Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2108814436', 'doi': 'https://doi.org/10.1161/strokeaha.114.008071', 'title': 'Letter by Gauberti and Vivien Regarding Article, “Amplification of Regulatory T Cells Using a CD28 Superagonist Reduces Brain Damage After Ischemic Stroke in Mice”', 'display_name': 'Letter by Gauberti and Vivien Regarding Article, “Amplification of Regulatory T Cells Using a CD28 Superagonist Reduces Brain Damage After Ischemic Stroke in Mice”', 'publication_year': 2015, 'publication_date': '2015-01-14', 'ids': {'openalex': 'https://openalex.org/W2108814436', 'doi': 'https://doi.org/10.1161/strokeaha.114.008071', 'mag': '2108814436', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25586834'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/strokeaha.114.008071', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.114.008071', 'source': {'id': 'https://openalex.org/S62532593', 'display_name': 'Stroke', 'issn_l': '0039-2499', 'issn': ['0039-2499', '1524-4628'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.114.008071', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023396427', 'display_name': 'Maxime Gauberti', 'orcid': 'https://orcid.org/0000-0003-0752-7342'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210154143', 'display_name': 'Cyceron', 'ror': 'https://ror.org/04zeq1c51', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210154143']}, {'id': 'https://openalex.org/I4210155656', 'display_name': 'Serine Proteases and Pathophysiology of the neurovascular Unit', 'ror': 'https://ror.org/04bky6g25', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210093160', 'https://openalex.org/I4210105918', 'https://openalex.org/I4210155656', 'https://openalex.org/I98702875']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Maxime Gauberti', 'raw_affiliation_strings': ['INSERM, INSERM UMR-S U919, Serine Proteases and Pathophysiology of the Neurovascular Unit, GIP Cyceron, University Caen Lower-Normandy, Bd Henri Becquerel, Caen, France'], 'affiliations': [{'raw_affiliation_string': 'INSERM, INSERM UMR-S U919, Serine Proteases and Pathophysiology of the Neurovascular Unit, GIP Cyceron, University Caen Lower-Normandy, Bd Henri Becquerel, Caen, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I4210154143', 'https://openalex.org/I4210155656']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5004749164', 'display_name': 'Denis Vivien', 'orcid': 'https://orcid.org/0000-0002-7636-2185'}, 'institutions': [{'id': 'https://openalex.org/I4210155656', 'display_name': 'Serine Proteases and Pathophysiology of the neurovascular Unit', 'ror': 'https://ror.org/04bky6g25', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210093160', 'https://openalex.org/I4210105918', 'https://openalex.org/I4210155656', 'https://openalex.org/I98702875']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210154143', 'display_name': 'Cyceron', 'ror': 'https://ror.org/04zeq1c51', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210154143']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Denis Vivien', 'raw_affiliation_strings': ['INSERM, INSERM UMR-S U919, Serine Proteases and Pathophysiology of the Neurovascular Unit, GIP Cyceron, University Caen Lower-Normandy, Bd Henri Becquerel, Caen, France'], 'affiliations': [{'raw_affiliation_string': 'INSERM, INSERM UMR-S U919, Serine Proteases and Pathophysiology of the Neurovascular Unit, GIP Cyceron, University Caen Lower-Normandy, Bd Henri Becquerel, Caen, France', 'institution_ids': ['https://openalex.org/I4210155656', 'https://openalex.org/I154526488', 'https://openalex.org/I4210154143']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.623762, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '46', 'issue': '2', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11266', 'display_name': 'Role of Microglia in Neurological Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11266', 'display_name': 'Role of Microglia in Neurological Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11872', 'display_name': 'Blood-Brain Barrier and Neurovascular Interactions', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11313', 'display_name': 'Macrophage Activation and Polarization', 'score': 0.9835, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/stroke', 'display_name': 'Stroke (engine)', 'score': 0.6286245}, {'id': 'https://openalex.org/keywords/neurodegeneration', 'display_name': 'Neurodegeneration', 'score': 0.473}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.89941037}, {'id': 'https://openalex.org/C2780645631', 'wikidata': 'https://www.wikidata.org/wiki/Q671554', 'display_name': 'Stroke (engine)', 'level': 2, 'score': 0.6286245}, {'id': 'https://openalex.org/C3020199598', 'wikidata': 'https://www.wikidata.org/wiki/Q12202', 'display_name': 'Ischemic stroke', 'level': 3, 'score': 0.52058846}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.4264093}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2410793}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.231783}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': True}, {'descriptor_ui': 'D020244', 'descriptor_name': 'Infarction, Middle Cerebral Artery', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020244', 'descriptor_name': 'Infarction, Middle Cerebral Artery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/strokeaha.114.008071', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.114.008071', 'source': {'id': 'https://openalex.org/S62532593', 'display_name': 'Stroke', 'issn_l': '0039-2499', 'issn': ['0039-2499', '1524-4628'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25586834', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/strokeaha.114.008071', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.114.008071', 'source': {'id': 'https://openalex.org/S62532593', 'display_name': 'Stroke', 'issn_l': '0039-2499', 'issn': ['0039-2499', '1524-4628'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 5, 'referenced_works': ['https://openalex.org/W2005839818', 'https://openalex.org/W2016092429', 'https://openalex.org/W2069791066', 'https://openalex.org/W2078428577', 'https://openalex.org/W2110895095'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2586801360', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'HomeStrokeVol.': [0], '46,': [1, 1408], 'No.': [2], '2Letter': [3], 'by': [4, 42, 154, 199, 318, 555, 654, 671, 1384], 'Gauberti': [5, 43, 74, 1073, 1320], 'and': [6, 44, 68, 81, 97, 107, 171, 249, 450, 490, 698, 793, 894, 927, 946, 983, 1054, 1092, 1177, 1183, 1205, 1213, 1233, 1271, 1287, 1298, 1325, 1366, 1375, 1386], 'Vivien': [7, 45, 100, 1081, 1231, 1326], 'Regarding': [8, 46], 'Article,': [9, 47], '"Amplification': [10, 48], 'of': [11, 49, 83, 109, 129, 138, 161, 194, 206, 214, 269, 300, 329, 335, 356, 365, 375, 379, 392, 401, 419, 424, 433, 482, 521, 530, 535, 628, 687, 741, 767, 785, 797, 803, 823, 916, 929, 1010, 1048, 1061, 1084, 1117, 1185, 1218, 1303, 1363, 1392, 1396], 'Regulatory': [12, 50, 1354], 'T': [13, 51, 1012, 1050, 1187, 1204, 1304, 1355], 'Cells': [14, 52, 1356], 'Using': [15, 53], 'a': [16, 54, 207, 258, 266, 344, 505, 771, 827, 914, 958, 1015], 'CD28': [17, 55, 1016], 'Superagonist': [18, 56], 'Reduces': [19, 57], 'Brain': [20, 58, 1359, 1364], 'Damage': [21, 59, 1365], 'After': [22, 60, 1368], 'Ischemic': [23, 61, 696, 1358], 'Stroke': [24, 62, 210, 959, 1342], 'in': [25, 63, 168, 178, 209, 216, 228, 275, 305, 343, 389, 398, 421, 430, 455, 473, 496, 504, 508, 515, 546, 566, 577, 598, 602, 622, 634, 673, 692, 708, 718, 737, 765, 805, 811, 844, 858, 912, 1024, 1090, 1125, 1151, 1189, 1211, 1247, 1311, 1332, 1357, 1389], 'Mice"': [26, 64], 'Free': [27], 'AccessLetterPDF/EPUBAboutView': [28], 'PDFView': [29], 'EPUBSections': [30], 'ToolsAdd': [31], 'to': [32, 223, 261, 416, 479, 550, 705, 777, 863, 902, 943, 1164, 1243, 1338], 'favoritesDownload': [33], 'citationsTrack': [34], 'citationsPermissions': [35], 'ShareShare': [36], 'onFacebookTwitterLinked': [37], 'InMendeleyReddit': [38], 'Jump': [39], 'toFree': [40], 'AccessLetterPDF/EPUBLetter': [41], 'Maxime': [65, 72], 'Gauberti,': [66, 919], 'PhD': [67, 71], 'Denis': [69, 98], 'Vivien,': [70, 921], 'GaubertiMaxime': [73], 'INSERM,': [75, 101], 'INSERM': [76, 102, 923], 'UMR-S': [77, 103, 924], 'U919,': [78, 104], 'Serine': [79, 105], 'Proteases': [80, 106, 926], 'Pathophysiology': [82, 108, 928], 'the': [84, 110, 134, 150, 185, 212, 235, 239, 280, 291, 301, 324, 333, 338, 354, 357, 366, 390, 399, 417, 422, 431, 474, 480, 499, 509, 522, 559, 609, 626, 684, 729, 738, 786, 801, 841, 859, 930, 944, 967, 1058, 1281, 1390], 'Neurovascular': [85, 111, 931], 'Unit,': [86, 112, 932], 'GIP': [87, 113, 933], 'Cyceron,': [88, 114], 'University': [89, 115], 'Caen': [90, 116, 935], 'Lower-Normandy,': [91, 117], 'Bd': [92, 118], 'Henri': [93, 119, 937], 'Becquerel,': [94, 120, 938], 'Caen,': [95, 121, 939], 'France': [96, 122], 'VivienDenis': [99], 'Originally': [123, 1421], 'published13': [124], 'Jan': [125], '2015https://doi.org/10.1161/STROKEAHA.114.008071Stroke.': [126], '2015;46:e50–e51Other': [127], 'version(s)': [128], 'this': [130, 139, 225, 536], 'articleYou': [131], 'are': [132, 272, 313, 458, 563, 590, 596, 748, 881], 'viewing': [133], 'most': [135, 348, 413], 'recent': [136, 152], 'version': [137], 'article.': [140], 'Previous': [141, 146, 1162], 'versions:': [142], 'January': [143], '1,': [144], '2015:': [145], 'Version': [147], '1': [148, 189], 'To': [149], 'Editor:The': [151], 'article': [153, 961, 964], 'Na': [155, 402, 434, 999], 'et': [156, 182, 394, 403, 426, 435, 1043, 1114, 1145], 'al1': [157], 'shows': [158], 'that': [159, 234, 464, 595, 906, 910], 'amplification': [160, 193, 825], 'regulatory': [162, 1011, 1049, 1186], 'T-cell': [163], '(Treg)': [164], 'improves': [165], 'stroke': [166, 197, 454, 753, 807, 815, 876, 1023, 1089, 1215], 'outcome': [167, 198], 'both': [169], 'permanent': [170, 306, 571], 'transient': [172, 322, 783], 'mechanical': [173], 'vascular': [174], 'occlusion': [175, 368, 383, 575], '(TMVO)': [176], 'models': [177, 307, 517, 548, 808, 867, 880], 'mice.': [179], 'Surprisingly,': [180], 'Schuhmann': [181, 393, 425, 1031], 'al2': [183, 395, 427], 'published': [184], 'exact': [186], 'opposite': [187], 'finding': [188], 'month': [190], 'before,': [191], 'ie,': [192], 'Treg': [195, 215, 243, 312, 330, 824], 'worsens': [196, 503], 'increasing': [200], 'thromboinflammation.': [201, 336, 778], 'One': [202], 'year': [203], 'after': [204, 359, 384, 453, 465, 527, 540, 619, 643, 789, 1021, 1087, 1307], 'publication': [205, 1198, 1224, 1254, 1293, 1317, 1348, 1403], 'controversy': [208], 'on': [211, 242, 290, 332, 350, 1381], 'role': [213, 328], 'acute': [217, 276, 1059, 1126], 'ischemic': [218, 277, 523, 541, 552, 668, 875, 1022, 1055, 1149, 1190, 1333], 'stroke,': [219, 888, 1191, 1308], 'we': [220, 832], 'thought': [221, 233], 'how': [222], 'explain': [224], 'persisting': [226], 'discrepancy': [227], 'preclinical': [229, 821], 'research': [230], 'results?': [231], 'We': [232], 'basis': [236], 'for': [237, 679, 819, 1239], 'all': [238, 635], 'paradoxical': [240], 'results': [241], 'has': [244, 681], 'not': [245, 257, 342, 397, 429, 564, 601, 616, 632, 734], 'been': [246, 703], 'correctly': [247], 'identified': [248], 'can': [250], 'be': [251, 706, 817, 834, 869, 896, 993], 'resumed': [252], 'as': [253, 315, 363, 388, 570, 652, 826, 873, 952], 'follows:': [254], 'thromboinflammation': [255, 339, 420, 449, 461, 610, 804], 'is': [256, 439, 444, 583, 631, 641, 646, 723, 770, 901, 974], 'universal': [259], 'response': [260], 'cerebral': [262, 492, 500, 573, 730], 'ischemia-reperfusion,': [263], 'but,': [264, 409], 'rather,': [265], 'specific': [267, 792], 'feature': [268, 796], 'TMVO': [270, 345, 497, 516, 547, 599, 675, 719, 798, 866], 'models.Treg': [271], 'double-edged': [273], 'sword': [274], 'stroke.': [278, 744], 'On': [279], 'one': [281], 'hand,': [282], 'they': [283, 293, 607], 'protect': [284], 'neurons': [285], 'from': [286, 683, 750, 756, 847, 1241], 'inflammation-related': [287], 'death': [288], 'and,': [289, 809], 'other,': [292], 'promote': [294], 'secondary': [295, 310, 451, 531, 585, 613, 629, 665, 735, 1085, 1148], 'microthrombosis': [296, 452, 614, 630, 1086], '(the': [297], 'final': [298], 'step': [299], 'thromboinflammatory': [302, 842], 'reaction).': [303], 'Therefore,': [304], '(eg,': [308], 'without': [309], 'microthrombosis),': [311], 'protective,': [314], 'consistently': [316, 702], 'shown': [317], 'several': [319], 'studies.': [320], 'In': [321, 513, 587, 712], 'models,': [323, 498, 568, 604, 676, 720], 'beneficial': [325], 'or': [326, 341, 576, 727, 962, 995], 'deleterious': [327], 'depends': [331, 347], 'occurrence': [334, 418], 'Whether': [337], 'occurs': [340, 526], 'model': [346], 'probably': [349, 459, 605, 794, 856], 'laboratory-specific': [351], 'methods': [352], 'influencing': [353], 'severity': [355], 'ischemia': [358, 620], 'filament': [360, 376, 385], 'insertion,': [361], 'such': [362, 569], 'size': [364, 554, 670], 'embolus,': [367], 'time': [369], '(30': [370], 'versus': [371], '60': [372], 'minutes),': [373], 'speed': [374], 'retrieval,': [377], 'persistence': [378], 'common': [380], 'carotid': [381], 'artery': [382, 574], 'removal': [386], '(such': [387], 'study': [391, 400, 423, 432], 'but': [396, 428, 600], 'al1),': [404], 'etc.': [405], 'These': [406], 'apparently': [407], 'small': [408], 'however,': [410], 'important': [411], 'differences': [412, 1276], 'likely': [414], 'led': [415], 'al1.': [436], 'Then,': [437], 'who': [438, 443, 754], 'right?': [440], 'More': [441], 'precisely,': [442], 'clinically': [445], 'relevant?': [446], 'Is': [447], 'there': [448, 582, 589, 645, 769], 'humans?': [456], 'Both': [457], 'right.The': [460], 'concept': [462], 'suggests': [463], 'arterial': [466, 511], 'recanalization,': [467], 'an': [468, 963], 'inflammatory': [469], 'reaction': [470, 843], 'takes': [471], 'place': [472], 'reperfused': [475], 'brain,': [476], 'ultimately': [477], 'leading': [478], 'reocclusion': [481], 'distal': [483], 'vessels': [484], '(secondary': [485], 'microthrombosis).': [486], 'Hence,': [487], 'despite': [488], 'recanalization': [489, 528, 640], 'early': [491], 'blood': [493, 501, 731], 'flow': [494, 502, 732], 'improvement': [495], 'delayed': [506, 772], 'manner': [507], 'affected': [510], 'territory.': [512], 'fact,': [514, 588, 713], 'with': [518, 743, 752, 814, 840, 871], 'thromboinflammation,': [519], '80%': [520], 'lesion': [524, 553, 650, 669, 1123], 'growth': [525, 651], 'because': [529, 581, 606, 852], 'microthrombosis.': [532], 'Thus,': [533], 'blockade': [534], 'phenomenon': [537], '≤3': [538], 'hours': [539], 'onset': [542], 'using': [543, 1014], 'different': [544], 'strategies': [545, 562], 'allows': [549], 'reduce': [551], '≈80%.': [556], 'Of': [557], 'note,': [558], 'same': [560], 'neuroprotective': [561, 593], 'efficient': [565, 597], 'non-TMVO': [567, 806], 'middle': [572], 'situ': [578], 'thrombin-induced': [579, 886, 1088], 'ischemia-reperfusion': [580], 'no': [584, 648, 677, 978], 'microthrombosis.3': [586], 'many': [591, 812], 'putative': [592], 'drugs': [594], 'other': [603], 'target': [608, 907], 'pathway.': [611], 'Notably,': [612], 'does': [615, 733], 'occur': [617], 'either': [618, 725], 'reperfusion': [621, 722, 849], 'nonhuman': [623], 'primates.3In': [624], 'humans,': [625], 'presence': [627], 'observed': [633], 'patients.': [636], 'For': [637], 'instance,': [638], 'when': [639], 'complete': [642], 'fibrinolysis,': [644], 'almost': [647], 'further': [649, 820], 'assessed': [653], 'longitudinal': [655, 760], 'MRI.4': [656], 'Moreover,': [657, 779, 862], 'whereas': [658], 'argatroban': [659, 688], '(a': [660], 'direct': [661], 'thrombin': [662], 'inhibitor': [663], 'blocking': [664], 'microthrombosis)': [666], 'reduces': [667, 1018], '≈70%': [672], 'rodent': [674], 'evidence': [678], 'efficacy': [680], 'come': [682], 'randomized': [685], 'trial': [686], 'ARGIS': [689], '(Argatroban': [690], 'Anticoagulation': [691], 'Patients': [693], 'With': [694], 'Acute': [695], 'Stroke)-1': [697], 'anticoagulation': [699], 'therapies': [700], 'have': [701], 'found': [704, 717], 'ineffective': [707], 'multiple': [709], 'clinical': [710, 1336], 'trials.': [711], 'unlike': [714], 'what': [715], 'was': [716], 'once': [721], 'achieved': [724], 'spontaneously': [726], 'pharmacologically,': [728], 'worsen': [736], 'vast': [739], 'majority': [740], 'patients': [742, 751, 781, 813, 845, 1152], 'However,': [745], 'intriguing': [746], 'data': [747, 762, 1337], 'available': [749, 883], 'benefit': [755], 'endovascular': [757, 848], 'reperfusion.': [758], 'Indeed,': [759], 'MRI': [761], 'showed': [763], 'that,': [764], '18%': [766], 'them,': [768, 949], 'infarction,5': [773], 'which': [774], 'may': [775, 992], 'correspond': [776], 'these': [780], 'present': [782], 'reversal': [784], 'cytotoxic': [787], 'edema': [788], 'reperfusion,': [790], 'another': [791], 'thromboinflammation-related': [795], 'models.To': [799], 'conclude,': [800], 'absence': [802], 'probably,': [810], 'should': [816, 833, 868, 895], 'reinsuring': [818], 'development': [822], 'potential': [828], 'therapeutic': [829], 'strategy.': [830], 'Nevertheless,': [831], 'particularly': [835], 'cautious': [836], 'about': [837], 'treatments': [838, 1238], 'interfering': [839], 'benefiting': [846], 'procedures,': [850], 'especially': [851], 'their': [853], 'number': [854], 'will': [855, 947], 'grow': [857], 'next': [860], 'future.': [861], 'our': [864], 'opinion,': [865], 'used': [870], 'caution': [872], 'generic': [874], 'models.': [877], 'Several': [878], 'alternative': [879], 'now': [882], '(permanent': [884], 'ischemia,': [885], 'thromboembolic': [887], 'autologous': [889], 'clot,': [890], 'ferric-chloride–induced': [891], 'thrombosis,': [892], 'etc)': [893], 'considered.': [897], 'The': [898, 971, 1329], 'underlying': [899], 'risk': [900], 'develop': [903], 'general': [904], 'therapeutics': [905], 'pathophysiological': [908], 'mechanisms': [909, 1184], 'exist': [911], 'only': [913], 'subgroup': [915], 'human': [917, 1214], 'strokes.Maxime': [918], 'PhDDenis': [920], 'PhDINSERM,': [922], 'U919Serine': [925], 'CyceronUniversity': [934], 'Lower-NormandyBd': [936], 'FranceDisclosuresNone.FootnotesStroke': [940], 'welcomes': [941], 'Letters': [942, 955, 991], 'Editor': [945], 'publish': [948], 'if': [950], 'suitable,': [951], 'space': [953], 'permits.': [954], 'must': [956], 'reference': [957], 'published-ahead-of-print': [960], 'printed': [965], 'within': [966], 'past': [968], '3': [969, 984], 'weeks.': [970], 'maximum': [972], 'length': [973], '750': [975], 'words': [976], 'including': [977], 'more': [979], 'than': [980], '5': [981], 'references': [982], 'authors.': [985], 'Please': [986], 'submit': [987], 'letters': [988], 'typed': [989], 'double-spaced.': [990], 'shortened': [994], 'edited.': [996], 'References': [997], '1.': [998], 'S-Y,': [1000], 'Mracsko': [1001], 'E,': [1002], 'Liesz': [1003, 1272, 1351], 'A,': [1004, 1105, 1228], 'Hünig': [1005], 'T,': [1006], 'Veltkamp': [1007, 1299], 'R.': [1008], 'Amplification': [1009], 'cells': [1013, 1051], 'superagonist': [1017], 'brain': [1019], 'damage': [1020], 'mice.Stroke.': [1025], '2015;': [1026, 1068], '46:212–220.': [1027], 'doi:': [1028, 1070, 1099, 1130, 1159], '10.1161/STROKEAHA.114.007756.Google': [1029], 'Scholar2.': [1030], 'MK,': [1032], 'Kraft': [1033], 'P,': [1034, 1144], 'Stoll': [1035], 'G,': [1036, 1140], 'Lorenz': [1037], 'K,': [1038], 'Meuth': [1039], 'SG,': [1040], 'Wiendl': [1041], 'H,': [1042], 'al.': [1044, 1115, 1146], 'Cd28': [1045], 'superagonist-mediated': [1046], 'boost': [1047], 'increases': [1052], 'thrombo-inflammation': [1053], 'neurodegeneration': [1056], 'during': [1057], 'phase': [1060], 'experimental': [1062, 1212, 1339], 'stroke.J': [1063], 'Cereb': [1064], 'Blood': [1065], 'Flow': [1066], 'Metab.': [1067], '35:6–10.': [1069], '10.1038/jcbfm.2014.175.Google': [1071], 'Scholar3.': [1072], 'M,': [1074, 1109, 1113, 1321], 'Martinez': [1075], 'de': [1076], 'Lizarrondo': [1077, 1323], 'S,': [1078, 1138], 'Orset': [1079], 'C,': [1080, 1262], 'D.': [1082], 'Lack': [1083], 'mice': [1091], 'non-human': [1093], 'primates.J': [1094], 'Thromb': [1095], 'Haemost.': [1096], '2014;': [1097], '12:409–414.': [1098], '10.1111/jth.12487.CrossrefMedlineGoogle': [1100], 'Scholar4.': [1101], 'Delgado-Mederos': [1102], 'R,': [1103, 1142, 1258], 'Rovira': [1104], 'Alvarez-Sabín': [1106], 'J,': [1107, 1111, 1172, 1174], 'Ribó': [1108], 'Munuera': [1110], 'Rubiera': [1112], 'Speed': [1116], 'tPA-induced': [1118], 'clot': [1119], 'lysis': [1120], 'predicts': [1121], 'DWI': [1122], 'evolution': [1124], 'stroke.Stroke.': [1127], '2007;': [1128], '38:955–960.': [1129], '10.1161/01.STR.0000257977.32525.6e.LinkGoogle': [1131], 'Scholar5.': [1132], 'Kidwell': [1133], 'CS,': [1134], 'Saver': [1135], 'JL,': [1136], 'Starkman': [1137], 'Duckwiler': [1139], 'Jahan': [1141], 'Vespa': [1143], 'Late': [1147], 'injury': [1150], 'receiving': [1153], 'intraarterial': [1154], 'thrombolysis.Ann': [1155], 'Neurol.': [1156], '2002;': [1157], '52:698–703.': [1158], '10.1002/ana.10380.CrossrefMedlineGoogle': [1160], 'Scholar': [1161], 'Back': [1163], 'top': [1165], 'Next': [1166], 'FiguresReferencesRelatedDetailsCited': [1167], 'By': [1168], 'Wu': [1169], 'Y,': [1170], 'Li': [1171], 'Shou': [1173], 'Zhang': [1175], 'W': [1176], 'Chen': [1178], 'C': [1179], '(2021)': [1180], 'Diverse': [1181], 'functions': [1182], 'cell': [1188, 1305], 'Experimental': [1192], 'Neurology,': [1193], '10.1016/j.expneurol.2021.113782,': [1194], '343,': [1195], '(113782),': [1196], 'Online': [1197, 1223, 1253, 1292, 1316, 1347, 1402], 'date:': [1199, 1225, 1255, 1294, 1318, 1349, 1404], '1-Sep-2021.': [1200], 'Wimmer': [1201], 'I,': [1202], 'Zrzavy': [1203], 'Lassmann': [1206], 'H': [1207, 1374], '(2018)': [1208, 1236], 'Neuroinflammatory': [1209], 'responses': [1210, 1306], 'lesions,': [1216], 'Journal': [1217, 1395], 'Neuroimmunology,': [1219], '10.1016/j.jneuroim.2018.07.003,': [1220], '323,': [1221], '(10-18),': [1222], '1-Oct-2018.': [1226], 'Drieu': [1227], 'Levard': [1229], 'D,': [1230, 1264, 1266], 'D': [1232, 1297, 1327], 'Rubio': [1234], 'M': [1235], 'Anti-inflammatory': [1237], 'stroke:': [1240, 1334], 'bench': [1242], 'bedside,': [1244], 'Therapeutic': [1245], 'Advances': [1246], 'Neurological': [1248], 'Disorders,': [1249, 1394], '10.1177/1756286418789854,': [1250], '11,': [1251], '(175628641878985),': [1252], '1-Jan-2018.': [1256], 'Sadler': [1257], 'Singh': [1259], 'V,': [1260], 'Benakis': [1261], 'Garzetti': [1263], 'Brea': [1265], 'Stecher': [1267], 'B,': [1268], 'Anrather': [1269], 'J': [1270], 'A': [1273, 1352, 1379], '(2017)': [1274], 'Microbiota': [1275], 'between': [1277], 'commercial': [1278], 'breeders': [1279], 'impacts': [1280], 'post-stroke': [1282], 'immune': [1283], 'response,': [1284], 'Brain,': [1285], 'Behavior,': [1286], 'Immunity,': [1288], '10.1016/j.bbi.2017.03.011,': [1289], '66,': [1290], '(23-30),': [1291], '1-Nov-2017.': [1295], 'Gill': [1296], 'R': [1300, 1377], '(2016)': [1301, 1328, 1353], 'Dynamics': [1302], 'Current': [1309], 'Opinion': [1310], 'Pharmacology,': [1312, 1398], '10.1016/j.coph.2015.09.009,': [1313], '26,': [1314], '(26-32),': [1315], '1-Feb-2016.': [1319], 'De': [1322], 'S': [1324], '"inflammatory': [1330], 'penumbra"': [1331], 'From': [1335], 'evidence,': [1340], 'European': [1341], 'Journal,': [1343], '10.1177/2396987316630249,': [1344], '1:1,': [1345], '(20-27),': [1346], '1-Mar-2016.': [1350], 'Injury': [1360], 'Non-Neuronal': [1361], 'Mechanisms': [1362], 'Repair': [1367], 'Stroke,': [1369], '10.1007/978-3-319-32337-4_11,': [1370], '(201-215),': [1371], '.': [1372], 'Gendelman': [1373], 'Mosley': [1376], '(2015)': [1378], 'Perspective': [1380], 'Roles': [1382], 'Played': [1383], 'Innate': [1385], 'Adaptive': [1387], 'Immunity': [1388], 'Pathobiology': [1391], 'Neurodegenerative': [1393], 'Neuroimmune': [1397], '10.1007/s11481-015-9639-4,': [1399], '10:4,': [1400], '(645-650),': [1401], '1-Dec-2015.': [1405], 'February': [1406], '2015Vol': [1407], 'Issue': [1409], '2': [1410], 'Advertisement': [1411, 1427], 'Article': [1412], 'InformationMetrics': [1413], '©': [1414], '2015': [1415, 1424], 'American': [1416], 'Heart': [1417], 'Association,': [1418], 'Inc.https://doi.org/10.1161/STROKEAHA.114.008071PMID:': [1419], '25586834': [1420], 'publishedJanuary': [1422], '13,': [1423], 'PDF': [1425], 'download': [1426], 'SubjectsIschemic': [1428], 'StrokeThrombosisTreatment': [1429]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2108814436', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-25T06:10:40.642703', 'created_date': '2016-06-24'}