Title: Surfactant protein-D and polymorphonuclear leukocyte elastase concen- trations in patients with septic acute respiratory distress syndrome
Abstract: Purpose: Inhibition of surfactant activities by the protein in pulmonary edematous fluid plays a role in the occurrence of respiratory failure in acute respiratory distress syndrome (ARDS). Polymorphonuclear (PMN) elastase may be involved in surfactant-mediated damage. Accordingly, the concentrations of surfactant protein-D (SP-D) and PMN elastase were determined in patients with sepsis, and the associations of these two factors with the occurrence of ARDS and prognosis were examined. Methods: Blood samples from 33 patients with sepsis and with or without ARDS were assayed. The SP-D and PMN elastase levels were determined using an enzyme-linked immunosorbent assay. Results: SP-D levels in groups with and without ARDS were 493.9 ± 373.3 ng/ml and 91.8 ± 30.1 ng/ml, respectively. The level in the ARDS group was significantly higher than that in the group with
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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