Cu(ii)-catalyzed C–H (SP3) oxidation and C–N cleavage: base-switched methylenation and formylation using tetramethylethylenediamine as a carbon source

Name: Work Video:
Duration: 3 min 30 s
Description: Base-switched methylenation and formylation using tetramethylethylenediamine (TMEDA) as a carbon source have been achieved under mild conditions, catalyzed by CuCl2, with atmospheric oxygen as oxidant. Bisindolylmethanes, diphenylmethanes and 3-formylindoles were synthesized with excellent regioselectivity and good yield.
Lei Zhang; Peng Chen; Dan Zhao; Yue Wang; Hai‐Jian Fu; Qi Shen; Jian‐Xin Li
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