Title: Tazarotene plus UVB phototherapy in the treatment of psoriasis
Abstract: <h2>Abstract</h2> <b>Background:</b> The addition of oral retinoids to phototherapy may accelerate and enhance antipsoriatic efficacy, but can result in systemic adverse events and additional laboratory monitoring costs. <b>Objective:</b> Our purpose was to determine whether the topical addition of tazarotene to UVB phototherapy improves efficacy without problems related to photosensitivity. <b>Methods:</b> Bilateral target plaques were randomized to receive two of the following, one on each plaque once daily for 14 days: tazarotene 0.1% gel, vehicle gel, or no treatment. Thereafter, the same treatments were continued 3 times per week, plus UVB phototherapy 3 times per week, for an additional 67 days. <b>Results:</b> Tazarotene plus UVB phototherapy achieved faster and significantly greater reductions in plaque elevation and scaling throughout treatment and achieved at least 50% improvement from the pretreatment baseline with a significantly lower median cumulative UVB exposure than vehicle gel plus UVB light or UVB phototherapy alone. No case of unusual photosensitivity was noted in the tazarotene plus UVB treatment group. <b>Conclusion:</b> The addition of tazarotene to UVB phototherapy improves and accelerates efficacy and maintains acceptable safety and tolerability. (J Am Acad Dermatol 2000;43:821-8.)
Publication Year: 2000
Publication Date: 2000-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 97
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