'Christopher': [2684], 'Garcia': [2685], 'K': [2686, 2835, 2871, 2955, 3081], 'Brunger': [2688], 'Structure': [2691], 'Interacting': [2698], 'DPPX,': [2700], 'Member': [2702], 'Dipeptidyl': [2705], 'Aminopeptidase': [2706], 'Family,': [2707], 'Biology,': [2711, 2773], '10.1016/j.jmb.2004.09.003,': [2712], '343:4,': [2713], '(1055-1065),': [2714], '1-Oct-2004.': [2718], 'Lewis': [2719, 2783, 2982], 'MinK,': [2727], 'MiRP1,': [2728], 'Diversify': [2731], 'Kv3.1': [2732, 2803], 'Kv3.2': [2734], 'Gating,': [2737], 'Biological': [2740, 3014], 'Chemistry,': [2741, 3015], '10.1074/jbc.M310501200,': [2742], '279:9,': [2743], '(7884-7892),': [2744], '1-Feb-2004.': [2748], 'Misonou': [2749], 'H': [2750], 'Trimmer': [2752], 'Determinants': [2755], 'Surface': [2760], 'Localization': [2763], 'Mammalian': [2765, 2807, 3004], 'Neurons,': [2766], 'Critical': [2767], 'Reviews': [2768], 'Biochemistry': [2770], '10.1080/10409230490475417,': [2774], '39:3,': [2775], '(125-145),': [2776], '1-Jan-2004.': [2780], 'Panaghie': [2785, 2984], 'Jordan': [2787], 'Christini': [2789], 'Lerner': [2791, 2990], '(2003)': [2796, 2839, 2872, 2913, 2954, 2995, 3040], 'MinK-Related': [2797], 'Peptide': [2798], '2': [2799], 'Kv2.1': [2801], 'Brain,': [2808], '10.1523/JNEUROSCI.23-22-08077.2003,': [2813], '23:22,': [2814], '(8077-8091),': [2815], '3-Sep-2003.': [2819], 'Tosaka': [2820], 'Casimiro': [2822], 'Rong': [2824], 'Tella': [2826], 'Oh': [2828], 'Katchman': [2830], 'Pezzullo': [2832], 'Pfeifer': [2834], 'Ebert': [2837], 'Nicotine': [2840], 'Induces': [2841], 'Phenotype': [2845], 'Kcnq1-Deficient': [2847], 'Mouse': [2848], 'Hearts,': [2849], 'Experimental': [2854], 'Therapeutics,': [2855], '10.1124/jpet.103.053017,': [2856], '306:3,': [2857], '(980-987),': [2858], '1-Sep-2003.': [2862, 2903], 'Decher': [2863], 'Bundis': [2865], 'Vajna': [2867], 'Steinmeyer': [2870], 'amplitudes': [2876], 'activation': [2878, 3046], 'HCN4:': [2881], 'members': [2886], 'HCN4': [2888], 'currents,': [2889], 'Pflügers': [2890], 'Archiv': [2891], '-': [2892], 'European': [2893], '10.1007/s00424-003-1127-7,': [2897], '446:6,': [2898], '(633-640),': [2899], 'Lu': [2904], 'Mahaut-Smith': [2906], 'Vandenberg': [2911], 'Mutant': [2914], 'modulate': [2917], 'gating:': [2921], 'mechanism': [2923, 3126], 'pro-arrhythmia': [2925], 'syndrome': [2929], '6,': [2931], '10.1111/j.1469-7793.2003.00253.x,': [2936], '551:1,': [2937], '(253-262),': [2938], '1-Aug-2003.': [2942], 'Clancy': [2943], 'Kurokawa': [2945], 'Tateyama': [2947], 'Wehrens': [2949], 'X': [2950], '+': [2956, 3082], 'Structure-Activity': [2958], 'Mechanisms': [2961], 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